公开(公告)号：US20120315658A1

公开(公告)日：2012-12-13

申请号：US13498127

申请日：2010-09-22

申请人： Susumu Mitsutake ,  Yasuyuki Igarashi ,  Kota Zama ,  Tetsuya Yoshida ,  Yoshikazu Tanaka ,  Hiroshi Takemoto

发明人： Susumu Mitsutake ,  Yasuyuki Igarashi ,  Kota Zama ,  Tetsuya Yoshida ,  Yoshikazu Tanaka ,  Hiroshi Takemoto

IPC分类号： C12Q1/48 ,  C12N5/10

CPC分类号： C12Q1/48 ,  G01N2333/9129 ,  G01N2800/044

摘要： Disclosed is a method for screening for a medicinal agent that can decrease a body weight, a medicinal agent that can reduce a visceral fat, a medicinal agent that can reduce a triglyceride in the liver, and a medicinal agent that can ameliorate obesity and fatty liver. The method involves a step of measuring the inhibitory activity of a candidate substance on a sphingomyelin synthase, wherein the candidate substance is determined to have at least one function selected from the group consisting of an anti-obesity agent, a visceral fat-reducing agent, a fatty liver-treating agent and an adiponectin expression enhancer when the candidate substance has an inhibitory activity on the sphingomyelin synthase.

摘要翻译： 本发明公开了一种能够降低体重的药剂的筛选方法，能够减少内脏脂肪的药剂，能够减少肝脏中的甘油三酯的药剂，以及能够改善肥胖和脂肪肝的药剂 。 该方法包括测定候选物质对鞘磷脂合成酶的抑制活性的步骤，其中所述候选物质被确定为具有至少一种选自抗肥胖剂，内脏脂肪减少剂， 脂肪肝处理剂和脂联素表达增强剂，当候选物质对鞘磷脂合成酶具有抑制活性时。

公开(公告)号：US20130231383A1

公开(公告)日：2013-09-05

申请号：US13821536

申请日：2011-09-21

申请人： Susumu Mitsutake ,  Kota Zama ,  Yasuyuki Igarashi ,  Tetsuya Yoshida ,  Yoshikazu Tanaka ,  Hiroshi Takemoto

发明人： Susumu Mitsutake ,  Kota Zama ,  Yasuyuki Igarashi ,  Tetsuya Yoshida ,  Yoshikazu Tanaka ,  Hiroshi Takemoto

IPC分类号： C12N15/113

CPC分类号： C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/3231 ,  C12Y207/08

摘要： The problem of the present invention is to prove a medicament for decreasing body weigh, a medicament for decreasing visceral fat, a medicament for decreasing triglyceride in the liver, and a method for screening a medicament for ameliorating obesity and fatty liver. The problem is solved by a method comprising measuring an activity of a candidate material for inhibiting a sphingomyelin synthetase wherein if the candidate material has an activity for inhibiting a sphingomyelin synthetase, the candidate material is judged to have at least one function selected from the consisting of an anti-obesity drug, a drug for decreasing visceral fat, a drug for treating fatty liver and an agent for increasing adiponectin expression.

摘要翻译： 本发明的问题是证明减轻体重的药物，用于降低内脏脂肪的药物，用于降低肝脏中甘油三酯的药物，以及筛选用于改善肥胖症和脂肪肝的药物的方法。 该问题通过包括测定用于抑制鞘磷脂合成酶的候选材料的活性的方法来解决，其中如果候选物质具有抑制鞘磷脂合成酶的活性，则该候选物质被判断为具有至少一种选自以下的功能： 抗肥胖药，用于降低内脏脂肪的药物，用于治疗脂肪肝的药物和用于增加脂联素表达的药剂。

公开(公告)号：US08889648B2

公开(公告)日：2014-11-18

申请号：US13821536

申请日：2011-09-21

申请人： Susumu Mitsutake ,  Kota Zama ,  Yasuyuki Igarashi ,  Tetsuya Yoshida ,  Yoshikazu Tanaka ,  Hiroshi Takemoto

发明人： Susumu Mitsutake ,  Kota Zama ,  Yasuyuki Igarashi ,  Tetsuya Yoshida ,  Yoshikazu Tanaka ,  Hiroshi Takemoto

IPC分类号： C12N15/113

CPC分类号： C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/3231 ,  C12Y207/08

摘要： The problem of the present invention is to prove a medicament for decreasing body weigh, a medicament for decreasing visceral fat, a medicament for decreasing triglyceride in the liver, and a method for screening a medicament for ameliorating obesity and fatty liver. The problem is solved by a method comprising measuring an activity of a candidate material for inhibiting a sphingomyelin synthetase wherein if the candidate material has an activity for inhibiting a sphingomyelin synthetase, the candidate material is judged to have at least one function selected from the consisting of an anti-obesity drug, a drug for decreasing visceral fat, a drug for treating fatty liver and an agent for increasing adiponectin expression.

