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公开(公告)号：US06642041B2
公开(公告)日：2003-11-04
申请号：US10067443
申请日：2002-02-05
IPC分类号： C12N948
CPC分类号： C12N9/6489 , C07K2299/00
摘要： The present invention provides novel polynucleotides encoding MP-1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MP-1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码MP-1多肽，其片段和同系物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型MP-1多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US07285633B2
公开(公告)日：2007-10-23
申请号：US11313356
申请日：2005-12-21
申请人： Shujian Wu , Jian Chen , John N. Feder , Liana Lee , Stanley R. Krystek
发明人： Shujian Wu , Jian Chen , John N. Feder , Liana Lee , Stanley R. Krystek
IPC分类号： A61K38/17
CPC分类号： C12N9/6489
摘要： The present invention provides novel polynucleotides encoding MMP-29 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MMP-29 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码MMP-29多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型MMP-29多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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3.发明授权Polynucleotide encoding a novel acyl coenzyme A, monoacylglycerol acyltransferase-3 (MGAT3), and uses thereof 有权编码新型酰基辅酶A，单酰基甘油酰基转移酶-3（MGAT3）的多核苷酸及其用途公开(公告)号：US07259002B2
公开(公告)日：2007-08-21
申请号：US10761905
申请日：2004-01-21
申请人： John N. Feder , Thomas C. Nelson , Jian Chen , Rupalie Meegalla , Michael Ramaker , Dong Cheng
发明人： John N. Feder , Thomas C. Nelson , Jian Chen , Rupalie Meegalla , Michael Ramaker , Dong Cheng
CPC分类号： C12N9/1029
摘要： The present invention provides novel polynucleotides encoding MGAT3 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing MGAT3 polypeptides, fragments, and homologues thereof. The invention further relates to diagnostic and therapeutic methods for applying these novel MGAT3 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, such as obesity. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码MGAT3多肽的新型多核苷酸，其片段及其同源物。 还提供载体，宿主细胞，抗体，以及用于产生MGAT3多肽，其片段及其同源物的重组和合成方法。 本发明还涉及将这些新型MGAT3多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症如肥胖症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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4.发明授权Polynucleotides encoding three novel human cell surface proteins with leucine rich repeats and immunologobulin folds, BGS2, 3, and 4 and variants thereof 失效编码具有富含亮氨酸重复序列和免疫球蛋白折叠的三种新型人细胞表面蛋白的多核苷酸，BGS2,3和4及其变体公开(公告)号：US07223558B2
公开(公告)日：2007-05-29
申请号：US10193477
申请日：2002-07-11
申请人： Shujian Wu , Stanley R. Krystek , Liana Lee , John N. Feder , Janet D. Cheng
发明人： Shujian Wu , Stanley R. Krystek , Liana Lee , John N. Feder , Janet D. Cheng
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides novel polynucleotides encoding BGS-2, 3, and 4 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-2, 3, and 4 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码BGS-2,3和4多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型BGS-2,3和4多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US07456256B2
公开(公告)日：2008-11-25
申请号：US11726220
申请日：2007-03-21
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides novel polynucleotides encoding BGS-2, 3, and 4 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing the polypeptides of the present invention. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-2, 3, and 4 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码BGS-2,3和4多肽的新型多核苷酸，其片段及其同源物。 还提供载体，宿主细胞，抗体，以及用于产生本发明多肽的重组和合成方法。 本发明还涉及将这些新型BGS-2,3和4多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US20090088385A1
公开(公告)日：2009-04-02
申请号：US12283245
申请日：2008-09-10
申请人： Shujian Wu , Stanley R. Krystek , Liana Lee , John N. Feder , Janet D. Cheng
发明人： Shujian Wu , Stanley R. Krystek , Liana Lee , John N. Feder , Janet D. Cheng
