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公开(公告)号：US5520639A
公开(公告)日：1996-05-28
申请号：US407867
申请日：1995-03-21
申请人： Steven F. Peterson , Charles N. McKinnon, Jr. , Paul E. Smith , Takaaki Nakagawa , Victor L. Bartholomew
发明人： Steven F. Peterson , Charles N. McKinnon, Jr. , Paul E. Smith , Takaaki Nakagawa , Victor L. Bartholomew
CPC分类号： A61M5/30 , A61M2005/31516 , A61M2205/583 , A61M5/2053
摘要： A needleless injection device includes an initiator valve controlling flow of compressed gas into a reservoir. A poppet valve connecting to the reservoir has a gas pressure regulation end to regulate flow from the initiator valve into the reservoir. A clamp piston is driven forward by gas pressure from the reservoir and causes jaws to clamp onto a plunger extending into an ampule. The poppet valve opens when reservoir pressure reaches the cracking pressure of the poppet valve. Gas from the reservoir rushes through the poppet valve into a drive chamber and forces a drive piston, containing the clamp piston and jaws, forward causing the plunger to slide into the ampule. A jet of injectant is discharged from the nozzle of the ampule and penetrates through the patient's skin. An improved method of needleless injection uses a specific pressure profile, ampule nozzle diameter, patient, injection site, and injectant parameters.
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公开(公告)号：US5399163A
公开(公告)日：1995-03-21
申请号：US97266
申请日：1993-07-23
申请人： Steven F. Peterson , Charles N. McKinnon, Jr. , Paul E. Smith , Takaaki Nakagawa , Victor L. Bartholomew
发明人： Steven F. Peterson , Charles N. McKinnon, Jr. , Paul E. Smith , Takaaki Nakagawa , Victor L. Bartholomew
CPC分类号： A61M5/30 , A61M2005/31516 , A61M2205/583 , A61M5/2053
摘要： A needleless injection device includes an initiator valve controlling flow of compressed gas into a reservoir. A poppet valve connecting to the reservoir has a gas pressure regulation end to regulate flow from the initiator valve into the reservoir. A clamp piston is driven forward by gas pressure from the reservoir and causes jaws to clamp onto a plunger extending into an ampule. The poppet valve opens when reservoir pressure reaches the cracking pressure of the poppet valve. Gas from the reservoir rushes through the poppet valve into a drive chamber and forces a drive piston, containing the clamp piston and jaws, forward causing the plunger to slide into the ampule. A jet of injectant is discharged from the nozzle of the ampule and penetrates through the patient's skin. An improved method of needleless injection uses a specific pressure profile, ampule nozzle diameter, patient, injection site, and injectant parameters.
摘要翻译： 无针注射装置包括控制压缩气体流入储存器的引发阀。 连接到储存器的提升阀具有气体压力调节端，以调节从引发阀到储存器的流动。 夹紧活塞通过来自储存器的气体压力向前驱动，并且使夹爪夹紧到延伸到安瓿中的柱塞上。 当储层压力达到提升阀的开启压力时，提升阀打开。 来自储存器的气体通过提升阀冲入驱动室，并迫使包含夹紧活塞和夹爪的驱动活塞向前，使柱塞滑入安瓿。 注射器射流从安瓿喷嘴排出并穿透病人的皮肤。 无针注射的改进方法使用特定压力分布，安瓿喷嘴直径，患者，注射部位和注射参数。
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公开(公告)号：US5383851A
公开(公告)日：1995-01-24
申请号：US920106
申请日：1992-07-24
申请人： Charles N. McKinnon, Jr. , Steven F. Peterson , Paul E. Smith , Takaaki Nakagawa , Victor L. Bartholomew
发明人： Charles N. McKinnon, Jr. , Steven F. Peterson , Paul E. Smith , Takaaki Nakagawa , Victor L. Bartholomew
CPC分类号： A61M5/30 , A61M2005/31516 , A61M2205/583 , A61M5/2053
摘要： A needless injection device includes an initiator valve controlling flow of compressed gas into a reservoir. A poppet valve connecting to the reservoir has a gas pressure regulation end to regulate flow from the initiator valve into the reservoir. A clamp piston is driven forward by gas pressure from the reservoir and causes jaws to clamp onto a plunger extending into an ampule. The poppet valve opens when reservoir pressure reaches the cracking pressure of the poppet valve. Gas from the reservoir rushes through the popper valve into a drive chamber and forces a drive piston, containing the clamp piston and jaws, forward causing the plunger to slide into the ampule. A jet of injectant sprays out of the nozzle of the ampule and penetrates through the patient's skin.
摘要翻译： 不必要的注射装置包括控制压缩气体流入储存器的引发阀。 连接到储存器的提升阀具有气体压力调节端，以调节从引发阀到储存器的流动。 夹紧活塞通过来自储存器的气体压力向前驱动，并且使夹爪夹紧到延伸到安瓿中的柱塞上。 当储层压力达到提升阀的开启压力时，提升阀打开。 来自储存器的气体通过弹簧阀冲入驱动室，并迫使包含夹紧活塞和夹爪的驱动活塞向前，使柱塞滑入安瓿。 注射器喷射从安瓿喷嘴喷出并穿透患者的皮肤。
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公开(公告)号：US5312577A
公开(公告)日：1994-05-17
申请号：US880249
申请日：1992-05-08
申请人： Steven F. Peterson , John W. Ashley , Victor L. Bartholomew , James P. Casey, Sr. , Charles N. McKinnon, Jr.
发明人： Steven F. Peterson , John W. Ashley , Victor L. Bartholomew , James P. Casey, Sr. , Charles N. McKinnon, Jr.
