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公开(公告)号：US10478488B2
公开(公告)日：2019-11-19
申请号：US15723793
申请日：2017-10-03
发明人： Xingguo Cheng , Kenneth H. Carson , Joseph A. McDonough , Renukaradhya J. Gourapura , Chang Won Lee , Santosh Dhakal
IPC分类号： A61K39/12 , A61K39/145 , A61K39/00
摘要： The present invention relates to the field of pharmaceutical and vaccine formulations. More specifically, formulations which comprise an antigen comprising a mixture of oligopeptides loaded into liposome nanoparticles, optionally including an adjuvant, to provide an improved immune response.
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公开(公告)号：US09770415B2
公开(公告)日：2017-09-26
申请号：US14075564
申请日：2013-11-08
发明人： Xingguo Cheng
CPC分类号： A61K9/127 , A61K9/1271 , A61K9/5153 , A61K38/1858 , A61K38/39
摘要： An aligned polymer article including substrates, wherein the substrates are not covalently bonded to the aligned collagen and a method of forming such articles wherein substrates are mixed with a polymer in solution to form a polymer-substrate mixture. The mixture is placed in an electrochemical cell and a voltage is applied to the cell generating a pH gradient, wherein the polymer aligns in the cell and migrates to the isoelectric plane of the polymer solution.
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3.发明授权公开(公告)号：US09044530B2
公开(公告)日：2015-06-02
申请号：US13720543
申请日：2012-12-19
发明人： Jian Ling , Ben Antebi , Xingguo Cheng , Jeffrey N. Harris
CPC分类号： A61L27/46 , A61L27/3821 , A61L27/54 , A61L27/56 , A61L2300/412 , A61L2430/02 , C08L89/06
摘要： The present disclosure is directed at a process to form bone grafting material. One may provide a porous collagen scaffold and insert the scaffold into a perfusion chamber of a perfusion flow system. This may then be followed by continuously providing a mineralization perfusion fluid flow through the scaffold at a flow rate to provide dynamic intrafibrillar mineralization of the scaffold and form a collagen/hydroxyapatite composite scaffold. One may optionally provide the scaffold with bone tissue forming cells and then deliver a perfusion fluid including oxygen and one or more nutrients through the collagen/hydroxyapatite composite scaffold and to the bone tissue forming cells at a flow rate such that the bone tissue forming cells remodel the collagen/hydroxyapatite composite scaffold and form a bone tissue extracellular matrix. The bone tissue extracellular matrix may then be decellularized to form an acellular bone repair scaffold.
摘要翻译： 本公开涉及形成骨移植材料的方法。 可以提供多孔胶原支架并将支架插入灌注流系统的灌注腔中。 然后可以继续以流速连续提供通过支架的矿化灌注流体流动，以提供支架的动态纤维内矿化并形成胶原/羟基磷灰石复合支架。 人们可以选择性地向支架提供骨组织形成细胞，然后以包括骨组织形成细胞改造的流速将包含氧和一种或多种营养物的灌注流体通过胶原/羟基磷灰石复合支架递送到骨组织形成细胞 胶原/羟基磷灰石复合支架，形成骨组织细胞外基质。 然后可以将骨组织细胞外基质脱细胞化以形成无细胞骨修复支架。
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公开(公告)号：US09566216B2
公开(公告)日：2017-02-14
申请号：US14083215
申请日：2013-11-18
CPC分类号： A61K6/0835 , A61F2/30 , A61K6/0008 , A61K6/0067 , A61K6/0082 , A61K6/0085 , A61K6/0215 , A61K6/023 , A61K6/0235 , A61K6/06 , A61K6/0643 , A61K6/083 , A61K49/1878 , A61L24/00 , A61L2300/44 , A61L2400/12 , C08L33/10
摘要： A bone cement formulation comprising: (a) magnetic calcium phosphate nanoparticles present in an amount of 5.0-95 wt. % and having a largest linear dimension of 150 nm to 50 microns; (b) polymerizable acrylate monomer present in an amount of 5.0-95 wt. %; and (c) polyacrylate polymer present in an amount of 0-80 wt. % and having a largest linear dimension from 5.0 to 500 microns. Upon exposure to an alternating magnetic field the formulation is heated which results in polymerization of the acrylate monomer component. The formulation may also be polymerized via the use of chain polymerization initiators.
