公开(公告)号：US09236232B2

公开(公告)日：2016-01-12

申请号：US12627372

申请日：2009-11-30

Applicant: Stuart C. Hansen ,  Gangqiang Li

Inventor： Stuart C. Hansen ,  Gangqiang Li

IPC: H01J49/00 ,  H01J49/04

CPC classification number: H01J49/0404

Abstract: A mass spectrometer system an ion source configured to produce ions and a non-metallic capillary configured to receive at least a portion of the ions from the ion source. The capillary includes an elongated body and multiple bores traversing the elongated body in a longitudinal direction. The bores transport the received ions through the capillary toward a mass analyzer of the mass spectrometer system for detection.

Abstract translation: 质谱仪系统，被配置为产生离子的离子源和被配置为从离子源接收至少一部分离子的非金属毛细管。 毛细管包括细长主体和在纵向方向上穿过细长主体的多个孔。 孔将接收到的离子通过毛细管运送到质谱仪系统的质谱仪进行检测。

公开(公告)号：US07557343B2

公开(公告)日：2009-07-07

申请号：US11224093

申请日：2005-09-13

Applicant: Stuart C. Hansen ,  Gangqiang Li ,  Gavin E. Reid

Inventor： Stuart C. Hansen ,  Gangqiang Li ,  Gavin E. Reid

IPC: H01J49/00

CPC classification number: H01J49/4225

Abstract: A method and apparatus for processing ions in mass spectrometry is provided. The apparatus includes an ion processing cell having segmented multipole rods and a means for admitting reactive reagent ions to the cell. Provision for timed sequence control of RF and DC voltages to the segmented multipole rods is included. Processing includes trapping analyte ions and subjecting them to selected reactions with reactive reagent ions and/or physical manipulation of the ions by changing the characteristics of the electric field and/or creating discrete regions in the field.

Abstract translation: 提供了一种在质谱法中处理离子的方法和装置。 该装置包括具有分段多极棒的离子处理单元和用于将反应性试剂离子引入该单元的装置。 包括对分段多极杆的RF和DC电压的定时序列控制。 处理包括捕获分析物离子并使其与反应性试剂离子进行选择的反应和/或通过改变电场的特性和/或在场中产生离散区域来离子的物理操作。

公开(公告)号：US07372042B2

公开(公告)日：2008-05-13

申请号：US11217248

申请日：2005-08-31

Applicant: Alexander Mordehai ,  Gangqiang Li ,  Stuart C. Hansen

Inventor： Alexander Mordehai ,  Gangqiang Li ,  Stuart C. Hansen

IPC: H01J49/00

CPC classification number: H01J49/04 ,  H01J43/06 ,  H01J49/10

Abstract: The invention provides a device for introducing ions into the primary ion path of a mass spectrometry system. In general, the device contains an electrical lens having a primary ion passageway and a secondary ion passageway that merges with the primary ion passageway. In certain embodiments, the electrical lens contains a first part and a second part that, together, form the primary ion passageway. The first part of the lens may contain the secondary ion passageway.

Abstract translation: 本发明提供了一种用于将离子引入质谱系统的一次离子路径的装置。 通常，该装置包含具有主离子通道和与主离子通道并入的次级离子通道的电透镜。 在某些实施例中，电透镜包含一起形成主离子通道的第一部分和第二部分。 透镜的第一部分可以包含二次离子通道。

