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    Novel antimycobacterial compounds
    5.
    发明申请
    Novel antimycobacterial compounds 失效
    新型抗分枝杆菌复合物

    公开(公告)号：US20050192275A1

    公开(公告)日：2005-09-01

    申请号：US11082947

    申请日：2005-03-18

    申请人： Sudershan Arora ,  Vijaykumar Patil ,  Prathap Nair ,  Prasad Dixit ,  Shankar Ajay ,  Rakesh Sinha

    发明人： Sudershan Arora ,  Vijaykumar Patil ,  Prathap Nair ,  Prasad Dixit ,  Shankar Ajay ,  Rakesh Sinha

    IPC分类号： A61P31/00 ,  C07D263/20 ,  C07D413/10 ,  C07D413/14 ,  A61K31/541 ,  A61K31/422 ,  A61K31/496 ,  A61K31/5377 ,  C07D413/02 ,  C07D417/02

    CPC分类号： C07D263/20 ,  C07D413/10 ,  C07D413/14

    摘要： Novel compounds belonging to the class of oxazolidinones possessing potent antimycobacterial properties especially useful in the treatment of acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium-intracellular complex, M. fortuitum and M. kansai. The compound and its pharmaceutically acceptable salts thereof act as antibacterial agents. Also disclosed is a method for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial conditions such as Mycobacterium tuberculosis, drug resistant Mycobacterium tuberculosis, Mycobacterium avium-intracellular complex, M. fortuitum and M. kansai, comprising administering an antimycobacterially effective amount of the said compound and/or pharmaceutically acceptable salts thereof. There is also disclosed a process for the manufacture of the said compound or its pharmaceutically acceptable salts.

    摘要翻译： 属于恶唑烷酮类的新型化合物具有强效的抗分支杆菌特性，特别适用于治疗结核分枝杆菌，鸟分枝杆菌 - 细胞内复合物，偶然遗传和关西等酸性快速生物。 该化合物及其药学上可接受的盐作为抗菌剂。 还公开了一种抑制分枝杆菌细胞生长的方法以及治疗结核分枝杆菌，耐药性结核分枝杆菌，鸟分枝杆菌 - 细胞内复合物，偶发性偶联菌和关西氏菌等分枝杆菌病症的方法，其包括施用抗分枝杆菌有效量 的所述化合物和/或其药学上可接受的盐。 还公开了制备所述化合物或其药学上可接受的盐的方法。

    Herbal extract comprising a mixture of saponins obtained from sapindus trifoliatus for anticonvulsant activity
    6.
    发明申请
    Herbal extract comprising a mixture of saponins obtained from sapindus trifoliatus for anticonvulsant activity 审中-公开
    草药提取物包含从三叶皂甙获得的皂苷混合物，用于抗惊厥活性

    公开(公告)号：US20050249831A1

    公开(公告)日：2005-11-10

    申请号：US10525992

    申请日：2003-08-27

    申请人： Sudershan Arora ,  Vandita Srivastava ,  Veeranjaneyulu Addepalli ,  Sridhar Natesan ,  Rajan Goel

    发明人： Sudershan Arora ,  Vandita Srivastava ,  Veeranjaneyulu Addepalli ,  Sridhar Natesan ,  Rajan Goel

    IPC分类号： A61K20060101 ,  A61K31/704 ,  A61K35/00 ,  A61K36/77 ,  A61P20060101 ,  A61P25/06 ,  A61K35/78

    CPC分类号： A61K36/77

    摘要： A pharmaceutical composition comprising a herbal extract, comprising a mixture of saponins prepared from the pericarp of Sapindus trifoliatus, with binding affinities for the receptor sites viz. GABA-A agonist site, Glutamate-AMPA site, Glutamate-Kainate site, Glutamate-NMDA agonistic site, Glutamate-NMDA glycine (strychnine insensitive) site and Sodium channel (site 2), having major mediatory role in anticonvulsant activity. A process for preparation of the herbal extract; isolation of six pure compounds from the mixture of saponins in the aqueous extract; and a pharmaceutical composition comprising the said extract in combination with pharmaceutically acceptable additives. A method of prophylactic treatment of migraine through anticonvulsant activity of the composition by its administration through intranasal route.

    摘要翻译： 包含草药提取物的药物组合物，其包含由Sapindus trifoliatus的果皮制备的皂苷的混合物，对受体位点的结合亲和力。 GABA-A激动剂位点，谷氨酸 - AMPA位点，谷氨酸 - 红藻酸酯位点，谷氨酸-N NMDA激动位点，谷氨酸-N NMDA甘氨酸（士的宁不敏感）位点和钠通道（位点2），在抗惊厥活性中具有主要的介导作用。 制备草药提取物的方法 在水提取物中从皂甙混合物中分离出六种纯化合物; 以及包含所述提取物与药学上可接受的添加剂组合的药物组合物。 一种通过鼻内途径施用组合物的抗惊厥活性来预防性治疗偏头痛的方法。