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公开(公告)号：US5079161A
公开(公告)日：1992-01-07
申请号：US370028
申请日：1989-06-22
IPC分类号： C12M3/02
CPC分类号： C12M27/02 , C12M25/16 , C12M27/22 , Y10S435/819
摘要： Cell cultivation is carried out by proliferating cells in a small preliminary culture tank containing immobilizing carriers, stripping proliferated cells from the carriers, forming a cell suspension of the stripped cells in culture medium in an intermediate reservoir, intermittently transferring the suspension into a main culture tank containing ceramic immobilizing carriers and further culturing the cells. The main culture tank has an inversed funnel-shaped inlet above the carriers with a perforated plate attached to the bottom of the inlet for uniform distribution of cell suspension from above the carriers, and a plate in the form of a net under the carriers on a perforated plate for uniform distribution of cell suspension from beneath the carriers. The main tank additionally has a lid detachably carrying the inversed funnel-shaped inlet an intermediate drum-shaped portion from which the lid is detachable and a lower portion detachably carrying the plate in the form of a net and being detachable from the drum-shaped portion. The lower portion is held on or separated from the drum-shaped portion by means of a link mechanism and a cylinder capable of lowering the lower portion to separate it from the drum-shaped portion.
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2.发明授权Process for cultivating adhesive cells in a packed bed of solid cell matrix 失效在固体电池基体的填充床中培养粘合剂细胞的方法
公开(公告)号：US5260211A
公开(公告)日：1993-11-09
申请号：US617644
申请日：1990-11-26
摘要： A process and system for cultivating adhesive cells in a packed bed of solid cell matrix is disclosed. Adhesive cells are adhered to a solid cell matrix, preferably ceramic particles, and packed in a cell culture tank to form the packed bed. The culture medium is circulated through the packed bed in a direction. The circulating of the culture medium is then stopped and the direction of the medium being circulated is reversed. This periodic switching of the direction of the culture medium reduces channelling of the culture medium. The bottom or head of the culture tank can also contain a separator to trap any bubble existing in the culture medium or to trap any quantity of cell matrix possibly running out from the culture tank.
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3.发明授权Crushing/discharging device for materials being dried in a multistage type vacuum drying apparatus 失效在多级真空干燥装置中干燥的材料的破碎/排出装置
公开(公告)号：US4417697A
公开(公告)日：1983-11-29
申请号：US306912
申请日：1981-09-21
申请人： Yukihiro Saiki , Eitaro Kumazawa , Yozo Ishioka
发明人： Yukihiro Saiki , Eitaro Kumazawa , Yozo Ishioka
IPC分类号： A23C1/01 , B02C13/06 , B02C13/286 , B02C18/06 , B02C18/14 , B02C21/00 , F26B5/04 , F26B17/02 , F26B25/04
CPC分类号： F26B5/041 , A23C1/01 , B02C18/06 , F26B17/023 , F26B25/04
摘要： An apparatus is disclosed wherein a highly viscous, heat-sensitive material such as concentrated whole milk or concentrated fruit juice is supplied onto a plural-stage belt conveyor stretched within a vacuum chamber and is dried and solidified by means of a heating member while moving along the belt conveyor. The resulting dried material is received by a fixed cutter provided within a casing disposed at the turning point where the belt conveyor is to turn to the return stroke side. This dried material is then crushed by a crushing device equipped with said fixed cutter and a rotary cutter cooperating therewith, and the thus crushed material is let fall within the casing and discharged to the outside of the vacuum chamber by means of a discharging device equipped with a screw wing installed in the lower part of the casing.
