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公开(公告)号:US5128134A
公开(公告)日:1992-07-07
申请号:US461188
申请日:1990-01-05
申请人: Svyatoslav N. Fyodorov , Sergey N. Bagrov , Tatyana S. Amstislavskaya , Irina A. Maklakova , Sergey V. Maslenkov
发明人: Svyatoslav N. Fyodorov , Sergey N. Bagrov , Tatyana S. Amstislavskaya , Irina A. Maklakova , Sergey V. Maslenkov
CPC分类号: A61L27/3604 , A61L27/24 , G09F3/202 , Y10S128/08 , Y10S514/912 , Y10S514/955
摘要: Ophthalmologic collagen coverings derived from animal eyes and a process for preparing such coverings comprising treatment of a fibrous tunic of an animal eye with an alkali metal hydroxide in a saturated solution of a salt of an alkali metal, followed by neutralization, dissolution in an aqueous solution of an organic acid, purification of the resulting solution of collagen by dialysis against a buffer solution while bringing the solution of collagen to a pH of 4.5 to 7.5 and drying the thus-obtained solution of collagen simultaneously with shaping spherical coverings therefrom.
摘要翻译: 衍生自动物眼睛的眼科胶原覆盖物和制备这种覆盖物的方法,包括用碱金属氢氧化物在碱金属盐的饱和溶液中处理动物眼睛的纤维束,然后中和,在水溶液中溶解 的有机酸,通过对缓冲溶液进行透析来纯化所得的胶原溶液,同时使胶原蛋白溶液的pH值达到4.5〜7.5,同时用这样得到的胶原溶液同时干燥。
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公开(公告)号:US5094855A
公开(公告)日:1992-03-10
申请号:US618026
申请日:1990-11-09
申请人: Svyatoslav N. Fyodorov , Sergey N. Bagrov , Tatyana S. Amstislavskaya , Irina A. Maklakova , Sergey V. Maslenkov
发明人: Svyatoslav N. Fyodorov , Sergey N. Bagrov , Tatyana S. Amstislavskaya , Irina A. Maklakova , Sergey V. Maslenkov
IPC分类号: A61L27/36
CPC分类号: A61L27/3641 , A61L27/3604 , A61L2430/16 , Y10S128/08 , Y10S514/912 , Y10S514/955
摘要: Ophthalmologic collagen coverings derived from animal eyes and a process preparing such coverings comprising treatment of a fibrous tunic of an animal eye with an alkali metal hydroxide in a saturated solution of a salt of an alkali metal, followed by neutralization, dissolution in an aqueous solution of an organic acid, purification of the resulting solution of collagen by dialysis against a buffer solution while bringing the solution of collagen to a pH of 4.5 to 7.5 and drying the thus-obtained solution of collagen simultaneously with shaping spherical coverings therefrom.
摘要翻译: 衍生自动物眼睛的眼科胶原覆盖物和制备这种覆盖物的方法,包括用碱金属氢氧化物在碱金属盐的饱和溶液中处理动物眼睛的纤维束,然后中和,在水溶液中溶解 的有机酸,通过对缓冲溶液进行透析来纯化所得的胶原溶液,同时使胶原蛋白溶液的pH值达到4.5〜7.5,同时用这样得到的胶原溶液同时干燥。
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公开(公告)号:US5093125A
公开(公告)日:1992-03-03
申请号:US587576
申请日:1990-09-21
申请人: Svyatoslav N. Fyodorov , Sergey N. Bagrov , Tatyana S. Amstislavskaya , Irina A. Maklakova , Sergey V. Maslenkov
发明人: Svyatoslav N. Fyodorov , Sergey N. Bagrov , Tatyana S. Amstislavskaya , Irina A. Maklakova , Sergey V. Maslenkov
IPC分类号: A61L27/36
CPC分类号: A61L27/3604 , A61L27/3683 , A61L2430/16 , A61L2430/40 , Y10S514/912
摘要: Ophthalmologic collagen coverings derived from animal eyes and a process preparing such coverings comprising treatment of a fibrous tunic of an animal eye with an alkali metal hydroxide in a saturated solution of a salt of an alkali metal, followed by neutralization, dissolution in an aqueous solution of an organic acid, purification of the resulting solution of collagen by dialysis against a buffer solution while bringing the solution of collagen to a pH of 4.5 to 7.5 and drying the thus-obtained solution of collagen simultaneously with shaping spherical coverings therefrom.
