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    System and Implantable Device for Treating Chronic Kidney Disease
    1.
    发明申请
    System and Implantable Device for Treating Chronic Kidney Disease 审中-公开
    用于治疗慢性肾脏疾病的系统和植入装置

    公开(公告)号：US20120289881A1

    公开(公告)日：2012-11-15

    申请号：US13462190

    申请日：2012-05-02

    申请人： SuPing Lyu ,  Thomas Edward Meyer ,  Mark Fredrick Daniels ,  Bryant J. Pudil

    发明人： SuPing Lyu ,  Thomas Edward Meyer ,  Mark Fredrick Daniels ,  Bryant J. Pudil

    IPC分类号： A61M1/16

    CPC分类号： A61M1/1678 ,  B01D61/18 ,  B01D61/28 ,  B01D63/084 ,  B01D2313/105

    摘要： An implantable dialysis device with a related medical system for intracorporeal dialysis and ultrafiltration of blood, and methods of use are described. The medical system includes an extracorporeal module, a cutaneous module, and an implantable module. Features of the implantable module facilitate delivery and flow of blood and dialysate through the medical system. A filter pack within the implantable module performs dialysis and ultrafiltration of blood. System cleansing is also described.

    摘要翻译： 描述了具有用于体内透析和血液超滤的相关医疗系统的植入式透析装置及其使用方法。 医疗系统包括体外模块，皮肤模块和可植入模块。 可植入模块的特征便于血液和透析液通过医疗系统的输送和流动。 可植入模块内的过滤器组件执行血液的透析和超滤。 还描述了系统清洁。

    HEMODIALYSIS SYSTEM HAVING A FLOW PATH WITH A CONTROLLED COMPLIANT VOLUME
    3.
    发明申请
    HEMODIALYSIS SYSTEM HAVING A FLOW PATH WITH A CONTROLLED COMPLIANT VOLUME 审中-公开
    具有控制合格体积的流路的血液透析系统

    公开(公告)号：US20130199998A1

    公开(公告)日：2013-08-08

    申请号：US13565733

    申请日：2012-08-02

    申请人： Thomas D. Kelly ,  SuPing Lyu ,  Bryant J. Pudil ,  Thomas E. Meyer

    发明人： Thomas D. Kelly ,  SuPing Lyu ,  Bryant J. Pudil ,  Thomas E. Meyer

    IPC分类号： A61M1/16

    CPC分类号： A61M1/3482 ,  A61M1/1696 ,  A61M2202/0021 ,  A61M2202/0413

    摘要： Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.

    摘要翻译： 公开了用于执行肾脏替代疗法的系统和方法，其具有或使用透析器，控制组件，吸附剂盒和流体储存器，其被配置为适于被需要治疗的个体穿戴或携带的重量和尺寸。 用于执行肾脏替代治疗的系统具有受控的依从性透析电路，其中控制泵控制流体穿过透析膜的双向运动。 透析电路和用于循环血液的体外循环通过透析膜流体连通。 在体外循环和透析回路之间移动的流体通量由控制泵运行的速率改变，从而可以控制超滤速率和对流间隙。 该系统提供对吸附剂盒的入口和出口导电性的监测，以提供量化或监测吸附剂盒去除尿素的设施。

    Hemodialysis system having a flow path with a controlled compliant volume
    4.
    发明授权
    Hemodialysis system having a flow path with a controlled compliant volume 有权

    公开(公告)号：US10695481B2

    公开(公告)日：2020-06-30

    申请号：US13565733

    申请日：2012-08-02

    申请人： Thomas D. Kelly ,  SuPing Lyu ,  Bryant J. Pudil ,  Thomas E. Meyer

    发明人： Thomas D. Kelly ,  SuPing Lyu ,  Bryant J. Pudil ,  Thomas E. Meyer

    IPC分类号： A61M1/34 ,  A61M1/16

    摘要： Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.

