公开(公告)号：US09651478B2

公开(公告)日：2017-05-16

申请号：US13347172

申请日：2012-01-10

申请人： Shoichi Kanayama ,  Tomoyuki Tada ,  Naotada Okada

发明人： Shoichi Kanayama ,  Tomoyuki Tada ,  Naotada Okada

IPC分类号： G01J3/00 ,  G01J3/04 ,  G01N21/25 ,  G01N3/00 ,  G01N3/04 ,  G01J3/36 ,  G01N21/64 ,  G01N30/74 ,  G01N35/02 ,  G01N21/03

CPC分类号： G01N21/253 ,  G01J3/36 ,  G01N3/00 ,  G01N3/04 ,  G01N21/255 ,  G01N30/74 ,  G01N35/025 ,  G01N2021/0325

摘要： The analyzer according to the embodiment comprises an irradiation optical part that irradiates a mixture inside reaction tubes with light from a light source. Moreover, a detection optical part detects light transmitted through the mixture. Moreover, the irradiation optical part comprises a first optical element in which the light source is disposed at the front focal position and that concentrates light from the light source. Moreover, a second optical element guides light transmitted through the first optical element to the reaction tubes. In addition, an incident numerical aperture adjustment member is provided at the rear side of the first optical element and adjusts the numerical aperture when light from the light source is incident on the reaction tubes.

公开(公告)号：US20120177538A1

公开(公告)日：2012-07-12

申请号：US13347172

申请日：2012-01-10

申请人： Shoichi Kanayama ,  Tomoyuki Tada ,  Naotada Okada

发明人： Shoichi Kanayama ,  Tomoyuki Tada ,  Naotada Okada

IPC分类号： G01N21/75

CPC分类号： G01N21/253 ,  G01J3/36 ,  G01N3/00 ,  G01N3/04 ,  G01N21/255 ,  G01N30/74 ,  G01N35/025 ,  G01N2021/0325

摘要： The analyzer according to the embodiment comprises an irradiation optical part that irradiates a mixture inside reaction tubes with light from a light source. Moreover, a detection optical part detects light transmitted through the mixture. Moreover, the irradiation optical part comprises a first optical element in which the light source is disposed at the front focal position and that concentrates light from the light source. Moreover, a second optical element guides light transmitted through the first optical element to the reaction tubes. In addition, an incident numerical aperture adjustment member is provided at the rear side of the first optical element and adjusts the numerical aperture when light from the light source is incident on the reaction tubes.

摘要翻译： 根据本实施方式的分析装置，具有：照射光反射部，其利用来自光源的光照射反应管内的混合物。 此外，检测光学部件检测透过混合物的光。 此外，照射光学部件包括其中光源设置在前焦点位置并且聚集来自光源的光的第一光学元件。 此外，第二光学元件将透过第一光学元件的光引导到反应管。 此外，在第一光学元件的后侧设置入射数值孔径调节构件，并且当来自光源的光入射到反应管上时调节数值孔径。

公开(公告)号：US07830518B2

公开(公告)日：2010-11-09

申请号：US12352337

申请日：2009-01-12

申请人： Shoichi Kanayama

发明人： Shoichi Kanayama

IPC分类号： G01N21/00

CPC分类号： G01N21/255

摘要： An automatic analysis apparatus and an automatic analysis method analysis that includes an optical convergence point adjusting unit in order to variably adjust an optical convergence point of irradiation light or an optical convergence point of detection light to or from a reaction cuvette in accordance with at least one of analysis conditions of a kind of reaction of a mixed solution contained in the reaction cuvette, a liquid volume of the mixed solution or a measurement wave length. The optical convergence point adjusting unit is provided in front the reaction cuvette, in back of the reaction cuvette, or both in order to variably control the position of an optical convergence point so as to maximize the irradiation light based on the volume of the mixed solution in the reaction cuvette. By variably controlling the convergence point of the optical convergence point adjusting unit based on each of the examination items, both measurements of a turbidimetric assay and a spectrophotometric assay can be performed in a single automatic analysis apparatus with good accuracy and precision.

