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    Recombinant mycobacterial methionyl-tRNA synthetase genes and methods of use therefore
    1.
    发明授权
    Recombinant mycobacterial methionyl-tRNA synthetase genes and methods of use therefore 失效
    重组分枝杆菌甲硫氨酰-tRNA合成酶基因及其使用方法

    公开(公告)号：US5798240A

    公开(公告)日：1998-08-25

    申请号：US584226

    申请日：1996-01-11

    申请人： Susan A. Martinis ,  Mandana Sassanfar ,  Sunghoon Kim ,  Sang Ho Lee ,  Paul R. Schimmel

    发明人： Susan A. Martinis ,  Mandana Sassanfar ,  Sunghoon Kim ,  Sang Ho Lee ,  Paul R. Schimmel

    IPC分类号： A61K38/00 ,  C12N9/00 ,  C07H21/04 ,  C12N1/20 ,  C12N15/00

    CPC分类号： C12N9/93 ,  A61K38/00 ,  Y10S435/863

    摘要： Isolated and/or recombinant nucleic acids encoding mycobacterial methionyl-tRNA synthetase have been characterized. Recombinant DNA constructs and vectors having a sequence which encodes mycobacterial methionyl-tRNA synthetase have been made, and can be used for the construction of tester strains as well as for the production of isolated and/or recombinant methionyl-tRNA synthetases. These enzymes or portions thereof are useful in the biochemical separation of methionine and quantification of methionine or ATP, and for producing antibodies useful in the purification and study of the enzyme, for example. Host cells and methods useful for producing recombinant mycobacterial methionyl-tRNA synthetases are described, as are tester strains, which are cells engineered to rely on the function of the tRNA synthetase encoded by an introduced cloned gene. Tester strains can be used to identify inhibitors of the essential tRNA synthetase enzyme encoded by the introduced cloned gene, and thus provide a means to assess the antimicrobial effect and specificity of the inhibitor without employing slow-growing, pathogenic strains of mycobacteria, such as Mycobacterium tuberculosis.

    摘要翻译： 已经表征了编码分枝杆菌甲硫氨酰-tRNA合成酶的分离和/或重组核酸。 已经制备了具有编码分枝杆菌甲硫氨酰-tRNA合成酶的序列的重组DNA构建体和载体，并且可用于构建测试菌株以及用于分离和/或重组甲硫氨酰-tRNA合成酶的产生。 这些酶或其部分可用于甲硫氨酸的生物化学分离和甲硫氨酸或ATP的定量，以及用于产生用于纯化和研究酶的抗体。 描述了可用于产生重组分枝杆菌甲硫氨酰-tRNA合成酶的宿主细胞和方法，试验菌株是被依赖于引入的克隆基因编码的tRNA合成酶的功能而被工程化的细胞。 测试菌株可以用于鉴定由引入的克隆基因编码的必需tRNA合成酶的抑制剂，并且因此提供了评估抑制剂的抗微生物效果和特异性的方法，而不使用分枝杆菌的缓慢生长的致病菌株，例如分枝杆菌 结核。

    Devices, systems, and methods for removing empyema from a pleural cavity
    4.
    发明授权
    Devices, systems, and methods for removing empyema from a pleural cavity 有权
    用于从胸膜腔清除脓胸的装置，系统和方法

    公开(公告)号：US08784300B2

    公开(公告)日：2014-07-22

    申请号：US13364876

    申请日：2012-02-02

    申请人： Olajire Idowu ,  Sunghoon Kim

    发明人： Olajire Idowu ,  Sunghoon Kim

    IPC分类号： A61B1/00

    CPC分类号： A61B1/00094 ,  A61B1/00165 ,  A61B1/05 ,  A61M27/00 ,  A61M2250/00

    摘要： Pleural empyema removal devices are provided and enable the removal of empyema from the pleural cavity of a human or veterinary patient. The pleural empyema removal devices may be coupled with one or more additional devices, such as suction source, gas source, light source and/or camera source, and monitor. The devices and systems including the devices facilitate the removal of empyema from the pleural cavity of a patient while providing protections from damage to untargeted tissues. The devices, systems, and methods can be used in the treatment process to treat pleural empyema resulting from pleural effusions and infections stemming from various illnesses and disorders, such as pneumonia.