摘要翻译： PCT No.PCT / JP81 / 00063 Sec。 371日期1981年9月21日 102（e）1981年9月21日PCT PCT Fils 3月25日PCT 公开号WO81 / 02689 日本公报1981年10月1日。公开了一种将真空室内拉伸的多级带式输送机供给高粘度的热敏感材料，例如浓缩全脂奶或浓缩果汁，并通过装置干燥固化 的加速构件沿着带式输送机移动。 所得到的干燥材料被设置在设置在带式输送机转向返回冲程侧的转向点的壳体内的固定切割器容纳。 然后将这种干燥的材料通过装备有所述固定切割器和与之配合的旋转切割器的破碎装置进行破碎，并且将这样被破碎的材料落入壳体内并且通过装备有排出装置的排出装置排出到真空室的外部 安装在壳体下部的螺钉翼。
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公开(公告)号：US07173008B2
公开(公告)日：2007-02-06
申请号：US11188091
申请日：2005-07-25
申请人： Katsumi Tanaka , Kanji Higashio , Eitaro Kumazawa
发明人： Katsumi Tanaka , Kanji Higashio , Eitaro Kumazawa
IPC分类号： A61K38/18 , C07K14/475
CPC分类号： A61K9/0019 , A61K9/19 , A61K38/1833 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/36
摘要： The invention relates to a lyophilized HGF preparation prepared by lyophilizing an aqueous solution containing HGF, and a lyophilized HGF preparation containing a stabilizer, sodium chloride, a buffer, and/or a surface active agent. According to the invention, HGF can be stabilized, and it can be stored for a long period.
摘要翻译： 本发明涉及通过将包含HGF的水溶液冻干制备的冻干HGF制剂和含有稳定剂，氯化钠，缓冲液和/或表面活性剂的冻干HGF制剂。 根据本发明，HGF可以稳定，并且可以长期储存。
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公开(公告)号：US4294018A
公开(公告)日：1981-10-13
申请号：US138812
申请日：1980-04-09
申请人： Eitaro Kumazawa , Yukihiro Saiki , Yozo Ishioka
发明人： Eitaro Kumazawa , Yukihiro Saiki , Yozo Ishioka
摘要： A material feed pipe for use in a belt-system continuous vacuum drier and oriented above a belt moving within a vacuum drying chamber. The feed pipe includes an inner tube having its one end provided with an inlet for material and the other end being closed. An outer tube has its two ends closed and encircling said inner tube with a radial space therebetween. A plurality of nozzle openings are provided in an upper part of the inner tube at a fixed pitch along the axial length thereof. The nozzle openings are so devised as to have a larger diameter in regular succession from the inlet end to the opposite end of the inner tube; and a plurality of further nozzle openings are provided in the lower part of the outer tube at a fixed pitch along the axial length thereof and have a fixed diameter.
摘要翻译： 一种用于带式连续真空干燥器并定向在真空干燥室内移动的带上方的料料供给管。 进料管包括一个内管，其一端设置有用于材料的入口，另一端封闭。 外管的两端封闭并围绕所述内管并在其间具有径向空间。 多个喷嘴开口沿其轴向长度以固定间距设置在内管的上部中。 喷嘴开口被设计成具有从内管的入口端到相对端的规则连续的较大直径; 并且多个另外的喷嘴开口沿其轴向长度以固定的间距设置在外管的下部，并且具有固定的直径。
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公开(公告)号：US20060229245A1
公开(公告)日：2006-10-12
申请号：US11188091
申请日：2005-07-25
申请人： Katsumi Tanaka , Kanji Higashio , Eitaro Kumazawa
发明人： Katsumi Tanaka , Kanji Higashio , Eitaro Kumazawa
IPC分类号： A61K38/18 , C07K14/475
CPC分类号： A61K9/0019 , A61K9/19 , A61K38/1833 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/36
摘要： The invention relates to a lyophilized HGF preparation prepared by lyophilizing an aqueous solution containing HGF, and a lyophilized HGF preparation containing a stabilizer, sodium chloride, a buffer, and/or a surface active agent. According to the invention, HGF can be stabilized, and it can be stored for a long period.
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公开(公告)号：US5510327A
公开(公告)日：1996-04-23
申请号：US198893
申请日：1994-02-18
IPC分类号： A61K9/08 , A61K38/00 , A61K38/18 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/42 , A61P1/16 , A61P13/12 , A61P17/02 , A61P35/00 , C07K14/52 , A61K38/17
CPC分类号： A61K38/1816 , A61K38/1833 , A61K47/02 , A61K47/12 , A61K47/183 , A61K9/0019 , C07K14/52 , Y10S514/97
摘要： This invention provides pharmaceutical preparations containing highly concentrated tumor cytotoxic factor (TCF). The pharmaceutical preparations of the present invention contain highly concentrated TCF and a basic amino acid or their salts, or an organic or inorganic salt as a solubizer. The resultant compositions described in the present invention dissolve TCF at high concentrations of 10 mg/ml or over under about neutral and isotonic conditions. The resultant compositions are stable and are suitable for injection preparations.