摘要翻译： 一种自动分析装置和自动分析方法分析，其包括光学会聚点调整单元，以便根据至少一个可变地调节照射光的光学会聚点或检测光的光学会聚点到反应试管 反应池中所含的混合溶液的反应的种类，混合溶液的液体体积或测定波长的分析条件。 光学会聚点调整单元设置在反应池的前面，反应池的背面或两者中，以便可变地控制光学会聚点的位置，以便基于混合溶液的体积来最大化照射光 在反应池中。 通过基于每个检查项可变地控制光学会聚点调整单元的会聚点，可以在单个自动分析装置中以良好的精度和精度进行比浊测定和分光光度测定的两种测量。

公开(公告)号：US20090180120A1

公开(公告)日：2009-07-16

申请号：US12352337

申请日：2009-01-12

申请人： Shoichi Kanayama

发明人： Shoichi Kanayama

IPC分类号： G01N21/59 ,  G02B3/12

CPC分类号： G01N21/255

摘要： An automatic analysis apparatus and an automatic analysis method analysis that includes an optical convergence point adjusting unit in order to variably adjust an optical convergence point of irradiation light or an optical convergence point of detection light to or from a reaction cuvette in accordance with at least one of analysis conditions of a kind of reaction of a mixed solution contained in the reaction cuvette, a liquid volume of the mixed solution or a measurement wave length. The optical convergence point adjusting unit is provided in front the reaction cuvette, in back of the reaction cuvette, or both in order to variably control the position of an optical convergence point so as to maximize the irradiation light based on the volume of the mixed solution in the reaction cuvette. By variably controlling the convergence point of the optical convergence point adjusting unit based on each of the examination items, both measurements of a turbidimetric assay and a spectrophotometric assay can be performed in a single automatic analysis apparatus with good accuracy and precision.

摘要翻译： 一种自动分析装置和自动分析方法分析，其包括光学会聚点调整单元，以便根据至少一个可变地调节照射光的光学会聚点或检测光的光学会聚点到反应试管 反应池中所含的混合溶液的反应的种类，混合溶液的液体体积或测定波长的分析条件。 光学会聚点调整单元设置在反应池的前面，反应池的背面或两者中，以便可变地控制光学会聚点的位置，以便基于混合溶液的体积来最大化照射光 在反应池中。 通过基于每个检查项可变地控制光学会聚点调整单元的会聚点，可以在单个自动分析装置中以良好的精度和精度进行比浊测定和分光光度测定的两种测量。

公开(公告)号：US5519320A

公开(公告)日：1996-05-21

申请号：US40857

申请日：1993-03-31

申请人： Shoichi Kanayama ,  Yoshimori Kassai

发明人： Shoichi Kanayama ,  Yoshimori Kassai

IPC分类号： A61B5/055 ,  G01R33/28 ,  G01R33/46 ,  G01R33/54 ,  G01R33/56 ,  G01V3/00

CPC分类号： G01R33/56 ,  G01R33/543 ,  G01R33/546

摘要： A nuclear magnetic resonance imaging capable of controlling a generation of a desired pulse sequence to be used interactively, realizing the adjustment of the pulse sequence easily and accurately, and realizing the high speed pulse sequence execution. The pulse sequence is automatically generated from a basic pulse sequence form and a parameter block storing the imaging parameters affected by the imaging conditions specified interactively. The pulse sequence is then automatically adjusted to an optimum setting by simulating an execution of the pulse sequence by using simulated RF pulses, gradient magnetic fields, static magnetic field, and nuclear spin density distribution, according to the characteristic parameters measured in advance. In the actual execution of the pulse sequence, the event codes stored in the event memory of the sequence controller are decoded by a plurality of decoders in parallel, and the rewriting of the event memory is realized by using a rewriting table having entries specifying a manner of rewriting each slot of each entry in the event memory, and flags in the event memory indicating an appropriate rewriting table entry for each slot.

