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33 条记录 (耗时 0.094 秒)

    Method of Producing Nerve Cell
    3.
    发明申请
    Method of Producing Nerve Cell 审中-公开
    产生神经细胞的方法

    公开(公告)号：US20080305544A1

    公开(公告)日：2008-12-11

    申请号：US11571580

    申请日：2005-07-06

    申请人： Hiroo Iwata ,  Yoshiki Sasai ,  Hironori Yamazoe ,  Masato Kobori ,  Mitsuo Satoh ,  Keiichi Yano

    发明人： Hiroo Iwata ,  Yoshiki Sasai ,  Hironori Yamazoe ,  Masato Kobori ,  Mitsuo Satoh ,  Keiichi Yano

    IPC分类号： C12N5/06

    CPC分类号： C12N5/0619 ,  C12N2500/38 ,  C12N2506/02

    摘要： An Object of the present invention is to provide a process for producing a nerve cell by inducing differentiation of an embryonic stem cell, a method for inducing differentiation of the embryonic stem cell into a nerve cell, a medium to be used in the production process or differentiation induction method, or a method for improving purity of the nerve cell obtained by inducing differentiation of the embryonic stem cell. The present invention provides a process for producing a nerve cell which is applicable to treatment of neurodegenerative disease or the like easily, selectively or inexpensively by inducing differentiation induction of an embryonic stem cell using vitamin B12 or a salt thereof and heparin, a substance having heparin-like activity or a salt.

    摘要翻译： 本发明的目的是提供一种通过诱导胚胎干细胞的分化来产生神经细胞的方法，用于诱导将胚胎干细胞分化成神经细胞的方法，用于生产过程的培养基或 分化诱导方法或通过诱导胚胎干细胞分化而获得的提高神经细胞的纯度的方法。 本发明提供了通过使用维生素B12或其盐诱导胚胎干细胞的分化诱导和肝素（含有肝素的物质），可以容易地，选择性地或廉价地治疗神经变性疾病等的神经细胞的制造方法 类活动或盐。

    Optical component, optical sensor, surface plasmon sensor and fingerprint recognition device
    4.
    发明授权
    Optical component, optical sensor, surface plasmon sensor and fingerprint recognition device 有权
    光学部件，光学传感器，表面等离子体传感器和指纹识别装置

    公开(公告)号：US07692795B2

    公开(公告)日：2010-04-06

    申请号：US11724681

    申请日：2007-03-15

    申请人： Syo Sasaki ,  Tomohiko Matsushita ,  Takeo Nishikawa ,  Natsuko Horiguchi ,  Hidetoshi Kotera ,  Hiroo Iwata

    发明人： Syo Sasaki ,  Tomohiko Matsushita ,  Takeo Nishikawa ,  Natsuko Horiguchi ,  Hidetoshi Kotera ,  Hiroo Iwata

    IPC分类号： G01N21/55

    CPC分类号： G01N21/553 ,  G06K9/0004

    摘要： A surface plasmon sensor includes a light guide reflection plate, a surface plasmon resonance layer formed on a first surface of the light guide reflection plate, a light emitting unit having a light source disposed on an end surface of the light guide reflection plate, and a light receiving element. The surface plasmon resonance layer includes a metal layer. The light guide reflection plate includes at least one first reflection surface inclined against the first surface. The light guide reflection plate is configured to transmit light emitted by the light source. The at least one first reflection surface is configured reflect the light to the surface plasmon resonance layer. The metal layer is configured to reflect the light reflected by the at least one first reflection surface. The light receiving element is configured to receive the light reflected by the metal layer.

    摘要翻译： 表面等离子体激元传感器包括导光反射板，形成在导光反射板的第一表面上的表面等离子体共振层，具有设置在导光反射板的端面上的光源的发光单元和 光接收元件。 表面等离子体共振层包括金属层。 光导反射板包括至少一个倾斜抵靠第一表面的第一反射表面。 导光反射板被配置为透射由光源发射的光。 所述至少一个第一反射表面被配置为将光反射到表面等离子体共振层。 金属层被配置为反射由至少一个第一反射表面反射的光。 光接收元件被配置为接收由金属层反射的光。

    Method of and apparatus for separating a balloon in a balloon catheter
    7.
    发明授权
    Method of and apparatus for separating a balloon in a balloon catheter 失效
    球囊导管中球囊分离方法及装置

    公开(公告)号：US4944746A

    公开(公告)日：1990-07-31

    申请号：US322923

    申请日：1989-03-14

    申请人： Hiroo Iwata ,  Sen Yamagata ,  Waro Taki ,  Takehisa Matsuda ,  Haruhiko Kikuchi ,  Yasuhiro Yonekawa ,  Yasuhiro Goto

