利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

12 条记录 (耗时 0.025 秒)

    Method, computer program product and data structure for representing two- or three-dimensional object modeling
    2.
    发明授权
    Method, computer program product and data structure for representing two- or three-dimensional object modeling 失效
    方法，用于表示二维或三维对象建模的计算机程序产品和数据结构

    公开(公告)号：US07557803B2

    公开(公告)日：2009-07-07

    申请号：US11113130

    申请日：2005-04-25

    申请人： Susumu Furukawa ,  Seiji Shimizu ,  Shinji Mukai ,  Yutaka Hara ,  Hroko Monma ,  Mamoru Fukushima

    发明人： Susumu Furukawa ,  Seiji Shimizu ,  Shinji Mukai ,  Yutaka Hara ,  Hroko Monma ,  Mamoru Fukushima

    IPC分类号： G06F17/00 ,  G06T1/00 ,  G06T15/00 ,  G06T17/00

    CPC分类号： G06T17/20

    摘要： A data structure for a graph, which is composed by points and line segments connecting adjacent pairs of the points, respectively, of a two- or three-dimensional object comprises a set of point data of the individual points, each of the point data of the points consists of a clockwise or counter clockwise circular ordered adjacency list written in storage areas of a storage medium individually allocated to the point. The adjacency list describes a plurality of adjacent points associated with the point sequentially according to a circular adjacency order as viewed from outside of the graph with address pointers to the storage areas allocated to the adjacent points, respectively, and location pointers associated with the address pointers, respectively, to storage locations of adjacency lists of the adjacent points, respectively, where an address pointer of the point is written.

    摘要翻译： 图形的数据结构由分别连接相邻的两点或三维对象对的点和线段组成，包括各个点的点数据集合，每个点数据的点数据 这些点由顺序或逆时针圆形的顺序相邻列表组成，写入到分配给该点的存储介质的存储区域中。 相邻列表分别根据从图的外部依次循环相邻顺序与点对应的多个相邻点，分别具有分配给相邻点的存储区域的地址指针，以及与地址指针相关联的位置指针 分别分别到写入点的地址指针的相邻点的相邻列表的存储位置。

    Model cell chip, apparatus for evaluating drug effect using the model cell chip and method of evaluating drug effect
    3.
    发明授权
    Model cell chip, apparatus for evaluating drug effect using the model cell chip and method of evaluating drug effect 有权
    模型细胞芯片，使用模型细胞芯片评估药物效应的装置和药物效应评价方法

    公开(公告)号：US08202720B2

    公开(公告)日：2012-06-19

    申请号：US12663468

    申请日：2008-06-06

    申请人： Kenji Yasuda ,  Atsushi Sugiyama ,  Kentaro Ando ,  Fumimasa Nomura ,  Hideyuki Terazono ,  Tomoyuki Kaneko ,  Mamoru Fukushima

    发明人： Kenji Yasuda ,  Atsushi Sugiyama ,  Kentaro Ando ,  Fumimasa Nomura ,  Hideyuki Terazono ,  Tomoyuki Kaneko ,  Mamoru Fukushima

    IPC分类号： C12M1/34 ,  C12M3/00 ,  C12N5/071 ,  A61K35/34

    CPC分类号： G01N33/5061 ,  C12N2503/02 ,  G01N33/4836 ,  G01N33/54366

    摘要： The present invention provides an apparatus for evaluating a drug effect enabling on-chip evaluation of the effect of a drug while the drug is acting on hERG-expressing cells. The present invention also provides a myocardial toxicity test apparatus and method therefor enabling in vitro myocardial toxicity testing that has previously been performed in vivo. A pulsating cell population and hERG-expressing cells (target model cells) are suitably isolated and arranged on a transparent substrate so that the two form gap junctions. The hERG-expressing cells are arranged on transparent electrodes provided on the transparent substrate. The hERG-expressing cells are exposed to a flow of a liquid containing a drug such that the drug acts thereon. The difference between the normal pulsation of hERG-expressing cells and the pulsation when a drug is acting thereon is captured via electric signals obtained from electrodes, and the properties of the change in potential are evaluated.