公开(公告)号：US06617768B1

公开(公告)日：2003-09-09

申请号：US09541209

申请日：2000-04-03

Applicant: Stuart C. Hansen

Inventor： Stuart C. Hansen

IPC: H01J4300

CPC classification number: H01J49/025 ,  H01J43/246

Abstract: A multi dynode device (MDD) for electron multiplication and detection and a hybrid detector using the MDD have high peak signal output currents and large dynamic range while preserving the time-dependent information of the input event and avoiding the generation of significant distortions or artifacts on the output signal. The MDD and hybrid detector overcome saturation problems observed in conventional hybrid detectors by providing a unique electron multiplier portion that avoids the path-length differences. The MDD and hybrid detector can be used in mass spectrometry, in particular, time-of-flight mass spectrometry. The MDD comprises a plurality of dynode plates arranged in a stacked configuration. Each dynode plate in the stack has a plurality of apertures for cascading secondary electrons through the stack. Each aperture comprises a mechanical bias or offset with respect to the apertures in adjacent plates. The offset is such that the electrons will impact with one or more of the dynode plates. The MDD further comprises a power source to provide a voltage bias to the dynode plates. The power source comprises a voltage supply and a voltage divider. Each dynode plate is connected to a tap on the voltage divider such that a voltage gradient is produced along the stack. The MDD can supply high peak currents. The hybrid detector comprises an input portion having a microchannel plate MCP and an output portion having the multi dynode device (MDD). The MCP and MDD are adjacent to one another. The MDD is planar, flat, and compact like that of the MCP, such that important temporal integrity of an input signal event is preserved.

Abstract translation: 用于电子倍增和检测的多重倍增器装置（MDD）和使用MDD的混合检测器具有高峰值信号输出电流和大动态范围，同时保留输入事件的时间依赖信息，并避免产生明显的失真或伪像 输出信号。 MDD和混合式检测器通过提供避免路径长度差异的独特的电子倍增器部分来克服常规混合检测器中观察到的饱和问题。 MDD和混合检测器可用于质谱，特别是飞行时间质谱。 MDD包括以堆叠配置布置的多个倍增极板。 堆叠中的每个倍增极板具有多个用于通过堆叠层叠二次电子的孔。 每个孔包括相对于相邻板中的孔的机械偏置或偏移。 偏移使得电子将与一个或多个倍增极板相撞。 MDD还包括向倍增极板提供电压偏置的电源。 电源包括电压源和分压器。 每个倍增电极板连接到分压器上的抽头，使得沿堆叠产生电压梯度。 MDD可以提供高峰值电流。 混合式检测器包括具有微通道板MCP的输入部分和具有多重倍增器装置（MDD）的输出部分。 MCP和MDD彼此相邻。 MDD是类似于MCP的平面，平坦和紧凑的，使得保持输入信号事件的重要的时间完整性。

公开(公告)号：US06717135B2

公开(公告)日：2004-04-06

申请号：US09976417

申请日：2001-10-12

Applicant: Stuart C. Hansen

Inventor： Stuart C. Hansen

IPC: B01D5944

CPC classification number: H01J49/405

Abstract: An apparatus for receiving and reflecting ions. The ion mirror of the present invention is integral to a mass spectrometer flight tube and includes a front electrode, middle electrode, and a rear electrode. Each of the three electrodes are designed for receiving and reflecting ions. The electrodes of the ion mirror have a conductive material used for creating electric fields that retard and reflect ions back toward an ion detector. The flight tube may be made of an insulating material such as fused silica or quartz.

Abstract translation: 用于接收和反射离子的装置。 本发明的离子镜与质谱飞行管成为一体，包括前电极，中间电极和后电极。 三个电极中的每一个被设计用于接收和反射离子。 离子反射镜的电极具有用于产生延迟并将离子反射回离子检测器的电场的导电材料。 飞行管可以由诸如熔融石英或石英的绝缘材料制成。

