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    Drug efflux pump inhibitor
    3.
    发明授权
    Drug efflux pump inhibitor 失效
    药物外排泵抑制剂

    公开(公告)号：US07056917B2

    公开(公告)日：2006-06-06

    申请号：US09842234

    申请日：2001-04-26

    申请人： Kiyoshi Nakayama ,  Masami Ohtsuka ,  Haruko Kawato ,  William Watkins ,  Jason Zhang ,  Monica Palme ,  Aesop Cho

    发明人： Kiyoshi Nakayama ,  Masami Ohtsuka ,  Haruko Kawato ,  William Watkins ,  Jason Zhang ,  Monica Palme ,  Aesop Cho

    IPC分类号： C07D417/06 ,  C07D417/12 ,  A61K31/427

    CPC分类号： C07D417/06 ,  A61K31/427 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/549 ,  A61K31/55 ,  A61K45/06 ,  C07D417/12 ,  C07D471/04 ,  C12Q1/18

    摘要： A medicament for preventive and/or therapeutic treatment of a microbial infection which comprises as an active ingredient a compound represented by the following general formula (I): wherein, R1 and R2 represent hydrogen atom, a halogen atom, hydroxyl group or the like, W1 represents —CH═CH—, —CH2O—, —CH2CH2— or the like; R3 represents hydrogen atom, a halogen atom, hydroxyl group or an amino group; R4 represents hydrogen atom, a group of —OZ0-4R5 (Z0-4 represents an alkylene group, a fluorine-substituted alkylene group or a single bond, and R5 represents a cyclic alkyl group, an aryl group or the like); W2 represents a single bond or —C(R8)═C(R9)— (R8 and R9 represent hydrogen atom, a halogen atom, a lower alkyl group or the like, Q represents an acidic group, but W2 and Q may together form vinylidenethiazolidinedione or an equivalent heterocyclic ring; m and n represent an integer of 0 to 2, and q represents an integer of 0 to 3.

    摘要翻译： 一种用于预防和/或治疗微生物感染的药物，其包含作为活性成分的由以下通式（I）表示的化合物：其中R 1和R 2， SUP>表示氢原子，卤素原子，羟基等，W 1表示-CH-CH - ， - CH 2 O - ， - CH- 2 CH 2 - 或类似物; R 3表示氢原子，卤素原子，羟基或氨基; R 4表示氢原子，-OZ 0-4R 5（Z 0-4）的基团表示 亚烷基，氟取代的亚烷基或单键，R 5表示环状烷基，芳基等）。 -C（R 9） - （R 9） - （R 9） - （R 8） >和R 9表示氢原子，卤素原子，低级烷基等，Q表示酸性基团，但W 2和Q可以一起形成亚乙烯基乙二胺二酮或 等价杂环; m和n表示0〜2的整数，q表示0〜3的整数。

    Drug efflux pump inhibitor
    4.
    发明申请
    Drug efflux pump inhibitor 审中-公开
    药物外排泵抑制剂

    公开(公告)号：US20060106034A1

    公开(公告)日：2006-05-18

    申请号：US11320229

    申请日：2005-12-29

    申请人： Kiyoshi Nakayama ,  Masami Ohtsuka ,  Haruko Kawato ,  William Watkins ,  Jason Zhang ,  Monica Palme ,  Aesop Cho

    发明人： Kiyoshi Nakayama ,  Masami Ohtsuka ,  Haruko Kawato ,  William Watkins ,  Jason Zhang ,  Monica Palme ,  Aesop Cho

    IPC分类号： A61K31/519

    CPC分类号： C07D417/06 ,  A61K31/427 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/549 ,  A61K31/55 ,  A61K45/06 ,  C07D417/12 ,  C07D471/04 ,  C12Q1/18

    摘要： A medicament for preventive and/or therapeutic treatment of a microbial infection which comprises as an active ingredient a compound represented by the following general formula (I): wherein, R1 and R2 represent hydrogen atom, a halogen atom, hydroxyl group or the like, W1 represents —CH═CH—, —CH2O—, —CH2CH2— or the like; R3 represents hydrogen atom, a halogen atom, hydroxyl group or an amino group; R4 represents hydrogen atom, a group of —OZ0-4R5 (Z0-4 represents an alkylene group, a fluorine-substituted alkylene group or a single bond, and R5 represents a cyclic alkyl group, an aryl group or the like); W2 represents a single bond or —C(R8)═C(R9)−(R8 and R9 represent hydrogen atom, a halogen atom, a lower alkyl group or the like, Q represents an acidic group, but W2 and Q may together form vinylidenethiazolidinedione or an equivalent heterocyclic ring; m and n represent an integer of 0 to 2, and q represents an integer of 0 to 3.