摘要翻译： 本发明的问题是证明减轻体重的药物，用于降低内脏脂肪的药物，用于降低肝脏中甘油三酯的药物，以及筛选用于改善肥胖症和脂肪肝的药物的方法。 该问题通过包括测定用于抑制鞘磷脂合成酶的候选材料的活性的方法来解决，其中如果候选物质具有抑制鞘磷脂合成酶的活性，则该候选物质被判断为具有至少一种选自以下的功能： 抗肥胖药，用于降低内脏脂肪的药物，用于治疗脂肪肝的药物和用于增加脂联素表达的药剂。

公开(公告)号：US09610094B2

公开(公告)日：2017-04-04

申请号：US13098598

申请日：2011-05-02

申请人： Tetsuya Yoshida ,  Yoko Okamura

发明人： Tetsuya Yoshida ,  Yoko Okamura

IPC分类号： A61B19/00 ,  A61B17/34 ,  A61B8/06 ,  A61B8/08 ,  A61B8/13 ,  A61B8/00 ,  A61B18/12 ,  A61B90/00

CPC分类号： A61B17/3403 ,  A61B8/06 ,  A61B8/0841 ,  A61B8/13 ,  A61B8/4245 ,  A61B8/4444 ,  A61B8/461 ,  A61B8/463 ,  A61B8/5238 ,  A61B18/12 ,  A61B2017/3413 ,  A61B2090/365

摘要： An apparatus for ultrasonic diagnosis including a probe configured to transmit ultrasonic waves and to receive reflected ultrasonic waves, an image generator configured to generate an ultrasonic image based on the reflected waves, an image synthesizing unit configured to generate a synthetic image in which a puncture guideline, which indicates a passing line of a puncture needle inserted from a puncture adapter attached to the probe, is superposed on the ultrasonic image, a display area adjusting unit configured to adjust a display area of the synthetic image based on the passing line of the puncture needle, and a display controller configured to display the synthetic image on a monitor based on the display area adjusted by the display area adjusting unit.

公开(公告)号：US08188194B2

公开(公告)日：2012-05-29

申请号：US12668301

申请日：2008-07-10

申请人： Tetsuya Yoshida ,  Satoshi Uehara

发明人： Tetsuya Yoshida ,  Satoshi Uehara

IPC分类号： C08F120/10 ,  C09K19/00 ,  C09D5/02 ,  G02B1/08

CPC分类号： C08K5/0025 ,  C08F220/06 ,  C08F220/18 ,  C08F2220/281 ,  C08L2312/00 ,  C09J133/066 ,  G02B5/3033 ,  Y10T428/1041 ,  Y10T428/105 ,  C08L33/04

摘要： An adhesive composition for polarizing plates in which an acrylic polymer, a tin compound having a dialkyl group and serving as a cross-linking accelerator and an isocyanate cross-linker are dissolved in an organic solvent, the acrylic polymer being formed by copolymerization of monomers containing an alkyl (meth)acrylate, a hydroxyl group containing monomer and/or a carboxyl group containing monomer, wherein preferably, a solution containing 30% by weight of the acrylic polymer which constitutes the adhesive composition, dissolved in 70% by weight of ethyl acetate has a viscosity in the range of 0.5 to 10.0 Pa·s measured at 23° C., and the acrylic polymer has a weight-average molecular weight in the range of 300,000 to 700,000.

摘要翻译： 一种用于偏光板的粘合剂组合物，其中丙烯酸类聚合物，具有二烷基并用作交联促进剂的锡化合物和异氰酸酯交联剂溶解在有机溶剂中，所述丙烯酸类聚合物通过使含有 （甲基）丙烯酸烷基酯，含羟基的单体和/或含羧基的单体，其中优选将含有30重量％构成粘合剂组合物的丙烯酸类聚合物的溶液溶于70重量％的乙酸乙酯 在23℃下测得的粘度为0.5〜10.0Pa·s，丙烯酸类聚合物的重均分子量为30万〜70万。

