利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

7 条记录 (耗时 0.071 秒)

    Cyclic Amine Compound and Use Thereof for the Prophylaxis or Treatment of Hypertension
    7.
    发明申请
    Cyclic Amine Compound and Use Thereof for the Prophylaxis or Treatment of Hypertension 审中-公开
    环胺化合物及其用途用于预防或治疗高血压

    公开(公告)号：US20100121048A1

    公开(公告)日：2010-05-13

    申请号：US12224046

    申请日：2007-02-15

    申请人： Takanobu Kuroita ,  Yasuhiro Imaeda ,  Naohiro Taya ,  Tsuneo Oda ,  Kouichi Iwanaga ,  Yasutomi Asano

    发明人： Takanobu Kuroita ,  Yasuhiro Imaeda ,  Naohiro Taya ,  Tsuneo Oda ,  Kouichi Iwanaga ,  Yasutomi Asano

    IPC分类号： C07D403/12 ,  C07D417/14 ,  C07D401/14 ,  C07D403/06 ,  C07D413/14 ,  C07D409/06 ,  C07D403/14

    CPC分类号： C07D403/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/06 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

    摘要： The present invention relates to a compound represented by the formula: (I) wherein ring A is a 5- or 6-membered aromatic heterocycle optionally having substituent (s); U, V and W are each independently C or N, provided that when any one of U, V and W is N, then the others should be C; Ra and Rb are each independently a cyclic group optionally having substituent(s), a C1-10alkyl group optionally having substituent(s), a C2-10 alkenyl group optionally having substituent(s), or a C2-10alkynyl group optionally having substituent(s); X is a bond, or a spacer having 1 to 6 atoms in the main chain; Y is a spacer having 1 to 6 atoms in the main chain; Rc is a hydrocarbon group optionally containing heteroatom(s) as the constituting atom(s), which optionally has substituent(s); m and n are each independently 1 or 2; and ring B optionally further has substituent(s), or a salt thereof. The compound of the present invention has excellent renin inhibitory activity, and thus is useful as an agent for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension, and the like.

    摘要翻译： 本发明涉及式（I）表示的化合物，其中环A是任选具有取代基的5-或6-元芳族杂环; U，V和W各自独立为C或N，条件是当U，V和W中的任何一个为N时，其他应为C; Ra和Rb各自独立地为任选具有取代基的环状基团，任选具有取代基的C 1-10烷基，任选具有取代基的C 2-10烯基或任选具有取代基的C 2-10炔基， （s）; X是键或在主链中具有1至6个原子的间隔基; Y是主链中具有1至6个原子的间隔基; Rc是任选地含有杂原子作为构成原子的烃基，其任选具有取代基; m和n各自独立地为1或2; 任选地，环B还具有取代基或其盐。 本发明的化合物具有优异的肾素抑制活性，因此可用作预防或治疗高血压，各种高血压器官损害等的药剂。