    Modular hemodialysis system
    5.
    发明授权
    Modular hemodialysis system 有权

    公开(公告)号：US10857277B2

    公开(公告)日：2020-12-08

    申请号：US13586824

    申请日：2012-08-15

    申请人： Thomas D. Kelly ,  SuPing Lyu ,  Bryant J. Pudil ,  Thomas E. Meyer

    发明人： Thomas D. Kelly ,  SuPing Lyu ,  Bryant J. Pudil ,  Thomas E. Meyer

    IPC分类号： A61M1/16 ,  A61M1/36

    摘要： Apparatuses, systems, and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. A first sorbent cartridge is provided for use in a portable treatment module having activated carbon and zirconium oxide. The system also provides for the monitoring of an inlet and outlet conductivity of a sorbent cartridge containing urease to provide a facility to quantify or monitor the removal of urea by a detachable urea removal module.

    MODULAR HEMODIALYSIS SYSTEM
    6.
    发明申请
    MODULAR HEMODIALYSIS SYSTEM 审中-公开
    模块化血液透析系统

    公开(公告)号：US20130213890A1

    公开(公告)日：2013-08-22

    申请号：US13586824

    申请日：2012-08-15

    申请人： Thomas D. Kelly ,  SuPing Lyu ,  Bryant J. Pudil ,  Thomas E. Meyer

    发明人： Thomas D. Kelly ,  SuPing Lyu ,  Bryant J. Pudil ,  Thomas E. Meyer

    IPC分类号： A61M1/16

    CPC分类号： A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/1696 ,  A61M1/3609 ,  A61M1/3612 ,  A61M2205/15 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3334 ,  A61M2205/50 ,  A61M2230/207

    摘要： Apparatuses, systems, and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. A first sorbent cartridge is provided for use in a portable treatment module having activated carbon and zirconium oxide. The system also provides for the monitoring of an inlet and outlet conductivity of a sorbent cartridge containing urease to provide a facility to quantify or monitor the removal of urea by a detachable urea removal module.

    摘要翻译： 公开了用于执行肾脏替代疗法的装置，系统和方法，其具有或使用透析器，控制组件，吸附剂盒和流体储存器，其被配置为适于被需要治疗的个体穿戴或携带的重量和尺寸。 该系统具有受控的依从性透析电路，其中控制泵控制流体穿过透析膜的双向运动。 第一吸附剂盒被提供用于具有活性炭和氧化锆的便携式处理组件中。 该系统还提供用于监测含有脲酶的吸附剂盒的入口和出口电导率，以提供通过可拆卸的尿素去除模块量化或监测尿素去除的设施。

    POLYSTYRENE SULFONATE RESIN FOR USE WITH A HEMODIALYSIS SYSTEM HAVING A CONTROLLED COMPLIANCE DIALYSIS CIRCUIT
    8.
    发明申请
    POLYSTYRENE SULFONATE RESIN FOR USE WITH A HEMODIALYSIS SYSTEM HAVING A CONTROLLED COMPLIANCE DIALYSIS CIRCUIT 审中-公开
    聚苯乙烯磺酸酯树脂与具有控制的合规性透析电路的血液透析系统一起使用

    公开(公告)号：US20130256227A1

    公开(公告)日：2013-10-03

    申请号：US13612701

    申请日：2012-09-12

    申请人： Thomas D. Kelly ,  SuPing Lyu

    发明人： Thomas D. Kelly ,  SuPing Lyu

    IPC分类号： A61M1/36

    CPC分类号： A61M1/3621 ,  A61M1/1696

    摘要： Sorbent cartridges having a polystyrene sulfonate resin saturated with calcium ions for the performance of kidney replacement therapy are disclosed. Systems and methods having or using a sorbent cartridge, a dialyzer, control components, a cartridge having a polystyrene sulfonate resin, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. A system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to quantify or monitor the removal of urea by the sorbent cartridge.

    摘要翻译： 公开了具有用钙离子饱和的聚苯乙烯磺酸盐树脂进行肾脏替代疗法的吸收性药筒。 公开了具有或使用吸附剂药筒，透析器，控制组件，具有聚苯乙烯磺酸酯树脂的药筒和被配置为具有适于由需要治疗的个体佩戴或携带的重量和尺寸的流体储存器的系统和方法。 用于执行肾脏替代治疗的系统具有受控的依从性透析电路，其中控制泵控制流体穿过透析膜的双向运动。 该系统提供对吸附剂盒的入口和出口导电性的监测，以量化或监测吸附剂盒的尿素去除。