公开(公告)号：US20110301457A1

公开(公告)日：2011-12-08

申请号：US13152675

申请日：2011-06-03

申请人： Hiroki YOSHIARA ,  Naohisa Kamiyama ,  Tetsuya Yoshida

发明人： Hiroki YOSHIARA ,  Naohisa Kamiyama ,  Tetsuya Yoshida

IPC分类号： A61B8/00

CPC分类号： G01S7/52071 ,  A61B6/481 ,  A61B6/504 ,  A61B8/08 ,  G01S7/52026 ,  G01S7/52074

摘要： According to one embodiment, an ultrasonic diagnostic apparatus which comprises an ultrasonic transmission/reception unit configured to transmit ultrasonic waves to a scan area including a predetermined region throughout an analysis period, receive reflected waves from the scan area, and acquire ultrasonic data associated with the scan area for each phase in the analysis period, an analysis unit configured to generate a luminance time curve associated with at least one analysis area included in the scan area by using the ultrasonic data in each phase in the analysis period and analyze a stagnant time of the contrast medium associated with at least one analysis area based on the generated luminance time curve, an image generation unit configured to generate a stagnant time image for each phase in the analysis period, with different hues being assigned to at least one analysis area in accordance with the stagnant times.

摘要翻译： 根据一个实施例，一种超声波诊断装置，包括：超声波发送/接收单元，被配置为在整个分析周期内将超声波发送到包括预定区域的扫描区域，接收来自扫描区域的反射波，并获取与该扫描区域相关联的超声波数据 扫描区域，分析单元，被配置为通过在分析周期中的每个阶段中使用超声波数据来生成与包括在扫描区域中的至少一个分析区域相关联的亮度时间曲线，并且分析停止时间 所述造影剂基于所生成的亮度时间曲线与至少一个分析区域相关联;图像生成单元，被配置为在分析周期中为每个相位生成停滞的时间图像，其中不同的色调被分配给至少一个分析区域 随着时间的流逝。

公开(公告)号：US20110270087A1

公开(公告)日：2011-11-03

申请号：US13098598

申请日：2011-05-02

申请人： Tetsuya Yoshida ,  Yoko Okamura

发明人： Tetsuya Yoshida ,  Yoko Okamura

IPC分类号： A61B8/14

CPC分类号： A61B17/3403 ,  A61B8/06 ,  A61B8/0841 ,  A61B8/13 ,  A61B8/4245 ,  A61B8/4444 ,  A61B8/461 ,  A61B8/463 ,  A61B8/5238 ,  A61B18/12 ,  A61B2017/3413 ,  A61B2090/365

摘要： An apparatus for ultrasonic diagnosis including a probe configured to transmit ultrasonic waves and to receive reflected ultrasonic waves, an image generator configured to generate an ultrasonic image based on the reflected waves, an image synthesizing unit configured to generate a synthetic image in which a puncture guideline, which indicates a passing line of a puncture needle inserted from a puncture adapter attached to the probe, is superposed on the ultrasonic image, a display area adjusting unit configured to adjust a display area of the synthetic image based on the passing line of the puncture needle, and a display controller configured to display the synthetic image on a monitor based on the display area adjusted by the display area adjusting unit.

摘要翻译： 一种超声波诊断装置，包括被配置为发送超声波并接收反射超声波的探针，被配置为基于反射波产生超声波图像的图像发生器，被配置为生成合成图像的图像合成图像，其中穿刺指南 ，其表示从安装在所述探针上的穿刺适配器插入的穿刺针的通过线叠加在所述超声波图像上，显示区域调整单元，被配置为基于所述穿刺的通过线来调整所述合成图像的显示区域 针和配置为基于由显示区域调整单元调整的显示区域将合成图像显示在监视器上的显示控制器。

公开(公告)号：US07855453B2

公开(公告)日：2010-12-21

申请号：US12055893

申请日：2008-03-26

申请人： Tetsuya Yoshida ,  Takuji Miyata

发明人： Tetsuya Yoshida ,  Takuji Miyata

IPC分类号： H01L23/48

CPC分类号： H01L29/7813 ,  H01L24/05 ,  H01L29/0619 ,  H01L29/0696 ,  H01L29/41741 ,  H01L29/7809 ,  H01L29/7811 ,  H01L2224/05552 ,  H01L2224/0603 ,  H01L2924/12032 ,  H01L2924/1301 ,  H01L2924/1305 ,  H01L2924/13055 ,  H01L2924/1306 ,  H01L2924/13062 ,  H01L2924/13091 ,  H01L2924/00

摘要： Provided is a semiconductor device in which a high concentration n type impurity region to be a conductive path and a drain electrode are disposed in an outer circumferential end of the chip to be an inactive region as a device region. Thereby, an up-drain structure is obtained without reducing the device region or without increasing the size of a semiconductor chip. The provided n type impurity region and drain electrode causes a depletion layer of a substrate to be terminated without needing an additional conventional annular region or shield metal. This is because the n type impurity region and the drain electrode also function as the annular region and the shield metal, respectively. With this configuration, a MOSFET with the up-drain structure having necessary components is obtained, while avoiding a reduction of the device region or an increase of the chip area.

