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公开(公告)号：US20060123492A1
公开(公告)日：2006-06-08
申请号：US11332753
申请日：2006-01-13
IPC分类号： A01K67/00 , G01N33/53 , A61K39/395
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C07K14/70571 , G01N33/566 , G01N33/6893 , G01N2500/04
摘要： Methods for screening for agents capable of modulating human neuromedin U receptor 2 (NMUR2) activity are provided, as well as therapeutic methods for treating NMUR2-mediated conditions. More specifically, methods are provided for identifying agents capable of inhibiting NMUR2-mediated pain or nociception.
摘要翻译： 提供了能够调节人神经介肽U受体2（NMUR2）活性的试剂的筛选方法，以及用于治疗NMUR2介导的病症的治疗方法。 更具体地，提供了用于鉴定能够抑制NMUR2介导的疼痛或伤害感受的药剂的方法。
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2.发明申请Assay methods for identifying modulators of OPSDL3 and transgenic knockouts 审中-公开用于鉴定OPSDL3和转基因敲除的调节剂的测定方法公开(公告)号：US20060117396A1
公开(公告)日：2006-06-01
申请号：US11292150
申请日：2005-11-30
申请人： Andrew Murphy , Y. Shanker , Susan Croll-Kalish , Richard Torres
发明人： Andrew Murphy , Y. Shanker , Susan Croll-Kalish , Richard Torres
CPC分类号： G01N33/74 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0393 , C07K14/723 , C12N15/8509 , G01N33/5041 , G01N33/9486
摘要： Methods for treating or alleviating pain by treating a subject in need thereof with an agonist of OPSDL3 activity or expression. Further provided are screening methods for identifying agents capable of activating OPSDL3, and transgenic non-human animals which homozygous for deletion of the endogenous OPSDL3 gene and/or comprise a human OPSDL3 gene.
摘要翻译： 通过用OPSDL3活性或表达的激动剂治疗有需要的受试者来治疗或缓解疼痛的方法。 进一步提供了用于鉴定能够活化OPSDL3的试剂的筛选方法，以及用于缺失内源OPSDL3基因和/或包含人OPSDL3基因纯合的转基因非人动物。
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3.发明申请Assay methods for identifying RE2-like antagonists, methods of use, and non-human transgenic animals 审中-公开用于鉴定RE2样拮抗剂，使用方法和非人转基因动物的测定方法公开(公告)号：US20060123502A1
公开(公告)日：2006-06-08
申请号：US11292149
申请日：2005-11-30
申请人： Andrew Murphy , Y. Shanker , Susan Croll-Kalish , Richard Torres
发明人： Andrew Murphy , Y. Shanker , Susan Croll-Kalish , Richard Torres
IPC分类号： A01K67/027 , A61K39/395 , A61K48/00
CPC分类号： C07K14/70571 , A01K67/0276 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , C12N15/8509
摘要： Provided is a human RE2-L protein, as well as the encoding nucleic acid, methods for screening for agents capable of modulating RE2-L related activity and treating RE2-L-mediated conditions. Further provided are animal models useful for screening agents capable of ameliorating or reducing anxiety related disorders and obsessive-compulsive disorders.
摘要翻译： 提供人类RE2-L蛋白质，以及编码核酸，筛选能够调节RE2-L相关活性和治疗RE2-L介导的病症的药物的方法。 还提供了可用于能够改善或减少焦虑相关疾病和强迫症的筛选剂的动物模型。
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公开(公告)号：US20130209564A1
公开(公告)日：2013-08-15
申请号：US13580212
申请日：2011-02-22
申请人： Shyam M. Rele , Andrew Murphy , Bolyn Hubby
发明人： Shyam M. Rele , Andrew Murphy , Bolyn Hubby
IPC分类号： A61K39/385
CPC分类号： A61K39/385 , A61K39/092 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , Y10S977/773
摘要： Particle compositions are prepared for use as polysaccharide particle vaccines.
摘要翻译： 制备颗粒组合物用作多糖颗粒疫苗。
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公开(公告)号：US20110151015A1
公开(公告)日：2011-06-23
申请号：US12920944
申请日：2009-03-04
申请人： Bolyn Hubby , Andrew Murphy , Jeff Kindig , Jesse White , Samantha Roth , Ashley L. Galloway , Laura Copp
发明人： Bolyn Hubby , Andrew Murphy , Jeff Kindig , Jesse White , Samantha Roth , Ashley L. Galloway , Laura Copp
IPC分类号： A61K9/14 , A61K39/385 , C07K1/00 , A61P37/04 , A61P31/16
CPC分类号： A61K39/39 , A61K39/385 , A61K47/646 , A61K47/6927 , A61K47/6931 , A61K47/6937 , A61K2039/55538 , A61K2039/6093 , A61K2039/627
摘要： A method of stimulating an immune response in a subject including administering a micrometer-sized particle coupled with an antigen to the subject, wherein increasing the aspect ratio of the micrometer-sized particle increases the immune response. A method of stimulating an immune response in a subject including administering to the subject a plurality of particles, wherein each particle is coupled with an immuno stimulating agent and a protein. A vaccine particle composition including a plurality of particles configured to release a first protein at a first rate and a second protein at a second rate and configured to provide priming and boosting capability in a single dose.
