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    High temperature materials processing furnace
    1.
    发明授权
    High temperature materials processing furnace 失效
    高温材料加工炉

    公开(公告)号：US06361312B1

    公开(公告)日：2002-03-26

    申请号：US09605603

    申请日：2000-06-28

    申请人： Sydney M. Pugh ,  Timothy J. N. Smith ,  D. Lowell Misener ,  Reginald W. Smith

    发明人： Sydney M. Pugh ,  Timothy J. N. Smith ,  D. Lowell Misener ,  Reginald W. Smith

    IPC分类号： F27B912

    CPC分类号： F27B17/00 ,  F27B17/02

    摘要： The invention is directed to an automated materials processing furnace capable of high temperature operation. The furnace is moveable and enables sample insertion into either end and includes a stationary sample affixed to a replaceable tray. The furnace enables the processing of material samples under both terrestrial and microgravity conditions and also provides for the monitoring of process parameters.

    摘要翻译： 本发明涉及能够进行高温操作的自动化材料加工炉。 炉子是可移动的，并使得样品插入任一端并且包括固定在可替换托盘上的固定样品。 该炉能够在地球和微重力条件下处理材料样品，并且还提供对工艺参数的监测。

    Sintering process for producing thin films of calcium phosphate entities
    4.
    发明授权
    Sintering process for producing thin films of calcium phosphate entities 失效
    用于生产磷酸钙实体薄膜的烧结工艺

    公开(公告)号：US5766669A

    公开(公告)日：1998-06-16

    申请号：US960702

    申请日：1997-10-30

    申请人： Sydney M. Pugh ,  Timothy J. N. Smith

    发明人： Sydney M. Pugh ,  Timothy J. N. Smith

    IPC分类号： A61L27/00 ,  A61F2/00 ,  A61L27/32 ,  C01B25/32 ,  C03C17/25 ,  C04B35/447 ,  C04B41/50 ,  B05D3/02 ,  B05D5/00

    CPC分类号： A61L27/32 ,  C03C17/25 ,  C04B41/5048 ,  A61F2310/00796 ,  C03C2217/23 ,  C03C2218/113 ,  C03C2218/32

    摘要： An improved process for producing a thin film of calcium phosphate entities to support bone cell activity thereon. The material to be sintered is prepared by combining a solution of ammonium phosphate with a solution of calcium nitrate to form a sol-gel containing hydroxyapatite. A film of the sol gel is applied to at least one side of the substrate and the film coated on the substrate is sintered to form a solid film of calcium phosphate entities. The improvement in the process comprising sintering the film at temperatures selected from a range of temperatures which optimize a composition of calcium phosphate entities in the film. The sintering step converts hydroxyapatite to .alpha.-tricalcium phosphate where extent of such conversion is temperature dependent. The optimized composition comprises a ratio of hydroxyapatite to .alpha.-tricalcium phosphate in the range of 50:50 to 20:80. A sintering temperature is selected to provide these ratios. The sintering temperature is selected from a range of 920.degree. C. up to 1100.degree. C. where the higher the select temperature, the greater the amount of .alpha.-tricalcium phosphate in the ratio.

    摘要翻译： 一种用于生产磷酸钙实体薄膜以支持骨细胞活性的改进方法。 待烧结的材料通过将磷酸铵溶液与硝酸钙溶液组合以形成含羟基磷灰石的溶胶 - 凝胶来制备。 将溶胶凝胶膜施加到基材的至少一侧，并将涂覆在基材上的膜烧结以形成磷酸钙实体的固体膜。 该方法的改进包括在选自优化膜中磷酸钙实体的组成的温度范围内的温度下烧结膜。 烧结步骤将羟基磷灰石转化为α-磷酸三钙，其中这种转化的程度是温度依赖性的。 优化的组合物包含羟基磷灰石与α-磷酸三钙的比例为50:50至20:80。 选择烧结温度以提供这些比例。 烧结温度选择在920℃至1100℃的范围内，其中选择温度越高，α磷酸三钙的量越大。