    摘要翻译： 一种用于预防和/或治疗微生物感染的药物，其包含作为活性成分的由以下通式（I）表示的化合物：其中R 1和R 2， SUP>表示氢原子，卤素原子，羟基等，W 1表示-CH-CH-，-CH 2 O - ， - CH- 2 CH 2 - 或类似物; R 3表示氢原子，卤素原子，羟基或氨基; R 4表示氢原子，-OZ 0-4R 5（Z 0-4）的基团表示 亚烷基，氟取代的亚烷基或单键，R 5表示环状烷基，芳基等）。 -C（R 9） - （R 9） - （R 9） - （R 8） >和R 9表示氢原子，卤素原子，低级烷基等，Q表示酸性基团，但W 2和Q可以一起形成亚乙烯基乙二胺二酮或 等价杂环; m和n表示0〜2的整数，q表示0〜3的整数。

    IN-VEHICLE INFORMATION APPARATUS
    5.
    发明申请
    IN-VEHICLE INFORMATION APPARATUS 有权
    车内信息装置

    公开(公告)号：US20120287262A1

    公开(公告)日：2012-11-15

    申请号：US13318376

    申请日：2011-01-26

    申请人： Kiyoshi Nakayama ,  Masato Takahashi

    发明人： Kiyoshi Nakayama ,  Masato Takahashi

    IPC分类号： H04N7/18

    CPC分类号： G01C21/3688 ,  B60K35/00 ,  B60K37/06 ,  B60K2350/1004 ,  B60K2350/1032 ,  B60K2350/1096

    摘要： An in-vehicle information apparatus according to the invention includes a main unit having a display device, and a navigation unit providing a navigation function to the main unit. The navigation unit includes a navigation processing unit which executes a process concerning the navigation function, a sub unit providing an addition function to the navigation unit, and a navigation unit screen generating unit which generates a navigation unit screen for displaying information concerning a function which the navigation unit provides. The main unit includes an operation unit which receives an input for selecting a function from a user, a main unit screen generating unit which generates a main unit screen for displaying information concerning a function which the main unit provides, and a video selector which selects one of the navigation unit screen and the main unit screen and provides the selected one to the display device. The addition function provided by the sub unit is executed by an interruption process, and the video selector selects one of the navigation unit screen and the main unit screen based on the function inputted to the operation unit and the addition function executed by the interruption process.

    摘要翻译： 根据本发明的车载信息装置包括具有显示装置的主单元和向主单元提供导航功能的导航单元。 导航单元包括执行与导航功能有关的处理的导航处理单元，向导航单元提供加法功能的子单元，以及导航单元画面生成单元，其生成导航单元屏幕，用于显示有关功能的信息， 导航单位提供。 主单元包括接收用户选择功能的输入的操作单元，产生用于显示与主单元提供的功能有关的信息的主单元屏幕的主单元屏幕生成单元，以及选择一个 的导航单元屏幕和主单元屏幕，并将所选择的屏幕提供给显示设备。 由子单元提供的附加功能通过中断处理执行，并且视频选择器基于输入到操作单元的功能和通过中断处理执行的加法函数来选择导航单元屏幕和主单元屏幕中的一个。

    Flat heating surface type gas stove
    7.
    发明授权
    Flat heating surface type gas stove 失效
    平面加热表面式燃气灶

    公开(公告)号：US06823859B2

    公开(公告)日：2004-11-30

    申请号：US10602723

    申请日：2003-06-25

    申请人： Yutaka Yamada ,  Kiyoshi Nakayama

    发明人： Yutaka Yamada ,  Kiyoshi Nakayama

    IPC分类号： F24C300

    CPC分类号： F24C3/067 ,  Y02B40/166

    摘要： There is disclosed a novel flat heating surface type gas stove which is capable of heating a heating substance across a heat resistance glass at practically applicable heating efficiency, overcoming any inconvenience resulting from the exposure of flame and facilitating the cleaning of the gas stove. This gas stove 10 comprises a heat resistance glass top plate 12 which is disposed over a burner 15, wherein a gas-permeable porous body 40 is disposed below said top plate 12, and a space between said top plate 12 and a surface of said gas-permeable porous body 40 is assigned to a combustion space S. Combustion gas generated is designed to be discharged through said gas-permeable porous body 40. As high-temperature combustion gas passes through said gas-permeable porous body 40, radiant heat B is generated from the surface of said gas-permeable porous body 40. Since the heating substance 4 is heated by both of heat conduction and radiation, high heating efficiency can be achieved.

    摘要翻译： 公开了一种新颖的平面加热表面式燃气灶，其能够以实际可用的加热效率加热加热物质穿过耐热玻璃，克服了由于火焰的暴露而导致的任何不便，并且便于清洁燃气灶。 该气体炉10包括设置在燃烧器15上方的耐热性玻璃顶板12，其中透气性多孔体40设置在所述顶板12的下方，并且所述顶板12与所述气体的表面之间的空间 将透气性多孔体40分配给燃烧空间S.产生的燃烧气体被设计成通过所述透气性多孔体40排出。当高温燃烧气体通过所述透气性多孔体40时，辐射热B为 从所述透气性多孔体40的表面产生。由于加热物质4被热传导和辐射两者加热，因此可以实现高的加热效率。

    Two-pack crosslinking aqueous adhesive
    8.
    发明授权
    Two-pack crosslinking aqueous adhesive 失效
    双组份交联水性胶粘剂

