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公开(公告)号：US08354240B2
公开(公告)日：2013-01-15
申请号：US13311259
申请日：2011-12-05
申请人： Steven J. Norris , Jing-Ren Zhang , John M. Hardham , Jemlyn K. Howell , Alan G. Barbour , George M. Weinstock
发明人： Steven J. Norris , Jing-Ren Zhang , John M. Hardham , Jemlyn K. Howell , Alan G. Barbour , George M. Weinstock
CPC分类号： C07K16/1207 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/40 , A61K39/44 , C07B59/008 , C07B2200/05 , C07B2200/11 , C07K14/20 , C07K2319/00 , G01N33/56911 , G01N2333/20 , G11B7/0065 , G11B7/00772 , G11B7/128 , Y02A50/40 , Y02A50/401 , Y02A50/57
摘要： The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borreliae, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
摘要翻译： 本发明涉及编码致病性疏螺旋体的Vmp样多肽的DNA序列，重组载体中的DNA序列用于表达多肽的用途，编码的氨基酸序列，DNA和氨基酸序列在产生抗原中的应用 用于免疫预防，免疫治疗和免疫诊断。 还公开了使用核酸序列作为检测引起莱姆病，复发性发热或相关病症的生物的探针或引物，以及旨在促进使用所述多肽，DNA区段和抗体的方法的试剂盒。
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公开(公告)号：US20120122238A1
公开(公告)日：2012-05-17
申请号：US13311259
申请日：2011-12-05
申请人： Steven J. Norris , Jing-Ren Zhang , John M. Hardham , Jemlyn K. Howell , Alan G. Barbour , George M. Weinstock
发明人： Steven J. Norris , Jing-Ren Zhang , John M. Hardham , Jemlyn K. Howell , Alan G. Barbour , George M. Weinstock
IPC分类号： G01N33/566 , C07K16/00
CPC分类号： C07K16/1207 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/40 , A61K39/44 , C07B59/008 , C07B2200/05 , C07B2200/11 , C07K14/20 , C07K2319/00 , G01N33/56911 , G01N2333/20 , G11B7/0065 , G11B7/00772 , G11B7/128 , Y02A50/40 , Y02A50/401 , Y02A50/57
摘要： The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borreliae, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
摘要翻译： 本发明涉及编码致病性疏螺旋体的Vmp样多肽的DNA序列，重组载体中的DNA序列用于表达多肽的用途，编码的氨基酸序列，DNA和氨基酸序列在产生抗原中的应用 用于免疫预防，免疫治疗和免疫诊断。 还公开了使用核酸序列作为检测引起莱姆病，复发性发热或相关病症的生物的探针或引物，以及旨在促进使用所述多肽，DNA区段和抗体的方法的试剂盒。
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公开(公告)号：US06437116B1
公开(公告)日：2002-08-20
申请号：US09125619
申请日：1999-01-27
申请人： Steven J. Norris , Jing-Ren Zhang , John M. Hardham , Jerrilyn K. Howell , Alan G. Barbour , George M. Weinstock
发明人： Steven J. Norris , Jing-Ren Zhang , John M. Hardham , Jerrilyn K. Howell , Alan G. Barbour , George M. Weinstock
IPC分类号： C07H2104
CPC分类号： C07K16/1207 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/40 , A61K39/44 , C07B59/008 , C07B2200/05 , C07B2200/11 , C07K14/20 , C07K2319/00 , G01N33/56911 , G01N2333/20 , G11B7/0065 , G11B7/00772 , G11B7/128 , Y02A50/40 , Y02A50/401 , Y02A50/57
摘要： The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the deletion of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
摘要翻译： 本发明涉及编码病原性疏螺旋体的Vmp样多肽的DNA序列，重组载体中的DNA序列用于表达多肽的用途，编码的氨基酸序列，将DNA和氨基酸序列应用于产生多肽作为抗原 用于免疫预防，免疫治疗和免疫诊断。 还公开了使用核酸序列作为探针或引物用于缺失导致莱姆病，复发性发热或相关病症的生物体，以及设计用于促进使用所述多肽，DNA区段和抗体的方法的试剂盒。
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公开(公告)号：US08071109B2
公开(公告)日：2011-12-06
申请号：US12853019
申请日：2010-08-09
申请人： Steven J. Norris , Jing-Ren Zhang , John M. Hardham , Jerrilyn K. Howell , Alan G. Barbour , George M. Weinstock
