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    Metalloprotease highly expressed in the testis, MMP-29
    1.
    发明授权
    Metalloprotease highly expressed in the testis, MMP-29 有权
    金属蛋白酶在睾丸中高度表达，MMP-29

    公开(公告)号：US07285633B2

    公开(公告)日：2007-10-23

    申请号：US11313356

    申请日：2005-12-21

    申请人： Shujian Wu ,  Jian Chen ,  John N. Feder ,  Liana Lee ,  Stanley R. Krystek

    发明人： Shujian Wu ,  Jian Chen ,  John N. Feder ,  Liana Lee ,  Stanley R. Krystek

    IPC分类号： A61K38/17

    CPC分类号： C12N9/6489

    摘要： The present invention provides novel polynucleotides encoding MMP-29 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MMP-29 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码MMP-29多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型MMP-29多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding a novel metalloprotease, MP-1
    2.
    发明授权
    Polynucleotides encoding a novel metalloprotease, MP-1 有权
    编码新型金属蛋白酶MP-1的多核苷酸

    公开(公告)号：US06642041B2

    公开(公告)日：2003-11-04

    申请号：US10067443

    申请日：2002-02-05

    申请人： Jian Chen ,  John N. Feder ,  Thomas C. Nelson ,  Stanley R. Krystek ,  Franck Duclos

    发明人： Jian Chen ,  John N. Feder ,  Thomas C. Nelson ,  Stanley R. Krystek ,  Franck Duclos

    IPC分类号： C12N948

    CPC分类号： C12N9/6489 ,  C07K2299/00

    摘要： The present invention provides novel polynucleotides encoding MP-1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MP-1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码MP-1多肽，其片段和同系物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型MP-1多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotide encoding a novel TRP channel family member, LTRPC3, and splice variants thereof
    3.
    发明授权
    Polynucleotide encoding a novel TRP channel family member, LTRPC3, and splice variants thereof 有权
    编码新型TRP通道家族成员的多核苷酸，LTRPC3及其剪接变体

    公开(公告)号：US07767418B2

    公开(公告)日：2010-08-03

    申请号：US12152547

    申请日：2008-05-15

    申请人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Liana M. Lee ,  Michael A. Blanar

    发明人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Liana M. Lee ,  Michael A. Blanar

    IPC分类号： C12P21/06 ,  C12N15/00 ,  C07K1/00 ,  C07H21/02

    CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码LTRPC3多肽的新型多核苷酸，其片段及其同源物。 本发明还提供了分别编码LTRPC3多肽，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f的变体和剪接变体的多核苷酸。 还提供载体，宿主细胞，以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型LTRPC3，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    TRP channel family member, LTRPC3 polypeptides
    4.
    发明授权
    TRP channel family member, LTRPC3 polypeptides 有权
    TRP频道家庭成员，LTRPC3e

    公开(公告)号：US07504481B2

    公开(公告)日：2009-03-17

    申请号：US10405793

    申请日：2003-03-28

    申请人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Liana M. Lee ,  Michael A. Blanar

    发明人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Liana M. Lee ,  Michael A. Blanar

    IPC分类号： C07K1/00 ,  C12P21/06 ,  C12P21/04 ,  C12N15/00 ,  A61K39/00

    CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing the novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码LTRPC3多肽的新型多核苷酸，其片段及其同源物。 本发明还提供了分别编码LTRPC3多肽，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f的变体和剪接变体的多核苷酸。 还提供了用于产生新型LTRPC3，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f多肽的载体，宿主细胞，抗体以及重组和合成方法。 本发明还涉及将这些新型LTRPC3，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotide encoding a TRP channel family member, TRP-PLIK2
    5.
    发明授权
    Polynucleotide encoding a TRP channel family member, TRP-PLIK2 有权
    编码TRP通道家族成员的多核苷酸TRP-PLIK2

