公开(公告)号：US06383488B1

公开(公告)日：2002-05-07

申请号：US09341833

申请日：1999-10-14

申请人： Susana Vazquez Ramudo ,  Guadalupe Guzman Tirado ,  Gerardo Enrique Guillen Nieto ,  Orlando Luis Pardo Lazo ,  Glay Chinea Santiago ,  Ana Beatriz Perez Diaz ,  Maritza Pupo Antunez ,  Rosmari Rodriguez Roche ,  Osvaldo Reyes Acosta ,  Hilda Elisa Garay Perez ,  Gabriel Padron Palomares ,  Maylin Alvarez Vera ,  Luis Morier Diaz ,  Omaida Perez Insuita ,  Jose Luis Pelegrino Martinez De La Cotera

发明人： Susana Vazquez Ramudo ,  Guadalupe Guzman Tirado ,  Gerardo Enrique Guillen Nieto ,  Orlando Luis Pardo Lazo ,  Glay Chinea Santiago ,  Ana Beatriz Perez Diaz ,  Maritza Pupo Antunez ,  Rosmari Rodriguez Roche ,  Osvaldo Reyes Acosta ,  Hilda Elisa Garay Perez ,  Gabriel Padron Palomares ,  Maylin Alvarez Vera ,  Luis Morier Diaz ,  Omaida Perez Insuita ,  Jose Luis Pelegrino Martinez De La Cotera

IPC分类号： A61K3912

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C12N2770/24122 ,  G01N2333/18 ,  Y02A50/386

摘要： The present invention relates to five synthetic peptides of pre-M/M protein of Dengue-2 virus, corresponding to amino acid sequences 3-31, 45-67, 57-92, 69-93 and 103-124. The anti-peptide immune response was evaluated in mice. Recombinant fusion proteins were also obtained, including regions of pre-M/M protein. The presence of B cell epitopes in both mice and humans was demonstrated in the pre-M/M protein peptides. Peptides 3-31 and 103-124 elicited neutralizing antibodies against the four serotypes of Dengue virus. Virus-specific proliferative responses were demonstrated in mice immunized with non-conjugated peptides 3-31 and 57-92. Mice immunized with conjugated peptides 3-31, 57-92, and 69-93 were protected when they were challenged with Dengue-2 virus. Thus, the presence of sequential epitopes in Pre-M/M protein of Dengue-2 virus was demonstrated, as well as their relevance in the immune response against this flavivirus.

摘要翻译： 本发明涉及对应于氨基酸序列3-31,45-67,57-92,69-93和103-124的五种登革热-2病毒前M / M蛋白的合成肽。 在小鼠中评估抗肽免疫应答。 还获得了重组融合蛋白，包括前M / M蛋白的区域。 在M-M蛋白肽前体中证实了小鼠和人体中B细胞表位的存在。 肽3-31和103-124引发针对登革热病毒的四种血清型的中和抗体。 在用非结合肽3-31和57-92免疫的小鼠中证明病毒特异性增殖应答。 当用登革热-2病毒攻击时，用缀合肽3-31,57-92和69-93免疫的小鼠被保护。 因此，证实了登革2型病毒的Pre-M / M蛋白中序列表位的存在，以及它们在针对该黄病毒的免疫应答中的相关性。

公开(公告)号：US20110250196A1

公开(公告)日：2011-10-13

申请号：US13121915

申请日：2009-09-30

申请人： Jesus Arturo Junco Barranco ,  Osvaldo Reyes Acosta ,  Eddy Emilio Bover Fuentes ,  Franklin Fuentes Aguilar ,  Eulogio Pimentel Vazquez ,  Roberto Basulto Baker ,  Gerardo Enrique Guillen Nieto ,  Yovisleidys Lopez Saez ,  Hilda Elisa Garay Perez ,  Lesvia Calzada Aguilera ,  Maria Castro Santana ,  Niurka Oneysi Arteaga More ,  Luis Alberto Aguero Barrocal

