公开(公告)号：US06486196B2

公开(公告)日：2002-11-26

申请号：US09849586

申请日：2001-05-04

申请人： Srinivas Nanduri ,  Sairam Pothukuchi ,  Sriram Rajagopal ,  Venkateswarlu Akella ,  Sunilkumar Bhadramma Kochunarayana Pillai ,  Ranjan Chakrabarti

发明人： Srinivas Nanduri ,  Sairam Pothukuchi ,  Sriram Rajagopal ,  Venkateswarlu Akella ,  Sunilkumar Bhadramma Kochunarayana Pillai ,  Ranjan Chakrabarti

IPC分类号： A61K31335

CPC分类号： C07D407/06 ,  C07D307/34

摘要： The present invention relates to novel anticancer agents, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable solvates. The present invention more particularly relates to novel derivatives of andrographolide, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable solvates. The novel derivatives of andrographolide have the general formula (I).

摘要翻译： 本发明涉及新型抗癌剂，其立体异构体，其多晶型物，其药学上可接受的盐及其药学上可接受的溶剂合物。 本发明更具体地涉及穿心莲内酯的新型衍生物，其立体异构体，其多晶型物，其药学上可接受的盐及其药学上可接受的溶剂合物。 穿心莲内酯的新衍生物具有通式（I）。

公开(公告)号：US06410590B1

公开(公告)日：2002-06-25

申请号：US09775533

申请日：2001-02-01

申请人： Srinivas Nanduri ,  Sriram Rajagopal ,  Sairam Pothukuchi ,  Sunilkumar Bhadramma Kochunarayana Pillai ,  Ranjan Chakrabarti

发明人： Srinivas Nanduri ,  Sriram Rajagopal ,  Sairam Pothukuchi ,  Sunilkumar Bhadramma Kochunarayana Pillai ,  Ranjan Chakrabarti

IPC分类号： A61K31341

CPC分类号： C07D407/06

摘要： The present invention relates to novel derivatives of Andrographolide, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable solvates. The novel derivatives of Andrographolide have the general formula (I) The andrographolide derivatives represented by general formula (I) are useful for treating cancer, HSV, HIV, psoriasis, restonosis, atherosclerosis, other cardiovascular disorders, and can be used as antiviral, antimalarial, antibacterial, hepatoprotective, and immunomodulating agents and for treatment of other metabolic disorders.

摘要翻译： 本发明涉及穿心莲内酯的新衍生物，其立体异构体，其多晶型物，其药学上可接受的盐及其药学上可接受的溶剂合物。 穿心莲内酯的新型衍生物具有通式（I）由通式（I）表示的穿心莲内酯衍生物可用于治疗癌症，HSV，HIV，牛皮癣，再狭窄，动脉粥样硬化，其他心血管疾病，可用作抗病毒，抗疟药 ，抗菌，肝保护和免疫调节剂和治疗其他代谢紊乱。

公开(公告)号：US08080668B2

公开(公告)日：2011-12-20

申请号：US11480032

申请日：2006-06-30

申请人： Vijay Kumar Potluri ,  Saibal Kumar Das ,  Pradip Kumar Sasmal ,  Javed Iqbal ,  Parimal Misra ,  Ranjan Chakrabarti ,  Rashmi Talwar

发明人： Vijay Kumar Potluri ,  Saibal Kumar Das ,  Pradip Kumar Sasmal ,  Javed Iqbal ,  Parimal Misra ,  Ranjan Chakrabarti ,  Rashmi Talwar

IPC分类号： A61K31/426 ,  C07D277/38 ,  C07D277/56

CPC分类号： C07D277/42

摘要： The present application provides novel thiazole derivatives that are useful as activators of Adenosine 5′-Monophosphate-Activated Protein Kinase and pharmaceutical compositions containing such compounds.

摘要翻译： 本申请提供了可用作腺苷5'-单磷酸激活蛋白激酶的激活剂的新型噻唑衍生物和含有这些化合物的药物组合物。

公开(公告)号：US07598293B2

公开(公告)日：2009-10-06

申请号：US11674465

申请日：2007-02-13

申请人： Bhuniya Debnath ,  Saibal Kumar Das ,  Gurram Ranga Madhaven ,  Javed Iqbal ,  Ranjan Chakrabarti ,  Reeba Kannimel Vikramadithyan

发明人： Bhuniya Debnath ,  Saibal Kumar Das ,  Gurram Ranga Madhaven ,  Javed Iqbal ,  Ranjan Chakrabarti ,  Reeba Kannimel Vikramadithyan

IPC分类号： A61K31/195 ,  C07C229/34

CPC分类号： A61K31/353 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  C07C309/66 ,  C07C309/73 ,  C07C311/53

摘要： The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.

摘要翻译： 本发明涉及式（I）的新型抗糖尿病，降血脂，抗胆固醇和低胆固醇血症化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和药学上可接受的组合物，其含有 他们。

公开(公告)号：US07348334B2

公开(公告)日：2008-03-25

申请号：US10119300

申请日：2002-04-08

申请人： Javed Iqbal ,  Gurram Ranga Madhavan ,  Saibal Kumar Das ,  Debnath Bhunia ,  Ranjan Chakrabarti ,  Ramanujam Rajagopalan

发明人： Javed Iqbal ,  Gurram Ranga Madhavan ,  Saibal Kumar Das ,  Debnath Bhunia ,  Ranjan Chakrabarti ,  Ramanujam Rajagopalan

IPC分类号： A61K31/506 ,  C07D239/22

CPC分类号： C07D239/36

摘要： The present invention relates to novel hypolipidemic, antihyperglycemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel β-aryl-α-oxysubstituted alkylcarboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.