摘要翻译： 提供一种半导体器件，其中作为导电路径的高浓度n型杂质区域和漏极电极设置在作为非活性区域的芯片的外周端中作为器件区域。 由此，在不减少器件区域的情况下或不增加半导体芯片的尺寸的情况下，获得上漏结构。 所提供的n型杂质区域和漏极电极导致衬底的耗尽层被终止，而不需要额外的常规环形区域或屏蔽金属。 这是因为n型杂质区域和漏极电极也分别用作环形区域和屏蔽金属。 利用这种配置，可以获得具有必要部件的上漏结构的MOSFET，同时避免了器件区域的减少或芯片面积的增加。

公开(公告)号：US20100208343A1

公开(公告)日：2010-08-19

申请号：US12668301

申请日：2008-07-10

申请人： Tetsuya Yoshida ,  Satoshi Uehara

发明人： Tetsuya Yoshida ,  Satoshi Uehara

IPC分类号： G02B1/08 ,  C08F120/10

CPC分类号： C08K5/0025 ,  C08F220/06 ,  C08F220/18 ,  C08F2220/281 ,  C08L2312/00 ,  C09J133/066 ,  G02B5/3033 ,  Y10T428/1041 ,  Y10T428/105 ,  C08L33/04

摘要： An adhesive composition for polarizing plates in which an acrylic polymer, a tin compound having a dialkyl group and serving as a cross-linking accelerator and an isocyanate cross-linker are dissolved in an organic solvent, the acrylic polymer being formed by copolymerization of monomers containing an alkyl (meth)acrylate, a hydroxyl group containing monomer and/or a carboxyl group containing monomer, wherein preferably, a solution containing 30% by weight of the acrylic polymer which constitutes the adhesive composition, dissolved in 70% by weight of ethyl acetate has a viscosity in the range of 0.5 to 10.0 Pa·s measured at 23° C., and the acrylic polymer has a weight-average molecular weight in the range of 300,000 to 700,000.

摘要翻译： 一种用于偏光板的粘合剂组合物，其中丙烯酸类聚合物，具有二烷基并用作交联促进剂的锡化合物和异氰酸酯交联剂溶解在有机溶剂中，丙烯酸类聚合物通过使含有 （甲基）丙烯酸烷基酯，含羟基的单体和/或含羧基的单体，其中优选将含有30重量％构成粘合剂组合物的丙烯酸类聚合物的溶液溶于70重量％的乙酸乙酯 在23℃下测得的粘度为0.5〜10.0Pa·s，丙烯酸类聚合物的重均分子量为30万〜70万。

公开(公告)号：US20090284852A1

公开(公告)日：2009-11-19

申请号：US12463670

申请日：2009-05-11

申请人： Ryozo HOSODA ,  Tetsuya Yoshida ,  Shinya Hatano

发明人： Ryozo HOSODA ,  Tetsuya Yoshida ,  Shinya Hatano

IPC分类号： G02B7/04 ,  G02B7/02

CPC分类号： G11B7/1376 ,  G11B7/0927

摘要： A lens drive mechanism includes a drive source; a lead screw that is connected to the drive source and rotated by operation of the drive source; a nut member that screws on the lead screw and moves as the lead screw rotates; a lens hold portion that is so disposed as to move as the nut member moves and hold a lens; a guide member that guides the lens hold portion to move in the same direction as that of movement of the nut member; and a leaf spring member that if the nut member is situated near one end of a thread portion of the lead screw, pressurizes the nut member toward the other end of the thread portion of the lead screw.

摘要翻译： 透镜驱动机构包括驱动源; 导螺杆，其连接到驱动源并通过驱动源的操作而旋转; 一个螺母，螺丝拧在导螺杆上，随着导螺杆的旋转而移动; 透镜保持部，其设置成随着螺母构件移动并保持透镜而移动; 引导构件，其引导透镜保持部沿与螺母构件的移动相同的方向移动; 以及板簧构件，如果所述螺母构件位于所述导螺杆的螺纹部的一端附近，则将所述螺母构件朝向所述丝杠的螺纹部的另一端加压。