IPC分类号： B29C39/26 , A61M5/30 , A61M5/31 , B29C33/30 , B29C39/10 , B29C45/14 , B29C45/26 , B29C45/36 , B29C65/00 , B29C70/76 , B29K69/00 , B29L22/00 , B29C45/17
CPC分类号： A61M5/30 , B29C33/304 , B29C39/10 , B29C45/261 , B29C45/36 , B29C70/766 , A61M2207/00 , A61M5/3007 , A61M5/3134 , B29K2069/00 , B29L2031/7544
摘要： A method and mold for making an ampule for a needleless or jet injector device. The tip of a core pin is guided into a clearance hole sufficiently large to prevent the tip from hitting the mold cavity. Plastic is injected into the mold and flows into the space between the core pin tip and the clearance hole forming a vestigial nozzle pilot cylinder around and over the ampule nozzle. The ampule is removed from the mold and the vestigial nozzle pilot cylinder is removed to form a finished ampule. A core pin tip is made of drawn wire or is separately replaceable on the core pin. A nozzle of an ampule is cast in place. An ampule is molded with an enlarged nozzle and a separate orifice is installed in the ampule to provide the desired nozzle opening.
摘要翻译： 一种用于制造无针或喷射装置的安瓿的方法和模具。 芯销的尖端被引导到足够大的间隙孔中，以防止尖端撞击模腔。 将塑料注射到模具中并流入芯销尖端和间隙孔之间的空间，在安瓿喷嘴周围和上方形成残留喷嘴先导筒。 将安瓿从模具中取出，并且去除残留喷嘴引导筒以形成成品安瓿。 芯针尖由拉丝制成，或者在芯针上单独更换。 将安瓿的喷嘴浇注到位。 用扩大的喷嘴模制安瓿，并在安瓿中安装独立的孔，以提供所需的喷嘴开口。
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公开(公告)号：US4263053A
公开(公告)日：1981-04-21
申请号：US32280
申请日：1979-04-23
CPC分类号： B01D67/0095 , B01D63/021 , B01D65/02 , D06B5/26 , B01D2321/168 , B01D2321/30
摘要： The removal of manufacturing oils from a pre-potted, wound bundle of hollow fibers used in dialysis equipment, is rapidly accomplished by subjecting the fiber assembly to centrifugal forces acting longitudinally of the fibers. Wicking pads may be used at the outer ends of the fibers during the centrifuging step if desired to counteract the capillary action of the fibers. Following the centrifuging, the fibers are repeatedly immersed, in a vertical direction, in a solvent into which any oil trapped in the pores of the fiber walls diffuses. The repeated rise and fall of the solvent in the fiber lumen continually re-introduces fresh solvent into the lumen to leach oil out of the pores at a rapid rate.In the same manner, moisture is then removed from the fibers by alternately evacuating the fiber lumens in a vacuum chamber and refilling them with warm, very dry air to rapidly remove any moisture contained in the cellulose of the fibers.
摘要翻译： 通过使纤维组件经受纤维纵向作用的离心力，迅速地将制造油从用于透析设备中的预先封装的中空纤维束去除。 如果需要，可以在离心步骤期间在纤维的外端使用芯吸垫来抵消纤维的毛细管作用。 离心后，将纤维沿垂直方向重复浸入溶于纤维壁孔中的任何油分散的溶剂中。 溶剂在纤维腔中的反复上升和下降持续地将新鲜溶剂重新引入内腔，以迅速的速率将油从孔中浸出。 以相同的方式，然后通过在真空室中交替抽出纤维流体并从而从纤维中除去水分，并用温暖，非常干燥的空气重新填充，以快速除去纤维素纤维中含有的任何水分。
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公开(公告)号：US07610840B2
公开(公告)日：2009-11-03
申请号：US11935588
申请日：2007-11-06
CPC分类号： F16B31/005 , B64G1/645 , F16B21/16 , F16B35/041 , F16B37/12 , Y10T403/4949
摘要： A non-frangible releasable coupling device as described herein includes an explosive element that, when detonated, bends a load carrying element in a manner that releases the coupled components from each other. Before detonation, the load carrying element is under axial compressive stress imparted by the components. Upon detonation, the explosive element causes the load carrying element to bend into a retraction cavity formed in one of the components, thus allowing the components to displace relative to each other.
摘要翻译： 本文所述的非易碎的可释放联接装置包括爆炸元件，其在引爆时以使得耦合部件彼此释放的方式弯曲承载元件。 在引爆之前，承载元件处于由部件施加的轴向压应力。 在爆炸时，爆炸元件使承载元件弯曲成形成在其中一个部件中的回缩腔，从而允许部件相对于彼此移位。
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公开(公告)号：US5505697A
公开(公告)日：1996-04-09
申请号：US182980
申请日：1994-01-14
CPC分类号： A61M5/30 , A61M2205/50 , A61M5/484
摘要： An electrically powered jet injector impacts a plunger driver against a plunger to generate a high initial pressure pulse, for piercing the skin. The plunger driver then continues to generate a lower delivery pressure until the injection is completed. A microprocessor within the injector controls the speed and direction of the electric motor which moves the plunger driver. The injector provides a subcutaneous injection especially useful for injecting insulin to treat diabetes.
摘要翻译： 电动喷射喷射器将柱塞驱动器撞击柱塞，以产生用于刺穿皮肤的高初始压力脉冲。 柱塞驱动器然后继续产生较低的输送压力，直到注射完成。 喷射器内的微处理器控制移动柱塞驱动器的电动机的速度和方向。 注射器提供特别适用于注射胰岛素治疗糖尿病的皮下注射。
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