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公开(公告)号：US07163956B2
公开(公告)日：2007-01-16
申请号：US10960449
申请日：2004-10-07
申请人： Stephen R. Wilson , Yi-Zhen Hu , Tong Zhu , Russ Lebovitz
发明人： Stephen R. Wilson , Yi-Zhen Hu , Tong Zhu , Russ Lebovitz
IPC分类号： A61K31/40 , A61K31/95 , C07C63/00 , C07C211/00 , C07D487/00
CPC分类号： B82Y40/00 , A61K8/19 , A61K47/6949 , A61K2800/522 , A61Q19/00 , B82Y5/00 , B82Y30/00 , C01B32/15 , C01B32/152
摘要： This patent discloses a substituted fullerenes, compositions comprising the same, and their use as antioxidants. The substituted fullerenes comprise a fullerene core (Cn) and at least one of: (i) from 1 to 6 (>CX1X2) groups bonded to the fullerene core; (ii) from 1 to 18 —X3 groups bonded to the fullerene core; (iii) from 1 to 6 —X4— groups bonded to the fullerene core; or (iv) from 1 to 6 dendrons bonded to the fullerene core.
摘要翻译： 该专利公开了一种取代的富勒烯，包含它们的组合物及其作为抗氧化剂的用途。 取代的富勒烯包含富勒烯核（Cn）和至少一个：（i）与富勒烯核键合的1至6个（> X 1，X 2，X 2） ; （ii）与富勒烯核键合的1至18个-X 3+基团; （iii）与富勒烯核键合的1至6个-X 4+基团; 或（iv）1至6个与富勒烯核心结合的树突。
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2.发明授权Methods for genetic plant transformation using water-soluble fullerene derivatives 有权使用水溶性富勒烯衍生物进行遗传植物转化的方法公开(公告)号：US08614366B2
公开(公告)日：2013-12-24
申请号：US12876671
申请日：2010-09-07
申请人： Stephen R. Wilson
发明人： Stephen R. Wilson
IPC分类号： C07K14/415 , B82Y30/00
CPC分类号： C12N15/8201
摘要： In various embodiments, methods described herein comprise the use of water-soluble cationic fullerene derivatives for improving plant genetic transformation. Cationic Fullerene derivatives of the invention possess DNA binding and compaction activity and provide a new method to deliver DNA into plant cells for plant transformation. Water-soluble fullerene derivatives of the invention with anionic or non-polar substituents possess antioxidant (free radical scavenging) activity, provide improved yields and efficiency of plant transformation methods such as biolistic, Agrobacterium tumefaciens, or electroporation methods by limiting cellular damage and resulting cell death leading to higher yields of viable transformed cells in the process.
摘要翻译： 在各种实施方案中，本文所述的方法包括使用水溶性阳离子富勒烯衍生物来改善植物遗传转化。 本发明的阳离子富勒烯衍生物具有DNA结合和压实活性，并提供了将DNA输送到植物转化植物细胞中的新方法。 具有阴离子或非极性取代基的本发明的水溶性富勒烯衍生物具有抗氧化（自由基清除）活性，通过限制细胞损伤和产生的细胞提供植物转化方法如生物射弹，根癌土壤杆菌或电穿孔方法的提高的产量和效率 死亡导致该过程中可行的转化细胞的产量更高。
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3.发明授权公开(公告)号：US08241648B2
公开(公告)日：2012-08-14
申请号：US12073230
申请日：2008-03-03
申请人： Zhiguo Zhou , Robert P. Lenk , Darren Macfarland , Kenneth L. Walker , Jing Zhang , Stephen R. Wilson
发明人： Zhiguo Zhou , Robert P. Lenk , Darren Macfarland , Kenneth L. Walker , Jing Zhang , Stephen R. Wilson
CPC分类号： A61K31/661 , A61K8/0208 , A61K8/19 , A61K9/0014 , A61K9/1271 , A61K38/28 , A61Q1/02 , A61Q5/02 , A61Q9/00 , A61Q13/00 , A61Q19/007 , A61K2300/00
摘要： Described herein are synthetically modified fullerene molecules, wherein the fullerene is preferably ellipsoid in shape with an equatorial band and two opposing poles, comprising an adduct at one or both poles, at least one adduct being a hydrophobic chemical moiety capable of anchoring the fullerene on or in a lipid membrane.
摘要翻译： 这里描述的是合成改性的富勒烯分子，其中富勒烯优选为具有赤道带和两个相对极的形状的椭圆体，包括一个或两个极处的加合物，至少一个加合物是能够将富勒烯锚定在其上的疏水化学部分 在脂质膜中。
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公开(公告)号：US20110124848A1
公开(公告)日：2011-05-26
申请号：US12739097
申请日：2008-10-22
申请人： Darren K. Macfarland , Robert P. Lenk , Rajesh Shukla , Kenneth L. Walker , Stephen R. Wilson , Zhiguo Zhou
发明人： Darren K. Macfarland , Robert P. Lenk , Rajesh Shukla , Kenneth L. Walker , Stephen R. Wilson , Zhiguo Zhou
IPC分类号： C07F5/00
CPC分类号： A61K49/189 , A61K47/6949 , A61K49/12 , B82Y5/00 , C07F5/00
摘要： Endohedral metallofullerene compounds, which in water has a relaxivity of about 30 mM−1 S−1 to about 300 mM−1 S−1 and forms a dispersion in water with entities having an average hydrodynamic radius of less than about 20 nm.