公开(公告)号：US5672870A

公开(公告)日：1997-09-30

申请号：US573703

申请日：1995-12-18

Applicant: Curt A. Flory ,  Stuart C. Hansen ,  Carl Myerholtz

Inventor： Curt A. Flory ,  Stuart C. Hansen ,  Carl Myerholtz

IPC: G01N27/62 ,  H01J49/06 ,  H01J49/42 ,  B01D59/44 ,  H01J49/00

CPC classification number: H01J49/4215 ,  H01J49/4285

Abstract: A notch filter for selectively removing a target ion with a specific mass-to-charge ratio from an ion beam is provided. The notch filter uses a quadrupole and a power supply for generating an rf electrical potential in the quadrupole. The quadrupole has two pairs of parallel electrodes of opposite polarities. Each pair is comprised of two parallel electrodes having equal electrical potential. The rf electrical potential generated by the power supply is a superposition of an rf quadrupole frequency component and an excision frequency component. The quadrupole has an inlet end and an outlet end and the ion beam traverses from the inlet end to the outlet end. As a result of the rf quadrupole frequency component, ions of above a selected mass-to-charge ratio are guided down the quadrupole. The excision frequency component, which is at the second harmonic of the dominant resonant frequency of the target ion, causes the target ion to resonate and be removed from the ion beam before exiting the quadrupole.

Abstract translation: 提供了一种用于从离子束以特定的质荷比选择性去除目标离子的陷波滤波器。 陷波滤波器使用四极杆和用于在四极杆中产生射频电位的电源。 四极具有两对相反极性的平行电极。 每对由两个具有相等电位的平行电极组成。 由电源产生的rf电位是rf四极杆频率分量和切除频率分量的叠加。 四极杆具有入口端和出口端，离子束从入口端到出口端横穿。 作为rf四极杆频率分量的结果，高于选择的质荷比的离子被引导到四极杆下方。 处于目标离子的主要共振频率的二次谐波的切除频率分量使靶离子在离开四极杆之前共振并从离子束中除去。

公开(公告)号：US4960991A

公开(公告)日：1990-10-02

申请号：US422936

申请日：1989-10-17

Applicant: Paul C. Goodley ,  Stuart C. Hansen

Inventor： Paul C. Goodley ,  Stuart C. Hansen

IPC: G01N27/62 ,  G01N30/72 ,  H01J27/08 ,  H01J49/10 ,  H01J49/14

CPC classification number: H01J49/107 ,  H01J27/08 ,  H01J49/145

Abstract: A multimode ionization source includes a resistive filament aligned with an exit cone orifice. The filament generates electrons that bombard molecules near the orifice. In electron impact mode, a pressure regulator selects a low pressure within an ionization chamber and gaseous analyte is injected through a gas inlet and ionized by electron bombardment. In chemical ionization mode, an intermediate pressure of reagent gas established; electrons ionize the reagent gas. Gaseous analyte is introduced is ionized by the reagent gas through chemical interaction. In thermospray mode, a high pressure is established and heated liquid analyte is introduced into the chamber as a spray which is ionized by ion evaporation; in a thermospray/chemical ionization submode, filament activation supplements ion evaporation. Ions produced in all modes can be directed to a mass analyzer for analysis.

公开(公告)号：US07208726B2

公开(公告)日：2007-04-24

申请号：US10927874

申请日：2004-08-27

Applicant: August Hidalgo ,  Stuart C. Hansen ,  Gangqiang Li

Inventor： August Hidalgo ,  Stuart C. Hansen ,  Gangqiang Li

IPC: H01J49/00 ,  H01J49/40

CPC classification number: H01J49/401 ,  H01J49/422 ,  H01J49/424

Abstract: An apparatus for analyzing ions is described. The apparatus includes an ion source, an ion trap positioned to receive ions from the ion source; a time of flight mass analyzer, and a detector operatively coupled to the time of flight. The time of flight mass analyzer includes a pulser region, and the pulser region is positioned to receive ions from the ion trap. The apparatus further includes a scanning delay timing circuit in operable relation to the pulser region. The scanning delay timing circuit is adapted to triggering an extraction pulse at the pulser region. Methods of analyzing ions by mass spectrometry are also described.