发明人： Jesus Arturo Junco Barranco ,  Osvaldo Reyes Acosta ,  Eddy Emilio Bover Fuentes ,  Franklin Fuentes Aguilar ,  Eulogio Pimentel Vazquez ,  Roberto Basulto Baker ,  Gerardo Enrique Guillen Nieto ,  Yovisleidys Lopez Saez ,  Hilda Elisa Garay Perez ,  Lesvia Calzada Aguilera ,  Maria Castro Santana ,  Niurka Oneysi Arteaga More ,  Luis Alberto Aguero Barrocal

IPC分类号： A61K39/395 ,  A61P35/00 ,  A61P37/04 ,  A61K39/00

CPC分类号： A61K39/0011 ,  A61K38/09 ,  A61K39/0006 ,  A61K47/48261 ,  A61K47/4833 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/585 ,  A61K2039/6037 ,  A61K2300/00

摘要： A pharmaceutical composition using natural gonadotropin-releasing hormone (GnRH), and/or some of its mimetic peptides, indistinctly bound by its amino or carboxyl extremes to a carrier molecule; in one case by its carboxyl extreme and in the other case by the amino terminal extreme, thus eliciting a faster and more potent immunological response against the endogenous GnRH hormone. This finally leads to the ablation of the GnRH and consequently of the rest of the involved hormones in the stream GnRH/LH-FSH/Testosterone-(estrogens). An advantage of this formulation consists on facilitating the exposition to the immune system of a greater number of epitopes of the GnRH or its mimetics, minimizing thus the steric hindrance produced by the carriers. This invention has a direct application in the castration of pets and animals of economic interest, in the control of human fertility as well as in the treatment of hormone-sensitive tumors, such as that of the prostate, the breast, ovary, the endometry, testicles, hypophysis, salivary glands and other kinds of human tumors.

摘要翻译： 使用天然促性腺激素释放激素（GnRH）和/或其一些模拟肽的药物组合物，其不明显地被其氨基或羧基末端与载体分子结合; 在一种情况下其羧基末端，另一种情况下由氨基末端极端，从而引发对内源GnRH激素的更快更有效的免疫应答。 这最终导致消化GnRH，从而导致流GnRH / LH-FSH /睾酮（雌激素）中涉及的其他激素的消融。 该制剂的优点在于促进免疫系统暴露于更多数量的GnRH或其模拟物的表位，从而最小化载体产生的空间位阻。 本发明直接应用于经济兴趣的宠物和动物的阉割，控制人的生育能力以及治疗激素敏感性肿瘤，如前列腺，乳腺，卵巢， 睾丸，垂体，唾液腺等多种人体肿瘤。

公开(公告)号：US08999931B2

公开(公告)日：2015-04-07

申请号：US13121915

申请日：2009-09-30

申请人： Jesus Arturo Junco Barranco ,  Osvaldo Reyes Acosta ,  Eddy Emilio Bover Fuentes ,  Franklin Fuentes Aguilar ,  Eulogio Pimentel Vazquez ,  Roberto Basulto Baker ,  Gerardo Enrique Guillen Nieto ,  Yovisleidys Lopez Saez ,  Hilda Elisa Garay Perez ,  Lesvia Calzada Aguilera ,  Maria Castro Santana ,  Niurka Oneysi Arteaga More ,  Luis Alberto Aguero Barrocal

发明人： Jesus Arturo Junco Barranco ,  Osvaldo Reyes Acosta ,  Eddy Emilio Bover Fuentes ,  Franklin Fuentes Aguilar ,  Eulogio Pimentel Vazquez ,  Roberto Basulto Baker ,  Gerardo Enrique Guillen Nieto ,  Yovisleidys Lopez Saez ,  Hilda Elisa Garay Perez ,  Lesvia Calzada Aguilera ,  Maria Castro Santana ,  Niurka Oneysi Arteaga More ,  Luis Alberto Aguero Barrocal

IPC分类号： A61K38/09 ,  A61K47/48 ,  A61K39/00

CPC分类号： A61K39/0011 ,  A61K38/09 ,  A61K39/0006 ,  A61K47/48261 ,  A61K47/4833 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/585 ,  A61K2039/6037 ,  A61K2300/00