摘要翻译： 本发明涉及新型降血脂，抗高血糖化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂化物和含有它们的药学上可接受的组合物。 更具体地，本发明涉及通式（I）的新型β-芳基-α-氧代取代的烷基羧酸，其衍生物，它们的类似物，其互变异构形式，它们的立体异构体，它们的多晶型物，其药学上可接受的盐，它们的药学上可接受的 溶剂合物和含有它们的药学上可接受的组合物。

公开(公告)号：US20070015665A1

公开(公告)日：2007-01-18

申请号：US11480032

申请日：2006-06-30

申请人： Vijay Potluri ,  Saibal Das ,  Pradip Sasmal ,  Javed Iqbal ,  Parimal Misra ,  Ranjan Chakrabarti ,  Rashmi Talwar

发明人： Vijay Potluri ,  Saibal Das ,  Pradip Sasmal ,  Javed Iqbal ,  Parimal Misra ,  Ranjan Chakrabarti ,  Rashmi Talwar

IPC分类号： C07D417/02 ,  A01N43/78

CPC分类号： C07D277/42

摘要： The present application provides novel thiazole derivatives that are useful as activators of Adenosine 5′-Monophosphate-Activated Protein Kinase and pharmaceutical compositions containing such compounds.

摘要翻译： 本申请提供了可用作腺苷5'-单磷酸激活蛋白激酶的激活剂的新型噻唑衍生物和含有这些化合物的药物组合物。

公开(公告)号：US20060089500A1

公开(公告)日：2006-04-27

申请号：US11296749

申请日：2005-12-07

申请人： Ranga Gurram ,  Venkateswarlu Akella ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Parimal Misra ,  Vidya Lohray ,  Braj Lohray ,  Rao Paraselli

发明人： Ranga Gurram ,  Venkateswarlu Akella ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Parimal Misra ,  Vidya Lohray ,  Braj Lohray ,  Rao Paraselli

IPC分类号： A61K31/513 ,  C07D239/02

CPC分类号： C07D239/36 ,  C07C217/22 ,  C07C237/32 ,  C07C247/04 ,  C07D239/90

摘要： The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel β-aryl-α-oxysubstituted alkylcarboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds, their analogs, their derivatives, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. The present invention also relates to novel intermediates, processes for their preparation and their use in the preparation of compounds of formula (I).

公开(公告)号：US6130214A

公开(公告)日：2000-10-10

申请号：US179141

申请日：1998-10-26

申请人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

发明人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

IPC分类号： C07C235/48 ,  C07C323/62 ,  C07C327/48 ,  C07D239/90 ,  C07D265/22 ,  C07D279/08 ,  A61K31/54 ,  A61K31/535 ,  C07D265/12 ,  C07D279/16

CPC分类号： C07C323/62 ,  C07C235/48 ,  C07C327/48 ,  C07D239/90 ,  C07D265/22 ,  C07D279/08

摘要： The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel .beta.-aryl-.alpha.-oxysubstituted alkylcarboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. ##STR1##

摘要翻译： 本发明涉及新型抗肥胖和低胆固醇血症化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。 更具体地说，本发明涉及通式（I）的新型β-芳基-α-氧基取代的烷基羧酸，其衍生物，它们的类似物，它们的互变异构形式，它们的立体异构体，它们的多晶型物，它们的药学上可接受的盐，它们的药学上可接受的 溶剂合物和含有它们的药学上可接受的组合物。

公开(公告)号：US20080221088A1

公开(公告)日：2008-09-11

申请号：US11917229

申请日：2006-06-23

申请人： Vijay Kumar Potluri ,  Saibal Kumar Das ,  Pradip Kumar Sasmal ,  Javed Iqbal ,  Parimal Misra ,  Ranjan Chakrabarti ,  Rashmi Talwar

发明人： Vijay Kumar Potluri ,  Saibal Kumar Das ,  Pradip Kumar Sasmal ,  Javed Iqbal ,  Parimal Misra ,  Ranjan Chakrabarti ,  Rashmi Talwar

IPC分类号： A61K31/541 ,  C07D277/587 ,  C07D401/12 ,  C07D417/12 ,  A61K31/427 ,  A61K31/4439

CPC分类号： C07D277/42 ,  C07D417/12

摘要： The present application provides novel thiazole derivatives that are useful as activators of Adenosine 5′-Monophosphate-Activated Protein Kinase and pharmaceutical compositions containing such compounds.

摘要翻译： 本申请提供了可用作腺苷5'-单磷酸激活蛋白激酶的激活剂的新型噻唑衍生物和含有这些化合物的药物组合物。

公开(公告)号：US20070142470A1

公开(公告)日：2007-06-21

申请号：US11674465

申请日：2007-02-13

申请人： Bhuniya Debnath ,  Saibal Das ,  Gurram Madhaven ,  Javed Iqbal ,  Ranjan Chakrabarti ,  Reeba Vikramadithyan

发明人： Bhuniya Debnath ,  Saibal Das ,  Gurram Madhaven ,  Javed Iqbal ,  Ranjan Chakrabarti ,  Reeba Vikramadithyan

IPC分类号： A61K31/195 ,  C07C229/54 ,  C07C225/32

CPC分类号： A61K31/353 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  C07C309/66 ,  C07C309/73 ,  C07C311/53

摘要： The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.

摘要翻译： 本发明涉及式（I）的新型抗糖尿病，降血脂，抗胆固醇和低胆固醇血症化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和药学上可接受的组合物，其含有 他们。