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14 条记录 (耗时 0.022 秒)

    Self-crosslinking compositions based on fluorine-containing polycondensates
    1.
    发明授权
    Self-crosslinking compositions based on fluorine-containing polycondensates 有权
    基于含氟缩聚物的自交联组合物

    公开(公告)号：US06630205B2

    公开(公告)日：2003-10-07

    申请号：US10148520

    申请日：2002-05-31

    申请人： Stefan Brueck ,  Christoph Lesniak ,  Hermann Schirra ,  Helmut Schmidt

    发明人： Stefan Brueck ,  Christoph Lesniak ,  Hermann Schirra ,  Helmut Schmidt

    IPC分类号： B05D302

    CPC分类号： C09D183/08 ,  C08G77/22 ,  C08G77/24 ,  C08G77/26 ,  C08L2666/54 ,  C08L83/00

    摘要： The invention relates to a method for coating a substrate according to which a self-crosslinking coating composition is produced on the basis of a) at least one hydrolysable silane with at least one nonhydrolysable substituent, said silane having one or more electrophilic groups X on at least one nonhydrolysable substitutent, b) at least one hydrolysable silane with at least one nonhydrolysable substituent, said silane having one or more nucleophilic groups Y on at least one nonhydrolysable substituent, c) at least one hydrolysable silane with at least one nonhydrolysable carbonic group that has an average of 2 to 30 fluorine atoms that are bound to one or more aliphatic carbon atoms that are separated from the silicon atom by at least two atoms. The silanes (a), (b) and/or (c) are optionally precondensed and either the silanes (a) may be completely or partially replaced by organic compounds with at least two groups X or the silanes (b) may be completely or partially replaced by organic compounds with at least two groups Y. The self-crosslinking coating composition is then applied to a substrate and allowed to cure at ambient temperature (below 40° C.) to form a coating.

    摘要翻译： 本发明涉及一种涂覆基材的方法，根据该方法，基于以下方式制备自交联涂料组合物：a）至少一种具有至少一个不可水解取代基的可水解硅烷，所述硅烷具有一个或多个亲电基团X 至少一种不可水解取代基，b）至少一种具有至少一个不可水解取代基的可水解硅烷，所述硅烷在至少一个不可水解取代基上具有一个或多个亲核基团Y，c）至少一种具有至少一个不可水解碳酸基的可水解硅烷， 具有平均2至30个氟原子，其结合于通过至少两个原子与硅原子分离的一个或多个脂族碳原子。 硅烷（a），（b）和/或（c）任选地被预稠化，并且硅烷（a）可以被具有至少两个X基团的有机化合物完全或部分替代，或者硅烷（b）可以是完全或 部分地被具有至少两个基团Y的有机化合物取代。然后将自交联涂料组合物施加到基底上并使其在环境温度（低于40℃）下固化以形成涂层。

    Process for preparing agglomerate-free nanoscalar iron oxide particles with a hydrolysis resistant coating
    3.
    发明授权
    Process for preparing agglomerate-free nanoscalar iron oxide particles with a hydrolysis resistant coating 有权
    用耐水解涂层制备无团聚的纳米级氧化铁颗粒的方法

    公开(公告)号：US06183658B2

    公开(公告)日：2001-02-06

    申请号：US09171065

    申请日：1998-10-09

    申请人： Christoph Lesniak ,  Thomas Schiestel ,  Rüdiger Nass ,  Helmut Schmidt

    发明人： Christoph Lesniak ,  Thomas Schiestel ,  Rüdiger Nass ,  Helmut Schmidt

    IPC分类号： C09D1700

    CPC分类号： B82Y30/00 ,  C01G49/02 ,  C01P2004/64 ,  C01P2006/80 ,  C01P2006/90 ,  C09C1/24 ,  C09C3/006 ,  C09C3/045 ,  C09C3/12 ,  Y10T428/2995

    摘要： A process for preparing an agglomerate-free suspension of nanosize iron-containing oxide particles coated in a stable manner comprises preparing an aqueous suspension of nanosize iron-containing oxide particles which are partially or completely in the form of agglomerates; adding a trialkoxysilane and a water-miscible polar organic solvent which has a boiling point at least 10° C. higher than the boiling point of water; treating the resulting suspension with ultrasound until at least 70% of the particles present are in the range of ±20% of the average particle diameter; removing the water by distillation under the action of ultrasound; and separating the non-disintegrated agglomerates.

    摘要翻译： 制备以稳定方式包被的纳米尺寸含铁氧化物颗粒的无附聚物悬浮液的方法包括制备部分或全部为附聚物形式的纳米级含铁氧化物颗粒的水性悬浮液; 加入沸点比水的沸点高至少10℃的三烷氧基硅烷和水混溶性极性有机溶剂; 用超声波处理所得到的悬浮液，直到存在的颗粒的至少70％在平均粒径的±20％的范围内; 在超声波作用下通过蒸馏除去水分; 并分离未崩解的附聚物。

    Nanoscale particles having an iron oxide-containing core enveloped by at least two shells
    6.
    发明授权
    Nanoscale particles having an iron oxide-containing core enveloped by at least two shells 失效
    具有包含至少两个壳的含氧化铁芯的纳米级颗粒