摘要翻译： 能够以交互方式控制产生期望脉冲序列的核磁共振成像，实现脉冲序列的调整容易且准确，实现高速脉冲序列的执行。 脉冲序列是从基本的脉冲序列形式和参数块自动产生的，该参数块存储影响参数的成像参数。 根据预先测量的特征参数，通过使用模拟RF脉冲，梯度磁场，静态磁场和核自旋密度分布模拟脉冲序列的执行，脉冲序列然后自动调整到最佳设置。 在脉冲序列的实际执行中，存储在序列控制器的事件存储器中的事件代码由多个解码器并行解码，并且通过使用具有指定方式的条目的重写表来实现事件存储器的重写 重写事件存储器中每个条目的每个时隙，并且在事件存储器中标记指示每个时隙的适当的重写表条目。

公开(公告)号：US09933358B2

公开(公告)日：2018-04-03

申请号：US13401047

申请日：2012-02-21

申请人： Kanako Iwamura ,  Shoichi Kanayama

发明人： Kanako Iwamura ,  Shoichi Kanayama

IPC分类号： G01N21/59 ,  G01N21/25 ,  G01N35/02 ,  G01N35/04

CPC分类号： G01N21/253 ,  G01N35/025 ,  G01N35/04 ,  G01N2035/0455 ,  G01N2201/0415 ,  G01N2201/124 ,  G01N2201/1245 ,  G01N2201/127

摘要： According to one embodiment, an automatic analyzer comprises a light source, a spectroscope, a photo detection unit, a storage unit, a selection unit, and a calculation unit. The storage unit stores photo detector identifiers related to photo detectors and wavelength band identifiers in association with each other. The selection unit selects a specific photo detector from photo detectors. The specific photo detector corresponds to a specific photo detector identifier associated with a wavelength band identifier of a wavelength band according to a measurement item of a sample. The calculation unit calculates an absorbance related to the measurement item based on a signal from the selected specific photo detector.

公开(公告)号：US09897623B2

公开(公告)日：2018-02-20

申请号：US12705149

申请日：2010-02-12

申请人： Kanako Iwamura ,  Shoichi Kanayama ,  Nobuyasu Kobayashi

发明人： Kanako Iwamura ,  Shoichi Kanayama ,  Nobuyasu Kobayashi

IPC分类号： G01N35/10

CPC分类号： G01N35/1011 ,  G01N2035/1025

摘要： Disclosed is an automatic analyzer that analyzes a component of a target layer of a test sample separated into a plurality of layers by transferring the component from an installed container, including: a dispensing probe that descends into the target layer and suctions the component; a detecting unit that detects the height of the layer surface of the target layer of the test sample; a calculating unit that calculates the depth from the layer surface of the target layer at which the total content of the component of the target layer reaches a target amount; and a controller that causes the dispensing probe to descend to the depth calculated by the calculating unit and suction the component.

公开(公告)号：US08315681B2

公开(公告)日：2012-11-20

申请号：US12418899

申请日：2009-04-06

申请人： Shoichi Kanayama ,  Omar S. Khalil ,  Tzyy-Wen Jeng ,  Shu-Jen Yeh

发明人： Shoichi Kanayama ,  Omar S. Khalil ,  Tzyy-Wen Jeng ,  Shu-Jen Yeh

IPC分类号： A61B5/1455

CPC分类号： A61B5/1455 ,  A61B5/0053 ,  A61B5/14532 ,  A61B5/1491 ,  A61B5/1495 ,  A61B5/6824 ,  A61B5/6843

摘要： A method for noninvasive measurement of glucose in a tissue of a subject, including the steps of bringing an adaptation device, which has a shape similar to a measurement probe, into contact with a skin part of a subject for stretching the skin part of the subject under a pressure that is higher than a pressure per unit area applied by the measurement probe during the noninvasive measurement, maintaining the contact for a predetermined period of time followed by relieving the contact, bringing the measurement probe into contact with the stretched skin part of the subject for the noninvasive measurement, collecting signals emitted from the subject, and estimating a glucose concentration based on the collected signals.