    摘要翻译： 提供胸膜积液除去装置，并能够从人或兽医患者的胸膜腔中除去脓胸。 胸膜积液除去装置可以与一个或多个附加装置（例如抽吸源，气体源，光源和/或照相机源）和监视器耦合。 包括装置的装置和系统有助于从患者的胸膜腔中除去脓肿，同时提供保护以免对非靶向组织的损伤。 装置，系统和方法可用于治疗由胸膜积液引起的胸膜积液和由各种疾病和疾病如肺炎引起的感染的治疗过程。

    Diagnostic marker for type 1 diabetes mellitus
    5.
    发明授权
    Diagnostic marker for type 1 diabetes mellitus 有权
    1型糖尿病诊断标志物

    公开(公告)号：US08563327B2

    公开(公告)日：2013-10-22

    申请号：US13198990

    申请日：2011-08-05

    申请人： Sang Gyu Park ,  Kyong Soo Park ,  Sunghoon Kim

    发明人： Sang Gyu Park ,  Kyong Soo Park ,  Sunghoon Kim

    IPC分类号： G01N33/564 ,  G01N33/536 ,  G01N33/543 ,  G01N33/573 ,  G01N33/66 ,  C07K16/40

    CPC分类号： G01N33/6893 ,  G01N2800/042

    摘要： The present invention provides, as a novel diagnosis marker for type 1 diabetes mellitus, a type 1 diabetes mellitus diagnostic composition comprising alanyl-tRNA synthetase, glycyl-tRNA synthetase, asparaginyl-tRNA synthetase, or tryptophanyl-tRNA synthetase, a diagnostic kit comprising the same, and a diagnostic method using the same. The composition, the kit, and the method, according to the present invention, may be used for early diagnosis and confirmed diagnosis of type 1 diabetes mellitus because type 1 diabetes mellitus can be easily diagnosed from a patient sample.

    摘要翻译： 本发明提供了作为1型糖尿病的新型诊断标记物，包含丙氨酰-tRNA合成酶，甘氨酰-tRNA合成酶，天冬酰胺酰-tRNA合成酶或色氨酰-tRNA合成酶的1型糖尿病诊断组合物，其包含 相同，以及使用其的诊断方法。 根据本发明的组合物，试剂盒和方法可以用于1型糖尿病的早期诊断和确认诊断，因为可以容易地从患者样品中诊断1型糖尿病。

    NOVEL 2, 4-PYRIMIDINE DERIVATIVES AND USE THEREOF
    6.
    发明申请
    NOVEL 2, 4-PYRIMIDINE DERIVATIVES AND USE THEREOF 有权
    新二氢吡啶衍生物及其用途

    公开(公告)号：US20120322802A1

    公开(公告)日：2012-12-20

    申请号：US13505651

    申请日：2010-11-02

    申请人： Sunghoon Kim ,  Jung Min Han ,  Hyeong Rae Kim ,  Dong Ju Jeon ,  Jong Hwan Song ,  Kyung Eun Park

    发明人： Sunghoon Kim ,  Jung Min Han ,  Hyeong Rae Kim ,  Dong Ju Jeon ,  Jong Hwan Song ,  Kyung Eun Park

    IPC分类号： A61K31/505 ,  C07D401/12 ,  A61K31/506 ,  C40B30/04 ,  A61K31/5377 ,  A61P29/00 ,  C07D409/12 ,  C07D239/60 ,  C07D413/12

    CPC分类号： C07D239/60 ,  C07D239/52 ,  C07D401/12

    摘要： The present invention relates to novel 2,4-pyrimidine derivatives and a use thereof, and more particularly, to pyrimidine derivatives which are effective for systemic lupus erythematosus, a composition for preventing and treating systemic lupus erythematosus comprising the same as an active ingredient and a method for screening the same. The present inventors found novel materials inhibiting surface translocation of gp96 by mimicking a function of AIMP1 which is a molecular anchor for an intracellular residence of gp96, and identified in vitro and in vivo activity of the materials for preventing and treating SLE by alleviating SLE plasma in autoimmune diseases. Therefore, the present invention provides a novel method for screening a therapeutic agent for SLE, and preventing or treating SLE using the mechanism.