发明人： Steven J. Norris , Jing-Ren Zhang , John M. Hardham , Jerrilyn K. Howell , Alan G. Barbour , George M. Weinstock
CPC分类号： C07K16/1207 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/40 , A61K39/44 , C07B59/008 , C07B2200/05 , C07B2200/11 , C07K14/20 , C07K2319/00 , G01N33/56911 , G01N2333/20 , G11B7/0065 , G11B7/00772 , G11B7/128 , Y02A50/40 , Y02A50/401 , Y02A50/57
摘要： The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borreliae, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
摘要翻译： 本发明涉及编码致病性疏螺旋体的Vmp样多肽的DNA序列，重组载体中的DNA序列用于表达多肽的用途，编码的氨基酸序列，DNA和氨基酸序列在产生抗原中的应用 用于免疫预防，免疫治疗和免疫诊断。 还公开了使用核酸序列作为检测引起莱姆病，复发性发热或相关病症的生物的探针或引物，以及旨在促进使用所述多肽，DNA区段和抗体的方法的试剂盒。
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公开(公告)号：US07135176B2
公开(公告)日：2006-11-14
申请号：US10852555
申请日：2004-05-24
申请人： Steven J. Norris , Jing-Ren Zhang , John M. Hardham , Jerrilyn K. Howell , Alan G. Barbour , George M. Weinstock
发明人： Steven J. Norris , Jing-Ren Zhang , John M. Hardham , Jerrilyn K. Howell , Alan G. Barbour , George M. Weinstock
IPC分类号： A61K39/00 , A61K39/395 , A61K39/02
CPC分类号： C07K16/1207 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/40 , A61K39/44 , C07B59/008 , C07B2200/05 , C07B2200/11 , C07K14/20 , C07K2319/00 , G01N33/56911 , G01N2333/20 , G11B7/0065 , G11B7/00772 , G11B7/128 , Y02A50/40 , Y02A50/401 , Y02A50/57
摘要： The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
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公开(公告)号：US07785597B2
公开(公告)日：2010-08-31
申请号：US11501166
申请日：2006-08-07
申请人： Steven J. Norris , Jing-Ren Zhang , John M. Hardham , Jerrilyn K. Howell , Alan G. Barbour , George M. Weinstock
发明人： Steven J. Norris , Jing-Ren Zhang , John M. Hardham , Jerrilyn K. Howell , Alan G. Barbour , George M. Weinstock
CPC分类号： C07K16/1207 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/40 , A61K39/44 , C07B59/008 , C07B2200/05 , C07B2200/11 , C07K14/20 , C07K2319/00 , G01N33/56911 , G01N2333/20 , G11B7/0065 , G11B7/00772 , G11B7/128 , Y02A50/40 , Y02A50/401 , Y02A50/57
摘要： The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
摘要翻译： 本发明涉及编码病原性疏螺旋体的Vmp样多肽的DNA序列，重组载体中的DNA序列用于表达多肽的用途，编码的氨基酸序列，将DNA和氨基酸序列应用于产生多肽作为抗原 用于免疫预防，免疫治疗和免疫诊断。 还公开了使用核酸序列作为检测引起莱姆病，复发性发热或相关病症的生物的探针或引物，以及旨在促进使用所述多肽，DNA区段和抗体的方法的试剂盒。
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公开(公告)号：US06878816B2
公开(公告)日：2005-04-12
申请号：US10222162
申请日：2002-08-16
申请人： Steven J. Norris , Jing-Ren Zhang , John M. Hardham , Jerrilyn K. Howell , Alan G. Barbour , George M. Weinstock
发明人： Steven J. Norris , Jing-Ren Zhang , John M. Hardham , Jerrilyn K. Howell , Alan G. Barbour , George M. Weinstock
IPC分类号： A61K38/00 , A61K39/00 , A61K39/02 , C07K14/20 , C12N1/21 , C12N15/31 , C12P21/04 , C12Q1/68 , G01N33/569 , G01N33/68 , G11B7/0065 , G11B7/125 , C07H21/04 , C07H21/02 , A61K31/70 , A61K49/00
CPC分类号： C07K16/1207 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/40 , A61K39/44 , C07B59/008 , C07B2200/05 , C07B2200/11 , C07K14/20 , C07K2319/00 , G01N33/56911 , G01N2333/20 , G11B7/0065 , G11B7/00772 , G11B7/128 , Y02A50/40 , Y02A50/401 , Y02A50/57