摘要翻译： 本发明提供含有高度浓缩的肿瘤细胞毒性因子（TCF）的药物制剂。 本发明的药物制剂含有高度浓缩的TCF和碱性氨基酸或其盐，或作为增溶剂的有机或无机盐。 本发明中所述的所得组合物在大约中性和等渗条件下以高浓度10mg / ml或更高浓度溶解TCF。 所得组合物是稳定的并且适合于注射制剂。
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公开(公告)号：US4904601A
公开(公告)日：1990-02-27
申请号：US309567
申请日：1989-02-13
摘要： Here is disclosed a cell culture tank comprising a cylindrical screen mounted upright within the cell culture tank and having upper and lower openings through which culture medium flows, a pipe for supply of oxygen or oxygen containing gas and an agitator adapted to produce a flow of the culture medium, both the pipe and the agitator being provided within the cylindrical screen, wherein the agitator drives the culture medium to flow downward through the lower opening of the cylindrical screen, then to flow upward into a space defined between the cylindrical screen and the inner wall of the cell culture tank, and a relationship between an ascending velocity of the culture medium and a sinking velocity of the adherent carriers produces in the space between the cylindrical screen and the inner wall of the cell culture tank a floating region within which the adherent carriers float in the culture medium and a separating region within which the adherent carriers are separated from the culture medium.
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公开(公告)号：US5000843A
公开(公告)日：1991-03-19
申请号：US417472
申请日：1989-10-05
申请人： Eitaro Kumazawa , Takao Hatai , Seiji Ishida , Atushi Baba , Masahiko Takahashi
发明人： Eitaro Kumazawa , Takao Hatai , Seiji Ishida , Atushi Baba , Masahiko Takahashi
摘要： There is provided between a concentrate tank and a membrane filter a circulating line which consists of a feed line and a return line. It is also possible to use an ultrafilter as the membrane filter. There is provided a leveling tube connected by respective pipes to the concentrate tank at top and bottom portions thereof, respectively. A buoy floats within the leveling tube and a position of this buoy is detected by means of transparency of the leveling tube itself or photosensors in order to detect a degree of concentration of the culture fluid progressing within the concentrate tank. There may be provided multi-stage circulating lines each connecting the associated concentrate tank to the associated membrane filter so that the culture fluid can be transferred during the process of concentration from the stage of the largest volume treatment to the state of the least volume treatment in order to concentrate the culture fluid more efficiently.
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10.发明授权
公开(公告)号：US4297793A
公开(公告)日：1981-11-03
申请号：US120950
申请日：1980-02-13
申请人： Yukihiro Saiki , Eitaro Kumazawa , Yozo Ishioka
发明人： Yukihiro Saiki , Eitaro Kumazawa , Yozo Ishioka
摘要： An improved apparatus for supplying materials, useful for belt type continuous vacuum dryer, is provided which comprises an inner cylinder equipped with a material-supplying duct fixed onto one end thereof, a distributing chamber formed inside the cylinder and communicating with the duct and a plurality of distributing nozzles fixed thereto; an outer cylinder having the inner cylinder rotatably inserted thereinto and having a plurality of distributing nozzles provided at the opposed locations to the former distributing nozzles; a screw feeder provided in freely rotatable manner inside the distributing chamber; and a driving mechanism for rotating the outer cylinder.According to this apparatus, it is possible to supply materials on a moving belt, continuously and uniformly over the whole surface of the belt.
摘要翻译： 提供了一种改进的用于带式连续真空干燥机的材料供给装置，其包括：内筒，其具有固定在其一端的材料供给管，分配室，形成在气缸内并与管道连通;多个 分配喷嘴固定到其上; 外筒，其具有可旋转地插入其中的内筒，并且具有设置在与前分配喷嘴相对的位置处的多个分配喷嘴; 螺旋进料器，其以可自由旋转的方式设置在所述分配室内; 以及用于旋转外筒的驱动机构。 根据该装置，可以在带的整个表面上连续均匀地在移动带上供给材料。
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