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公开(公告)号：US6114515A
公开(公告)日：2000-09-05
申请号：US961564
申请日：1997-10-30
申请人： Shujian Wu , Raymond W. Sweet , Alemseged Truneh
发明人： Shujian Wu , Raymond W. Sweet , Alemseged Truneh
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P17/00 , A61P37/02 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/12 , C12P21/02 , C12R1/91 , G01N33/15 , G01N33/50 , C07H21/02 , C07H21/04
CPC分类号： C07K14/70503 , A61K39/00
摘要： PIGRL-1 polypeptide and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing PIGRL-1 polypeptide and polynucleotides in the design of protocols for the treatment of Hyper-IgM Immunodeficiency (HIM), X-linked Severe Combined Immunodeficiency (XSCID), and IgA deficiency (IgA-D), among others and diagnostic assays for such conditions.
摘要翻译： 公开了PIGRL-1多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗超IgM免疫缺陷（HIM），X连锁严重联合免疫缺陷（XSCID）和IgA缺乏（IgA-D）的方案中使用PIGRL-1多肽和多核苷酸的方法等 和这些病症的诊断测定。
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公开(公告)号：US07560112B2
公开(公告)日：2009-07-14
申请号：US11413561
申请日：2006-04-28
申请人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
发明人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
IPC分类号： A61K39/395 , C07K16/24 , C12N5/12
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译： 抗IL-6抗体，包括编码至少一种抗IL-6抗体，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用的方法具有在诊断和/或治疗组合物中的应用 ，方法和设备。
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公开(公告)号：USRE43672E1
公开(公告)日：2012-09-18
申请号：US13178998
申请日：2011-07-08
申请人： Yan Chan , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
发明人： Yan Chan , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
IPC分类号： A61K39/395 , C07K16/24 , C12N5/12
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译： 抗IL-6抗体，包括编码至少一种抗IL-6抗体，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用的方法具有在诊断和/或治疗组合物中的应用 ，方法和设备。
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公开(公告)号：US08067003B2
公开(公告)日：2011-11-29
申请号：US12901200
申请日：2010-10-08
申请人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
发明人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
IPC分类号： A61K39/395
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Anti-IL-6 antibodies are used to treat IL-6 related conditions, such as rheumatoid arthritis, osteoarthritis, osteolysis, aseptic loosening of orthopedic implants, systemic lupus erythematosus, cutaneous lupus erythematosus, lupus nephritis, type 2 diabetes mellitus, chronic obstructive pulmonary disease, and renal cell carcinoma.
摘要翻译： 抗IL-6抗体用于治疗IL-6相关病症，如类风湿性关节炎，骨关节炎，骨质溶解，骨科植入物无菌松动，系统性红斑狼疮，皮肤红斑狼疮，狼疮肾炎，2型糖尿病，慢性阻塞性肺炎 疾病和肾细胞癌。
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公开(公告)号：US08623362B2
公开(公告)日：2014-01-07
申请号：US13524684
申请日：2012-06-15
申请人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
发明人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
IPC分类号： A61K39/395
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译： 抗IL-6抗体，包括编码至少一种抗IL-6抗体，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用的方法具有在诊断和/或治疗组合物中的应用 ，方法和设备。
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公开(公告)号：US20130017208A1
公开(公告)日：2013-01-17
申请号：US13524684
申请日：2012-06-15
申请人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
发明人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
IPC分类号： A61K39/395 , A61P19/04 , A61P35/00 , A61P37/04 , A61P35/02 , A61P19/08 , A61P5/50 , A61P25/28 , A61P9/10 , A61P19/10 , C07K16/24 , A61P29/00
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译： 抗IL-6抗体，包括编码至少一种抗IL-6抗体，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用的方法具有在诊断和/或治疗组合物中的应用 ，方法和设备。
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公开(公告)号：US08226611B2
公开(公告)日：2012-07-24
申请号：US13283177
申请日：2011-10-27
申请人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
发明人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
IPC分类号： A61M37/00 , A61M5/32 , A61K39/395 , C07K16/24
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
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公开(公告)号：US20100021477A1
公开(公告)日：2010-01-28
申请号：US12546850
申请日：2009-08-25
申请人： Ping Tsui , Lei Shi , Jin Lu , John Wheeler , Brian Whitaker , Lionella Borozdina-Birch , Juan C. Almagro , Bernard Amegadzie , Mark Tornetta , Ramachandra Reddy , David M. Knight , Jinquan Luo , Raymond W. Sweet , Qiang Chen
发明人： Ping Tsui , Lei Shi , Jin Lu , John Wheeler , Brian Whitaker , Lionella Borozdina-Birch , Juan C. Almagro , Bernard Amegadzie , Mark Tornetta , Ramachandra Reddy , David M. Knight , Jinquan Luo , Raymond W. Sweet , Qiang Chen
CPC分类号： C12N15/1037 , C40B30/04 , C40B40/02
摘要： Described and claimed herein are combinatorial synthetic Fab libraries displayed on a phage pIX protein. The libraries were built on scaffolds representing the most frequently used genes in human antibodies, which were diversified to mirror the variability of natural antibodies. After selection using a diverse panel of proteins, numerous specific and high-affinity Fabs were isolated. By a process called in-line maturation the affinity of some antibodies was improved up to one hundred-fold yielding low pM binders suitable for in vivo use. This work thus demonstrates the feasibility of displaying complex Fab libraries as pIX-fusion proteins for antibody discovery and lays the foundations for studies on the structure-function relationship of antibodies.