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides novel polynucleotides encoding BGS-4 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing the polypeptides of the present invention. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-4 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码BGS-4多肽的新型多核苷酸，其片段和同源物。 还提供载体，宿主细胞，抗体，以及用于产生本发明多肽的重组和合成方法。 本发明还涉及将这些新型BGS-4多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US07705134B2
公开(公告)日：2010-04-27
申请号：US12283245
申请日：2008-09-10
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides novel polynucleotides encoding BGS-4 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing the polypeptides of the present invention. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-4 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码BGS-4多肽的新型多核苷酸，其片段和同源物。 还提供载体，宿主细胞，抗体，以及用于产生本发明多肽的重组和合成方法。 本发明还涉及将这些新型BGS-4多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US07741025B2
公开(公告)日：2010-06-22
申请号：US11900344
申请日：2007-09-10
申请人： John N. Feder , Shujian Wu , Thomas C. Nelson , Liana M. Lee
发明人： John N. Feder , Shujian Wu , Thomas C. Nelson , Liana M. Lee
CPC分类号： C12N9/93 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K2319/00 , G01N33/57423 , G01N2333/9015 , Y10S435/81
摘要： The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码BGS-42多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型BGS-42多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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9.发明授权Methods of diagnosing colon adenocarcinoma using mRNA encoding the human g-protein coupled receptor, HGPRBMY23 有权使用编码人g-蛋白偶联受体HGPRBMY23的mRNA诊断结肠腺癌的方法公开(公告)号：US07713699B2
公开(公告)日：2010-05-11
申请号：US11897997
申请日：2007-08-31
申请人： John N. Feder , Thomas C. Nelson , Chandra S. Ramanathan , Rolf-Peter Ryseck , Michael G. Kornacker
发明人： John N. Feder , Thomas C. Nelson , Chandra S. Ramanathan , Rolf-Peter Ryseck , Michael G. Kornacker
IPC分类号： C12N1/68 , G01N33/48 , C07K14/705
CPC分类号： G01N33/5008 , A61K38/00 , A61K2039/505 , C07K14/705 , C07K16/28 , C07K2319/30 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N33/5091 , G01N33/566 , G01N33/57415 , G01N33/57419 , G01N33/6893 , G01N2333/726 , G01N2500/04 , G01N2510/00 , G01N2800/347 , Y10T436/143333
摘要： The present invention provides novel polynucleotides encoding HGPRBMY23 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY23 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly renal diseases and/or disorders, colon cancer, breast cancer, and diseases and disorders related to aberrant NFKB modulation. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码HGPRBMY23多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY23多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症，特别是肾脏疾病和/或病症，结肠癌，乳腺癌的诊断和治疗方法 以及与异常NFκB调节相关的疾病和病症。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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10.发明授权Polynucleotides encoding the novel human phosphatase, RET31, and variants thereof 有权编码新型人磷酸酶RET31的多核苷酸及其变体公开(公告)号：US07153678B2
公开(公告)日：2006-12-26
申请号：US10029345
申请日：2001-12-20
申请人： Donald G. Jackson , Chandra S. Ramanathan , John N. Feder , Liana Lee , Thomas C. Nelson , Nathan Siemers , Suzanne J. Suchard , Joshua Finger , C. Gordon Todderud , Dana Banas
发明人： Donald G. Jackson , Chandra S. Ramanathan , John N. Feder , Liana Lee , Thomas C. Nelson , Nathan Siemers , Suzanne J. Suchard , Joshua Finger , C. Gordon Todderud , Dana Banas
CPC分类号： G06F19/16 , A61K38/00 , C07K2319/00 , C07K2319/30 , C12N9/16 , C12Q1/6883 , C12Q2600/158 , C12Y301/03048 , G01N33/573 , G01N33/6893 , G01N2333/916 , G01N2500/00 , G01N2500/04 , Y02A90/26
摘要： The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供编码人磷酸酶多肽，其片段和同源物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型人磷酸酶多肽应用于诊断，治疗和/或预防与这些多肽，特别是心血管疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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