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21 条记录 (耗时 0.022 秒)

    PERIVASCULAR MESENCHYMAL PRECURSOR CELLS
    1.
    发明申请
    PERIVASCULAR MESENCHYMAL PRECURSOR CELLS 审中-公开
    周围蛋白前体细胞

    公开(公告)号：US20120082649A1

    公开(公告)日：2012-04-05

    申请号：US13098892

    申请日：2011-05-02

    申请人： Stan Gronthos ,  Andrew Zannettino ,  Songtao Shi

    发明人： Stan Gronthos ,  Andrew Zannettino ,  Songtao Shi

    IPC分类号： A61K35/12 ,  C12N5/077

    摘要： Mesenchymal precursors cells have been isolated from perivascular niches from a range of tissues utilizing a perivascular marker. A new mesenchymal precursor cell phenotype is described characterized by the presence of the perivascular marker 3G5, and preferably also alpha smooth muscle actin together with early developmental markers such as MUC 18, VCAM-1 and STRO-1bri. The perivascular mesenchymal precursor cell is multipotential and is shown to form, vascular tissue, as well as bone marrow dentin and pulp. A method of enriching using cell sorting based on these markers is also described.

    摘要翻译： 间充质前体细胞已经使用血管周围标志物从一系列组织的血管周围位置中分离出来。 描述了新的间充质前体细胞表型，其特征在于存在血管周围标志物3G5，并且优选还包括α平滑肌肌动蛋白以及早期发育标志物如MUC18，VCAM-1和STRO-1bri。 血管周围间质前体细胞是多能的，并且显示出形成血管组织，以及骨髓牙本质和纸浆。 还描述了使用基于这些标记的细胞分选进行富集的方法。

    Perivascular mesenchymal precursor cells
    3.
    发明申请
    Perivascular mesenchymal precursor cells 有权
    血管周围间充质前体细胞

    公开(公告)号：US20070065938A1

    公开(公告)日：2007-03-22

    申请号：US10551162

    申请日：2004-03-29

    申请人： Stan Gronthos ,  Andrew Zannettino ,  Songtao Shi

    发明人： Stan Gronthos ,  Andrew Zannettino ,  Songtao Shi

    IPC分类号： C12N5/08

    CPC分类号： C12N5/0663 ,  A61K9/0014 ,  A61K35/28 ,  A61K35/44 ,  A61K38/00 ,  C12N5/0668 ,  C12N5/0691 ,  C12N2500/42 ,  C12N2501/11 ,  C12N2501/135 ,  C12N2501/165 ,  C12N2501/235 ,  C12N2501/39 ,  C12N2506/1392 ,  A61K2300/00

    摘要： Mesenchymal precursors cells have been isolated from perivascular niches from a range of tissues utilizing a perivascular marker. A new mesenchymal precursor cell phenotype is described characterized by the presence of the perivascular marker 3G5, and preferably also alpha smooth muscle actin together with early developmental markers such as MUC 18, VCAM-1 and STRO-1bri. The perivascular mesenchymal precursor cell is multipotential and is shown to form, vascular tissue, as well as bone marrow dentin and pulp. A method of enriching using cell sorting based on these markers is also described.

    摘要翻译： 间充质前体细胞已经使用血管周围标志物从一系列组织的血管周围位置中分离出来。 描述了一种新的间充质前体细胞表型，其特征在于存在血管周围标志物3G5，并且优选还包括α平滑肌肌动蛋白以及早期发育标志物如MUC18，VCAM-1和STRO-1Bri / 。 血管周围间质前体细胞是多能的，并且显示出形成血管组织，以及骨髓牙本质和纸浆。 还描述了使用基于这些标记的细胞分选进行富集的方法。

