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    Methods and Compositions for Improved Tissue Regeneration by Suppression of Interferon-Gamma and Tumor Necrosis Factor-Alpha
    1.
    发明申请
    Methods and Compositions for Improved Tissue Regeneration by Suppression of Interferon-Gamma and Tumor Necrosis Factor-Alpha 审中-公开
    通过抑制干扰素 - γ和肿瘤坏死因子-α改善组织再生的方法和组合

    公开(公告)号：US20140154220A1

    公开(公告)日：2014-06-05

    申请号：US14114070

    申请日：2012-04-25

    申请人： Songtao Shi ,  Yi Liu ,  Lei Wang

    发明人： Songtao Shi ,  Yi Liu ,  Lei Wang

    IPC分类号： A61K35/28 ,  A61K31/616

    CPC分类号： A61K35/28 ,  A61K31/616 ,  A61K35/17 ,  A61K45/06 ,  A61L27/3834 ,  A61L27/54 ,  A61L2300/41 ,  A61K2300/00

    摘要： The present invention discloses methods, compositions and devices for improving tissue regeneration by suppressing the effects of several proinflammatory cytokines such as TNF-α and IFN-γ. Compositions and devices of this invention will generally include one or more anti-inflammatory agent(s) capable of reducing the level of TNF-α, IFN-γ, or both. Methods for improving tissue regeneration in accordance with this invention will generally have the step of applying a composition or device of the invention to a site in need of the composition or device. Also disclosed are methods for forming composition and devices of the invention and pharmaceutical compositions comprising one or more anti-inflammatory agent(s) effective of inhibiting or reducing the levels of TNF-α, IFN-γ, or both.

    摘要翻译： 本发明公开了通过抑制TNF-α和IFN-γ等促炎细胞因子的作用来改善组织再生的方法，组合物和装置。 本发明的组合物和装置通常包括能够降低TNF-α，IFN-γ或两者的水平的一种或多种抗炎剂。 根据本发明的用于改善组织再生的方法通常具有将本发明的组合物或装置应用于需要组合物或装置的部位的步骤。 还公开了用于形成本发明的组合物和装置的方法和包含一种或多种有效抑制或降低TNF-α，IFN-γ或两者的水平的抗炎药的药物组合物。

    Methods for Improving Efficiency of Cell Electroporation Using Dielectrophoreses
    2.
    发明申请
    Methods for Improving Efficiency of Cell Electroporation Using Dielectrophoreses 审中-公开
    提高细胞电穿孔效率的方法

    公开(公告)号：US20090000948A1

    公开(公告)日：2009-01-01

    申请号：US12097409

    申请日：2007-01-04

    申请人： Lei Wang ,  Lei Wang ,  Min Guo ,  Jing Cheng

    发明人： Lei Wang ,  Lei Wang ,  Min Guo ,  Jing Cheng

    IPC分类号： G01N27/26 ,  G01N27/00

    CPC分类号： C12N13/00 ,  C12M23/16 ,  C12M33/00 ,  C12M35/02

    摘要： The present invention provides methods for enhancing the efficiency of cell electroporation using dielectrophoresis-assisted cell localization and uses thereof in a microfluidic biochip system. Cells are first subject to dielectrophoresis and localized to regions where the electric field intensity is high enough to render cells electroporated. The invention enhances the efficiency of in situ cell electroporation on a traditional microfluidic biochip.

    摘要翻译： 本发明提供使用介电电泳辅助细胞定位提高细胞电穿孔效率的方法及其在微流体生物芯片系统中的用途。 细胞首先进行介导电泳，并定位于电场强度足以使细胞电穿孔的区域。 本发明增强了传统微流体生物芯片上原位细胞电穿孔的效率。

    Method of operating a tubular string assembly within a wellbore
    3.
    发明授权
    Method of operating a tubular string assembly within a wellbore 有权

    公开(公告)号：US11365608B2

    公开(公告)日：2022-06-21

    申请号：US16148684

    申请日：2018-10-01

    申请人： Haining Zheng ,  Lei Wang ,  Michael W. Walker

    发明人： Haining Zheng ,  Lei Wang ,  Michael W. Walker

    IPC分类号： E21B41/00 ,  E21B47/00 ,  E21B44/00 ,  E21B21/08 ,  E21B21/06

    摘要： A method of moving a string assembly within a wellbore is disclosed. In some embodiments, the method comprises moving the string assembly within the wellbore; obtaining surface data regarding at least one parameter associated with moving the string assembly within the wellbore over a range of depths; modeling the at least one parameter over the range of depths for a plurality of assumed friction factors to obtain modeled data for each assumed friction factor; calculating a derivative of the surface data over the range of depths; calculating a derivative of the modeled data over the range of depths; comparing the derivative of the surface data to the derivative of the modeled data; determining one or more local friction factors for the range of depths based on the comparison; and adjusting at least one string assembly operating parameter based on the one or more local friction factors.