    公开(公告)号：US07223557B2

    公开(公告)日：2007-05-29

    申请号：US10153244

    申请日：2002-05-22

    申请人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Han Chang ,  Liana M. Le ,  Michael A. Blanar ,  David Bol

    发明人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Han Chang ,  Liana M. Le ,  Michael A. Blanar ,  David Bol

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/02 ,  C12N5/06 ,  C07K14/705

    CPC分类号： C07K14/705

    摘要： The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码TRP-PLIK2多肽的新型多核苷酸，其片段和同源物。 本发明还提供分别编码TRP-PLIK2多肽，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d的变体和剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型TRP-PLIK2，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d多肽应用于诊断，治疗和/或预防与这些相关的各种疾病和/或病症的诊断和治疗方法 多肽。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotide encoding a novel TRP channel family member, LTRPC3, and splice variants thereof
    7.
    发明申请
    Polynucleotide encoding a novel TRP channel family member, LTRPC3, and splice variants thereof 有权
    编码新型TRP通道家族成员的多核苷酸，LTRPC3及其剪接变体

    公开(公告)号：US20080274505A1

    公开(公告)日：2008-11-06

    申请号：US12152547

    申请日：2008-05-15

    申请人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Liana M. Lee ,  Michael A. Blanar ,  David Bol ,  Paul C. Lavesque ,  Lucy Sun

    发明人： Ning Lee ,  Jian Chen ,  John N. Feder ,  Shujian Wu ,  Liana M. Lee ,  Michael A. Blanar ,  David Bol ,  Paul C. Lavesque ,  Lucy Sun

    IPC分类号： C12N15/12 ,  C12N15/63 ,  C12P21/00 ,  C12N5/10

    CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码LTRPC3多肽的新型多核苷酸，其片段及其同源物。 本发明还提供了分别编码LTRPC3多肽，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f的变体和剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型LTRPC3，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding a human cell surface protein with immunoglobulin folds, BGS-19
    8.
    发明授权
    Polynucleotides encoding a human cell surface protein with immunoglobulin folds, BGS-19 有权
    编码具有免疫球蛋白折叠的人细胞表面蛋白的多核苷酸，BGS-19

    公开(公告)号：US07202056B2

    公开(公告)日：2007-04-10

    申请号：US10403938

    申请日：2003-03-28

    申请人： Liana M. Lee ,  John N. Feder ,  Shujian Wu ,  Jian Chen

    发明人： Liana M. Lee ,  John N. Feder ,  Shujian Wu ,  Jian Chen

    IPC分类号： C12P21/06 ,  C12N15/87 ,  C12N1/20 ,  C12N15/74 ,  C07H21/04

    CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K14/70503

    摘要： The present invention provides novel polynucleotides encoding BGS-19 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying the novel BGS-19 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码BGS-19多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将新型BGS-19多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotide encoding a novel TRP channel family member, TRP-PLIK2, and splice variants thereof
    10.
    发明申请
    Polynucleotide encoding a novel TRP channel family member, TRP-PLIK2, and splice variants thereof 有权
    编码新型TRP通道家族成员的多核苷酸，TRP-PLIK2及其剪接变体

    公开(公告)号：US20070172880A1

    公开(公告)日：2007-07-26

    申请号：US11726234

    申请日：2007-03-21

    申请人： Ning Lee ,  Jian Chen ,  John Feder ,  Shujian Wu ,  Han Chang ,  Liana Lee ,  Michael Blanar ,  David Bol

    发明人： Ning Lee ,  Jian Chen ,  John Feder ,  Shujian Wu ,  Han Chang ,  Liana Lee ,  Michael Blanar ,  David Bol

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  A61K38/17 ,  C07K14/705 ,  C07K16/28 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/705

    摘要： The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码TRP-PLIK2多肽的新型多核苷酸，其片段和同源物。 本发明还提供分别编码TRP-PLIK2多肽，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d的变体和剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型TRP-PLIK2，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d多肽应用于诊断，治疗和/或预防与这些相关的各种疾病和/或病症的诊断和治疗方法 多肽。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。