摘要翻译： 在此描述和要求保护的是在噬菌体pIX蛋白上显示的组合合成Fab文库。 图书馆建立在代表人抗体中最常用基因的支架上，多种多样化以反映天然抗体的变异性。 在使用不同的蛋白质组进行选择后，分离出许多特异性和高亲和力的Fab。 通过称为在线成熟的方法，一些抗体的亲和力得到改善，高达一百倍，产生适于体内使用的低pM粘合剂。 因此，该工作证明了展示复合Fab文库作为抗体发现的pIX融合蛋白的可行性，并为研究抗体的结构 - 功能关系奠定了基础。
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公开(公告)号：US5110906A
公开(公告)日：1992-05-05
申请号：US160348
申请日：1988-02-24
申请人： Paul J. Maddon , Richard Axel , Raymond W. Sweet , James Arthos
发明人： Paul J. Maddon , Richard Axel , Raymond W. Sweet , James Arthos
IPC分类号： C12N15/09 , A61K38/00 , A61P31/12 , C07K14/00 , C07K14/725 , C07K14/73 , C07K16/28 , C12N5/10 , C12P21/02 , C12Q1/70 , C12R1/91
CPC分类号： C12Q1/703 , C07K14/70514 , C07K16/2812 , A61K38/00 , Y10S435/974 , Y10S530/821 , Y10S930/221
摘要： This invention provides a therapeutic agent capable of specifically forming a complex with human immunodeficiency virus envelope glycoprotein which comprises a polypeptide. In one embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence shown in FIG. 6 from about +1 to about +185 fused to the amino acid sequence from about +353 to about +371. In another embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence shown in FIG. 6 from about +1 to about +106 fused to the amino acid sequence from about +353 to about +371. In yet a further embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence shown in FIG. 6 from about +1 to about +185.This invention also provides a method for treating a subject infected with a human immunodeficiency virus. The method comprises administering to the subject an effective amount of a pharmaceutical composition comprising an effective amount of a therapeutic agent of the invention and a pharmaceutically acceptable carrier.
摘要翻译： 本发明提供能够特异性形成与包含多肽的人免疫缺陷病毒包膜糖蛋白复合物的治疗剂。 在本发明的一个实施方案中，多肽的氨基酸序列包含图1所示的氨基酸序列。 约1 + 1至约+ 18 5的氨基酸序列与约+353至约+ 371融合。 在本发明的另一个实施方案中，多肽的氨基酸序列包含图1所示的氨基酸序列。 与约+353至约+ 371的氨基酸序列融合的约1 + 1至约+ 10 6。 在本发明的另一个实施方案中，多肽的氨基酸序列包含图1所示的氨基酸序列。 6从约+1到约+185。 本发明还提供了治疗感染人免疫缺陷病毒的受试者的方法。 该方法包括向受试者施用有效量的包含有效量的本发明治疗剂和药学上可接受的载体的药物组合物。
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公开(公告)号：US09062305B2
公开(公告)日：2015-06-23
申请号：US12546850
申请日：2009-08-25
申请人： Ping Tsui , Lei Shi , Jin Lu , John Wheeler , Brian Whitaker , Lionella Borozdina-Birch , Juan C. Almagro , Bernard Amegadzie , Mark Tornetta , Ramachandra Reddy , David M. Knight , Jinquan Luo , Raymond W. Sweet , Qiang Chen
发明人： Ping Tsui , Lei Shi , Jin Lu , John Wheeler , Brian Whitaker , Lionella Borozdina-Birch , Juan C. Almagro , Bernard Amegadzie , Mark Tornetta , Ramachandra Reddy , David M. Knight , Jinquan Luo , Raymond W. Sweet , Qiang Chen
CPC分类号： C12N15/1037 , C40B30/04 , C40B40/02
摘要： Described and claimed herein are combinatorial synthetic Fab libraries displayed on a phage pIX protein. The libraries were built on scaffolds representing the most frequently used genes in human antibodies, which were diversified to mirror the variability of natural antibodies. After selection using a diverse panel of proteins, numerous specific and high-affinity Fabs were isolated. By a process called in-line maturation the affinity of some antibodies was improved up to one hundred-fold yielding low pM binders suitable for in vivo use. This work thus demonstrates the feasibility of displaying complex Fab libraries as pIX-fusion proteins for antibody discovery and lays the foundations for studies on the structure-function relationship of antibodies.
摘要翻译： 在此描述和要求保护的是在噬菌体pIX蛋白上显示的组合合成Fab文库。 图书馆建立在代表人抗体中最常用基因的支架上，多种多样化以反映天然抗体的变异性。 在使用不同的蛋白质组进行选择后，分离出许多特异性和高亲和力的Fab。 通过称为在线成熟的方法，一些抗体的亲和力得到改善，高达一百倍，产生适于体内使用的低pM粘合剂。 因此，该工作证明了展示复合Fab文库作为抗体发现的pIX融合蛋白的可行性，并为研究抗体的结构 - 功能关系奠定了基础。
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