公开(公告)号：US08058471B2

公开(公告)日：2011-11-15

申请号：US12376803

申请日：2007-08-08

申请人： Susumu Amano ,  Akio Fujii ,  Shohei Yamamoto ,  Masaru Mitsuda

发明人： Susumu Amano ,  Akio Fujii ,  Shohei Yamamoto ,  Masaru Mitsuda

IPC分类号： C07C59/00 ,  C07C65/21

CPC分类号： C07B53/00 ,  C07B2200/07 ,  C07C51/00 ,  C07C51/367 ,  C07C201/12 ,  C07C59/48 ,  C07C205/56

摘要： The present invention has its object to provide a method for producing an optically active hydroxycarboxylic acid derivative which is an intermediate important for production of medicines, agrochemicals, chemical products, and so on. The production method of the present invention comprises: carrying out a hydrogen-transfer reduction of a ketocarboxylic acid or a salt thereof by the reaction of an optically active diamine complex to produce an optically active hydroxycarboxylic acid derivative. According to the present invention, it is possible to safely and efficiently produce an industrially-useful optically active hydroxycarboxylic acid derivative.

摘要翻译： 本发明的目的在于提供一种光学活性羟基羧酸衍生物的制造方法，该方法是制备药物，农药，化学品等的重要中间体。 本发明的制造方法包括：通过光学活性二胺配合物的反应进行酮羧酸或其盐的氢转移还原反应，生成光学活性羟基羧酸衍生物。 根据本发明，可以安全有效地制备工业上有用的光学活性羟基羧酸衍生物。

公开(公告)号：US08383833B2

公开(公告)日：2013-02-26

申请号：US12993661

申请日：2009-06-02

申请人： Shohei Yamamoto ,  Akio Fujii ,  Masaru Mitsuda

发明人： Shohei Yamamoto ,  Akio Fujii ,  Masaru Mitsuda

IPC分类号： C07D295/03

CPC分类号： C07B51/00 ,  C07B53/00 ,  C07C227/18 ,  C07C229/08 ,  C07C229/28 ,  C07C2601/02 ,  C07D207/12 ,  C07D211/60 ,  C07D295/18 ,  C07D403/12 ,  C07D495/04

摘要： The present application relates to a method for producing an optically active α-amino acid derivative, comprising steps of reacting an α-haloester derivative represented by the general formula (1): of which alcohol part of the ester group is an optically active alcohol derivative, with an amine compound; then deprotecting the obtained compound; further carrying out an ester exchange reaction. According to the present invention method, it is possible to easily produce an optically active α-amino acid ester derivative which is useful as an intermediate for drugs with high selectivity.

摘要翻译： 本申请涉及一种光学活性α-氨基酸衍生物的制造方法，包括使由通式（1）表示的α-卤代酯衍生物：酯基的醇部分为光学活性醇衍生物 ，与胺化合物; 然后使所得化合物脱保护; 进一步进行酯交换反应。 根据本发明的方法，可以容易地制备可用作高选择性药物的中间体的光学活性α-氨基酸酯衍生物。

公开(公告)号：US20110166354A1

公开(公告)日：2011-07-07

申请号：US12993661

申请日：2009-06-02

申请人： Shohei Yamamoto ,  Akio Fujii ,  Masaru Mitsuda

发明人： Shohei Yamamoto ,  Akio Fujii ,  Masaru Mitsuda

IPC分类号： C07C227/08 ,  C07D207/06 ,  C07D495/04 ,  C07D401/12 ,  C07D211/60

CPC分类号： C07B51/00 ,  C07B53/00 ,  C07C227/18 ,  C07C229/08 ,  C07C229/28 ,  C07C2601/02 ,  C07D207/12 ,  C07D211/60 ,  C07D295/18 ,  C07D403/12 ,  C07D495/04

摘要： The present application relates to a method for producing an optically active α-amino acid derivative, comprising steps of reacting an α-haloester derivative represented by the general formula (1): of which alcohol part of the ester group is an optically active alcohol derivative, with an amine compound; then deprotecting the obtained compound; further carrying out an ester exchange reaction. According to the present invention method, it is possible to easily produce an optically active α-amino acid ester derivative which is useful as an intermediate for drugs with high selectivity.

