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公开(公告)号：US20070185516A1
公开(公告)日：2007-08-09
申请号：US11621633
申请日：2007-01-10
申请人： Stefan Schosnig , Wolfgang Handel , Wolfgang Jost , Lydia Kolonko , Hans List , Jack Griffis , Brian Leutz , Jeff Stout , Gwenn Kennedy , Bradley Koeppel , Jeff Noble
发明人： Stefan Schosnig , Wolfgang Handel , Wolfgang Jost , Lydia Kolonko , Hans List , Jack Griffis , Brian Leutz , Jeff Stout , Gwenn Kennedy , Bradley Koeppel , Jeff Noble
IPC分类号： A61B17/32
CPC分类号： A61B5/15144 , A61B5/150022 , A61B5/150183 , A61B5/150412 , A61B5/150519 , A61B5/150564 , A61B5/150618 , A61B5/150717 , A61B5/150916 , A61B5/15113 , A61B5/15117
摘要： The present invention provides a puncture aid comprising a housing in which a lancet holder with a lancet is displaceably mounted, the lancet holder being connected to a spring element. The lancet holder has at least one bearing element and the housing has a support surface arranged such that the bearing element rests on the support surface in a first position of the lancet holder. A trigger unit is provided, actuation of which transfer the lancet holder to a second position by means of a relative rotational movement of the bearing element and the support surface, so that the bearing element falls from the support surface in the second position of the lancet holder, and the tensioned spring element at least partially relaxes and moves the lancet holder such that the tip of the lancet emerges from the opening of the housing. The puncture aid includes a blocking element which is arranged such that it blocks a relative rotational movement of the bearing element and the support surface with respect to one another after the trigger unit has transferred the lancet holder to the second position with the result that reuse of the puncture aid is prevented.
摘要翻译： 本发明提供一种穿刺辅助装置，其具有可拆卸地安装有刺血针的柳叶刀套的壳体，所述柳叶刀套与弹簧元件连接。 所述柳叶刀套具有至少一个轴承元件，并且所述壳体具有布置成使得所述轴承元件在所述刺血针保持器的第一位置处于所述支撑表面上的支撑表面。 提供了一种触发单元，其致动通过轴承元件和支撑表面的相对旋转运动将刺血针保持器传递到第二位置，使得轴承元件在刺血针的第二位置从支撑表面落下 并且张紧的弹簧元件至少部分地松弛和移动刺血针保持器，使得柳叶刀的尖端从壳体的开口露出。 穿刺辅助件包括阻挡元件，其被布置成使得其在触发单元将刺血针保持器转移到第二位置之后阻止轴承元件和支撑表面相对于彼此的相对旋转运动，结果是重新使用 可以防止穿刺辅助。
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公开(公告)号：US08361099B2
公开(公告)日：2013-01-29
申请号：US11621633
申请日：2007-01-10
申请人： Stefan Schosnig , Wolfgang Handel , Wolfgang Jost , Lydia Kolonko , Hans List , Jack Griffis , Brian Leutz , Jeff Stout , Gwenn Kennedy , Bradley Koeppel , Jeff Noble
发明人： Stefan Schosnig , Wolfgang Handel , Wolfgang Jost , Lydia Kolonko , Hans List , Jack Griffis , Brian Leutz , Jeff Stout , Gwenn Kennedy , Bradley Koeppel , Jeff Noble
CPC分类号： A61B5/15144 , A61B5/150022 , A61B5/150183 , A61B5/150412 , A61B5/150519 , A61B5/150564 , A61B5/150618 , A61B5/150717 , A61B5/150916 , A61B5/15113 , A61B5/15117
摘要： The present invention provides a puncture aid comprising a housing in which a lancet holder with a lancet is displaceably mounted, the lancet holder being connected to a spring element. The lancet holder has at least one bearing element and the housing has a support surface arranged such that the bearing element rests on the support surface in a first position of the lancet holder. A trigger unit is provided, actuation of which transfer the lancet holder to a second position by means of a relative rotational movement of the bearing element and the support surface, so that the bearing element falls from the support surface in the second position of the lancet holder, and the tensioned spring element at least partially relaxes and moves the lancet holder such that the tip of the lancet emerges from the opening of the housing. The puncture aid includes a blocking element which is arranged such that it blocks a relative rotational movement of the bearing element and the support surface with respect to one another after the trigger unit has transferred the lancet holder to the second position with the result that reuse of the puncture aid is prevented.