    公开(公告)号：US5739201A

    公开(公告)日：1998-04-14

    申请号：US795309

    申请日：1997-02-04

    申请人： Masaki Ugai ,  Kiyoshi Nakayama ,  Masahito Mori

    发明人： Masaki Ugai ,  Kiyoshi Nakayama ,  Masahito Mori

    IPC分类号： C09J201/02 ,  C09J11/06 ,  C09J201/04 ,  C09J201/08 ,  C08L83/00

    CPC分类号： C09J201/04 ,  C09J201/08

    摘要： A two-pack, crosslinking aqueous adhesive, which comprises (A) an adhesive component comprising an aqueous liquid of a polymer containing at least one of a halogen atom, a carboxyl group or an ester bond in the backbone chain or side chain of the polymer molecule and (B) a curing component comprising an active silyl compound containing at least one of an amino group or an imino group in the molecule, which has excellent emulsion stability after mixing the components, long pot-life and excellent heat resistance and is suitable for adhesion of materials which require heat resistance such as interior automotive trims.

    摘要翻译： 一种双组分交联水性粘合剂，其包含（A）粘合剂组分，其包含聚合物的水性液体，所述聚合物含有聚合物的主链或侧链中的至少一个卤素原子，羧基或酯键 分子和（B）包含在分子中含有氨基或亚氨基中的至少一个的活性甲硅烷基化合物的固化组分，其在混合组分后具有优异的乳液稳定性，长的适用期和优异的耐热性，并且是合适的 用于粘附需要耐热性的材料，例如内部汽车饰件。

    Method for producing (R)-malic acid from maleic acid using microbial maleate hydratase
    9.
    发明授权
    Method for producing (R)-malic acid from maleic acid using microbial maleate hydratase 失效
    使用微生物马来酸盐水解酶从马来酸生产（R） - 马来酸的方法

    公开(公告)号：US5270190A

    公开(公告)日：1993-12-14

    申请号：US821197

    申请日：1992-01-15

    申请人： Kiyoshi Nakayama ,  Yukie Kobayashi

    发明人： Kiyoshi Nakayama ,  Yukie Kobayashi

    IPC分类号： C12N9/88 ,  C12P7/46

    CPC分类号： C12P7/46 ,  C12N9/88 ,  Y10S435/822 ,  Y10S435/911

    摘要： This invention relates to a method for producing (R)-malic acid comprising contacting, in a reaction medium, maleic acid with (A) a microbial maleate hydratase capable of hydrating maleic acid to form (R)-malic acid or (B) a microorganism containing the maleate hydratase, microbial maleate hydratase and a method for producing same. In accordance with the present invention (R)-malic acid with high optical purity is supplied efficiently and economically.

    摘要翻译： 本发明涉及一种制备（R） - 马来酸的方法，包括在反应介质中使马来酸与（A）能够水合马来酸形成（R） - 马来酸的微生物马来酸盐水合酶或（B） 含有马来酸盐水合酶的微生物，马来酸微生物水合酶及其制备方法。 根据本发明，高效且经济地提供了具有高光学纯度的（R） - 丙二酸。

    Control system for foldable outside rearview mirror
    10.
    发明授权
    Control system for foldable outside rearview mirror 失效
    可折叠外部后视镜控制系统

    公开(公告)号：US4798967A

    公开(公告)日：1989-01-17

    申请号：US173154

    申请日：1988-03-24

    申请人： Tohru Yamana ,  Kiyoshi Nakayama ,  Kazuhiko Sato

    发明人： Tohru Yamana ,  Kiyoshi Nakayama ,  Kazuhiko Sato

    IPC分类号： B60R1/074 ,  G02B7/182 ,  G02B7/18 ,  G05B19/10

    CPC分类号： G02B7/1827 ,  B60R1/074

    摘要： A control system for a foldable outside rearview mirror comprises an electric motor having an electric motor circuit, an operation switch, trigger element connected with the operation switch for outputting a trigger pulse in response to actuation of the operation switch, timer element connected with the trigger element for outputting a pulse of a predetermined pulse width to drive the electric motor only for a set time upon receipt of the trigger pulse from the trigger element, polarity changing element having a pair of outputs of high and low level and formed for reversely switching the electric motor by inverting the pair of the outputs upon receipt of the trigger pulse from the trigger element, and switching element for switching a voltage applied to the electric motor to react or fold a rearview mirror upon receipt of the output of the polarity changing element.

    摘要翻译： 一种用于可折叠的外部后视镜的控制系统包括具有电动机电路的电动机，操作开关，与操作开关连接的触发元件，用于响应于操作开关的致动而输出触发脉冲，与触发器连接的定时器元件 元件，用于输出预定脉冲宽度的脉冲，以便在从触发元件接收到触发脉冲时只设定一定时间来驱动电动机，极性改变元件具有一对高电平和低电平的输出，并形成用于反向切换 电动机通过在从触发元件接收到触发脉冲时反转一对输出，以及用于切换施加到电动机的电压的开关元件，以在接收到极性改变元件的输出时反应或折叠后视镜。