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1.发明申请FUSED TRICYCLIC COMPOUNDS AND DERIVATIVES THEREOF USEFUL FOR THE TREATMENT OF VIRAL DISEASES 审中-公开用于治疗病毒性疾病的融合三聚体化合物及其衍生物公开(公告)号：US20120276047A1
公开(公告)日：2012-11-01
申请号：US13512073
申请日：2010-11-23
IPC分类号： A61K31/437 , C07D471/14 , C07D491/048 , C07D495/04 , A61K31/4188 , C07D513/04 , A61K31/429 , C07D498/04 , A61K31/424 , A61K31/4184 , A61P31/12 , A61P37/02 , A61K31/7088 , A61K39/00 , A61K39/395 , A61K38/21 , C07D471/04
CPC分类号： C07D471/04 , C07D471/14 , C07D493/04 , C07D495/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to novel fused tricyclic compounds, compositions comprising at least one fused tricyclic compound, and methods of using fused tricyclic compounds for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译： 本发明涉及新的稠合三环化合物，包含至少一种稠合三环化合物的组合物，以及使用稠合三环化合物治疗或预防患者病毒感染或病毒相关病症的方法。
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2.发明授权Antiviral compounds of three linked aryl moieties to treat diseases such as hepatitis C 有权三个连接的芳基部分的抗病毒化合物来治疗诸如丙型肝炎的疾病公开(公告)号：US08980920B2
公开(公告)日：2015-03-17
申请号：US13375094
申请日：2010-05-28
申请人： Qingbei Zeng , Kevin X. Chen , Anilkumar Gopinadhan Nair , Stuart B. Rosenblum , Joseph A. Kozlowski , F. George Njoroge
发明人： Qingbei Zeng , Kevin X. Chen , Anilkumar Gopinadhan Nair , Stuart B. Rosenblum , Joseph A. Kozlowski , F. George Njoroge
IPC分类号： A61K31/41 , A61K31/4192 , A61K31/4439 , A61K31/423 , A61K31/5377 , A61K31/496 , A61K31/427 , A61K31/422 , A61K31/4196 , C07D213/60 , C07D233/64 , C07D235/04 , C07D239/28 , C07D241/14 , C07D403/14
CPC分类号： C07D403/14
摘要： The present invention relates to novel Linked Tricyclic Aryl Compounds, compositions comprising at least one Linked Tricyclic Compound, and methods of using Linked Tricyclic Aryl Compounds for treating or preventing HCV infection in a patient. in one aspect, the present invention provides Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein: Non-limiting examples of the Compounds of Formula (II) include compound 56.
摘要翻译： 本发明涉及新的连接三环芳基化合物，包含至少一种连接的三环化合物的组合物，以及使用连接的三环芳基化合物治疗或预防患者HCV感染的方法。 一方面，本发明提供式（I）的化合物及其药学上可接受的盐，其中：式（II）化合物的非限制性实例包括化合物56。
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3.发明申请FUSED TRICYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEAS 审中-公开融合三聚体化合物及其用于治疗病毒性疾病的方法公开(公告)号：US20130156731A1
公开(公告)日：2013-06-20
申请号：US13518336
申请日：2010-12-20
IPC分类号： A61K45/06 , A61K31/454 , C07D403/14 , C07D409/14 , A61K31/4184
CPC分类号： C07D403/14 , A61K31/4184 , A61K31/454 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/08 , C07D409/14
摘要： The present invention relates to novel Fused Tricyclic Compounds, compositions comprising at least one Fused Tricyclic Compound, and methods of using Fused Tricyclic Compounds for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译： 本发明涉及新型融合三环化合物，包含至少一种熔融三环化合物的组合物，以及使用熔融三环化合物治疗或预防患者病毒感染或病毒相关病症的方法。
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4.发明申请ANTIVIRAL COMPOUNDS OF THREE LINKED ARYL MOIETIES TO TREAT DISEASES SUCH AS HEPATITIS C 有权三种连接的ARYL动物的抗病毒化合物治疗疾病如HEPATITIS C公开(公告)号：US20120258078A1
公开(公告)日：2012-10-11
申请号：US13375094
申请日：2010-05-28
申请人： Qingbei Zeng , Kevin X. Chen , Anilkumar Gopinadhan Nair , Stuart B. Rosenblum , Joseph A. Kozlowski , F. George Njoroge
发明人： Qingbei Zeng , Kevin X. Chen , Anilkumar Gopinadhan Nair , Stuart B. Rosenblum , Joseph A. Kozlowski , F. George Njoroge
IPC分类号： A61K31/4178 , C07D413/14 , A61K31/422 , C07D417/14 , A61K31/427 , C07D401/14 , A61K31/4439 , C07D403/14 , A61K31/506 , A61K31/497 , A61K38/21 , A61K31/713 , A61K39/42 , A61K31/7056 , A61P31/14 , C07D405/14