摘要翻译： 一种用于对受试者的组织中的葡萄糖进行非侵入性测量的方法，包括以下步骤：将具有与测量探针类似的形状的适应装置与受试者的皮肤部分接触以拉伸受试者的皮肤部分 在非侵入性测量期间高于测量探针施加的每单位面积的压力的压力下，将接触保持预定的时间段，然后释放接触，使测量探针与被拉伸的皮肤部分接触 主观无创测量，收集从受试者发射的信号，并根据收集的信号估计葡萄糖浓度。

公开(公告)号：US20110066023A1

公开(公告)日：2011-03-17

申请号：US12950689

申请日：2010-11-19

申请人： Shoichi Kanayama ,  Kazuhiro Itsumi

发明人： Shoichi Kanayama ,  Kazuhiro Itsumi

IPC分类号： A61B5/05

CPC分类号： A61B8/14 ,  A61B5/0035 ,  A61B5/0091 ,  A61B5/0095 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/4312 ,  A61B8/5238 ,  A61B2562/046 ,  G01N29/0609 ,  G01N2291/02809

摘要： A non-invasive subject-information imaging apparatus according to this invention includes a light generating unit which generates light containing a specific wavelength component, a light irradiation unit which radiates the generated light into a subject, a waveguide unit which guides the light from the light generating unit to the irradiation unit, a plurality of two-dimensionally arrayed electroacoustic transducer elements, a transmission/reception unit which transmits ultrasonic waves to the subject by driving the electroacoustic transducer elements, and generates a reception signal from electrical signals converted by electroacoustic transducer elements, and a signal processing unit which generates volume data of a living body function by processing a reception signal corresponding to acoustic waves generated in the subject by light irradiation, and generates volume data of a tissue morphology by processing a reception signal corresponding to echoes generated in the subject upon transmission of the ultrasonic waves.

摘要翻译： 根据本发明的非侵入性被摄体信息成像装置包括产生包含特定波长分量的光的光产生单元，将产生的光辐射到被摄体中的光照射单元，引导来自光的光的波导单元 生成单元，多个二维排列的电声换能器元件，发送/接收单元，其通过驱动电声换能器元件向对象发送超声波，并且由电声换能器元件转换的电信号产生接收信号 以及信号处理单元，其通过处理与通过光照射在对象中产生的声波相对应的接收信号来生成生物体功能的体数据，并且通过处理对应于生成的回波的接收信号来生成组织形态的体数据 主题在tr 输出超声波。

公开(公告)号：US5603319A

公开(公告)日：1997-02-18

申请号：US305589

申请日：1994-09-14

申请人： Shigehide Kuhara ,  Shoichi Kanayama

发明人： Shigehide Kuhara ,  Shoichi Kanayama

IPC分类号： G01R33/48 ,  G01R33/561 ,  G01R33/563 ,  A61B5/055

CPC分类号： G01R33/5615 ,  G01R33/563 ,  G01R33/4806 ,  G01R33/5618

摘要： A magnetic resonance imaging apparatus capable of obtaining a brain functional image without spending much time and of facillitating to distinguish a vein portion from a cortex portion. The magnetic resonance imaging apparatus includes: a first unit which acquires at least one of data emphasizing a signal from a blood portion in a region of interest in a biological body to be examined and data least affected by inhomogeneity of a static magnetic field; a second unit which acquires data in which a change of magnetic field inhomogeneity (T.sub.2 *) in the region of interest is emphasized; and a control unit which executes simultaneously the first acquiring unit and the second acquiring unit during a predetermined pulse sequence after a radio-frequency magnetic field is applied to the biological body.

摘要翻译： 一种磁共振成像装置，其能够获得大脑功能图像，而不花费大量的时间并且能够将静脉部分与皮质部分区分开。 磁共振成像装置包括：第一单元，其获取强调来自所检查的生物体中的感兴趣区域中的血液部分的信号的数据和受到静态磁场的不均匀性影响的数据中的至少一个; 获取其中强调感兴趣区域中的磁场不均匀性（T2 *）的变化的数据的第二单元; 以及控制单元，其在对生物体施加射频磁场之后的预定脉冲序列期间同时执行第一获取单元和第二获取单元。