    PERIVASCULAR MESENCHYMAL PRECURSOR CELLS
    4.
    发明申请
    PERIVASCULAR MESENCHYMAL PRECURSOR CELLS 审中-公开
    周围蛋白前体细胞

    公开(公告)号：US20150368614A1

    公开(公告)日：2015-12-24

    申请号：US14746960

    申请日：2015-06-23

    申请人： Stan Gronthos ,  Andrew Zannettino ,  Songtao Shi

    发明人： Stan Gronthos ,  Andrew Zannettino ,  Songtao Shi

    IPC分类号： C12N5/0775

    摘要： Mesenchymal precursors cells have been isolated from perivascular niches from a range of tissues utilizing a perivascular marker. A new mesenchymal precursor cell phenotype is described characterized by the presence of the perivascular marker 3G5, and preferably also alpha smooth muscle actin together with early developmental markers such as MUC 18, VCAM-1 and STRO-1bri. The perivascular mesenchymal precursor cell is multipotential and is shown to form, vascular tissue, as well as bone marrow dentin and pulp. A method of enriching using cell sorting based on these markers is also described.

    摘要翻译： 间充质前体细胞已经使用血管周围标志物从一系列组织的血管周围位置中分离出来。 描述了新的间充质前体细胞表型，其特征在于存在血管周围标志物3G5，并且优选还包括α平滑肌肌动蛋白以及早期发育标志物如MUC18，VCAM-1和STRO-1bri。 血管周围间质前体细胞是多能的，并且显示出形成血管组织，以及骨髓牙本质和纸浆。 还描述了使用基于这些标记的细胞分选进行富集的方法。

    Stem Cell Modified Animal Model for Aging-Related Degenerations, Stem Cell Based Methods and Compositions for Extending Lifespan and Treating SLE-Like Autoimmune Diseases
    10.
    发明申请
    Stem Cell Modified Animal Model for Aging-Related Degenerations, Stem Cell Based Methods and Compositions for Extending Lifespan and Treating SLE-Like Autoimmune Diseases 审中-公开
    用于老化相关变性的干细胞修饰动物模型，用于延长寿命和治疗SLE样自身免疫疾病的基于干细胞的方法和组合物

    公开(公告)号：US20110283371A1

    公开(公告)日：2011-11-17

    申请号：US13133638

    申请日：2009-12-09

    申请人： Songtao Shi ,  Takayoshi Yamaza ,  Kentaro Akiyama

    发明人： Songtao Shi ,  Takayoshi Yamaza ,  Kentaro Akiyama

    IPC分类号： C12N5/0775 ,  A61K35/36 ,  G01N33/567 ,  A01K67/027

    CPC分类号： A01K67/0275 ,  A01K2227/105 ,  A01K2267/03

    摘要： This invention discloses a stem cell modified animal model useful as a research tool for investigating aging-related degeneration processes and treatments. The animal model is preferably a rodent subcutaneously transplanted with a mesenchymal stem cell capable of generating a functional bone or marrow element. Also provided are a method for extending the lifespan and improving the quality of life of a subject by subcutaneously transplanting a plurality of mesenchymal stem cells to the subject, wherein the mesenchymal stem cells are capable of generating a functional bone or marrow element. Compositions and source of stem cells suitable for use with the methods of this invention, including stem cells from human exfoliated deciduous teeth (SHED), are also disclosed. Further disclosed is a method for identifying progenitor bone marrow mesenchymal stem cells, and a method for treating SLE-like autoimmune diseases by infusion of mesenchymal stem cells.

    摘要翻译： 本发明公开了一种干细胞修饰动物模型，可用作研究老化相关变性过程和治疗的研究工具。 动物模型优选是皮下移植能够产生功能性骨或骨髓元件的间充质干细胞的啮齿动物。 还提供了一种延长寿命并通过将多个间充质干细胞皮下移植到受试者来提高受试者的生活质量的方法，其中间充质干细胞能够产生功能性骨或骨髓元件。 还公开了适用于本发明方法的干细胞的组合物和来源，包括来自人脱落落叶牙（SHED）的干细胞。 进一步公开了一种鉴定祖细胞骨髓间充质干细胞的方法，以及通过输注间充质干细胞治疗SLE样自身免疫性疾病的方法。