    摘要翻译： 本发明提供了一种药物效应评价装置，其能够在药物作用于表达hERG的细胞的同时对药物的作用进行片上评价。 本发明还提供一种心肌毒性试验装置及其方法，其能够进行体外心肌毒性试验，其先前已在体内进行。 脉动细胞群体和表达hERG的细胞（靶模型细胞）被适当地分离并排列在透明基底上，使得两个形成间隙连接。 hERG表达细胞设置在设置在透明基板上的透明电极上。 将表达hERG的细胞暴露于含有药物的液体流中，使药物作用于其上。 通过从电极获得的电信号捕获hERG表达细胞的正常脉动与药物作用于其上的脉动之间的差异，并评估电位变化的性质。

    MODEL CELL CHIP, APPARATUS FOR EVALUATING DRUG EFFECT USING THE MODEL CELL CHIP AND METHOD OF EVALUATING DRUG EFFECT
    5.
    发明申请
    MODEL CELL CHIP, APPARATUS FOR EVALUATING DRUG EFFECT USING THE MODEL CELL CHIP AND METHOD OF EVALUATING DRUG EFFECT 有权
    模型细胞芯片，使用模型细胞芯片评估药物效应的装置和评估药物效应的方法

    公开(公告)号：US20100178692A1

    公开(公告)日：2010-07-15

    申请号：US12663468

    申请日：2008-06-06

    申请人： Kenji Yasuda ,  Atsushi Sugiyama ,  Kentaro Ando ,  Fumimasa Nomura ,  Hideyuki Terazono ,  Tomoyuki Kaneko ,  Mamoru Fukushima

    发明人： Kenji Yasuda ,  Atsushi Sugiyama ,  Kentaro Ando ,  Fumimasa Nomura ,  Hideyuki Terazono ,  Tomoyuki Kaneko ,  Mamoru Fukushima

    IPC分类号： C12M1/34

    CPC分类号： G01N33/5061 ,  C12N2503/02 ,  G01N33/4836 ,  G01N33/54366

    摘要： The present invention provides an apparatus for evaluating a drug effect enabling on-chip evaluation of the effect of a drug while the drug is acting on hERG-expressing cells. The present invention also provides a myocardial toxicity test apparatus and method therefor enabling in vitro myocardial toxicity testing that has previously been performed in vivo.A pulsating cell population and hERG-expressing cells (target model cells) are suitably isolated and arranged on a transparent substrate so that the two form gap junctions. The hERG-expressing cells are arranged on transparent electrodes provided on the transparent substrate. The hERG-expressing cells are exposed to a flow of a liquid containing a drug such that the drug acts thereon. The difference between the normal pulsation of hERG-expressing cells and the pulsation when a drug is acting thereon is captured via electric signals obtained from electrodes, and the properties of the change in potential are evaluated.

    摘要翻译： 本发明提供了一种药物效应评价装置，其能够在药物作用于表达hERG的细胞的同时对药物的作用进行片上评价。 本发明还提供一种心肌毒性试验装置及其方法，其能够进行体外心肌毒性试验，其先前已在体内进行。 脉动细胞群体和表达hERG的细胞（靶模型细胞）被适当地分离并排列在透明基底上，使得两个形成间隙连接。 hERG表达细胞设置在设置在透明基板上的透明电极上。 将表达hERG的细胞暴露于含有药物的液体流中，使药物作用于其上。 通过从电极获得的电信号捕获hERG表达细胞的正常脉动与药物作用于其上的脉动之间的差异，并评估电位变化的性质。

    Method and apparatus for controlling excitation of a generator
    7.
    发明授权
    Method and apparatus for controlling excitation of a generator 失效
    用于控制发电机的激励的方法和装置

