公开(公告)号：US20040137164A1

公开(公告)日：2004-07-15

申请号：US10745080

申请日：2003-12-23

Applicant: SURMODICS, INC.

Inventor： Dale G. Swan ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Ralph A. Chappa ,  Sean M. Stucke ,  Peter H. Duquette

IPC: C08G002/00

CPC classification number: C08J7/18 ,  A61L27/28 ,  A61L27/34 ,  A61L29/08 ,  A61L29/085 ,  A61L31/08 ,  A61L31/10 ,  A61L33/06 ,  A61L33/12 ,  B05D1/00 ,  B05D3/06 ,  B05D3/061 ,  B05D3/067 ,  B05D7/52 ,  G01N33/54353 ,  G01N33/54393 ,  Y10T428/31855

Abstract: A method of forming a polymer layer on a support surface by the use of a coating agent and polymerizable compounds. The coating agent provides photoreactive groups adapted to attach the agent to the surface, as well as photoreactive groups adapted to remain unattached to the surface, and thus serve as photoinitiators for the activation of polymerizable compounds in order to form a polymer layer thereon. Also provided are coating agents, per se, as well as a method of using such agents and the resultant surfaces and devices fabricated therefrom.

Abstract translation: 通过使用涂布剂和可聚合化合物在支撑体表面上形成聚合物层的方法。 涂覆剂提供适于将试剂连接到表面的光反应性基团，以及适于保持不附着于表面的光反应性基团，因此用作活化可聚合化合物的光引发剂，以在其上形成聚合物层。 本发明还提供涂层剂，以及使用这种试剂的方法以及由其制造的所得表面和装置。

公开(公告)号：US20040203075A1

公开(公告)日：2004-10-14

申请号：US10412063

申请日：2003-04-10

Applicant: SurModics, Inc.

Inventor： Stephen J. Chudzik ,  Dale G. Swan

IPC: G01N033/53

CPC classification number: A61K9/5026 ,  A61K9/1635 ,  A61K47/32 ,  Y10S516/911 ,  Y10S522/904 ,  Y10S623/92

Abstract: Initiator polymers having an initiator group and a ligand group are provided. The initiator polymers are capable of specifically binding to a receptor on a surface. Using a macromer system, the initiator polymers are useful for the formation of a polymeric matrix on the surface of a material. In particular, initiator polymers are provided that have specificity to pancreatic null cells and can be used to encapsulate cells for transplantation and the treatment of diabetes.

Abstract translation: 提供了具有引发剂基团和配体基团的引发剂聚合物。 引发剂聚合物能够特异性结合表面上的受体。 使用大分子单体体系，引发剂聚合物可用于在材料表面上形成聚合物基质。 特别地，提供对胰腺β细胞具有特异性的引发剂聚合物，并且可用于包封用于移植和治疗糖尿病的细胞。

公开(公告)号：US20040202774A1

公开(公告)日：2004-10-14

申请号：US10412081

申请日：2003-04-10

Applicant: SurModics, Inc.

Inventor： Stephen J. Chudzik ,  Ronald F. Ofstead ,  Dale G. Swan

IPC: B05D003/00 ,  C12N011/04

CPC classification number: C12N11/08 ,  A61K2035/126

Abstract: Positively-charged initiator polymers having a polymerization initiator group and a cationic portion are provided. The initiator polymers can be used with a polymerizable material for the formation of a polymeric matrix on a surface. The initiator polymers are particularly useful for cell encapsulation using macromers.

Abstract translation: 提供具有聚合引发剂基团和阳离子部分的带正电荷的引发剂聚合物。 引发剂聚合物可以与用于在表面上形成聚合物基质的可聚合材料一起使用。 引发剂聚合物特别适用于使用大分子单体的细胞包封。

公开(公告)号：US20040209305A1

公开(公告)日：2004-10-21

申请号：US10844667

申请日：2004-05-12

Applicant: SurModics, Inc.

Inventor： Dale G. Swan ,  Melvin J. Swanson

IPC: C12Q001/68 ,  C08G063/48 ,  B05D003/00

CPC classification number: C40B80/00 ,  B01J2219/00317 ,  B01J2219/00531 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00711 ,  B01J2219/00716 ,  B01J2219/00722 ,  B82Y30/00 ,  C07B2200/11 ,  C07C45/63 ,  C07C235/84 ,  C07C323/42 ,  C07H21/00 ,  C08L63/00 ,  C09D4/00 ,  C12Q1/6834 ,  C40B40/06 ,  C40B60/14 ,  C07C49/813

Abstract: Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes epoxide groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.

Abstract translation: 用于将目标分子（例如核酸）共价连接到基底表面上的方法和试剂组合物。 试剂组合物包括能够与靶分子共价结合的环氧基。 任选地，组合物可以含有用于将试剂组合物附着到表面上的光反应性基团。 试剂组合物可用于提供用于制备核酸微阵列的活性载玻片。

公开(公告)号：US20030148308A1

公开(公告)日：2003-08-07

申请号：US10192917

申请日：2002-07-09

Applicant: SurModics, Inc.

Inventor： Ralph A. Chappa ,  Sheau-Ping Hu ,  Dale G. Swan ,  Melvin J. Swanson ,  Patrick E. Guire

IPC: C12Q001/68 ,  C12M001/34 ,  B05D003/00

CPC classification number: B82Y30/00 ,  B01J2219/00317 ,  B01J2219/00531 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00711 ,  B01J2219/00716 ,  B01J2219/00722 ,  C07B2200/11 ,  C07C45/63 ,  C07C235/84 ,  C07C323/42 ,  C07H21/00 ,  C12Q1/6834 ,  C40B40/06 ,  C40B60/14 ,  C07C49/813

Abstract: Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.