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公开(公告)号:US4913904A
公开(公告)日:1990-04-03
申请号:US131958
申请日:1987-12-11
申请人: Svyatoslav N. Fyodorov , Sergey N. Bagrov , Tatyana S. Amstislavskaya , Irina A. Maklakova , Sergey V. Maslenkov
发明人: Svyatoslav N. Fyodorov , Sergey N. Bagrov , Tatyana S. Amstislavskaya , Irina A. Maklakova , Sergey V. Maslenkov
CPC分类号: A61L27/3687 , A61L27/3604 , A61L2430/16
摘要: Ophthalmologic collagen coverings derived from animal eyes and a process for preparing such coverings comprising treatment of a fibrous tunic of an animal eye with an alkali metal hydroxide in a saturated solution of a salt of an alkali metal, followed by neutralization, dissolution in an aqueous solution of an organic acid, purification of the resulting solution of collagen by dialysis against a buffer solution while bringing the solution of collagen to a pH of 4.5 to 7.5 and drying the thus-obtained solution of collagen simultaneously with shaping spherical coverings therefrom.
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公开(公告)号:US5094856A
公开(公告)日:1992-03-10
申请号:US611339
申请日:1990-11-09
申请人: Svyatoplay N. Fyodorov , Sergey N. Bagrov , Fatyana S. Amstislavskaya , Irina A. Maklakova , Sergey V. Maslenkov
发明人: Svyatoplay N. Fyodorov , Sergey N. Bagrov , Fatyana S. Amstislavskaya , Irina A. Maklakova , Sergey V. Maslenkov
IPC分类号: A61L27/36
CPC分类号: A61L27/3604 , A61L27/3641 , A61L27/3683 , A61L2430/16 , Y10S128/08 , Y10S514/912 , Y10S514/955
摘要: Ophthalmologic collagen coverings derived from animal eyes and a process preparing such coverings comprising treatment of a fibrous tunic of an animal eye with an alkali metal hydroxide in a saturated solution of a salt of an alkali metal, followed by neutralization, dissolution in an aqueous solution of an organic acid, purification of the resulting solution of collagen by dialysis against a buffer solution while bringing the solution of collagen to a pH of 4.5 to 7.5 and drying the thus-obtained solution of collagen simultaneously with shaping spherical coverings therefrom.
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公开(公告)号:US5286829A
公开(公告)日:1994-02-15
申请号:US549452
申请日:1990-07-06
申请人: Svyatoslav N. Fedorov , Sergei N. Bagrov , Alexei V. Osipov , Elena A. Linnik , Irina A. Maklakova , Alexei N. Kosmynin , Evgeny V. Larionov
发明人: Svyatoslav N. Fedorov , Sergei N. Bagrov , Alexei V. Osipov , Elena A. Linnik , Irina A. Maklakova , Alexei N. Kosmynin , Evgeny V. Larionov
IPC分类号: G02C7/04 , A61K35/12 , A61K35/44 , A61L27/00 , A61L27/16 , A61L27/36 , A61L27/56 , C08F2/44 , C08F2/46 , C08F289/00 , C08F292/00 , C08F299/00 , C08H1/00 , C08H1/06 , G02B1/04 , C08H5/00 , C08G63/48 , C08G63/91
CPC分类号: C08F292/00 , A61L27/16 , A61L27/3604 , A61L27/56 , C08F289/00 , G02B1/043 , A61F2/14
摘要: A biocompatible material which is the product of graft-copolymerization of a water-soluble vinyl and/or an acrylate monomer with a sorption complex of polysilicic acid and collagen that has been rid of pigments, glycoproteins and proteoglycans, or a product obtained by virtue of chemical destruction, with the aid of hydrofluoric acid, of the afore-mentioned product of graft-copolymerization, containing up to 25 mass percent of polysilicic acid (in terms of SiO.sub.2), up to 12 mass percent of protein, and maximum 1 10.sup.-6 mole/g of an anion of hydrofluoric and hydrofluoric acids, methods of making the same and products produced thereby.
摘要翻译: 一种生物相容性材料,其是水溶性乙烯基和/或丙烯酸酯单体与已除去颜料,糖蛋白和蛋白多糖的聚硅酸和胶原的吸附络合物的接枝共聚物或由于 上述的接枝共聚产物的氢氟酸的化学破坏,含有多达25质量%的聚硅酸(以SiO2计),最高达12质量%的蛋白质, 6摩尔/ g氢氟酸和氢氟酸的阴离子,其制备方法和由此产生的产物。
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