摘要翻译： 本申请涉及一种光学活性α-氨基酸衍生物的制造方法，包括使由通式（1）表示的α-卤代酯衍生物：酯基的醇部分为光学活性醇衍生物 ，与胺化合物; 然后使所得化合物脱保护; 进一步进行酯交换反应。 根据本发明的方法，可以容易地制备可用作高选择性药物的中间体的光学活性α-氨基酸酯衍生物。

公开(公告)号：US20100191011A1

公开(公告)日：2010-07-29

申请号：US12376803

申请日：2007-08-08

申请人： Susumu Amano ,  Akio Fujii ,  Shohei Yamamoto ,  Masaru Mitsuda

发明人： Susumu Amano ,  Akio Fujii ,  Shohei Yamamoto ,  Masaru Mitsuda

IPC分类号： C07C51/347

CPC分类号： C07B53/00 ,  C07B2200/07 ,  C07C51/00 ,  C07C51/367 ,  C07C201/12 ,  C07C59/48 ,  C07C205/56

摘要： The present invention has its object to provide a method for producing an optically active hydroxycarboxylic acid derivative which is an intermediate important for production of medicines, agrochemicals, chemical products, and so on. The production method of the present invention comprises: carrying out a hydrogen-transfer reduction of a ketocarboxylic acid or a salt thereof by the reaction of an optically active diamine complex to produce an optically active hydroxycarboxylic acid derivative. According to the present invention, it is possible to safely and efficiently produce an industrially-useful optically active hydroxycarboxylic acid derivative.

摘要翻译： 本发明的目的在于提供一种光学活性羟基羧酸衍生物的制造方法，该方法是制备药物，农药，化学品等的重要中间体。 本发明的制造方法包括：通过光学活性二胺配合物的反应进行酮羧酸或其盐的氢转移还原反应，生成光学活性羟基羧酸衍生物。 根据本发明，可以安全有效地制备工业上有用的光学活性羟基羧酸衍生物。

公开(公告)号：US07947722B2

公开(公告)日：2011-05-24

申请号：US12309729

申请日：2007-05-14

申请人： Yasuhiro Saka ,  Akio Fujii ,  Kazumi Okuro ,  Masaru Mitsuda

发明人： Yasuhiro Saka ,  Akio Fujii ,  Kazumi Okuro ,  Masaru Mitsuda

IPC分类号： A61K31/4166 ,  C07D233/32

CPC分类号： C07D233/32 ,  C07C227/22 ,  C07C231/10 ,  C07C229/14 ,  C07C229/22 ,  C07C229/36 ,  C07C237/06

摘要： The objective of the present invention is to provide an optically active imidazolidinone derivative widely usable for synthesizing an optically active amino acid, a method of easily producing the derivative, and a method of easily producing an optically active amino acid by using the derivative. The objective can be achieved by producing an optically active amino acid using a novel optically active imidazolidinone derivative represented by a general formula (3) and the like. According to the method of the present invention, an optically active imidazolidinone derivative can be obtained by preferential crystallization from a mixture of isomers of the imidazolidinone derivative. Therefore, an optically active amino acid can be easily and stereoselectively produced without cumbersome procedures required for the conventional methods, such as resolution of diastereomers, synthesis from an optically active amino acid and resolution of isomers by silica gel column chromatography.

摘要翻译： 本发明的目的是提供广泛用于合成光学活性氨基酸的光学活性咪唑啉酮衍生物，易于制备衍生物的方法，以及通过使用该衍生物容易地制备光学活性氨基酸的方法。 可以通过使用由通式（3）等表示的新的光学活性咪唑烷酮衍生物制造光学活性氨基酸来实现。 根据本发明的方法，可以通过从咪唑烷酮衍生物的异构体的混合物中优先结晶获得光学活性咪唑烷酮衍生物。 因此，光学活性氨基酸可以容易地和立体选择性地产生，而不需要常规方法所需的繁琐程序，例如拆分非对映异构体，由光学活性氨基酸的合成和通过硅胶柱色谱法拆分异构体。