摘要翻译： 本发明提供一种穿刺辅助装置，其具有可拆卸地安装有刺血针的柳叶刀套的壳体，所述柳叶刀套与弹簧元件连接。 所述柳叶刀套具有至少一个轴承元件，并且所述壳体具有布置成使得所述轴承元件在所述刺血针保持器的第一位置处于所述支撑表面上的支撑表面。 提供了一种触发单元，其致动通过所述轴承元件和所述支撑表面的相对旋转运动将所述刺血针保持器传递到第二位置，使得所述轴承元件从所述支撑表面落入所述柳叶刀的第二位置 并且张紧的弹簧元件至少部分地松弛和移动刺血针保持器，使得柳叶刀的尖端从壳体的开口露出。 穿刺辅助件包括阻挡元件，其被布置成使得其在触发单元将刺血针保持器转移到第二位置之后阻止轴承元件和支撑表面相对于彼此的相对旋转运动，结果是重新使用 可以防止穿刺辅助。
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公开(公告)号：US09051577B2
公开(公告)日：2015-06-09
申请号：US12373268
申请日：2007-07-11
CPC分类号： C07K16/283 , C07K16/00 , C07K2317/14 , C07K2317/41 , C07K2317/52 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C12N15/8258
摘要： The present invention relates to an antibody preparation comprising modified antibodies of an animal or derivatives or fragments thereof, specific for an antigen, characterized in that • the antibodies or derivatives or fragments thereof comprise an N-glycan structure free of fucose and xylose, and • at least 90%, preferably at least 95%, more preferred at least 99%, most preferred at least 100% of the modified antibodies, derivatives or fragments thereof lack a C-terminal lysine residue.
摘要翻译： 本发明涉及包含对抗原特异性的动物或其衍生物或其片段的修饰抗体的抗体制剂，其特征在于：抗体或其衍生物或片段包含不含岩藻糖和木糖的N-聚糖结构，和 至少90％，优选至少95％，更优选至少99％，最优选至少100％的修饰抗体，其衍生物或片段缺少C-末端赖氨酸残基。
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公开(公告)号：US08869564B2
公开(公告)日：2014-10-28
申请号：US12161502
申请日：2007-01-22
申请人： Andreas Gross , Hildegard Roemer , Norbert Greulich-Hickmann , Guido Raeke , Guenter Weidmann , Thomas Stelle , Volker Ohmstede , Wolfgang Jost
发明人： Andreas Gross , Hildegard Roemer , Norbert Greulich-Hickmann , Guido Raeke , Guenter Weidmann , Thomas Stelle , Volker Ohmstede , Wolfgang Jost
摘要： For permitting temperature manipulation of a melt even at a conductivity below 10−1 Ω−1 cm−1 and thus permitting refining of the melt at temperatures about 1700° C., the invention provides a method and a device for temperature manipulation of a melt (16), in particular in a refiner unit. The melt (16) is heated at least by ohmic resistance heating with at least two electrodes (4) that are arranged in the melt (16). At least a part of the melt (16) is cooled. The device (1) for temperature manipulation, refining, purification and homogenisation of a melt (16) comprises at least one arrangement for accommodating melt material (36, 16), defining an inner chamber, and at least two electrodes (4) for ohmic resistance heating of the melt (16). The electrodes (4) project into the inner chamber of the arrangement, in particular of a vessel (2).
摘要翻译： 为了允许即使在低于10-1＆OHgr -1 -1cm -1的电导率下的熔体的温度操纵，并且因此允许在约1700℃的温度下对熔体进行精炼，本发明提供了一种用于温度操纵的方法和装置 熔化（16），特别是在精磨机中。 至少通过布置在熔体（16）中的至少两个电极（4），通过欧姆电阻加热将熔体（16）加热。 至少一部分熔体（16）被冷却。 用于熔体（16）的温度调节，精炼，纯化和均化的装置（1）包括至少一个用于容纳限定内室的熔化材料（36,16）和用于欧姆的至少两个电极（4）的装置 熔体（16）的电阻加热。 电极（4）突出到装置的内腔中，特别是容器（2）的内腔。
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公开(公告)号：US07834167B2
公开(公告)日：2010-11-16
申请号：US12134665
申请日：2008-06-06
CPC分类号： C12N15/8216
摘要： Disclosed are isolated nucleic acid molecules encoding wild type nucleus derived moss expression promoting regions (MEPRs) as well as a method for producing recombinant polypeptides using such MEPRs.
摘要翻译： 公开了编码野生型核衍生的苔藓表达促进区（MEPR）的分离的核酸分子以及使用这种MEPR产生重组多肽的方法。
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公开(公告)号：US07538259B2
公开(公告)日：2009-05-26
申请号：US10568156
申请日：2004-07-30
CPC分类号： C12N15/8216
摘要： Disclosed are isolated nucleic acid molecules encoding wild type nucleus derived moss expression promoting regions (MEPRs) as well as a method for producing recombinant polypeptides using such MEPRs.