Abstract translation: 描述了用于分析离子的装置。 该装置包括离子源，定位成从离子源接收离子的离子阱; 飞行时间质量分析器，以及可操作地耦合到飞行时间的检测器。 飞行时间质量分析器包括脉冲发生器区域，并且脉冲发生器区域被定位成从离子阱接收离子。 该装置还包括与脉冲发生器区域可操作的扫描延迟定时电路。 扫描延迟定时电路适于在脉冲发生器区域触发提取脉冲。 还描述了通过质谱分析离子的方法。

公开(公告)号：US07105807B2

公开(公告)日：2006-09-12

申请号：US10617597

申请日：2003-07-11

Applicant: Stuart C. Hansen

Inventor： Stuart C. Hansen

IPC: H01J49/26

CPC classification number: H01J49/025 ,  H01J43/246

Abstract: A multi dynode device (MDD) for electron multiplication and detection and a hybrid detector using the MDD have high peak signal output currents and large dynamic range while preserving the time-dependent information of the input event and avoiding the generation of significant distortions or artifacts on the output signal. The MDD and hybrid detector overcome saturation problems observed in conventional hybrid detectors by providing a unique electron multiplier portion that avoids the path-length differences. The MDD and hybrid detector can be used in mass spectrometry, in particular, time-of-flight mass spectrometry. The MDD comprises a plurality of dynode plates arranged in a stacked configuration. Each dynode plate in the stack has a plurality of apertures for cascading secondary electrons through the stack. Each aperture comprises a mechanical bias or offset with respect to the apertures in adjacent plates. The offset is such that the electrons will impact with one or more of the dynode plates. The MDD further comprises a power source to provide a voltage bias to the dynode plates. The power source comprises a voltage supply and a voltage divider. Each dynode plate is connected to a tap on the voltage divider such that a voltage gradient is produced along the stack. The MDD can supply high peak currents. The hybrid detector comprises an input portion having a microchannel plate MCP and an output portion having the multi dynode device (MDD). The MCP and MDD are adjacent to one another. The MDD is planar, flat, and compact like that of the MCP, such that important temporal integrity of an input signal event is preserved.

公开(公告)号：US06469296B1

公开(公告)日：2002-10-22

申请号：US09484374

申请日：2000-01-14

Applicant: Stuart C. Hansen ,  James Foote

Inventor： Stuart C. Hansen ,  James Foote

IPC: H01J4840

CPC classification number: H01J49/403

Abstract: An ion acceleration apparatus and method, and a mass spectrometer using the apparatus and method, require only a single pulse generator for the collection and acceleration of ions. The apparatus, method and mass spectrometer are useful in time-of-flight mass spectrometry (TOFMS). The apparatus, method and spectrometer save on manufacturing costs and complexity, without compromising measurement sensitivity or reliability. The ion acceleration apparatus comprises a plurality of conductive plates comprising a pulser electrode, three grids and preferably, a plurality of frames units, in a stacked relationship. The pulser electrode and a third grid form the outside ends of the ion acceleration apparatus. The plates of the stack are spaced apart and electrically insulated from one another. A power source provides fill, pulse and bias voltages to the plates. The power source comprises a pulse generator that provides fill and pulse voltages to the pulser electrode and to a first grid that is adjacent to the pulser electrode. A second grid is electrically connected to ground potential and is between the first grid and the plurality of guard frames. The power source further comprises a voltage source for supplying a fixed high voltage bias to the third grid and preferably to the frame units. During the fill period, analyte ions from an ion source are collected in a fill region between the pulser electrode and the first grid. The pulser electrode and first grid are supplied with a small magnitude voltage of a polarity opposite to a polarity of a charge of the analyte ions. During the pulse period, the analyte ions are induced to move from the fill region and into an acceleration region by the application of the pulse voltage to the pulse electrode and the first grid. The pulse voltage is a large magnitude voltage of the same polarity as the polarity of the charge on the analyte ions. A field produced by the fixed voltage bias applied to the third grid and guard frames accelerates the analyte ions once they enter the acceleration region.