    Method of Operating a Tubular String Assembly within a Wellbore
    5.
    发明申请
    Method of Operating a Tubular String Assembly within a Wellbore 审中-公开

    公开(公告)号：US20190178059A1

    公开(公告)日：2019-06-13

    申请号：US16148684

    申请日：2018-10-01

    申请人： Haining Zheng ,  Lei Wang ,  Michael W. Walker

    发明人： Haining Zheng ,  Lei Wang ,  Michael W. Walker

    IPC分类号： E21B41/00 ,  E21B47/00

    摘要： A method of moving a string assembly within a wellbore is disclosed. In some embodiments, the method comprises moving the string assembly within the wellbore; obtaining surface data regarding at least one parameter associated with moving the string assembly within the wellbore over a range of depths; modeling the at least one parameter over the range of depths for a plurality of assumed friction factors to obtain modeled data for each assumed friction factor; calculating a derivative of the surface data over the range of depths; calculating a derivative of the modeled data over the range of depths; comparing the derivative of the surface data to the derivative of the modeled data; determining one or more local friction factors for the range of depths based on the comparison; and adjusting at least one string assembly operating parameter based on the one or more local friction factors.

    Systems and methods for characterizing a spatial frequency of interface regions within a subterranean formation
    6.
    发明授权
    Systems and methods for characterizing a spatial frequency of interface regions within a subterranean formation 有权

    公开(公告)号：US10302812B2

    公开(公告)日：2019-05-28

    申请号：US14830777

    申请日：2015-08-20

    申请人： Lei Wang ,  Richard E. Beckham ,  Scott R. Buechler

    发明人： Lei Wang ,  Richard E. Beckham ,  Scott R. Buechler

    IPC分类号： G01V11/00 ,  E21B44/00

    摘要： Systems and methods for characterizing a spatial frequency of interface regions within a subterranean formation. A first method may include drilling a wellbore with a drilling assembly and measuring a downhole parameter during the drilling. The downhole parameter may be indicative of a lithology of a portion of the subterranean formation that is proximal to the drilling assembly. The first method also may include calculating an information entropy of the downhole parameter and characterizing the spatial frequency of the interface regions based upon the information entropy. A second method may include calculating the information entropy as a function of distance within a first wellbore and characterizing the spatial frequency of the interface regions. The second method also may include drilling a second wellbore within the subterranean formation and regulating the drilling based upon the spatial frequency of the interface regions. The systems include systems that perform the methods.

    End user authentication using a virtual private network
    8.
    发明授权
    End user authentication using a virtual private network 有权

    公开(公告)号：US09942200B1

    公开(公告)日：2018-04-10

    申请号：US14558669

    申请日：2014-12-02

    申请人： Dan Tan ,  Lei Wang ,  Bin Shi ,  Liulin Yang

    发明人： Dan Tan ,  Lei Wang ,  Bin Shi ,  Liulin Yang

    IPC分类号： H04L29/06

    CPC分类号： H04L63/0272 ,  H04L63/0281 ,  H04L63/0823 ,  H04L63/083

    摘要： A user is provisioned for a Web service by supplying a user name and password. A digital certificate and VPN identifier are generated and downloaded to the user's computer. The VPN identifier and user identifier are stored into a database. The user accesses the Web service and establishes a VPN using the certificate and VPN identifier. A user identifier, user name or user password is not required. A gateway computer uses the VPN identifier to access the database previously established during the provisioning session to retrieve the user identifier. Retrieval of the user identifier validates that the computing device is authorized to use the Web service. The gateway computer stores the client IP address and a mapping to the user identifier into a database. A proxy server retrieves the user identifier from the database using the IP address and includes the user identifier in Web traffic for a remote computer.