利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

5 条记录 (耗时 0.043 秒)

    AMINOPYRIDINE DERIVATIVE
    4.
    发明申请
    AMINOPYRIDINE DERIVATIVE 审中-公开
    氨基吡啶衍生物

    公开(公告)号：US20130005710A1

    公开(公告)日：2013-01-03

    申请号：US13509668

    申请日：2010-11-17

    申请人： Tetsuya Tsukamoto ,  Takeshi Wakabayashi ,  Norihito Tokunaga ,  Yuhei Miyanohana

    发明人： Tetsuya Tsukamoto ,  Takeshi Wakabayashi ,  Norihito Tokunaga ,  Yuhei Miyanohana

    IPC分类号： A61K31/496 ,  A61K31/5377 ,  C07D417/14 ,  C07D401/04 ,  A61P25/28 ,  C07D405/14 ,  A61K31/4545 ,  A61K31/551 ,  C07D413/14 ,  C07D409/14 ,  C07D413/04 ,  C07D401/14

    CPC分类号： C07D213/74 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/551 ,  C07D213/76 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04

    摘要： The present invention provides a novel aminopyridine derivative that is excellent in pharmaceutical effects such as a neuroprotective effect, a neurogenesis or nerve regeneration promoting effect, and a cognitive function improving effect and, preferably, is low toxic and delivered at a high rate to the central nervous system. Specifically, the present invention provides a compound represented by the formula (I), wherein ring A represents a monocyclic aromatic hydrocarbon ring or the like; ring B may further have a substituent(s); ring D represents a monocyclic aromatic hydrocarbon ring or the like; L represents a bond, or a methylene group or the like; X represents —NRa- or the like, wherein Ra represents a hydrogen atom or the like; n represents 1 or 2; and R1 to R3 each represent a hydrogen atom or the like, wherein ring A and ring D each may be condensed with another ring to form a condensed ring which may have a substituent(s), and ring A-L- in the formula (I) may be bonded to X, provided that when ring A is pyrazole which may be substituted and ring D is benzene which may be substituted, L is a bond; or a salt thereof.

    摘要翻译： 本发明提供一种新颖的氨基吡啶衍生物，其具有优异的药效，如神经保护作用，神经发生或神经再生促进作用，以及认知功能改善作用，优选为低毒性，高速递送至中枢 神经系统。 具体地，本发明提供式（I）表示的化合物，其中环A表示单环芳香烃环等; 环B还可以具有取代基; 环D表示单环芳香烃环等; L表示键或亚甲基等; X表示-NR a等，其中R a表示氢原子等; n表示1或2; 并且R 1至R 3各自表示氢原子等，其中环A和环D各自可与另一个环缩合形成可具有取代基的稠环，式（I）中的环 - 可以与X键合，条件是当环A是可被取代的吡唑时，环D是可被取代的苯，L是一个键; 或其盐。