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    Cyclic Amine Compound and Use Thereof for the Prophylaxis or Treatment of Hypertension
    5.
    发明申请
    Cyclic Amine Compound and Use Thereof for the Prophylaxis or Treatment of Hypertension 审中-公开
    环胺化合物及其用途用于预防或治疗高血压

    公开(公告)号：US20100121048A1

    公开(公告)日：2010-05-13

    申请号：US12224046

    申请日：2007-02-15

    申请人： Takanobu Kuroita ,  Yasuhiro Imaeda ,  Naohiro Taya ,  Tsuneo Oda ,  Kouichi Iwanaga ,  Yasutomi Asano

    发明人： Takanobu Kuroita ,  Yasuhiro Imaeda ,  Naohiro Taya ,  Tsuneo Oda ,  Kouichi Iwanaga ,  Yasutomi Asano

    IPC分类号： C07D403/12 ,  C07D417/14 ,  C07D401/14 ,  C07D403/06 ,  C07D413/14 ,  C07D409/06 ,  C07D403/14

    CPC分类号： C07D403/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/06 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

    摘要： The present invention relates to a compound represented by the formula: (I) wherein ring A is a 5- or 6-membered aromatic heterocycle optionally having substituent (s); U, V and W are each independently C or N, provided that when any one of U, V and W is N, then the others should be C; Ra and Rb are each independently a cyclic group optionally having substituent(s), a C1-10alkyl group optionally having substituent(s), a C2-10 alkenyl group optionally having substituent(s), or a C2-10alkynyl group optionally having substituent(s); X is a bond, or a spacer having 1 to 6 atoms in the main chain; Y is a spacer having 1 to 6 atoms in the main chain; Rc is a hydrocarbon group optionally containing heteroatom(s) as the constituting atom(s), which optionally has substituent(s); m and n are each independently 1 or 2; and ring B optionally further has substituent(s), or a salt thereof. The compound of the present invention has excellent renin inhibitory activity, and thus is useful as an agent for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension, and the like.

    摘要翻译： 本发明涉及式（I）表示的化合物，其中环A是任选具有取代基的5-或6-元芳族杂环; U，V和W各自独立为C或N，条件是当U，V和W中的任何一个为N时，其他应为C; Ra和Rb各自独立地为任选具有取代基的环状基团，任选具有取代基的C 1-10烷基，任选具有取代基的C 2-10烯基或任选具有取代基的C 2-10炔基， （s）; X是键或在主链中具有1至6个原子的间隔基; Y是主链中具有1至6个原子的间隔基; Rc是任选地含有杂原子作为构成原子的烃基，其任选具有取代基; m和n各自独立地为1或2; 任选地，环B还具有取代基或其盐。 本发明的化合物具有优异的肾素抑制活性，因此可用作预防或治疗高血压，各种高血压器官损害等的药剂。

    Electric shaver
    10.
    发明授权
    Electric shaver 失效
    电动剃须刀

    公开(公告)号：US4363169A

    公开(公告)日：1982-12-14

    申请号：US240074

    申请日：1981-03-03

    申请人： Sataro Nasu ,  Hikoyoshi Hara ,  Kouichi Iwanaga

    发明人： Sataro Nasu ,  Hikoyoshi Hara ,  Kouichi Iwanaga

    IPC分类号： B26B19/38 ,  B26B19/14

    CPC分类号： B26B19/14

    摘要： Electric shaver of battery powered and washable type having a watertight housing structure. A battery covering detachably mounted to housing bottom opening for holding batteries inside the housing includes a lock and seal which are activated, responsive to the covering's mounting operation, respectively in directions transversing the housing axis to lock the covering to the housing interior wall and in the housing axial directions to achieve uniform abuttment of the covering to the interior wall for clamping therebetween a watertight ring seal. At the housing head where shaving blade assembly is coupled to rotary shaft of electric motor, the shaft is projected out of an axial cylinder of motor mounting member through a double-lip shape bushing watertightly sealing around the shaft with both axial end and outer peripheral projections compressively deformed by inward flange and inner periphery of the axial cylinder and motor shaft bearing so as to maintain a proper sealing pressure about the shaft, while allowing water passed through cut-hair reservoir between the motor and the blade assembly with side wall apertures of the reservoir closable by a shutter ring slidably fitted therearound, and in a housing side wall a reed-switch inside the housing is controlled over the side wall by a magnet carried by a handle slidably fitted outside the wall.

    摘要翻译： 电动电动洗衣机电动剃须刀具有防水外壳结构。 可拆卸地安装到壳体底部开口以用于将电池保持在壳体内部的电池盖包括锁和密封件，该锁和密封件响应于覆盖物的安装操作分别沿着横过壳体轴线的方向被激活，以将覆盖物锁定到壳体内壁，并且在 容纳轴向方向以实现覆盖物与内壁的均匀抵靠，以在其间夹紧水密环密封。 在剃须刀组件联接到电动机的旋转轴的壳体头部处，轴通过双轴唇形衬套突出到电动机安装构件的轴向圆柱体中，该双唇形衬套围绕轴水平密封，轴向端部和外周突出部 通过轴向圆柱体和马达轴承的向内凸缘和内周被压缩变形，以便保持围绕轴的适当的密封压力，同时允许水通过马达和叶片组件之间的切割头储存器与侧壁孔 通过可滑动地安装在其周围的快门环可闭合的储存器，并且在壳体侧壁中，壳体内的簧片开关通过由可滑动地装配在壁外的手柄承载的磁体在侧壁上控制。