摘要翻译： 内含金属富勒烯化合物，其在水中具有约30mM-1S-1至约300mM-1S-1的松弛度，并且在平均流体动力学半径小于约20nm的实体中形成水分散体。
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公开(公告)号：US20080193490A1
公开(公告)日：2008-08-14
申请号：US11841087
申请日：2007-08-20
CPC分类号： B82Y30/00 , A61K9/0092 , A61K47/6949 , A61K49/0004 , B82Y5/00
摘要： Compositions and methods for administering a therapeutic agent to a mammal are disclosed. The compositions comprise either (i) vesicles comprising an amphiphilic substituted fullerene, wherein the therapeutic agent is present in the vesicle interior or between layers of the vesicle wall, (ii) a substituted fullerene, comprising a fullerene core and a functional moiety, wherein the therapeutic agent is associated with the substituted fullerene, or (iii) carbon nanotubes, wherein the therapeutic agent is associated with the carbon nanotubes.
摘要翻译： 公开了向哺乳动物施用治疗剂的组合物和方法。 所述组合物包含（i）包含两亲性取代的富勒烯的囊泡，其中所述治疗剂存在于泡囊内部或囊泡壁的层之间，（ii）包含富勒烯核心和功能部分的取代的富勒烯，其中 治疗剂与取代的富勒烯相关，或（iii）碳纳米管，其中治疗剂与碳纳米管相关联。
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公开(公告)号：US09233177B2
公开(公告)日：2016-01-12
申请号：US12739097
申请日：2008-10-22
申请人： Darren K. Macfarland , Robert P. Lenk , Rajesh Shukla , Kenneth L. Walker , Stephen R. Wilson , Zhiguo Zhou
发明人： Darren K. Macfarland , Robert P. Lenk , Rajesh Shukla , Kenneth L. Walker , Stephen R. Wilson , Zhiguo Zhou
CPC分类号： A61K49/189 , A61K47/6949 , A61K49/12 , B82Y5/00 , C07F5/00
摘要： Endohedral metallofullerene compounds, which in water has a relaxivity of about 30 mM−1 S−1 to about 300 mM−1 S−1 and forms a dispersion in water with entities having an average hydrodynamic radius of less than about 20 nm.
摘要翻译： 内含金属富勒烯化合物，其在水中具有约30mM-1S-1至约300mM-1S-1的松弛度，并且在平均流体动力学半径小于约20nm的实体中形成水分散体。
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公开(公告)号：US08680125B2
公开(公告)日：2014-03-25
申请号：US12921049
申请日：2009-03-03
申请人： Christopher L. Kepley , Robert P. Lenk , Stephen R. Wilson , Zhiguo Zhou , Darren K. MacFarland
发明人： Christopher L. Kepley , Robert P. Lenk , Stephen R. Wilson , Zhiguo Zhou , Darren K. MacFarland
IPC分类号： A61K31/41 , A61K31/235 , C07D403/00 , C07C67/48
CPC分类号： C07D249/04 , C07C69/00 , C07C69/753 , C07C2601/14 , C07C2604/00
摘要： Described herein are methods for treating inflammatory disorders. The methods comprise administering to a subject in need thereof a therapeutically effective amount of a synthetically modified fullerene.
摘要翻译： 本文描述的是治疗炎症性疾病的方法。 所述方法包括向有需要的受试者施用治疗有效量的合成改性的富勒烯。
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公开(公告)号：US20110009486A1
公开(公告)日：2011-01-13
申请号：US12921072
申请日：2009-03-03
IPC分类号： A61K31/216 , A61P17/04 , C07C69/76
CPC分类号： A61K31/16 , A61K31/015 , A61K31/19 , A61K31/225 , A61K33/00 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are methods of treating pruritus in a subject in need thereof. A method of treating pruritus comprises administering a therapeutically effective amount of fullerenes to a subject in need thereof.
摘要翻译： 本文公开了在有需要的受试者中治疗瘙痒的方法。 治疗瘙痒的方法包括向有需要的受试者施用治疗有效量的富勒烯。
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公开(公告)号：US20110003773A1
公开(公告)日：2011-01-06
申请号：US12921106
申请日：2009-03-03
IPC分类号： A61K31/685 , C07C229/02 , A61K31/215 , C07C69/74 , A61P17/14
CPC分类号： C07D519/00 , A61K8/19 , A61Q7/00 , C07F9/091
摘要： Described herein are methods for treating lack of hair growth or a reduction or loss of existing hair by stimulating and/or restoring hair growth, or preventing hair loss. The methods comprise administering to a subject in need thereof a therapeutically effective amount of a fullerene.
摘要翻译： 本文描述了通过刺激和/或恢复毛发生长或防止脱发来治疗毛发生长缺乏或现有毛发减少或损失的方法。 所述方法包括向有需要的受试者施用治疗有效量的富勒烯。
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公开(公告)号：US07070810B2
公开(公告)日：2006-07-04
申请号：US10367646
申请日：2003-02-14
申请人： Andreas Hirsch , Uri Sagman , Stephen R. Wilson
发明人： Andreas Hirsch , Uri Sagman , Stephen R. Wilson
CPC分类号： B82Y30/00 , A61K47/6949 , A61K49/0004 , B82Y5/00 , Y10S516/901 , Y10S977/734 , Y10T428/1352 , Y10T428/1393
摘要： Compositions and methods for administering a therapeutic agent to a mammal are disclosed. The compositions comprise either (i) vesicles comprising an amphiphilic substituted fullerene, wherein the therapeutic agent is present in the vesicle interior or between layers of the vesicle wall, (ii) a substituted fullerene, comprising a fullerene core and a functional moiety, wherein the therapeutic agent is associated with the substituted fullerene, or (iii) carbon nanotubes, wherein the therapeutic agent is covalently bonded to the carbon nanotubes.
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