摘要： The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
摘要翻译： 本发明涉及编码病原性疏螺旋体的Vmp样多肽的DNA序列，重组载体中的DNA序列用于表达多肽的用途，编码的氨基酸序列，将DNA和氨基酸序列应用于产生多肽作为抗原 用于免疫预防，免疫治疗和免疫诊断。 还公开了使用核酸序列作为检测引起莱姆病，复发性发热或相关病症的生物的探针或引物，以及旨在促进使用所述多肽，DNA区段和抗体的方法的试剂盒。
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公开(公告)号：US06740744B2
公开(公告)日：2004-05-25
申请号：US10143024
申请日：2002-07-31
申请人： Steven J. Norris , Jing-Ren Zhang , John M. Hardham , Jerrilyn K. Howell , Alan G. Barbour , George M. Weinstock
发明人： Steven J. Norris , Jing-Ren Zhang , John M. Hardham , Jerrilyn K. Howell , Alan G. Barbour , George M. Weinstock
IPC分类号： C07H2104
CPC分类号： C07K16/1207 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/40 , A61K39/44 , C07B59/008 , C07B2200/05 , C07B2200/11 , C07K14/20 , C07K2319/00 , G01N33/56911 , G01N2333/20 , G11B7/0065 , G11B7/00772 , G11B7/128 , Y02A50/40 , Y02A50/401 , Y02A50/57
摘要： The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
摘要翻译： 本发明涉及编码病原性疏螺旋体的Vmp样多肽的DNA序列，重组载体中的DNA序列用于表达多肽的用途，编码的氨基酸序列，将DNA和氨基酸序列应用于产生多肽作为抗原 用于免疫预防，免疫治疗和免疫诊断。 还公开了使用核酸序列作为检测引起莱姆病，复发性发热或相关病症的生物的探针或引物，以及旨在促进使用所述多肽，DNA区段和抗体的方法的试剂盒。
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公开(公告)号：US06719983B2
公开(公告)日：2004-04-13
申请号：US10222566
申请日：2002-08-16
申请人： Steven J. Norris , Jing-Ren Zhang , John M. Hardham , Jerrilyn K. Howell , Alan G. Barbour , George M. Weinstock
发明人： Steven J. Norris , Jing-Ren Zhang , John M. Hardham , Jerrilyn K. Howell , Alan G. Barbour , George M. Weinstock
IPC分类号： A61K3902
CPC分类号： C07K16/1207 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/40 , A61K39/44 , C07B59/008 , C07B2200/05 , C07B2200/11 , C07K14/20 , C07K2319/00 , G01N33/56911 , G01N2333/20 , G11B7/0065 , G11B7/00772 , G11B7/128 , Y02A50/40 , Y02A50/401 , Y02A50/57
摘要： The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
摘要翻译： 本发明涉及编码病原性疏螺旋体的Vmp样多肽的DNA序列，重组载体中的DNA序列用于表达多肽的用途，编码的氨基酸序列，将DNA和氨基酸序列应用于产生多肽作为抗原 用于免疫预防，免疫治疗和免疫诊断。 还公开了使用核酸序列作为检测引起莱姆病，复发性发热或相关病症的生物的探针或引物，以及旨在促进使用所述多肽，DNA区段和抗体的方法的试剂盒。
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公开(公告)号：US20070117970A1
公开(公告)日：2007-05-24
申请号：US11501166
申请日：2006-08-07
申请人： Steven Norris , Jing-Ren Zhang , John Hardham , Jerrilyn Howell , Alan Barbour , George Weinstock
发明人： Steven Norris , Jing-Ren Zhang , John Hardham , Jerrilyn Howell , Alan Barbour , George Weinstock
IPC分类号： G01N33/554 , C07H21/04 , C12N15/74 , G01N33/569 , C07K14/195 , C07K16/12
CPC分类号： C07K16/1207 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/40 , A61K39/44 , C07B59/008 , C07B2200/05 , C07B2200/11 , C07K14/20 , C07K2319/00 , G01N33/56911 , G01N2333/20 , G11B7/0065 , G11B7/00772 , G11B7/128 , Y02A50/40 , Y02A50/401 , Y02A50/57
摘要： The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.
摘要翻译： 本发明涉及编码病原性疏螺旋体的Vmp样多肽的DNA序列，重组载体中的DNA序列用于表达多肽的用途，编码的氨基酸序列，将DNA和氨基酸序列应用于产生多肽作为抗原 用于免疫预防，免疫治疗和免疫诊断。 还公开了使用核酸序列作为检测引起莱姆病，复发性发热或相关病症的生物的探针或引物，以及旨在促进使用所述多肽，DNA区段和抗体的方法的试剂盒。
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