CPC分类号： C07D403/14
摘要： The present invention relates to novel Linked Tricyclic Aryl Compounds, compositions comprising at least one Linked Tricyclic Compound, and methods of using Linked Tricyclic Aryl Compounds for treating or preventing HCV infection in a patient. in one aspect, the present invention provides Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein: Non-limiting examples of the Compounds of Formula (II) include compound 56
摘要翻译： 本发明涉及新的连接三环芳基化合物，包含至少一种连接的三环化合物的组合物，以及使用连接的三环芳基化合物治疗或预防患者HCV感染的方法。 一方面，本发明提供式（I）的化合物及其药学上可接受的盐，其中：式（II）化合物的非限制性实例包括化合物56
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公开(公告)号：US08143305B2
公开(公告)日：2012-03-27
申请号：US12675897
申请日：2008-08-27
申请人： Gopinadhan N. Anilkumar , Frank Bennett , Tin-Yau Chan , Kevin X. Chen , Mousumi Sannigrahi , Francisco Velazquez , Srikanth Venkatraman , Qingbei Zeng , Jose S. Duca , Charles A. Lesburg , Joseph A. Kozlowski , F. George Njoroge , Stuart B. Rosenblum , Neng-Yang Shih , Stephen J. Gavalas , Yueheng Jiang , Patrick A. Pinto , Haiyan Pu , Oleg B. Selyutin , Bancha Vibulbhan , Li Wang , Wanli Wu , Weiying Yang , Yuhua Huang , Hsueh-Cheng Huang , Robert Palermo , Boris Feld
发明人： Gopinadhan N. Anilkumar , Frank Bennett , Tin-Yau Chan , Kevin X. Chen , Mousumi Sannigrahi , Francisco Velazquez , Srikanth Venkatraman , Qingbei Zeng , Jose S. Duca , Charles A. Lesburg , Joseph A. Kozlowski , F. George Njoroge , Stuart B. Rosenblum , Neng-Yang Shih , Stephen J. Gavalas , Yueheng Jiang , Patrick A. Pinto , Haiyan Pu , Oleg B. Selyutin , Bancha Vibulbhan , Li Wang , Wanli Wu , Weiying Yang , Yuhua Huang , Hsueh-Cheng Huang , Robert Palermo , Boris Feld
IPC分类号： A01N43/38 , A61K31/40 , C07D209/04
CPC分类号： C07D417/14 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to 2,3-Substituted Indole Derivatives, compositions comprising at least one 2,3-Substituted Indole Derivative, and methods of using the 2,3-Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译： 本发明涉及2,3-取代的吲哚衍生物，包含至少一种2,3-取代的吲哚衍生物的组合物和使用2,3-取代的吲哚衍生物用于治疗或预防病毒感染或病毒相关的方法 病人无序。
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6.发明申请公开(公告)号：US20100260711A1
公开(公告)日：2010-10-14
申请号：US12743023
申请日：2008-11-13
IPC分类号： A61K31/549 , C07D417/14 , A61K31/4439 , C07D401/06 , A61P31/12 , A61P31/14 , A61K38/21 , A61K39/395
CPC分类号： C07D417/14
摘要： The present invention relates to 3-Aminosulfonyl Substituted Indole Derivatives, compositions comprising at least one 3-Aminosulfonyl Substituted Indole Derivative, and methods of using the 3-Aminosulfonyl Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译： 本发明涉及3-氨基磺酰基取代的吲哚衍生物，包含至少一种3-氨基磺酰基取代的吲哚衍生物的组合物，以及使用3-氨基磺酰基取代的吲哚衍生物用于治疗或预防病毒感染或病毒相关病症的方法 患者。
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公开(公告)号：US08901139B2
公开(公告)日：2014-12-02
申请号：US12997654
申请日：2009-06-10
申请人： Srikanth Venkatraman , Anilkumar Gopinadhan Nair , Kevin X. Chen , Francisco Velazquez , Qingbei Zeng , Duan Liu , Yueheng Jiang , Joseph A. Kozlowski , F. George Njoroge , Stuart B. Rosenblum , Stephen J. Gavalas , Patrick A. Pinto , Oleg B. Selyutin , Bancha Vibulbhan
发明人： Srikanth Venkatraman , Anilkumar Gopinadhan Nair , Kevin X. Chen , Francisco Velazquez , Qingbei Zeng , Duan Liu , Yueheng Jiang , Joseph A. Kozlowski , F. George Njoroge , Stuart B. Rosenblum , Stephen J. Gavalas , Patrick A. Pinto , Oleg B. Selyutin , Bancha Vibulbhan
