利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

10 条记录 (耗时 0.033 秒)

    PHAGE DISPLAYED CELL BINDING PEPTIDES
    3.
    发明申请
    PHAGE DISPLAYED CELL BINDING PEPTIDES 有权
    PHAGE显示细胞结合肽

    公开(公告)号：US20100137225A1

    公开(公告)日：2010-06-03

    申请号：US12701397

    申请日：2010-02-05

    申请人： Richard E. Herman ,  Ekaterina G. Makienko ,  Douglas L. Badders ,  Mark Fuller

    发明人： Richard E. Herman ,  Ekaterina G. Makienko ,  Douglas L. Badders ,  Mark Fuller

    IPC分类号： A61K38/08 ,  C07K1/107 ,  A61P43/00

    CPC分类号： C07K14/001 ,  A61K47/62 ,  C07K2319/035 ,  C07K2319/33 ,  C12N15/1037

    摘要： This disclosure provides the construction, expression, and selection of the mutated genes that encode novel Trp cage polypeptides with desirable binding properties, as well as the novel Trp cage polypeptides themselves. The substances or targets bound by these novel Trp cage polypeptides may be but need not be proteins or polypeptides. Targets may include other biological or synthetic macromolecules as well as other organic and inorganic substances. Further, targets may also include a single or multiple cell or tissue types. The present invention achieves genetic variants of Trp cage-encoding nucleic acids through controlled random mutagenesis of the nucleic acids yielding a mixture of Trp cage polypeptides that are capable of binding targets.

    摘要翻译： 本公开提供编码具有所需结合特性的新型Trp笼多肽的突变基因的构建，表达和选择，以及新型Trp笼多肽本身。 由这些新型Trp笼多肽结合的物质或靶标可能不一定是蛋白质或多肽。 目标可以包括其他生物或合成大分子以及其它有机和无机物质。 此外，靶也可以包括单个或多个细胞或组织类型。 本发明通过控制随机诱变获得Trp笼编码核酸的遗传变体，产生能够结合靶标的Trp笼多肽的混合物。

    Phage displayed cell binding peptides
    4.
    发明授权
    Phage displayed cell binding peptides 有权
    噬菌体展示细胞结合肽

    公开(公告)号：US07772189B2

    公开(公告)日：2010-08-10

    申请号：US12701397

    申请日：2010-02-05

    申请人： Richard E. Herman ,  Ekaterina G. Makienko ,  Douglas L. Badders ,  Mark Fuller

    发明人： Richard E. Herman ,  Ekaterina G. Makienko ,  Douglas L. Badders ,  Mark Fuller

    IPC分类号： A61K38/00 ,  C07K7/06

    CPC分类号： C07K14/001 ,  A61K47/62 ,  C07K2319/035 ,  C07K2319/33 ,  C12N15/1037

    摘要： This disclosure provides the construction, expression, and selection of the mutated genes that encode novel Trp cage polypeptides with desirable binding properties, as well as the novel Trp cage polypeptides themselves. The substances or targets bound by these novel Trp cage polypeptides may be but need not be proteins or polypeptides. Targets may include other biological or synthetic macromolecules as well as other organic and inorganic substances. Further, targets may also include a single or multiple cell or tissue types. The present invention achieves genetic variants of Trp cage-encoding nucleic acids through controlled random mutagenesis of the nucleic acids yielding a mixture of Trp cage polypeptides that are capable of binding targets.

    摘要翻译： 本公开提供编码具有所需结合特性的新型Trp笼多肽的突变基因的构建，表达和选择，以及新型Trp笼多肽本身。 由这些新型Trp笼多肽结合的物质或靶标可能不一定是蛋白质或多肽。 目标可以包括其他生物或合成大分子以及其它有机和无机物质。 此外，靶还可以包括单个或多个细胞或组织类型。 本发明通过控制随机诱变获得Trp笼编码核酸的遗传变体，产生能够结合靶标的Trp笼多肽的混合物。

    Phage displayed cell binding peptides
    6.
    发明授权
    Phage displayed cell binding peptides 失效
    噬菌体展示细胞结合肽

    公开(公告)号：US07704953B2

    公开(公告)日：2010-04-27

    申请号：US11627863

    申请日：2007-01-26

    申请人： Richard E. Herman ,  Ekaterina G. Makienko ,  Douglas L. Badders ,  Mark Fuller

    发明人： Richard E. Herman ,  Ekaterina G. Makienko ,  Douglas L. Badders ,  Mark Fuller

    IPC分类号： A61K38/00

    CPC分类号： C07K14/001 ,  A61K47/62 ,  C07K2319/035 ,  C07K2319/33 ,  C12N15/1037

    摘要： The present disclosure relates to the construction, expression, and selection of genes that encode novel Trp cage polypeptides with desirable cell and/or tissue binding properties, as well as the novel Trp cage polypeptides themselves. A polypeptide of this disclosure may contain all or part of amino acid sequence AAADX1YX2QWLX3X4X5GPX6SGRPPPX7 (SEQ ID NO: 4), wherein Xn represents an amino acid found in position n, the polypeptide comprising a tryptophan cage (Trp cage).