    发明人： Hiroo Iwata ,  Sen Yamagata ,  Waro Taki ,  Takehisa Matsuda ,  Haruhiko Kikuchi ,  Yasuhiro Yonekawa ,  Yasuhiro Goto

    IPC分类号： A61M25/00 ,  A61B17/12

    CPC分类号： A61B17/12109 ,  A61B17/12136 ,  A61M2025/1054

    摘要： An apparatus for separating a balloon from a catheter member of a balloon is capable of melting and breaking a heat-meltable connecting member through which the balloon is connected to the catheter body by causing an electric current to flow between at least a pair of electrodes arranged on or in the vicinity of the connecting member. The apparatus has impedance measuring means for measuring the impedance of an electrode circuit including a pair of electrodes and lead lines connected to the electrodes, and judging means for comparing the measured value of the impedance with a predetermined reference range and capable of producing an abnormal signal when the measured value of the impedance does not fall within the predetermined reference range. The apparatus enables the operator to judge whether the electrode circuit is in safe condition, before changing the balloon with a settable liquid and to charge a settable liquid into the balloon only when the safe condition of the electrode circuit is confirmed, so that the balloon after the setting of the liquid can be separated from the catheter body without fail, thus eliminating any risk for the catheter body to dangerously remain in the living body.

    摘要翻译： 用于从球囊的导管构件分离球囊的装置能够熔化和破坏可热熔连接构件，气球通过该热连接构件连接到导管主体，通过使电流在布置的至少一对电极之间流动 在连接构件上或附近。 该装置具有用于测量电极电路的阻抗的阻抗测量装置，该电极电路包括一对连接到电极的电极和引线，以及判断装置，用于将阻抗的测量值与预定的参考范围进行比较，并且能够产生异常信号 当阻抗的测量值不在预定参考范围内时。 该设备使得操作者能够在电极回路处于安全状态之前，在用可固化液体改变球囊之前，仅在电极回路的安全状态被确认之后才将可固定液体充入球囊中， 液体的设置可以不导通地与导管体分离，从而消除导管体危险地残留在生物体中的任何风险。

    Method of making a stent
    8.
    发明授权
    Method of making a stent 有权
    制作支架的方法

    公开(公告)号：US09040111B2

    公开(公告)日：2015-05-26

    申请号：US13729630

    申请日：2012-12-28

    申请人： JAPAN STENT TECHNOLOGY CO., LTD. ,  TOKAI UNIVERSITY EDUCATIONAL SYSTEM ,  TOYO ADVANCED TECHNOLOGIES CO., LTD. ,  Hiroo Iwata

    发明人： Ikuo Omura ,  Zhen Yu Jin ,  Shuzo Yamashita ,  Hiroo Iwata ,  Akira Mochizuki

    IPC分类号： A61F2/00 ,  A61L33/00 ,  A61F2/82 ,  A61F2/915 ,  A61K9/00 ,  A61L31/10 ,  A61L31/16 ,  A61F2/91

    CPC分类号： A61F2/82 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2250/0067 ,  A61K9/0024 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/608 ,  A61L2420/08

    摘要： A method of making a stent, including preparing a solution containing a composition, the composition comprising a biodegradable polymer and a vascular intimal hyperplasia inhibitor of a kind, including argatroban, which does not inhibit proliferation of endothelial cells, the weight compositional ratio of the polymer to the vascular intimal hyperplasia inhibitor being within the range of 8:2 to 3:7, the composition dissolved in a solvent selected from the group consisting of a mixture of a lower alkyl ketone and methanol, a mixture of a lower alkyl ester and methanol or a mixture of a lower halogenated hydrocarbon and methanol; coating at least an outer surface of a stent body of a cylindrical configuration having outer and inner surfaces with a diamond-like thin film coated on the surfaces; and after the coating, removing the solvent to complete a first coated layer.

    摘要翻译： 一种制备支架的方法，包括制备含有组合物的溶液，所述组合物包含可生物降解的聚合物和包括不抑制内皮细胞增殖的阿格曲班的血管内膜增生抑制剂，聚合物的重量组成比 至血管内膜增生抑制剂的浓度在8:2至3:7的范围内，该组合物溶于选自低级烷基酮和甲醇的混合物，低级烷基酯和甲醇的混合物的溶剂中 或低级卤代烃和甲醇的混合物; 涂覆具有外表面和内表面的具有涂覆在表面上的类金刚石薄片的圆柱形构造的支架主体的至少外表面; 并且在涂覆之后，除去溶剂以完成第一涂层。

