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1.发明授权Polynucleotides encoding three novel human cell surface proteins with leucine rich repeats and immunologobulin folds, BGS2, 3, and 4 and variants thereof 失效编码具有富含亮氨酸重复序列和免疫球蛋白折叠的三种新型人细胞表面蛋白的多核苷酸，BGS2,3和4及其变体公开(公告)号：US07223558B2
公开(公告)日：2007-05-29
申请号：US10193477
申请日：2002-07-11
申请人： Shujian Wu , Stanley R. Krystek , Liana Lee , John N. Feder , Janet D. Cheng
发明人： Shujian Wu , Stanley R. Krystek , Liana Lee , John N. Feder , Janet D. Cheng
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides novel polynucleotides encoding BGS-2, 3, and 4 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-2, 3, and 4 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码BGS-2,3和4多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型BGS-2,3和4多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US20090088385A1
公开(公告)日：2009-04-02
申请号：US12283245
申请日：2008-09-10
申请人： Shujian Wu , Stanley R. Krystek , Liana Lee , John N. Feder , Janet D. Cheng
发明人： Shujian Wu , Stanley R. Krystek , Liana Lee , John N. Feder , Janet D. Cheng
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides novel polynucleotides encoding BGS-4 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing the polypeptides of the present invention. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-4 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码BGS-4多肽的新型多核苷酸，其片段和同源物。 还提供载体，宿主细胞，抗体，以及用于产生本发明多肽的重组和合成方法。 本发明还涉及将这些新型BGS-4多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US07456256B2
公开(公告)日：2008-11-25
申请号：US11726220
申请日：2007-03-21
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides novel polynucleotides encoding BGS-2, 3, and 4 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing the polypeptides of the present invention. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-2, 3, and 4 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码BGS-2,3和4多肽的新型多核苷酸，其片段及其同源物。 还提供载体，宿主细胞，抗体，以及用于产生本发明多肽的重组和合成方法。 本发明还涉及将这些新型BGS-2,3和4多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US07705134B2
公开(公告)日：2010-04-27
申请号：US12283245
申请日：2008-09-10
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides novel polynucleotides encoding BGS-4 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing the polypeptides of the present invention. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-4 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码BGS-4多肽的新型多核苷酸，其片段和同源物。 还提供载体，宿主细胞，抗体，以及用于产生本发明多肽的重组和合成方法。 本发明还涉及将这些新型BGS-4多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US07285633B2
公开(公告)日：2007-10-23
申请号：US11313356
申请日：2005-12-21
申请人： Shujian Wu , Jian Chen , John N. Feder , Liana Lee , Stanley R. Krystek
发明人： Shujian Wu , Jian Chen , John N. Feder , Liana Lee , Stanley R. Krystek
IPC分类号： A61K38/17
CPC分类号： C12N9/6489
摘要： The present invention provides novel polynucleotides encoding MMP-29 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MMP-29 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码MMP-29多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型MMP-29多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US06642041B2
公开(公告)日：2003-11-04
申请号：US10067443
申请日：2002-02-05
IPC分类号： C12N948
CPC分类号： C12N9/6489 , C07K2299/00
摘要： The present invention provides novel polynucleotides encoding MP-1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MP-1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码MP-1多肽，其片段和同系物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型MP-1多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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7.发明授权Antibodies directed to the testis-specific tubulin tyrosine-ligase-like protein, BGS42 有权针对睾丸特异性微管蛋白酪氨酸连接酶样蛋白BGS42的抗体公开(公告)号：US07309779B2
公开(公告)日：2007-12-18
申请号：US11445988
申请日：2006-06-02
申请人： John N. Feder , Shujian Wu , Thomas C. Nelson , Liana M. Lee
发明人： John N. Feder , Shujian Wu , Thomas C. Nelson , Liana M. Lee
CPC分类号： C12N9/93 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K2319/00 , G01N33/57423 , G01N2333/9015 , Y10S435/81
摘要： The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码BGS-42多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型BGS-42多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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8.发明授权Method of diagnosing testicular tumors using polynucleotides encoding a novel testis-specific tubulin tyrosine-ligase-like protein, BGS42 有权使用编码新型睾丸特异性微管蛋白酪氨酸连接酶样蛋白BGS42的多核苷酸诊断睾丸肿瘤的方法公开(公告)号：US07273706B2
公开(公告)日：2007-09-25
申请号：US11496357
申请日：2006-07-31
申请人： John N. Feder , Shujian Wu , Thomas C. Nelson , Liana M. Lee
发明人： John N. Feder , Shujian Wu , Thomas C. Nelson , Liana M. Lee
CPC分类号： C12N9/93 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K2319/00 , G01N33/57423 , G01N2333/9015 , Y10S435/81
摘要： The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码BGS-42多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型BGS-42多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US07741025B2
公开(公告)日：2010-06-22
申请号：US11900344
申请日：2007-09-10
申请人： John N. Feder , Shujian Wu , Thomas C. Nelson , Liana M. Lee
发明人： John N. Feder , Shujian Wu , Thomas C. Nelson , Liana M. Lee
CPC分类号： C12N9/93 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K2319/00 , G01N33/57423 , G01N2333/9015 , Y10S435/81
摘要： The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码BGS-42多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型BGS-42多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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10.发明授权Polynucleotide encoding a novel TRP channel family member, LTRPC3, and splice variants thereof 有权编码新型TRP通道家族成员的多核苷酸，LTRPC3及其剪接变体公开(公告)号：US07767418B2
公开(公告)日：2010-08-03
申请号：US12152547
申请日：2008-05-15
申请人： Ning Lee , Jian Chen , John N. Feder , Shujian Wu , Liana M. Lee , Michael A. Blanar
发明人： Ning Lee , Jian Chen , John N. Feder , Shujian Wu , Liana M. Lee , Michael A. Blanar
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码LTRPC3多肽的新型多核苷酸，其片段及其同源物。 本发明还提供了分别编码LTRPC3多肽，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f的变体和剪接变体的多核苷酸。 还提供载体，宿主细胞，以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型LTRPC3，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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