摘要:
Isolated and/or recombinant nucleic acids encoding mycobacterial methionyl-tRNA synthetase have been characterized. Recombinant DNA constructs and vectors having a sequence which encodes mycobacterial methionyl-tRNA synthetase have been made, and can be used for the construction of tester strains as well as for the production of isolated and/or recombinant methionyl-tRNA synthetases. These enzymes or portions thereof are useful in the biochemical separation of methionine and quantification of methionine or ATP, and for producing antibodies useful in the purification and study of the enzyme, for example. Host cells and methods useful for producing recombinant mycobacterial methionyl-tRNA synthetases are described, as are tester strains, which are cells engineered to rely on the function of the tRNA synthetase encoded by an introduced cloned gene. Tester strains can be used to identify inhibitors of the essential tRNA synthetase enzyme encoded by the introduced cloned gene, and thus provide a means to assess the antimicrobial effect and specificity of the inhibitor without employing slow-growing, pathogenic strains of mycobacteria, such as Mycobacterium tuberculosis.
摘要:
Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a β-lactam antibiotic.
摘要:
A method for a terminal including a first media access control (MAC) layer and a second MAC layer to create an authorization key includes performing a first network entry process to a base station through the first MAC layer, and performing a second network entry process for a frequency overlay to the base station through the second MAC layer. In this instance, the first network entry process includes acquiring a key for generating an authorization key through an authentication process according to an authentication method negotiated with the base station, and generating a first authorization key through the key for generating the authorization key. The second network entry process includes generating a second authorization key by using the key generated in the first network entry process for generating the authorization key.
摘要:
Disclosed is a method for receiving MBMS services from a base station supporting multi-carriers, including: receiving first system information including information on all the carriers; receiving second system information including information on multi-carriers supported by the base station; receiving MBMS control information through an MBMS control channel; and receiving the MBMS services through an MBMS transmission channel based on the MBMS control information.
摘要:
A method and apparatus for multimedia broadcast and multicast service (MBMS) counting is provided. A user equipment (UE) may transmit selected service information to a multi-cell and multicast coordination entity (MCE) through a target evolved node base station (eNB), every time that a service requiring counting is received or cancelled and thus, the MCE may accurately manage a number of UEs that receive a service for each eNB. Also, the use may transmit selected service information to the MCE through the target eNB every time that the UE enters a new cell and thus, the MCE may accurately manage a number of UEs that receive a service for each eNB.
摘要:
The present invention relates to the use of inhibitors of FtsZ, an ancestral tubulin of prokaryotes, to restore susceptibility to β-lactam antibiotics, including carbapenems and cephalosporins, particularly in methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphyloccus epidermis (MRSE), and other coagulase negative staphylococci (MRCNS).
摘要:
The present invention relates to a method of managing a paging group in a mobile terminal that is in an idle mode. A method of managing a paging group according to an exemplary embodiment of the invention includes: collecting paging group ID information including paging group levels and local IDs; determining, on the basis of the collected paging group ID information, whether or not a location update occurs; and if it is determined that the location update occurs, comparing a location update cycle according to a location update time with a threshold value, selecting a paging group level on the basis of the comparison result, and selecting a paging group corresponding to the selected paging group level.
摘要:
A proximity sensing method of a portable terminal and a proximity sensing apparatus thereof are provided. The proximity sensing method of a portable terminal with an illumination sensor includes determining an output of the illumination sensor, determining that the portable terminal is proximate to an object when the output of the illumination sensor has a set pattern, and determining that the portable terminal is not proximate to the object when the output of the illumination sensor does not the set pattern. The proximity sensing method of a portable terminal may support a proximity sensing function using an illumination sensor instead of a proximity sensor to reduce a manufacturing cost of the portable terminal. In addition, since the method does not need a separate proximity sensor, it may address a lack of mounting space problem.
摘要:
Provided is a pharmaceutical composition for preventing or treating mucus hypersecretion in airways or chronic obstructive pulmonary diseases (COPDs), the pharmaceutical composition including an epidermal growth factor (EGF) and a pharmaceutically acceptable carrier. In addition, a combined preparation capable of respectively administering the pharmaceutical composition and chemotherapeutics is provided.
摘要:
A data strobe signal noise prevention apparatus and semiconductor integrated circuit includes a transition protection unit configured to protect a transition of a data strobe signal in response to a control signal and a controller configured to determine when a burst operation completes and to generate the control signal.