摘要翻译： 公开了编码野生型核衍生的苔藓表达促进区（MEPR）的分离的核酸分子以及使用这种MEPR产生重组多肽的方法。
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公开(公告)号：US20100218558A1
公开(公告)日：2010-09-02
申请号：US12161502
申请日：2007-01-22
申请人： Andreas Gross , Hildegard Roemer , Norbert Greulich-Hickmann , Guido Raeke , Guenter Weidmann , Thomas Stelle , Volker Ohmstede , Wolfgang Jost
发明人： Andreas Gross , Hildegard Roemer , Norbert Greulich-Hickmann , Guido Raeke , Guenter Weidmann , Thomas Stelle , Volker Ohmstede , Wolfgang Jost
摘要： For permitting temperature manipulation of a melt even at a conductivity below 10−1 Ω−1 cm−1 and thus permitting refining of the melt at temperatures about 1700° C., the invention provides a method and a device for temperature manipulation of a melt (16), in particular in a refiner unit. The melt (16) is heated at least by ohmic resistance heating with at least two electrodes (4) that are arranged in the melt (16). At least a part of the melt (16) is cooled. The device (1) for temperature manipulation, refining, purification and homogenisation of a melt (16) comprises at least one arrangement for accommodating melt material (36, 16), defining an inner chamber, and at least two electrodes (4) for ohmic resistance heating of the melt (16). The electrodes (4) project into the inner chamber of the arrangement, in particular of a vessel (2).
摘要翻译： 为了允许即使在低于10-1＆OHgr -1 -1cm -1的电导率下的熔体的温度操纵，并且因此允许在约1700℃的温度下对熔体进行精炼，本发明提供了一种用于温度操纵的方法和装置 熔化（16），特别是在精磨机中。 至少通过布置在熔体（16）中的至少两个电极（4），通过欧姆电阻加热将熔体（16）加热。 至少一部分熔体（16）被冷却。 用于熔体（16）的温度调节，精炼，纯化和均化的装置（1）包括至少一个用于容纳限定内室的熔化材料（36,16）和用于欧姆的至少两个电极（4）的装置 熔体（16）的电阻加热。 电极（4）突出到装置的内腔中，特别是容器（2）的内腔。
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公开(公告)号：US20090111187A1
公开(公告)日：2009-04-30
申请号：US12134665
申请日：2008-06-06
CPC分类号： C12N15/8216
摘要： Disclosed are isolated nucleic acid molecules encoding wild type nucleus derived moss expression promoting regions (MEPRs) as well as a method for producing recombinant polypeptides using such MEPRs.
摘要翻译： 公开了编码野生型核衍生的苔藓表达促进区（MEPR）的分离的核酸分子以及使用这种MEPR产生重组多肽的方法。
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公开(公告)号：US20100050292A1
公开(公告)日：2010-02-25
申请号：US12443377
申请日：2007-09-28
申请人： Heike Launhardt , Christian Stemmer , Wolfgang Jost , Gilbert Gorr , Ralf Reski , Stefan Rensing
发明人： Heike Launhardt , Christian Stemmer , Wolfgang Jost , Gilbert Gorr , Ralf Reski , Stefan Rensing
CPC分类号： C12N9/1051 , C12N15/8257
摘要： The invention discloses DNA molecules encoding galactosyltransferases, recombinant host cells, tissues or organisms comprising dysfunctional galactosyltransferase gene(s), recombinant host cells, tissues or organisms comprising an introduced functional galactosyltransferase gene, methods for the production of proteins therewith, methods for the production of galactosyltransferase and vectors and uses thereof.
摘要翻译： 本发明公开了编码半乳糖基转移酶，重组宿主细胞，包含功能失活的半乳糖基转移酶基因的组织或生物的DNA分子，重组宿主细胞，包含引入的功能性半乳糖基转移酶基因的组织或生物，用于生产蛋白质的方法， 半乳糖基转移酶和载体及其用途。
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公开(公告)号：US20090291078A1
公开(公告)日：2009-11-26
申请号：US12373268
申请日：2007-07-11
IPC分类号： A61K39/395 , C07K16/00 , G01N33/53 , C12P21/04
CPC分类号： C07K16/283 , C07K16/00 , C07K2317/14 , C07K2317/41 , C07K2317/52 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C12N15/8258
摘要： The present invention relates to an antibody preparation comprising modified antibodies of an animal or derivatives or fragments thereof, specific for an antigen, characterized in that • the antibodies or derivatives or fragments thereof comprise an N-glycan structure free of fucose and xylose, and • at least 90%, preferably at least 95%, more preferred at least 99%, most preferred at least 100% of the modified antibodies, derivatives or fragments thereof lack a C-terminal lysine residue.
摘要翻译： 本发明涉及一种包含动物特异性抗体的动物或其衍生物或片段的修饰抗体的抗体制剂，其特征在于。 抗体或其衍生物或片段包含不含岩藻糖和木糖的N-聚糖结构， 至少90％，优选至少95％，更优选至少99％，最优选至少100％的修饰抗体，其衍生物或片段缺少C-末端赖氨酸残基。
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