摘要： A pharmaceutical composition using natural gonadotropin-releasing hormone (GnRH), and/or some of its mimetic peptides, indistinctly bound by its amino or carboxyl extremes to a carrier molecule; in one case by its carboxyl extreme and in the other case by the amino terminal extreme, thus eliciting a faster and more potent immunological response against the endogenous GnRH hormone. This finally leads to the ablation of the GnRH and consequently of the rest of the involved hormones in the stream GnRH/LH-FSH/Testosterone-(estrogens). An advantage of this formulation consists on facilitating the exposition to the immune system of a greater number of epitopes of the GnRH or its mimetics, minimizing thus the steric hindrance produced by the carriers. This invention has a direct application in the castration of pets and animals of economic interest, in the control of human fertility as well as in the treatment of hormone-sensitive tumors, such as that of the prostate, the breast, ovary, the endometry, testicles, hypophysis, salivary glands and other kinds of human tumors.

摘要翻译： 使用天然促性腺激素释放激素（GnRH）和/或其一些模拟肽的药物组合物，其不明显地被其氨基或羧基末端与载体分子结合; 在一种情况下其羧基末端，另一种情况下由氨基末端极端，从而引发对内源GnRH激素的更快更有效的免疫应答。 这最终导致消化GnRH，从而导致流GnRH / LH-FSH /睾酮（雌激素）中涉及的其他激素的消融。 该制剂的优点在于促进免疫系统暴露于更多数量的GnRH或其模拟物的表位，从而最小化载体产生的空间位阻。 本发明直接应用于经济兴趣的宠物和动物的阉割，控制人的生育能力以及治疗激素敏感性肿瘤，如前列腺，乳腺，卵巢， 睾丸，垂体，唾液腺等多种人体肿瘤。

公开(公告)号：US20110251140A1

公开(公告)日：2011-10-13

申请号：US13120855

申请日：2009-09-30

申请人： Alicia Santos Savio ,  Osvaldo Reyes Acosta ,  Haydee Geronimo Perez ,  Hilda Elisa Garay Perez ,  Yunier Rodriguez Alvarez ,  Gerardo Enrique Guillen Nieto

发明人： Alicia Santos Savio ,  Osvaldo Reyes Acosta ,  Haydee Geronimo Perez ,  Hilda Elisa Garay Perez ,  Yunier Rodriguez Alvarez ,  Gerardo Enrique Guillen Nieto

IPC分类号： A61K38/08 ,  C07H21/00 ,  A61P19/02 ,  A61P35/00 ,  A61P17/06 ,  A61P29/00 ,  C07K7/06 ,  C12N15/63

CPC分类号： C07K14/5443 ,  A61K38/00

摘要： The present invention is related to the field of molecular immunology, particularly to a peptide derived from the sequence of interleukine-15 (IL-15), wherein said peptide was optimized to inhibit the biological activity of this molecule. In the present invention, it is shown that this peptide inhibits IL-15-induced T cell proliferation, Tumor Necrosis Factor α (TNFα) induction and the expression of IL-8 and IL-6 by the IL-15 receptor a subunit (IL-15Rα), all these effects mediated by the binding of the peptide to the IL-15Rα. The invention is also related to the use of the peptide to treat pathologies where the abnormal expression of IL-15 or IL-15Rα is related to the course of the disease, such as rheumatoid arthritis (RA) and prostate cancer.