    Method of inhibiting vascular intimal hyperplasia using stent
    9.
    发明授权
    Method of inhibiting vascular intimal hyperplasia using stent 有权
    使用支架抑制血管内膜增生的方法

    公开(公告)号：US08968392B2

    公开(公告)日：2015-03-03

    申请号：US13561828

    申请日：2012-07-30

    申请人： Ikuo Omura ,  Zhen Yu Jin ,  Shuzo Yamashita ,  Hiroo Iwata ,  Akira Mochizuki

    发明人： Ikuo Omura ,  Zhen Yu Jin ,  Shuzo Yamashita ,  Hiroo Iwata ,  Akira Mochizuki

    IPC分类号： A61F2/82 ,  A61F2/00 ,  A61L33/00 ,  A61F2/915 ,  A61K9/00 ,  A61L31/10 ,  A61L31/16 ,  A61F2/91

    CPC分类号： A61F2/82 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2250/0067 ,  A61K9/0024 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/608 ,  A61L2420/08

    摘要： A method of inhibiting vascular intimal hyperplasia including: placing a stent within a blood vessel, the stent having a stent body of a cylindrical configuration having outer and inner surfaces with a diamond-like thin film coated on the surfaces, a first coated layer coating at least the outer surface of the stent body, the first coated layer being prepared of a first composition comprising a biodegradable polymer and a vascular intimal hyperplasia inhibitor of a kind, comprising argatroban, which does not inhibit proliferation of endothelial cells, the weight composition ratio of the polymer to the vascular intimal hyperplasia inhibitor being within the range of 8:2 to 7:3, and a second coated layer; and causing argatroban to be released from the stent to thereby inhibit the vascular intimal hyperplasia without inhibiting proliferation of endothelial cells.

    摘要翻译： 一种抑制血管内膜增生的方法，包括：将支架放置在血管内，所述支架具有圆柱形构造的支架主体，其外表面和内表面具有涂覆在其上的金刚石状薄膜，第一涂层涂层 至少支架体的外表面，第一涂层由包含生物可降解聚合物和一种血管内膜增生抑制剂的第一组合物制成，其包含不抑制内皮细胞增殖的阿加曲班，其重量组成比 血管内膜增生抑制剂的聚合物在8:2至7:3的范围内，以及第二涂层; 并使阿加曲班从支架释放，从而抑制血管内膜增生而不抑制内皮细胞的增殖。

    METHOD OF INHIBITING VASCULAR INTIMAL HYPERPLASIA USING STENT
    10.
    发明申请
    METHOD OF INHIBITING VASCULAR INTIMAL HYPERPLASIA USING STENT 审中-公开
    使用静脉阻塞血管紧张素血症的方法

    公开(公告)号：US20130018455A1

    公开(公告)日：2013-01-17

    申请号：US13561828

    申请日：2012-07-30

    申请人： Ikuo Omura ,  Zhen Yu Jin ,  Shuzo Yamashita ,  Hiroo Iwata ,  Akira Mochizuki

    发明人： Ikuo Omura ,  Zhen Yu Jin ,  Shuzo Yamashita ,  Hiroo Iwata ,  Akira Mochizuki

    IPC分类号： A61F2/82 ,  A61K9/00

    CPC分类号： A61F2/82 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2250/0067 ,  A61K9/0024 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/608 ,  A61L2420/08

    摘要： A method of inhibiting vascular intimal hyperplasia including: placing a stent within a blood vessel, the stent having a stent body of a cylindrical configuration having outer and inner surfaces with a diamond-like thin film coated on the surfaces, a first coated layer coating at least the outer surface of the stent body, the first coated layer being prepared of a first composition comprising a biodegradable polymer and a vascular intimal hyperplasia inhibitor of a kind, comprising argatroban, which does not inhibit proliferation of endothelial cells, the weight composition ratio of the polymer to the vascular intimal hyperplasia inhibitor being within the range of 8:2 to 7:3, and a second coated layer; and causing argatroban to be released from the stent to thereby inhibit the vascular intimal hyperplasia without inhibiting proliferation of endothelial cells.

    摘要翻译： 一种抑制血管内膜增生的方法，包括：将支架放置在血管内，所述支架具有圆柱形构造的支架主体，其外表面和内表面具有涂覆在其上的金刚石状薄膜，第一涂层涂层 至少支架体的外表面，第一涂层由包含生物可降解聚合物和一种血管内膜增生抑制剂的第一组合物制成，其包含不抑制内皮细胞增殖的阿加曲班，其重量组成比 血管内膜增生抑制剂的聚合物在8:2至7:3的范围内，以及第二涂层; 并使阿加曲班从支架释放，从而抑制血管内膜增生而不抑制内皮细胞的增殖。