公开(公告)号：US20110009609A1

公开(公告)日：2011-01-13

申请号：US12919295

申请日：2009-02-26

申请人： Hirofumi Maeda ,  Akio Fujii ,  Masaru Mitsuda

发明人： Hirofumi Maeda ,  Akio Fujii ,  Masaru Mitsuda

IPC分类号： C07H19/22 ,  C07H19/00

CPC分类号： C07H19/067 ,  C07H19/167

摘要： The present invention relates to a method for producing a 2′-hydroxy-protected nucleoside derivative by reacting a ribonucleoside with an acylating reagent in the presence of a metal complex consisting of a copper compound and an optically active ligand. By the method according to the present invention, a 2′-hydroxy-protected ribonucleoside derivative, which is an important intermediate for producing an oligonucleoside, can be easily produced with good regioselectivity from a nucleoside derivative of which 2′,3′-hydroxy groups are not protected.

摘要翻译： 本发明涉及通过在由铜化合物和光学活性配体组成的金属络合物的存在下使核糖核苷与酰化剂反应来制备2'-羟基保护的核苷衍生物的方法。 通过本发明的方法，可以容易地制备作为制备寡核苷酸的重要中间体的2'-羟基保护的核糖核苷衍生物，其从2'，3'-羟基的核苷衍生物具有良好的区域选择性 没有保护。

公开(公告)号：US08252919B2

公开(公告)日：2012-08-28

申请号：US12919295

申请日：2009-02-26

申请人： Hirofumi Maeda ,  Akio Fujii ,  Masaru Mitsuda

发明人： Hirofumi Maeda ,  Akio Fujii ,  Masaru Mitsuda

IPC分类号： C07H23/00 ,  C07H19/00 ,  C07H19/167 ,  C07H19/173

CPC分类号： C07H19/067 ,  C07H19/167

摘要： The present invention relates to a method for producing a 2′-hydroxy-protected nucleoside derivative by reacting a ribonucleoside with an acylating or a carbamoylating reagent in the presence of a metal complex consisting of a copper compound and an optically active ligand. By the method according to the present invention, a 2′-hydroxy-protected ribonucleoside derivative, which is an important intermediate for producing an oligonucleoside, can be easily produced with good regioselectivity from a nucleoside derivative of which 2′,3′-hydroxy groups are not protected.

摘要翻译： 本发明涉及通过在由铜化合物和光学活性配体组成的金属络合物的存在下使核糖核苷与酰化剂或氨基甲酰化试剂反应来制备2'-羟基保护的核苷衍生物的方法。 通过本发明的方法，可以容易地制备作为制备寡核苷酸的重要中间体的2'-羟基保护的核糖核苷衍生物，其从2'，3'-羟基的核苷衍生物具有良好的区域选择性 没有保护。

公开(公告)号：US20090209768A1

公开(公告)日：2009-08-20

申请号：US12309729

申请日：2007-05-14

申请人： Yasuhiro Saka ,  Akio Fujii ,  Kazumi Okuro ,  Masaru Mitsuda

发明人： Yasuhiro Saka ,  Akio Fujii ,  Kazumi Okuro ,  Masaru Mitsuda

IPC分类号： C07D233/32 ,  C07C229/36 ,  C07C229/08 ,  C07C229/22

CPC分类号： C07D233/32 ,  C07C227/22 ,  C07C231/10 ,  C07C229/14 ,  C07C229/22 ,  C07C229/36 ,  C07C237/06

摘要： The objective of the present invention is to provide an optically active imidazolidinone derivative widely usable for synthesizing an optically active amino acid, a method of easily producing the derivative, and a method of easily producing an optically active amino acid by using the derivative. The objective can be achieved by producing an optically active amino acid using a novel optically active imidazolidinone derivative represented by a general formula (3) and the like. According to the method of the present invention, an optically active imidazolidinone derivative can be obtained by preferential crystallization from a mixture of isomers of the imidazolidinone derivative. Therefore, an optically active amino acid can be easily and stereoselectively produced without cumbersome procedures required for the conventional methods, such as resolution of diastereomers, synthesis from an optically active amino acid and resolution of isomers by silica gel column chromatography.