    Advanced tissue engineering system
    5.
    发明授权
    Advanced tissue engineering system 有权
    高级组织工程系统

    公开(公告)号：US09499780B2

    公开(公告)日：2016-11-22

    申请号：US11597550

    申请日：2005-05-26

    申请人： Timothy J. N. Smith ,  Sydney M. Pugh ,  Lowell Misener ,  Guy Oram ,  Rupert Hagg ,  Roberto Tommasini ,  Yves Larcher

    发明人： Timothy J. N. Smith ,  Sydney M. Pugh ,  Lowell Misener ,  Guy Oram ,  Rupert Hagg ,  Roberto Tommasini ,  Yves Larcher

    IPC分类号： C12M1/00 ,  C12M3/00 ,  C12M1/12

    CPC分类号： C12M21/08 ,  C12M23/24 ,  C12M23/34 ,  C12M23/44 ,  C12M25/14 ,  C12M27/16 ,  C12M41/12 ,  C12M45/09 ,  C12M47/04

    摘要： The invention is an automated advanced tissue engineering system that comprises a housing in which one or more tissue engineering modules are accommodated together with a central microprocessor that controls functioning of the tissue engineering modules. In one embodiment, the tissue engineering module comprises a housing supporting one or more bioreactor chamber assemblies and a fluid reservoir operationally engageable with the housing. The bioreactor chamber assemblies may be selected depending on the end product option desired and may include, for example, a cell therapy bioreactor chamber, a single implant bioreactor chamber and a multiple (mosaic) implant bioreactor chamber.

    摘要翻译： 本发明是一种自动化的高级组织工程系统，其包括壳体，其中一个或多个组织工程模块与控制组织工程模块功能的中央微处理器一起容纳在一起。 在一个实施例中，组织工程模块包括支撑一个或多个生物反应器室组件的壳体和可操作地与壳体接合的流体储存器。 可以根据期望的最终产品选择来选择生物反应器室组件，并且可以包括例如细胞治疗生物反应器室，单个植入物生物反应器室和多个（镶嵌）植入物生物反应器室。

    Multi-well bone culture device for use in assessment of bone cell activity
    10.
    发明授权
    Multi-well bone culture device for use in assessment of bone cell activity 失效
    用于评估骨细胞活性的多孔骨培养装置

    公开(公告)号：US5861306A

    公开(公告)日：1999-01-19

    申请号：US847889

    申请日：1997-04-28

    申请人： Sydney M. Pugh ,  Timothy J. N. Smith

    发明人： Sydney M. Pugh ,  Timothy J. N. Smith

    IPC分类号： C12M1/18 ,  B01L3/00 ,  C12M1/34 ,  C12N5/06 ,  C12Q1/06 ,  C12Q1/20 ,  C12M3/00

    CPC分类号： C12M23/12 ,  B01L3/5085 ,  C12M41/46

    摘要： The present invention describes a multi-well bone cell culture device for use in the quantitative and/or qualitative assessment of bone cell activity, the device comprising a flat base having a sintered film of calcium phosphate entities on one side and an open-ended multi chamber unit positioned on top of the film which by a sealing means is sealed to the film coated base forming individual containment wells. The device is useful in the analysis of bone cell function, for the screening and determination of bone cell disease, and the development of drugs to alter bone cell activity.

    摘要翻译： 本发明描述了一种用于定量和/或定性评估骨细胞活性的多孔骨细胞培养装置，该装置包括具有一侧的磷酸钙实体的烧结膜的平坦基底和开放端多孔 位于薄膜顶部的室单元通过密封装置密封到形成单个容纳孔的薄膜包衣基底上。 该装置可用于分析骨细胞功能，用于筛选和测定骨细胞疾病，以及开发用于改变骨细胞活性的药物。