    摘要翻译： 本公开涉及编码具有期望的细胞和/或组织结合特性的新型Trp笼多肽的基因的构建，表达和选择，以及新型Trp笼多肽本身。 本公开的多肽可以包含氨基酸序列AAADX1YX2QWLX3X4X5GPX6SGRPPPX7（SEQ ID NO：4）的全部或部分，其中Xn表示位置n中发现的氨基酸，所述多肽包含色氨酸笼（Trp笼）。

    Security system for pay-TV channel
    9.
    发明授权
    Security system for pay-TV channel 失效
    付费电视频道安全系统

    公开(公告)号：US4091413A

    公开(公告)日：1978-05-23

    申请号：US760160

    申请日：1977-01-17

    申请人： Richard E. Herman

    发明人： Richard E. Herman

    IPC分类号： H04N7/167 ,  H04N21/6543 ,  H04N21/81 ,  H04N1/44

    CPC分类号： H04N21/812 ,  H04N21/6543 ,  H04N7/167

    摘要： A system for securing a pay-TV channel by coherently moving the RF components of the channel (with or without an encoding signal) beyond the AFC holding range of commercially available tuners. The system is comprised of means for mixing the channel carrier with a signal that is varied beyond that AFC holding range at a low rate between approximately 0.75 Hz and 1000 Hz. For greater security, an amplitude-modulated encoding signal is injected at an IF frequency that is between the audio subcarrier and the video subcarrier. The encoding signal is preferably a multiple of the line scanning frequency in order to interfere with both video and audio components. For decoding, a converter with adequate AFC holding range at the receiver of a subscriber is coupled to the receiver by a sharply tuned filter which traps the injected encoding signal.

    摘要翻译： 一种用于通过将通道的RF分量（有或者没有编码信号）相干移动超过市售调谐器的AFC保持范围来保护付费电视频道的系统。 该系统包括用于将信道载波与在大约0.75Hz和1000Hz之间的低速率超过该AFC保持范围的信号混合的装置。 为了更高的安全性，以音频副载波和视频副载波之间的IF频率注入幅度调制编码信号。 编码信号优选地是行扫描频率的倍数，以便干扰视频和音频分量。 对于解码，在订户的接收机处具有足够的AFC保持范围的转换器通过尖锐调谐的滤波器耦合到接收机，该滤波器捕获注入的编码信号。

    Method and system for dispensing live bacteria into animal feed and drinking water
    10.
    发明授权
    Method and system for dispensing live bacteria into animal feed and drinking water 失效
    将生物细菌分配到动物饲料和饮用水中的方法和系统

    公开(公告)号：US5139792A

    公开(公告)日：1992-08-18

    申请号：US555910

    申请日：1990-07-19

    申请人： Douglas R. Ware ,  Richard E. Herman ,  Leslie A. Walter

    发明人： Douglas R. Ware ,  Richard E. Herman ,  Leslie A. Walter

    IPC分类号： A23K1/00 ,  A61K35/74 ,  A61K35/747

    CPC分类号： A61K35/747 ,  A23K10/18 ,  Y10S426/807

    摘要： A method for preparing, at an animal feedlot, a suspension of microaerophilic or anaerobic bacteria at a known, accurate concentration in anticipation of dispensing the suspension of bacteria into animal feed or drinking water. The method allows the livestock feedlot or poultry operators to maintain the suspension of bacteria in a substantially viable condition without significant loss of viability and without requiring constant or intermittent agitation after the suspension is created. Refrigeration of the suspension is also unnecessary if the suspension of bacteria is dispensed within a predetermined period of time after preparation.

    摘要翻译： 在动物饲养场，以已知的准确浓度制备微量嗜厌菌或厌氧细菌的悬浮液的方法，预期将细菌悬浮液分配到动物饲料或饮用水中。 该方法允许家畜饲养场或家禽操作者将细菌的悬浮液维持在基本上可行的状态，而不会显着丧失生存力，并且在产生悬浮液之后不需要恒定或间歇搅动。 如果细菌悬浮液在预备的预定时间内分配，则也不需要制冷。