-
公开(公告)号：US4795809A
公开(公告)日：1989-01-03
申请号：US900744
申请日：1986-08-27
IPC分类号： C12N9/02 , A61K31/397 , A61K31/42 , A61P31/04 , C07D205/08 , C07D498/04 , C07D503/00 , C12N9/00 , C12N9/99 , C12P17/18 , C12R1/465
CPC分类号： C12R1/465 , C07D205/08 , C07D503/00 , C12P17/188
摘要： A compound having the formula (I): ##STR1## is described, together with salts thereof and an enzymatic process for converting such compounds into clavulanic acid.A process for the preparation of the compound of formula (I) and its salts is disclosed, together with intermediates for use therein. This process involves the use of a novel enzyme system to effect the desired cyclization, which enzyme system is preferably derived from a micro-organism, in particular a species of Streptomyces.
摘要翻译： 其中描述了具有式（I）的化合物：其中的盐以及用于将这些化合物转化成克拉维酸的酶法。 公开了制备式（I）化合物及其盐的方法以及其中使用的中间体。 该方法涉及使用新的酶系统来实现期望的环化，该酶系统优选衍生自微生物，特别是链霉菌的种类。
-
公开(公告)号：US5130241A
公开(公告)日：1992-07-14
申请号：US632633
申请日：1990-12-26
IPC分类号： C12N9/02 , A61K31/397 , A61K31/42 , A61P31/04 , C07D205/08 , C07D498/04 , C07D503/00 , C12N9/00 , C12N9/99 , C12P17/18 , C12R1/465
CPC分类号： C12R1/465 , C07D205/08 , C07D503/00 , C12P17/188
摘要： A compound having the formula (I): ##STR1## is described, together with salts thereof and an enzymatic process for converting such compounds into clavulanic acid.A process for the preparation of the compound of formula (I) and its salts is disclosed, together with intermediates for use therein. This process involves the use of a novel enzyme system to effect the desired cyclisation, which enzyme system is preferably derived from a micro-organism, in particular a species of Streptomyces.
-
公开(公告)号：US4212979A
公开(公告)日：1980-07-15
申请号：US850786
申请日：1977-11-11
申请人： Keith H. Baggaley
发明人： Keith H. Baggaley
IPC分类号： A61K31/41 , A61K31/428 , A61K31/44 , A61K31/445 , A61K31/47 , C07D275/04 , C07D417/06 , C07D513/04
CPC分类号： C07D417/06 , A61K31/41 , A61K31/44 , A61K31/445 , A61K31/47 , C07D275/04 , Y10S514/822 , Y10S514/878
摘要： A class of 2-substituted benzisothiazolones carrying a nitrogen-containing heterocyclic ring are effective in inhibiting platelet aggregation and are therefore of value in the prophylactic and therapeutic treatment of thrombotic diseases.
摘要翻译： 携带含氮杂环的2-取代苯并异噻唑酮类有效抑制血小板聚集，因此在预防和治疗血栓性疾病方面具有价值。
-
公开(公告)号：US4341708A
公开(公告)日：1982-07-27
申请号：US230539
申请日：1981-02-02
IPC分类号： A61K31/40 , A61P7/02 , A61P11/08 , C07D207/26 , C07D207/273 , C07D207/36 , C07D491/04 , C07D491/044 , C07D491/048 , C07F3/14
CPC分类号： C07D207/273 , C07D207/36 , C07D491/04 , C07F3/14 , Y10S514/822
摘要： An intermediate compound which is a perhydrofuro [3,2-6] pyrrole of the formula: ##STR1## wherein: R.sub.2 is hydrogen or C.sub.1-4 alkyl; andR.sub.3 is C.sub.4-9 alkyl, C.sub.5-7 cycloalkyl or C.sub.5-7 cycloalkyl C.sub.1-6 alkyl;for use in the synthesis of prostacyclin aza analogues having anti-thrombotic activity.
-
公开(公告)号：US4206145A
公开(公告)日：1980-06-03
申请号：US859557
申请日：1977-12-12
IPC分类号： C07C87/28
摘要： Certain substituted aralkylanilines in which the aromatic aniline ring carries, at the para position to the amino function, a substituent which comprises a carboxylic acid, salt or ester, an alkyl, hydroxyalkyl, cyano or acyl group, have hypolipidaemic activity.
摘要翻译： 其中芳香族苯胺环在氨基官能的对位具有含羧酸，盐或酯，烷基，羟基烷基，氰基或酰基的取代基的某些取代的芳烷基苯胺具有降血脂活性。
-
公开(公告)号：US4212872A
公开(公告)日：1980-07-15
申请号：US936861
申请日：1978-08-25
申请人： Keith H. Baggaley
发明人： Keith H. Baggaley
IPC分类号： A61K31/41 , A61K31/428 , A61K31/44 , A61K31/445 , A61K31/47 , C07D275/04 , C07D417/06 , C07D417/04 , A61K31/425
CPC分类号： C07D417/06 , A61K31/41 , A61K31/44 , A61K31/445 , A61K31/47 , C07D275/04 , Y10S514/822 , Y10S514/878
摘要： A class of 2-substituted benzisothiazolones carrying a nitrogen-containing heterocyclic ring are effective in inhibiting platelet aggregation and are therefore of value in the prophylactic and therapeutic treatment of thrombotic diseases.
