NATURAL KILLER CELLS AND USES THEREOF
    9.
    发明申请
    NATURAL KILLER CELLS AND USES THEREOF 审中-公开
    自然杀伤细胞及其用途

    公开(公告)号:US20150225697A1

    公开(公告)日:2015-08-13

    申请号:US14421059

    申请日:2013-08-13

    IPC分类号: C12N5/0783 A61K35/17

    摘要: Provided herein are methods of producing natural killer (NK) cells and NK progenitor cell populations using a two-step expansion and differentiation method. Also provided herein are methods of producing populations of NK cells and NK progenitor cell populations using a three-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation using the NK cells, the NK cell populations, and the NK progenitor cell populations produced by the methods described herein, as well as methods of treating individuals having cancer or a viral infection, comprising administering the NK cells, the NK cell populations, and the NK progenitor cell populations produced by the methods described herein to an individual having the cancer or viral infection.

    摘要翻译: 本文提供了使用两步扩增和分化方法产生天然杀伤(NK)细胞和NK祖细胞群体的方法。 本文还提供了使用三步扩增和分化方法产生NK细胞和NK祖细胞群的群体的方法。 本文还提供了使用本文所述方法产生的NK细胞,NK细胞群和NK祖细胞群抑制肿瘤细胞增殖的方法,以及治疗患有癌症或病毒感染的个体的方法,包括施用 NK细胞,NK细胞群体和通过本文所述方法产生的NK祖细胞群体具有癌症或病毒感染的个体。