摘要翻译： 本发明的目的是提供广泛用于合成光学活性氨基酸的光学活性咪唑啉酮衍生物，易于制备衍生物的方法，以及使用该衍生物容易地制备光学活性氨基酸的方法。 可以通过使用由通式（3）等表示的新的光学活性咪唑烷酮衍生物制造光学活性氨基酸来实现。 根据本发明的方法，可以通过从咪唑烷酮衍生物的异构体的混合物中优先结晶获得光学活性咪唑烷酮衍生物。 因此，光学活性氨基酸可以容易地和立体选择性地产生，而不需要常规方法所需的繁琐程序，例如拆分非对映异构体，由光学活性氨基酸的合成和通过硅胶柱色谱法拆分异构体。

公开(公告)号：US08279298B2

公开(公告)日：2012-10-02

申请号：US12404169

申请日：2009-03-13

申请人： Akio Fujii

发明人： Akio Fujii

IPC分类号： H04N5/225 ,  H04N5/235 ,  H04N5/76

CPC分类号： H04N1/333 ,  H04N1/212 ,  H04N5/23245 ,  H04N5/772 ,  H04N5/781 ,  H04N5/85 ,  H04N5/907 ,  H04N9/7921 ,  H04N9/8042 ,  H04N9/8047 ,  H04N19/115 ,  H04N19/124 ,  H04N19/152 ,  H04N19/154 ,  H04N19/60 ,  H04N19/61 ,  H04N2201/212 ,  H04N2201/33357

摘要： An imaging apparatus includes a signal processing unit that generates moving image data and still image data using image data output from an imaging unit, a moving image coding unit that encodes the moving image data, a still image coding unit that encodes the still image data, a recording unit that records the coded moving and still image data on a recording medium, a setting unit that sets a data rate of the coded moving image data, and a control unit that controls the moving and still image coding units. The control unit controls the moving image coding unit based on the set data rate to adjust the data rate of the moving image data and the still image coding unit based on the set data rate and a recording data rate of the recording medium to adjust an amount of the still image data.

摘要翻译： 一种成像装置，包括：信号处理单元，其使用从成像单元输出的图像数据生成运动图像数据和静止图像数据;运动图像编码单元，对运动图像数据进行编码;静止图像编码单元，对静止图像数据进行编码; 记录单元，其将编码的移动和静止图像数据记录在记录介质上，设置单元，其设置编码的运动图像数据的数据速率;以及控制单元，其控制移动和静止图像编码单元。 控制单元基于设定的数据速率来控制运动图像编码单元，以基于设定的数据速率和记录介质的记录数据速率来调整运动图像数据和静止图像编码单元的数据速率，以调整量 的静止图像数据。

公开(公告)号：US20100054714A1

公开(公告)日：2010-03-04

申请号：US12547113

申请日：2009-08-25

申请人： Akio Fujii

发明人： Akio Fujii

IPC分类号： H04N7/26

CPC分类号： G11B27/005

摘要： An image recording playback apparatus which, when recording moving image data, performs image capture at high-speed read time Dt, records all the captured images, and records a playback rate Ft (Vt), the read time Dt and image valid time St, with the image data, on a recording medium. Then upon playback of moving image data, the image recording playback apparatus plays back the recorded image data within the image valid time St in accordance with the playback rate. The image recording playback apparatus having this configuration can perform playback intended by a user. Further, when sharpness is to be changed, a playback image with different sharpness can be obtained by changing the image valid time St upon playback.

摘要翻译： 一种图像记录播放装置，当记录运动图像数据在高速读取时间Dt进行图像捕获时，记录所有拍摄图像，并记录播放速率Ft（Vt），读取时间Dt和图像有效时间St， 与图像数据一起在记录介质上。 然后，在播放运动图像数据时，图像记录重放装置根据回放速率在图像有效时间St内重放记录图像数据。 具有这种配置的图像记录播放设备可以执行用户想要的播放。 此外，当要改变锐度时，通过在重放时改变图像有效时间St可以获得具有不同清晰度的重放图像。