    公开(公告)号：US4326159A

    公开(公告)日：1982-04-20

    申请号：US71403

    申请日：1979-08-30

    申请人： Hiroaki Aotsu ,  Akira Isono ,  Tsutomu Inayama ,  Mamoru Fukushima

    发明人： Hiroaki Aotsu ,  Akira Isono ,  Tsutomu Inayama ,  Mamoru Fukushima

    IPC分类号： H02P9/10 ,  H02P9/14

    CPC分类号： H02P9/10

    摘要： Voltage, current and field voltage of a generator connected to an electric power system are sampled at a predetermined period for analog-digital conversion and then led to a digital computer. In addition to computation for AVR, the computer computes from its input the generator output power, and also monitors the occurrence of a fault, the removal of the fault and variation in the generator output in the system. After the occurrence of a fault, the field excitation of the generator is intensified until the generator output power reaches substantially a peak value, but after the peak value is substantially passed by, the excitation is conversely depressed to a value below the level which is present before the fault occurs. When the generator output power recovers the value which is present before the fault occurs, the computer returns to deliver the AVR output.

    摘要翻译： 连接到电力系统的发电机的电压，电流和电场电压以预定的时间被采样以进行模数转换，然后被引导到数字计算机。 除了计算AVR之外，计算机还可以从输入端计算发电机的输出功率，同时监测故障的发生，故障的消除和系统发电机输出的变化。 在故障发生之后，发电机的场激励增强，直到发电机输出功率达到基本上的峰值，但是在峰值基本上过去之后，激励被反而下降到低于存在的水平的值 在故障发生之前。 当发电机输出功率恢复故障发生之前存在的值时，计算机返回以传送AVR输出。

    Fuel sealing structure
    8.
    发明申请
    Fuel sealing structure 审中-公开
    燃油密封结构

    公开(公告)号：US20070181580A1

    公开(公告)日：2007-08-09

    申请号：US10598881

    申请日：2005-03-14

    申请人： Kazuhiko Kimura ,  Toru Mashimo ,  Mamoru Fukushima ,  Noriyuki Ohsawa ,  Satoshi Komada

    发明人： Kazuhiko Kimura ,  Toru Mashimo ,  Mamoru Fukushima ,  Noriyuki Ohsawa ,  Satoshi Komada

    IPC分类号： B65D53/00

    CPC分类号： B65D41/045

    摘要： To provide a fuel sealing structure capable of preventing the leakage of not only liquid fuel but also gasified fuel, an annular packing 30 is interposed between an annular sealing surface 15 on an opening part 11 of a container 20 and an annular sealing surface 25 of a closure 20. The distance between the second regions 15b, 25b of the sealing surfaces 15, 25 is shorter than that between the first regions 15a, 25a. The packing 30 includes a first sealing part 31 sandwiched between the first regions 15a,25a and a second sealing part 32 sandwiched between the 15b, 25b. The second sealing part 32 is smaller in thickness than the first sealing part 31 and the difference of the thicknesses is larger than the difference of distances between the above-mentioned regions. With the closure 20 attached, the compression ratio of the second sealing part 32 is smaller than that of the first sealing part 31.

    摘要翻译： 为了提供能够防止液体燃料而且气化燃料泄漏的燃料密封结构，环形密封件30插入在容器20的开口部11上的环形密封表面15和位于容器20的环形密封表面25之间 封闭20。 密封表面15,25的第二区域15b，25b之间的距离比第一区域15a，25a之间的距离短。 填料30包括夹在第一区域15a，25a和夹在15b，25b之间的第二密封部分32的第一密封部分31。 第二密封部件32的厚度小于第一密封部件31，并且厚度差大于上述区域之间的距离差。 在封闭件20附接时，第二密封部32的压缩比小于第一密封部31的压缩比。

    Fluorescent lamp, method for manufacturing the same, and fluorescent lamp device
    9.
    发明授权
    Fluorescent lamp, method for manufacturing the same, and fluorescent lamp device 失效
    荧光灯，其制造方法以及荧光灯装置

