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    TRICYCLIC INDOLE-DERIVED SPIRO DERIVATIVES AS CRTH2 MODULATORS
    5.
    发明申请
    TRICYCLIC INDOLE-DERIVED SPIRO DERIVATIVES AS CRTH2 MODULATORS 审中-公开
    作为CRTH2调节剂的TRICYCLIC INDOLE-DIVIVED SPIRO DERIVATIVES

    公开(公告)号：US20120115895A1

    公开(公告)日：2012-05-10

    申请号：US13383857

    申请日：2010-07-14

    申请人： Stefano Crosignani ,  Catherine Jorand-Lebrun ,  Tania Grippi-Vallotton

    发明人： Stefano Crosignani ,  Catherine Jorand-Lebrun ,  Tania Grippi-Vallotton

    IPC分类号： A61K31/4439 ,  A61K31/422 ,  A61K31/4188 ,  C07D487/10 ,  A61P19/02 ,  A61P29/00 ,  A61P37/08 ,  A61P11/06 ,  A61P1/00 ,  A61K31/427 ,  A61P25/00

    CPC分类号： C07D487/10

    摘要： The present invention relates to compounds of formula (I) for use as pharmaceutical active compounds, as well as pharmaceutical formulations containing the same, for the treatment of allergic diseases. The compounds according to Formula (I) are suitable as modulators of CRTH2. The invention provides Spiro derivatives according to Formula (I) and related formulae that are useful in the treatment and/or prevention of diseases selected from allergic diseases such as allergic asthma, allergic rhinitis, allergic conjunctivitis, and inflammatory dermatoses such as atopic dermatitis, contact hypersensitivity, allergic contact dermatitis, chronic urticaria/chronic idiopathic/autoimmune urticaria, drag-induced exanthems (e.g., toxic epidermal necrolysis or Lyell's syndrome/Stevens-Johnson syndrome/drug hypersensitivity syndrome), photodermatosis or polymorphous light emption (e.g., photoirritant contact dermatitis, photoallergy contact dermatitis, chronic actinic dermatitis), and myositis neurodegenerative disorders such as neuropatic pain and other diseases with an inflammatory component such as rheumatoid arthritis, multiple sclerosis, osteoarthritis, and inflammatory bowel disease (IBD).

    摘要翻译： 本发明涉及用作药物活性化合物的式（I）化合物，以及含有该化合物的用于治疗过敏性疾病的药物制剂。 根据式（I）的化合物适合作为CRTH2的调节剂。 本发明提供了可用于治疗和/或预防选自过敏性疾病如过敏性哮喘，过敏性鼻炎，过敏性结膜炎和炎性皮肤病如特应性皮炎，接触的疾病的式（I）和相关配方的螺衍生物 超敏反应，过敏性接触性皮炎，慢性荨麻疹/慢性特发性/自身免疫性荨麻疹，牵引性外阴（例如中毒性表皮坏死松解症或莱尔综合征/史蒂文斯 - 约翰逊综合征/药物过敏综合征），光照皮肤病或多形态光吸收（如光刺激性接触性皮炎 ，光敏性接触性皮炎，慢性光化性皮炎）和肌炎神经变性疾病如神经性疼痛和其它具有炎性成分的疾病，例如类风湿性关节炎，多发性硬化症，骨关节炎和炎症性肠病（IBD）。