摘要翻译： 刺激受试者中的免疫应答的方法包括给受试者施用与抗原偶联的微米大小的颗粒，其中增加微米尺寸颗粒的长宽比增加免疫应答。 一种刺激受试者的免疫应答的方法，包括向受试者施用多个颗粒，其中每个颗粒与免疫刺激剂和蛋白质偶联。 一种疫苗颗粒组合物，其包括构造成以第一速率释放第一蛋白质的多个颗粒和以第二速率释放第二蛋白质并被配置成以单一剂量提供起始和升高能力的多个颗粒。
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公开(公告)号：USD612337S1
公开(公告)日：2010-03-23
申请号：US29324991
申请日：2008-09-24
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公开(公告)号：US20070061900A1
公开(公告)日：2007-03-15
申请号：US11595427
申请日：2006-11-09
申请人： Andrew Murphy , George Yancopoulos
发明人： Andrew Murphy , George Yancopoulos
IPC分类号： A01K67/027 , C12P21/04
CPC分类号： C12P21/00 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/05 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/28 , C07K16/462 , C07K2317/10 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C12N15/67 , C12N15/85 , C12N15/8509 , C12N15/902 , C12N15/907 , C12N2800/204
摘要： A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification.
摘要翻译： 一种用于工程化和利用大型DNA载体通过同源重组靶向并以任何所需方式修饰真核细胞中的内源基因和染色体基因座的方法。 用于真核细胞的这些大的DNA靶向载体，称为LTVEC，衍生自克隆基因组DNA的片段，大于通常用于在真核细胞中进行同源靶向的其它方法通常使用的那些。 还提供了检测真核细胞的快速和方便的方法，其中LTVEC已经正确靶向和修饰了所需的内源基因或染色体基因座（位点），以及使用这些细胞产生具有遗传修饰的生物体。
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公开(公告)号：US20060231100A1
公开(公告)日：2006-10-19
申请号：US11106833
申请日：2005-04-15
申请人： Garry Walker , Desmond Curran , Andrew Murphy , Derek Parkin
发明人： Garry Walker , Desmond Curran , Andrew Murphy , Derek Parkin
IPC分类号： A62B18/02
摘要： The present invention pertains to a supplied air respirator that uses an adjustable length hose as a conduit between the respirator facepiece and the clean air supply source.
摘要翻译： 本发明涉及一种使用可调节长度的软管作为呼吸器面罩和清洁空气供应源之间的导管的供气式呼吸器。
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公开(公告)号：US20050202875A1
公开(公告)日：2005-09-15
申请号：US10800331
申请日：2004-03-12
申请人： Andrew Murphy , Yasser Asmi , Alice Steinglass
发明人： Andrew Murphy , Yasser Asmi , Alice Steinglass
CPC分类号： A63F13/71 , A63F13/12 , A63F13/79 , A63F2300/532
摘要： Techniques are disclosed to silently sign-in a user of an offline game title onto an online service. The user is afforded access to select online services to facilitate future online gaming. In a described implementation, a method is disclosed. The method silently signs in a user of an offline game title onto an online gaming service. As a result, the signed-in user may receive one or more online services such as an in-game notification, a friend request (e.g., inviting a user to become a friend), a cross-title game invitation, and/or data corresponding to a friends list.
摘要翻译： 披露技术以静默地登录到在线服务上的离线游戏标题的用户。 用户可以访问选择的在线服务，以方便未来的在线游戏。 在所述的实施方式中，公开了一种方法。 该方法在离线游戏标题的用户中无声地登录到在线游戏服务。 因此，登录用户可以接收一个或多个在线服务，例如游戏内通知，朋友请求（例如邀请用户成为朋友），跨标题游戏邀请和/或数据 对应一个朋友列表。
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10.发明授权公开(公告)号：US09861896B2
公开(公告)日：2018-01-09
申请号：US12204236
申请日：2008-09-04
申请人： Thomas A. Langan , Vipul Hingne , Ryan Ross Cooper , Tian Lim , Andrew Murphy
发明人： Thomas A. Langan , Vipul Hingne , Ryan Ross Cooper , Tian Lim , Andrew Murphy
IPC分类号： A63F13/795 , A63F13/85 , H04L29/06 , A63F13/30
CPC分类号： A63F13/795 , A63F13/12 , A63F13/79 , A63F13/85 , A63F2300/209 , A63F2300/556 , A63F2300/5566 , H04L65/40
摘要： A method and system for a platform wide party system that may be deployed in a multiplayer gaming environment. Players may associate themselves with one or more parties, wherein players within a party may choose to automatically exchange messages associated with changes in state of the players in a gaming environment. The party system exposes an API providing a plurality of function calls that may be integrated seamlessly with game play. A first player may indicate desired notification events to be received from a second player associated with the same party as the first player. Upon detection of a desired notification event on the video game console of the second player, an event notification may be communicated to a video game console of the first player causing an action to be performed on the first player's video game console. Actions may include event notifications via text and/or sound, which may be displayed to the first player while engaged in any game session and without requiring the first player to exit the current game session.
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