摘要翻译： 本发明涉及分子免疫学领域，特别涉及衍生自白介素-15（IL-15）序列的肽，其中所述肽被优化以抑制该分子的生物学活性。 在本发明中，表明该肽抑制IL-15诱导的T细胞增殖，肿瘤坏死因子α（TNFα）诱导和IL-8受体a亚基（IL）的IL-8和IL-6的表达 -15Rα），所有这些作用由肽与IL-15Rα的结合介导。 本发明还涉及使用肽治疗其中IL-15或IL-15Rα的异常表达与疾病进程相关的病症，例如类风湿性关节炎（RA）和前列腺癌。

公开(公告)号：US20090221508A1

公开(公告)日：2009-09-03

申请号：US12278990

申请日：2007-02-23

申请人： Maribel Guerra Vallespi ,  Isis del Carmen Torrrens Madrazo ,  Osvaldo Reyes Acosta ,  Hilda Elisa Garay Perez ,  Gerardo Enrique Guillen Nieto ,  Boris Ernesto Acevedo Castro ,  Raimundo Ubieta Gomez

发明人： Maribel Guerra Vallespi ,  Isis del Carmen Torrrens Madrazo ,  Osvaldo Reyes Acosta ,  Hilda Elisa Garay Perez ,  Gerardo Enrique Guillen Nieto ,  Boris Ernesto Acevedo Castro ,  Raimundo Ubieta Gomez

IPC分类号： A61K38/10 ,  C07K14/00 ,  A61P35/04

CPC分类号： C07K14/43509 ,  A61K38/00

摘要： The present invention is related to the development of peptides derived from the sequence HYRIKPTFRRLKWKKYKGKFW, showing aminoacids substitutions, these peptides unable to bind to the lipopolysaccharide and bearing anti-tumoral and immunomodulatory capacities. These peptides alone or in combination are useful to treat cancer, and also in synergy with conventional therapies.

摘要翻译： 本发明涉及来自序列HYRIKPTFRRLKWKKYKGKFW的肽的开发，显示出氨基酸取代，这些肽不能结合脂多糖并具有抗肿瘤和免疫调节能力。 单独或组合的这些肽可用于治疗癌症，并且与常规疗法协同作用。

公开(公告)号：US20140112976A1

公开(公告)日：2014-04-24

申请号：US14005855

申请日：2012-03-21

申请人： María del Carmen Abrahantes Pérez ,  Glay Chinea Santiago ,  Eduardo Martínez Díaz ,  Hilda Elisa Garay Perez ,  Osvaldo Reyes Acosta ,  Ernesto Lopez Mola ,  Cruz Matilde Lopez Abad ,  Sonia Gonzalez Blanco

发明人： María del Carmen Abrahantes Pérez ,  Glay Chinea Santiago ,  Eduardo Martínez Díaz ,  Hilda Elisa Garay Perez ,  Osvaldo Reyes Acosta ,  Ernesto Lopez Mola ,  Cruz Matilde Lopez Abad ,  Sonia Gonzalez Blanco

IPC分类号： A61K38/12 ,  A61K31/4025 ,  A61K45/06 ,  C07K7/64

CPC分类号： A61K38/12 ,  A61K9/0019 ,  A61K9/127 ,  A61K9/5031 ,  A61K31/4025 ,  A61K38/00 ,  A61K45/06 ,  A61K47/60 ,  C07K7/06 ,  C07K7/08 ,  C07K7/64

摘要： The present invention comprises cyclic peptides bearing antitumor and antiangiogenic properties, as well as their corresponding pharmaceutically-suitable salts and also pharmaceutical compositions containing it. These cyclic peptides are used to prepare medicines for human and/or veterinary therapeutics, and additionally in diagnosis. These compounds can be used to detect, monitor and/or control a range of cellular proliferation-related disorders, such as oncological diseases and undesired angiogenesis. Moreover, they can be included as part of controlled release systems, and used more precisely in the field of nanobiotechnology, either because of their self-assembly capacity or as part of other systems.

摘要翻译： 本发明包括具有抗肿瘤和抗血管生成特性的环肽，以及它们相应的药学上合适的盐以及含有它的药物组合物。 这些环肽用于制备用于人和/或兽医治疗剂的药物，另外用于诊断。 这些化合物可用于检测，监测和/或控制一系列细胞增殖相关疾病，例如肿瘤疾病和不期望的血管生成。 此外，它们可以作为控制释放系统的一部分进行纳入，并且在纳米生物技术领域更加精确地使用，无论是由于其自组装能力还是作为其他系统的一部分。