摘要翻译： 携带含氮杂环的2-取代苯并异噻唑酮类有效抑制血小板聚集，因此在预防和治疗血栓性疾病方面具有价值。
-
7.发明授权
公开(公告)号：US4154850A
公开(公告)日：1979-05-15
申请号：US821772
申请日：1977-08-04
IPC分类号： C07C69/92 , A61K31/085 , A61K31/10 , A61K31/125 , A61K31/135 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/275 , A61K31/357 , A61K31/36 , A61P3/06 , C07C41/00 , C07C43/205 , C07C43/23 , C07C45/00 , C07C47/277 , C07C47/575 , C07C49/255 , C07C49/84 , C07C51/00 , C07C59/64 , C07C59/68 , C07C65/21 , C07C65/24 , C07C67/00 , C07C69/035 , C07C69/612 , C07C69/708 , C07C69/734 , C07C69/736 , C07C201/00 , C07C205/37 , C07C213/00 , C07C217/84 , C07C231/00 , C07C231/12 , C07C235/34 , C07C235/46 , C07C241/00 , C07C243/32 , C07C243/38 , C07C253/00 , C07C255/37 , C07D317/56 , A61K31/235 , C07C69/76
CPC分类号： C07C321/00 , C07C49/255 , C07C49/84
摘要： A class of di-(substituted phenoxy) alkanes having from 7 to 25 carbon atoms in the alkane moiety have hypolipidaemic activity.
摘要翻译： 一类在烷烃部分具有7至25个碳原子的二（取代苯氧基）烷烃具有降脂活性。
-
公开(公告)号：US4350702A
公开(公告)日：1982-09-21
申请号：US202711
申请日：1980-10-31
申请人： Keith H. Baggaley
发明人： Keith H. Baggaley
IPC分类号： A61K31/41 , A61K31/428 , A61K31/44 , A61K31/445 , A61K31/47 , C07D275/04 , C07D417/06 , A61K31/425
CPC分类号： C07D417/06 , A61K31/41 , A61K31/44 , A61K31/445 , A61K31/47 , C07D275/04 , Y10S514/822 , Y10S514/878
摘要： A class of 2-substituted benzisothiazolones carrying a nitrogen-containing heterocyclic ring are effective in inhibiting platelet aggregation and are therefore of value in the prophylactic and therapeutic treatment of thrombotic diseases.
摘要翻译： 携带含氮杂环的2-取代苯并异噻唑酮类有效抑制血小板聚集，因此在预防和治疗血栓性疾病方面具有价值。
-
9.发明授权2-[Gamma-(1-piperidinyl)propyl]-1,2-benzisothiazole-3-one, its salts, and pharmaceutical compositions 失效2- [γ-（1-哌啶基）丙基] -1,2-苯并异噻唑-3-酮，其盐和药物组合物
公开(公告)号：US4186203A
公开(公告)日：1980-01-29
申请号：US917069
申请日：1978-06-19
申请人： Barbara Nunn , Keith H. Baggaley
发明人： Barbara Nunn , Keith H. Baggaley
IPC分类号： C07D295/00 , C07D275/00 , C07D275/04 , C07D417/06 , A61K31/445 , C07D417/08
CPC分类号： C07D275/04
摘要： The compound 2-[gamma-(1-piperidinyl)propyl]-1,2-benzisothiazole-3-one or a pharmaceutically acceptable acid addition salt thereof and pharmaceutical compositions containing an effective amount of such compound or salt and a carrier, preferably compositions in orally administrable form. The compound or salt is characterized by antithrombotic activity, especially for inhibiting platelet aggregation. Procedures for preparation of the compound are described.
摘要翻译： 化合物2- [γ-（1-哌啶基）丙基] -1,2-苯并异噻唑-3-酮或其药学上可接受的酸加成盐和含有效量的这种化合物或盐和载体的药物组合物，优选组合物 口服给药。 化合物或盐的特征在于抗血栓形成活性，特别是用于抑制血小板聚集。 描述了该化合物的制备方法。
-
公开(公告)号：US4362892A
公开(公告)日：1982-12-07
申请号：US859379
申请日：1977-12-12
IPC分类号： A61K31/135 , A61K20060101 , A61K31/04 , A61K31/16 , A61K31/165 , A61K31/185 , A61K31/19 , A61K31/195 , A61K31/21 , A61K31/215 , A61K31/24 , A61K31/275 , A61K31/36 , A61P3/06 , C07C20060101 , C07C67/00 , C07C209/00 , C07C209/10 , C07C209/18 , C07C209/50 , C07C209/52 , C07C211/44 , C07C213/00 , C07C215/68 , C07C225/22 , C07C227/00 , C07C227/04 , C07C227/16 , C07C227/18 , C07C229/42 , C07C229/60 , C07C231/00 , C07C231/12 , C07C253/00 , C07C255/42 , C07D317/30 , C07C87/28 , C07C91/00
CPC分类号： A61K31/04 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/185 , A61K31/19 , A61K31/195 , A61K31/21 , A61K31/215 , A61K31/24 , A61K31/275 , A61K31/36 , C07C1/00 , C07C209/00 , C07C209/10 , C07C209/18 , C07C209/50 , C07C209/52 , C07C211/44 , C07C213/00 , C07C215/68 , C07C225/22 , C07C227/00 , C07C227/04 , C07C227/16 , C07C227/18 , C07C229/42 , C07C229/60 , C07C231/00 , C07C231/12 , C07C253/00 , C07C255/42 , C07C67/00 , C07D317/30
摘要： Certain substituted aralkylanilines in which the aromatic aniline ring carries, at the para position to the amino function, a substituent which comprises a carboxylic acid, salt or ester, an alkyl, hydroxyalkyl, cyano or acyl group, have hypolipidaemic activity.
摘要翻译： 其中芳香族苯胺环在氨基官能的对位具有含羧酸，盐或酯，烷基，羟基烷基，氰基或酰基的取代基的某些取代的芳烷基苯胺具有降血脂活性。
-
-
-
-
-
-
-
-
-
搜索结果
13 条记录 (耗时 0.024 秒)
