利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

26 条记录 (耗时 0.038 秒)

    METHODS AND COMPOSITIONS TO DETECT A BIOLOGICAL ACTIVITY
    5.
    发明申请
    METHODS AND COMPOSITIONS TO DETECT A BIOLOGICAL ACTIVITY 有权
    检测生物活性的方法和组合物

    公开(公告)号：US20130230876A1

    公开(公告)日：2013-09-05

    申请号：US13883620

    申请日：2011-10-28

    申请人： Stephen B. Roscoe ,  Kurt J. Halverson ,  Jesse D. Miller ,  Stephanie J. Moeller ,  Jason W. Bjork

    发明人： Stephen B. Roscoe ,  Kurt J. Halverson ,  Jesse D. Miller ,  Stephanie J. Moeller ,  Jason W. Bjork

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6486 ,  C12Q1/04

    摘要： Compositions that comprise water, a first indicator reagent that can be converted by a first biological activity to a first biological derivative, and a plurality of particles are provided. The first indicator reagent can comprise a fluorogenic enzyme substrate having a fluorophore selected from the group consisting of umbelliferone, 7-aminocoumarin, β-naphthylamine, β-naphthol, fluorescein, resorufin, 9H-(1,3-dichloro-9,9-dimethyl acridin-2-one), rhodamine 110, a derivative of any of the foregoing fluorophores, and a combination of any of the foregoing fluorophores. The particles are capable of receiving and retaining the first biological derivative from an aqueous liquid. The first biological derivative can be indicative of a microorganism. The compositions further can comprise a gelling agent. Methods of using the compositions to detect the presence or absence of a microorganism in a sample are also provided.

    摘要翻译： 提供了包含水，可以通过第一生物活性转化为第一生物衍生物的第一指示剂试剂和多个颗粒的组合物。 第一指示剂可以包括具有选自伞形酮，7-氨基香豆素，β-萘胺，β-萘酚，荧光素，再次吸收的9H-（1,3-二氯-9,9-四氢 - 二甲基吖啶-2-酮），罗丹明110，任何前述荧光团的衍生物，以及任何上述荧光团的组合。 颗粒能够从水性液体中接收和保留第一生物衍生物。 第一种生物衍生物可以指示微生物。 组合物还可以包含胶凝剂。 还提供了使用组合物来检测样品中微生物的存在或不存在的方法。

    METHOD OF DETECTION OF BIOANALYTES BY ACOUSTO-MECHANICAL DETECTION SYSTEMS COMPRISING THE ADDITION OF LIPOSOMES
    6.
    发明申请
    METHOD OF DETECTION OF BIOANALYTES BY ACOUSTO-MECHANICAL DETECTION SYSTEMS COMPRISING THE ADDITION OF LIPOSOMES 审中-公开
    通过包含脂质体添加剂的机械检测系统检测生物质的方法

    公开(公告)号：US20100151553A1

    公开(公告)日：2010-06-17

    申请号：US12521611

    申请日：2007-12-28

    申请人： Jason W. Bjork ,  Samuel J. Gason ,  Michael C. Palazzotto ,  Stephen B. Roscoe

    发明人： Jason W. Bjork ,  Samuel J. Gason ,  Michael C. Palazzotto ,  Stephen B. Roscoe

    IPC分类号： C12N13/00

    CPC分类号： G01N33/54373 ,  G01N29/022 ,  G01N29/30 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0422 ,  G01N2291/0423

    摘要： Methods for detecting target biological analytes within sample material using acousto-mechanical energy generated by a sensor are disclosed. The acousto-mechanical energy may be provided using an acousto-mechanical sensor, e.g., a surface acoustic wave sensor such as, e.g., a shear horizontal surface acoustic wave sensor (e.g., a LSH-SAW sensor). The detection of the target biological analytes in sample material are enhanced by contacting the target biological analyte and/or the sensor surface with liposomes that amplify the sensor sensitivity by (1) modifying the rheological properties of the fluid near the sensor surface; (2) changing the mass attached to the surface; and/or (3) modifying the dielectric properties of the fluid near the sensor surface, the sensor surface itself and/or any intervening layers on the sensor surface.

    摘要翻译： 公开了使用由传感器产生的声 - 机械能来检测样品材料内的目标生物分析物的方法。 声机械能可以使用诸如例如剪切水平声表面波传感器（例如LSH-SAW传感器）的表面声波传感器的声 - 机械传感器来提供。 通过使目标生物分析物和/或传感器表面与通过（1）修改传感器表面附近的流体的流变特性来扩大传感器灵敏度的脂质体接触来增强样品材料中目标生物分析物的检测; （2）改变附着在表面上的质量; 和/或（3）修改传感器表面附近的流体的介电特性，传感器表面本身和/或传感器表面上的任何中间层。

    Rapid Detection of Molds that Produce Glucose Oxidase
    9.
    发明申请
    Rapid Detection of Molds that Produce Glucose Oxidase 有权
    快速检测产生葡萄糖氧化酶的模具

    公开(公告)号：US20120301911A1

    公开(公告)日：2012-11-29

    申请号：US13515856

    申请日：2010-12-21

    申请人： Stephen B. Roscoe ,  Michael J. Svarovsky ,  Stephanie J. Moeller

    发明人： Stephen B. Roscoe ,  Michael J. Svarovsky ,  Stephanie J. Moeller

    IPC分类号： G01N21/78

    CPC分类号： C12Q1/04 ,  C12Q1/045 ,  C12Q1/26 ,  C12Q1/54

    摘要： Methods and kits are disclosed for detecting microorganisms that produce glucose oxidase. The method includes providing a culture medium and a hydrogen peroxide indicating reagent comprising a chromogenic substrate that can provide a detectable chromogenic reaction indicating the presence of a microorganism that produces glucose oxidase, and additional methods are disclosed for differentiating microorganisms by the detection of an additional chromogenic reaction.

    摘要翻译： 公开了用于检测产生葡萄糖氧化酶的微生物的方法和试剂盒。 该方法包括提供培养基和过氧化氢指示试剂，其包含可产生可产生葡萄糖氧化酶的微生物存在的可检测的生色反应的显色底物，并且公开了用于通过检测另外的显色性来分化微生物的另外的方法 反应。