公开(公告)号：US08420311B2

公开(公告)日：2013-04-16

申请号：US12298808

申请日：2007-04-26

申请人： Vivian Huerta Galindo ,  Glay Chinea Santiago ,  Noralvis Fleitas Salazar ,  Alejandro Miguel Martin Dunn ,  Monica Sarria Nunez ,  Osmany Guirola Cruz ,  Patricia Gabriela Toledo Mayora ,  Aniel Sanchez Puente ,  Vladimir Armando Besada Perez ,  Osvaldo Reyes Acosta ,  Hilda Elisa Garay Perez ,  Ania Cabrales Rico ,  Alexis Musacchio Lasa ,  Gabriel Ramon Padron Palomares ,  Luis Javier Gonzalez Lopez

发明人： Vivian Huerta Galindo ,  Glay Chinea Santiago ,  Noralvis Fleitas Salazar ,  Alejandro Miguel Martin Dunn ,  Monica Sarria Nunez ,  Osmany Guirola Cruz ,  Patricia Gabriela Toledo Mayora ,  Aniel Sanchez Puente ,  Vladimir Armando Besada Perez ,  Osvaldo Reyes Acosta ,  Hilda Elisa Garay Perez ,  Ania Cabrales Rico ,  Alexis Musacchio Lasa ,  Gabriel Ramon Padron Palomares ,  Luis Javier Gonzalez Lopez

IPC分类号： C12Q1/70 ,  A61K39/12

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07K14/70596 ,  C07K14/8107 ,  C12N2770/24122 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/394 ,  Y02A50/396

摘要： The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.

摘要翻译： 本发明涉及一种基于干扰病毒包膜蛋白与细胞受体的直接相互作用或其通过载体蛋白与所述细胞受体的间接相互作用而阻断登革热病毒感染细胞的方法，以及相关的 用途; 其中所述细胞受体是α-2巨球蛋白受体，也称为低密度受体相关蛋白或CD91，所述载体蛋白是人α-2巨球蛋白。

公开(公告)号：US08431524B2

公开(公告)日：2013-04-30

申请号：US13120855

申请日：2009-09-30

申请人： Alicia Santos Savio ,  Osvaldo Reyes Acosta ,  Haydee Geronimo Perez ,  Hilda Elisa Garay Perez ,  Yunier Rodriguez Alvarez ,  Gerardo Enríque Guillen Nieto

发明人： Alicia Santos Savio ,  Osvaldo Reyes Acosta ,  Haydee Geronimo Perez ,  Hilda Elisa Garay Perez ,  Yunier Rodriguez Alvarez ,  Gerardo Enríque Guillen Nieto

IPC分类号： A61K38/04 ,  C12Q1/68

CPC分类号： C07K14/5443 ,  A61K38/00

摘要： The present invention is related to the field of molecular immunology, particularly to a peptide derived from the sequence of interleukine-15 (IL-15), wherein said peptide was optimized to inhibit the biological activity of this molecule. In the present invention, it is shown that this peptide inhibits IL-15-induced T cell proliferation, Tumor Necrosis Factor α (TNFα) induction and the expression of IL-8 and IL-6 by the IL-15 receptor α subunit (IL-15Rα), all these effects mediated by the binding of the peptide to the IL-15Rα. The invention is also related to the use of the peptide to treat pathologies where the abnormal expression of IL-15 or IL-15Rα is related to the course of the disease, such as rheumatoid arthritis (RA) and prostate cancer.

摘要翻译： 本发明涉及分子免疫学领域，特别涉及衍生自白介素-15（IL-15）序列的肽，其中所述肽被优化以抑制该分子的生物学活性。 在本发明中，显示该肽抑制IL-15诱导的T细胞增殖，肿瘤坏死因子α（TNFalpha）诱导和IL-8受体α亚基（IL）的IL-8和IL-6的表达 -15Rα），所有这些作用由肽与IL-15Rα的结合介导。 本发明还涉及使用肽来治疗其中IL-15或IL-15Rα异常表达与疾病进程如类风湿性关节炎（RA）和前列腺癌相关的病理学。