摘要翻译： 一种骨水泥制剂，其包含：（a）以5.0-95重量％的量存在的磁性磷酸钙纳米颗粒。 并且具有150nm至50微米的最大线性尺寸; （b）可聚合的丙烯酸酯单体，其量为5.0-95wt。 ％; 和（c）以0-80wt。％的量存在的聚丙烯酸酯聚合物。 并且具有5.0至500微米的最大直线尺寸。 在暴露于交变磁场之后，加热制剂，导致丙烯酸酯单体组分的聚合。 制剂也可以通过使用链聚合引发剂进行聚合。
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5.发明授权公开(公告)号：US09770533B2
公开(公告)日：2017-09-26
申请号：US14728336
申请日：2015-06-02
发明人： Jian Ling , Ben Antebi , Xingguo Cheng , Jeffrey N. Harris , Xiao-Dong Chen
CPC分类号： A61L27/46 , A61L27/3821 , A61L27/54 , A61L27/56 , A61L2300/412 , A61L2430/02 , C08L89/06
摘要： The present disclosure is directed at a process to form bone grafting material. One may provide a porous collagen scaffold and insert the scaffold into a perfusion chamber of a perfusion flow system. This may then be followed by continuously providing a mineralization perfusion fluid flow through the scaffold at a flow rate to provide dynamic intrafibrillar mineralization of the scaffold and form a collagen/hydroxyapatite composite scaffold. One may optionally provide the scaffold with bone tissue forming cells and then deliver a perfusion fluid including oxygen and one or more nutrients through the collagen/hydroxyapatite composite scaffold and to the bone tissue forming cells at a flow rate such that the bone tissue forming cells remodel the collagen/hydroxyapatite composite scaffold and form a bone tissue extracellular matrix. The bone tissue extracellular matrix may then be decellularized to form an acellular bone repair scaffold.
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公开(公告)号：US09752117B2
公开(公告)日：2017-09-05
申请号：US14467879
申请日：2014-08-25
发明人： Jeffrey N. Harris , Jian Ling , Xingguo Cheng
CPC分类号： C12N5/0068 , A61L27/18 , A61L27/24 , A61L27/26 , A61L27/38 , A61L27/56 , A61L2400/06 , C12N2533/30 , C12N2533/50 , C12N2533/54 , C12N2533/56 , C12N2535/00
摘要： A hybrid tissue scaffold is provided which comprises a porous primary scaffold having a plurality of pores and a porous secondary scaffold having a plurality of pores, wherein the secondary scaffold resides in the pores of the primary scaffold to provide a hybrid scaffold. The pores of the porous primary scaffold may have a pore size in a range of 0.50 mm to 5.0 mm, and the pores of the porous secondary scaffold may have a pore size in a range of 50 μm to 600 μm. The primary scaffold may provide 5% to 30% of a volume of the hybrid scaffold.
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公开(公告)号：US08815594B2
公开(公告)日：2014-08-26
申请号：US13712583
申请日：2012-12-12
发明人： Jeffrey Nelson Harris , Jian Ling , Xingguo Cheng
CPC分类号： C12N5/0068 , A61L27/18 , A61L27/24 , A61L27/26 , A61L27/38 , A61L27/56 , A61L2400/06 , C12N2533/30 , C12N2533/50 , C12N2533/54 , C12N2533/56 , C12N2535/00
摘要： A hybrid tissue scaffold is provided which comprises a porous primary scaffold having a plurality of pores and a porous secondary scaffold having a plurality of pores, wherein the secondary scaffold resides in the pores of the primary scaffold to provide a hybrid scaffold. The pores of the porous primary scaffold may have a pore size in a range of 0.50 mm to 5.0 mm, and the pores of the porous secondary scaffold may have a pore size in a range of 50 μm to 600 μm. The primary scaffold may provide 5% to 30% of a volume of the hybrid scaffold.
摘要翻译： 提供了一种混合组织支架，其包括具有多个孔的多孔性主要支架和具有多个孔的多孔辅助支架，其中所述辅助支架位于所述主要支架的孔中以提供混合支架。 多孔性主支架的孔的孔径可以在0.50mm〜5.0mm的范围内，多孔性二级支架的孔的孔径可以在50μm〜600μm的范围内。 主要支架可以提供混合支架体积的5％至30％。
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