IPC分类号： C07D491/04 , C07D519/00 , C07D491/048 , A61K31/517 , A61P31/12 , C07D401/14
CPC分类号： C07D491/048 , C07D491/04 , C07D519/00
摘要： The present invention relates to Tricyclic Indole Derivatives, compositions comprising at least one Tricyclic Indole Derivatives, and methods of using the Tricyclic Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译： 本发明涉及三环吲哚衍生物，包含至少一种三环吲哚衍生物的组合物，以及使用三环吲哚衍生物治疗或预防患者病毒感染或病毒相关病症的方法。
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公开(公告)号：US08268803B2
公开(公告)日：2012-09-18
申请号：US12519975
申请日：2007-12-17
申请人： Frank Bennett , Srikanth Venkatraman , F. George Njoroge , Kevin X. Chen , Neng-Yang Shih , Stuart B. Rosenblum , Joseph A. Kozlowski
发明人： Frank Bennett , Srikanth Venkatraman , F. George Njoroge , Kevin X. Chen , Neng-Yang Shih , Stuart B. Rosenblum , Joseph A. Kozlowski
IPC分类号： A61K31/437 , C07D209/04 , C07D243/36
CPC分类号： C07D513/04 , C07D401/04 , C07D471/04 , C07D491/04
摘要： The present invention relates to 5,6-ring annulated indole derivatives of the formula (I), compositions comprising at least one 5,6-ring annulated indole derivatives, and methods of using the 5,6-ring annulated indole derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译： 本发明涉及式（I）的5,6环环状吲哚衍生物，包含至少一种5,6环环状吲哚衍生物的组合物，以及使用5,6环环状吲哚衍生物用于治疗或 预防患者的病毒感染或病毒相关疾病。
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9.发明授权公开(公告)号：US09139569B2
公开(公告)日：2015-09-22
申请号：US13320427
申请日：2010-05-12
申请人： Stuart B. Rosenblum , Kevin X. Chen , Joseph A. Kozlowski , F. George Njoroge , Craig A. Coburn
发明人： Stuart B. Rosenblum , Kevin X. Chen , Joseph A. Kozlowski , F. George Njoroge , Craig A. Coburn
IPC分类号： C07D493/04 , C07D491/044 , C07D487/04 , C07D471/04 , C07D403/14 , C07C403/04
CPC分类号： C07D403/14 , C07C403/04 , C07D403/04 , C07D471/04 , C07D487/04 , C07D491/044 , C07D493/04
摘要： The present invention relates to novel Fused Tricyclic Aryl Compounds, compositions comprising at least one Fused Tricyclic Aryl Compound, and methods of using the Fused Tricyclic Aryl Compounds for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及新的熔融三环芳基化合物，包含至少一种稠合三环芳基化合物的组合物，以及使用稠合三环芳基化合物治疗或预防患者HCV感染的方法。
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10.发明授权Antiviral compounds composed of three aligned aryl moieties to treat diseases such as hepatitis C 有权由三个对齐的芳基部分组成的抗病毒化合物，用于治疗诸如丙型肝炎的疾病公开(公告)号：US08772505B2
公开(公告)日：2014-07-08
申请号：US13375088
申请日：2010-05-28
申请人： Kevin X. Chen , Anilkumar Gopinadhan Nair , Qingbei Zeng , Stuart B. Rosenblum , Joseph A. Kozlowski , F. George Njoroge
发明人： Kevin X. Chen , Anilkumar Gopinadhan Nair , Qingbei Zeng , Stuart B. Rosenblum , Joseph A. Kozlowski , F. George Njoroge
IPC分类号： A61K31/4418 , A61K31/4184 , C07D403/14 , C07D401/14
CPC分类号： C07D401/14 , C07D403/14 , C07D409/14 , C07D417/14
摘要： The present invention relates to novel Tricyclic Compounds, compositions comprising at least one Tricyclic Compound, and methods of using Tricyclic Compounds for treating or preventing a viral infection or a virus-related disorder in a patient. The present invention provides Tricyclic Compounds of Formula (I): Non-limiting examples of the Compounds of Formula (I) include compound 44 The Compounds of Formula (II) can be useful for inhibiting HCV viral replication or replicon activity, and for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及新型三环化合物，包含至少一种三环化合物的组合物，以及使用三环化合物治疗或预防患者病毒感染或病毒相关疾病的方法。 本发明提供式（I）的三环化合物：式（I）化合物的非限制性实例包括化合物44式（II）化合物可用于抑制HCV病毒复制或复制子活性，并且可用于治疗或 预防患者的HCV感染。
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