    公开(公告)号：US06979466B2

    公开(公告)日：2005-12-27

    申请号：US10391356

    申请日：2003-03-17

    申请人： Christoph Lesniak ,  Thomas Schiestel ,  Helmut Schmidt ,  Andreas Jordan

    发明人： Christoph Lesniak ,  Thomas Schiestel ,  Helmut Schmidt ,  Andreas Jordan

    IPC分类号： A61K9/16 ,  A61K41/00 ,  A61P35/00 ,  A61K9/51

    CPC分类号： A61K41/0052

    摘要： The invention relates to nanoscale particles suited especially for use in tumor therapy by hyperthermia. Said particles comprise a (preferably superparamagnetic) iron oxide-containing core and at least two shells surrounding said core. The (innermost) shell adjoining the core is an envelope which comprises groups capable of forming cationic groups and is broken down by human or animal tissue at such a slow rate as to allow for association of the core surrounded by said envelope with the surface of cells and/or for absorption of said core into the inside of cells. The outer shell(s) consist(s) of species having neutral and/or anionic groups which allow the nanoscale particles to appear to the outside as having a neutral or negative charge and which are broken down by human or animal tissue more rapidly than the innermost shell—and in so doing uncover the shells underneath—but still sufficiently slowly so as to ensure that the nanoscale particles are adequately distributed in a tissue infiltrated with same particles in a particular point.

    摘要翻译： 本发明涉及特别适用于通过高热治疗肿瘤治疗的纳米级颗粒。 所述颗粒包含（优选超顺磁性）含氧化铁的芯和围绕所述芯的至少两个壳。 与核心相邻的（最内侧）壳是包含能够形成阳离子基团并且以如此慢的速率被人或动物组织分解以允许由所述包膜包围的核与细胞表面缔合的基团 和/或用于将所述核吸收到细胞内部。 外壳由具有中性和/或阴离子基团的物质组成，其允许纳米级颗粒以外面的形式出现在外部，具有中性或负电荷，并且比人或动物组织更快地分解 最内层的壳体，并且在其中露出壳下面，但是仍然足够缓慢，以便确保纳米级颗粒在特定的点上适当地分布在渗透有相同颗粒的组织中。

    Particles having a magnetic core and outer glass layer for separating biological material
    7.
    发明授权
    Particles having a magnetic core and outer glass layer for separating biological material 失效
    具有用于分离生物材料的磁芯和外部玻璃层的颗粒

    公开(公告)号：US06255477B1

    公开(公告)日：2001-07-03

    申请号：US08952969

    申请日：1998-03-11

    申请人： Jörg Kleiber ,  Thomas Walter ,  Herbert Harttig ,  Christoph Lesniak ,  Martin Mennig ,  Michael Riedling ,  Helmut Schmidt

    发明人： Jörg Kleiber ,  Thomas Walter ,  Herbert Harttig ,  Christoph Lesniak ,  Martin Mennig ,  Michael Riedling ,  Helmut Schmidt

    IPC分类号： C12N1500

    CPC分类号： C03C3/111 ,  B03C1/01 ,  B82Y25/00 ,  C03C3/078 ,  C03C3/083 ,  C03C3/085 ,  C03C3/087 ,  C03C3/089 ,  C03C3/091 ,  C03C3/102 ,  C03C3/105 ,  C03C3/108 ,  C07H21/00 ,  C12N15/1013 ,  C12Q1/6804 ,  C12Q1/6806 ,  C12Q1/6834 ,  H01F1/0063 ,  H01F1/112 ,  H01F1/36 ,  Y10S428/90 ,  Y10S435/814 ,  Y10T428/2996

    摘要： Magnetic glass particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free glass surface. The particles are used for separating biological material such as nucleic acids. A preferred process of preparing the particles is by forming a mixture of magnetic cores with a sol formed from an alcohol and a metal alkoxide, spray-drying the mixture to coat the cores with a layer of gelled sol, and heating the coated cores to obtain the magnetic glass particles. Preferably, the particles have an average particle size of less than 100 &mgr;m and any pores of the glass surface have a diameter of less than 10 nm. The magnetic core may be a composite material containing a mica core and magnetite particles immobilized on the mica core, and the glass layer may contain boron oxide. Magnetic core materials include magnetite (Fe3O4) and Fe2O3. In using the magnetic glass particles to separate a biological material, the particles are contacted with a fluid containing the biological material such that the biological material binds to the glass surface, and the bound biological material is separated from the fluid such as by using a magnetic field. Before applying a magnetic field, the magnetic particles may sediment when contacted with the biological material.

    摘要翻译： 制备磁性玻璃颗粒，其包含涂覆有具有基本无孔玻璃表面的玻璃层的磁芯。 颗粒用于分离生物材料如核酸。 制备颗粒的优选方法是通过用由醇和金属醇盐形成的溶胶形成磁芯的混合物，喷雾干燥混合物以用一层凝胶溶胶涂覆芯，并加热涂覆的芯以获得 磁性玻璃颗粒。 优选地，颗粒的平均粒度小于100μm，并且玻璃表面的任何孔具有小于10nm的直径。 磁芯可以是包含固定在云母芯上的云母芯和磁铁矿颗粒的复合材料，并且玻璃层可以含有氧化硼。 磁芯材料包括磁铁矿（Fe3O4）和Fe2O3。 在使用磁性玻璃颗粒分离生物材料时，颗粒与包含生物材料的流体接触，使得生物材料结合到玻璃表面，并且结合的生物材料与流体分离，例如通过使用磁性 领域。 在施加磁场之前，当与生物材料接触时，磁性颗粒可能沉淀。