    公开(公告)号：US06756723B2

    公开(公告)日：2004-06-29

    申请号：US10034322

    申请日：2002-01-03

    申请人： Mamoru Fukushima ,  Yasuo Kobayashi ,  Soichiro Ogawa

    发明人： Mamoru Fukushima ,  Yasuo Kobayashi ,  Soichiro Ogawa

    IPC分类号： H01J6100

    CPC分类号： H01J9/28 ,  H01J61/045 ,  H01J61/366 ,  H01J61/72

    摘要： A fluorescent lamp having a stem provided with first and second lead wires for energization of an electrode and an electrically-insulating member provided therein with a first hole and a second hole larger in cross-sectional area than said second lead wire. The first and second lead wires are inserted in the first and second holes of the electrically-insulating member, respectively, and an outer diameter of a glass envelope of the fluorescent lamp is not smaller than 13 mm and not larger than 29 mm.

    摘要翻译： 一种荧光灯，具有设置有用于激励电极的第一和第二引线以及设置在其中的电绝缘部件的杆，所述第一和第二引线具有比所述第二引线更大的横截面积的第一孔和第二孔。 第一和第二引线分别插入电绝缘构件的第一和第二孔中，荧光灯的玻璃外壳的外径不小于13mm且不大于29mm。

    CARDIAC REENTRY MODEL CHIP AND APPARATUS AND METHOD FOR EVALUATING DRUG USING THE CARDIAC REENTRY MODEL CHIP
    10.
    发明申请
    CARDIAC REENTRY MODEL CHIP AND APPARATUS AND METHOD FOR EVALUATING DRUG USING THE CARDIAC REENTRY MODEL CHIP 审中-公开
    心脏复苏模型芯片和装置以及使用心脏重吸收模型评估药物的方法

    公开(公告)号：US20100173351A1

    公开(公告)日：2010-07-08

    申请号：US12663441

    申请日：2008-06-06

    申请人： Kenji Yasuda ,  Atsushi Sugiyama ,  Kentaro Ando ,  Fumimasa Nomura ,  Hideyuki Terazono ,  Tomoyuki Kaneko ,  Mamoru Fukushima

    发明人： Kenji Yasuda ,  Atsushi Sugiyama ,  Kentaro Ando ,  Fumimasa Nomura ,  Hideyuki Terazono ,  Tomoyuki Kaneko ,  Mamoru Fukushima

    IPC分类号： C12Q1/02 ,  C12M1/00

    CPC分类号： G01N33/5061 ,  G01N33/48728 ,  G01N33/5438

    摘要： A chip has been developed that can accurately measure cell potential and cell morphology on a single cell basis. The chip also constitutes a cardiac model that comprises a closed loop whereupon cardiomyocytes and fibroblasts are suitably dispersed and arranged, and that can evaluate the effects of a drug thereon. An in vitro cardiac reentry model chip is fabricated by constructing a closed loop comprising cardiomyocytes and fibroblasts arrayed on transparent electrodes formed on a transparent substrate by using a constitution where single cells are enclosed in a specific spatial configuration. A pulse wave of a random cardiomyocyte or a specific cardiomyocyte is propagated on both sides of the loop, and the pulsation status of the cells in the loop is detected electrically. A drug is applied to this cardiac reentry model chip, and the benefit or toxicity of the drug to cardiomyocytes is evaluated by measuring the cell potentials of individual cells.

    摘要翻译： 已经开发了可以在单个细胞基础上精确测量细胞电位和细胞形态的芯片。 该芯片还构成了心脏模型，其包括闭合环，由此心肌细胞和成纤维细胞适当地分散和排列，并且可以评价药物对其的影响。 通过使用单细胞被封闭在特定的空间结构中的构造，构建包括心肌细胞和成纤维细胞的闭环，制成排列在透明电极上形成的透明电极上的闭环回路模型芯片。 随机心肌细胞或特定心肌细胞的脉搏波在环的两侧传播，电路中检测到细胞的脉动状态。 将药物应用于该心脏再入模型芯片，并通过测量个体细胞的细胞电位来评估药物对心肌细胞的益处或毒性。