    摘要翻译： 本发明涉及新的2,4-嘧啶衍生物及其用途，更具体地涉及对系统性红斑狼疮有效的嘧啶衍生物，用于预防和治疗包含其作为活性成分的系统性红斑狼疮的组合物和 筛选方法 本发明人通过模拟作为gp96细胞内宿主的分子锚的AIMP1的功能，发现抑制gp96的表面易位的新型材料，并通过减轻SLE等离子体来预防和治疗SLE的材料的体外和体内活性 自身免疫性疾病 因此，本发明提供了用于筛选SLE治疗剂以及使用该机制预防或治疗SLE的新方法。

    METHOD FOR STIMULATING WOUND HEALING
    8.
    发明申请
    METHOD FOR STIMULATING WOUND HEALING 审中-公开
    刺激治疗方法

    公开(公告)号：US20120010141A1

    公开(公告)日：2012-01-12

    申请号：US13155750

    申请日：2011-06-08

    申请人： Sunghoon Kim

    发明人： Sunghoon Kim

    IPC分类号： A61K38/18 ,  A61P17/02 ,  A61K38/16

    CPC分类号： A61K38/19

    摘要： The present invention relates to a method for stimulating wound healing, and more particularly to a method for stimulating wound healing in a subject in need thereof, comprising administering to a wound of the subject an effective amount for stimulating wound healing of a composition, wherein the composition comprises p43 having an amino acid sequence set forth in SEQ ID NO: 1 or functional equivalents thereof. The composition used in the method of the present invention can be efficiently utilized for the wound healing, since p43, an effective ingredient of the composition, has an excellent effect on the wound healing by its action including the induction of macrophage/monocyte and endothelial cell re-epithelization, proliferation of fibroblasts or angiogenesis.

    摘要翻译： 本发明涉及一种刺激伤口愈合的方法，更具体地涉及刺激有需要的受试者的伤口愈合的方法，包括对受试者的伤口施用有效量刺激组合物的伤口愈合，其中 组合物包含具有SEQ ID NO：1所示氨基酸序列的p43或其功能等同物。 本发明方法中使用的组合物可有效地用于伤口愈合，因为组合物的有效成分p43通过包括诱导巨噬细胞/单核细胞和内皮细胞的作用对伤口愈合具有优异的作用 再上皮化，成纤维细胞增殖或血管生成。

    Method for stimulating wound healing
    10.
    发明授权
    Method for stimulating wound healing 失效
    刺激伤口愈合的方法

    公开(公告)号：US07282208B2

    公开(公告)日：2007-10-16

    申请号：US10623567

    申请日：2003-07-22

    申请人： Sunghoon Kim

    发明人： Sunghoon Kim

    IPC分类号： A61K38/17 ,  A61K38/18 ,  C07K14/435 ,  C07K14/475

    CPC分类号： A61K38/19

    摘要： The present invention relates to a method for stimulating wound healing, and more particularly to a method for stimulating wound healing in a subject in need thereof, comprising administering to a wound of the subject an effective amount for stimulating wound healing of a composition, wherein the composition comprises p43 having an amino acid sequence set forth in SEQ ID NO: 1 or functional equivalents thereof. The composition used in the method of the present invention can be efficiently utilized for the wound healing, since p43, an effective ingredient of the composition, has an excellent effect on the wound healing by its action including the induction of macrophage/monocyte and endothelial cell, re-epithelization, proliferation of fibroblasts or angiogenesis.

    摘要翻译： 本发明涉及一种刺激伤口愈合的方法，更具体地涉及刺激有需要的受试者的伤口愈合的方法，包括对受试者的伤口施用有效量刺激组合物的伤口愈合，其中 组合物包含具有SEQ ID NO：1所示氨基酸序列的p43或其功能等同物。 用于本发明方法的组合物可以有效地用于伤口愈合，因为组合物的有效成分p43通过包括诱导巨噬细胞/单核细胞和内皮细胞的作用对伤口愈合具有优异的效果 ，再上皮化，成纤维细胞增殖或血管发生。