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    Advanced tissue engineering system
    1.
    发明授权
    Advanced tissue engineering system 有权
    高级组织工程系统

    公开(公告)号：US09499780B2

    公开(公告)日：2016-11-22

    申请号：US11597550

    申请日：2005-05-26

    申请人： Timothy J. N. Smith ,  Sydney M. Pugh ,  Lowell Misener ,  Guy Oram ,  Rupert Hagg ,  Roberto Tommasini ,  Yves Larcher

    发明人： Timothy J. N. Smith ,  Sydney M. Pugh ,  Lowell Misener ,  Guy Oram ,  Rupert Hagg ,  Roberto Tommasini ,  Yves Larcher

    IPC分类号： C12M1/00 ,  C12M3/00 ,  C12M1/12

    CPC分类号： C12M21/08 ,  C12M23/24 ,  C12M23/34 ,  C12M23/44 ,  C12M25/14 ,  C12M27/16 ,  C12M41/12 ,  C12M45/09 ,  C12M47/04

    摘要： The invention is an automated advanced tissue engineering system that comprises a housing in which one or more tissue engineering modules are accommodated together with a central microprocessor that controls functioning of the tissue engineering modules. In one embodiment, the tissue engineering module comprises a housing supporting one or more bioreactor chamber assemblies and a fluid reservoir operationally engageable with the housing. The bioreactor chamber assemblies may be selected depending on the end product option desired and may include, for example, a cell therapy bioreactor chamber, a single implant bioreactor chamber and a multiple (mosaic) implant bioreactor chamber.

    摘要翻译： 本发明是一种自动化的高级组织工程系统，其包括壳体，其中一个或多个组织工程模块与控制组织工程模块功能的中央微处理器一起容纳在一起。 在一个实施例中，组织工程模块包括支撑一个或多个生物反应器室组件的壳体和可操作地与壳体接合的流体储存器。 可以根据期望的最终产品选择来选择生物反应器室组件，并且可以包括例如细胞治疗生物反应器室，单个植入物生物反应器室和多个（镶嵌）植入物生物反应器室。

    Advanced Tissue Engineering System
    2.
    发明申请
    Advanced Tissue Engineering System 有权
    高级组织工程系统

    公开(公告)号：US20080113426A1

    公开(公告)日：2008-05-15

    申请号：US11597550

    申请日：2005-05-26

    申请人： Timothy J.N. Smith ,  Sydney M. Pugh ,  Lowell Misener ,  Guy Oram ,  Rupert Hagg ,  Roberto Tommasini ,  Yves Larcher

    发明人： Timothy J.N. Smith ,  Sydney M. Pugh ,  Lowell Misener ,  Guy Oram ,  Rupert Hagg ,  Roberto Tommasini ,  Yves Larcher

    IPC分类号： C12M3/00

    CPC分类号： C12M21/08 ,  C12M23/24 ,  C12M23/34 ,  C12M23/44 ,  C12M25/14 ,  C12M27/16 ,  C12M41/12 ,  C12M45/09 ,  C12M47/04

    摘要： The invention is an automated advanced tissue engineering system that comprises a housing in which one or more tissue engineering modules are accomodated together with a central microprocessor that controls functioning of the tissue engineering modules. In one embodiment, the tissue engineering module comprises a housing supporting one or more bioreactor chamber assemblies and a fluid reservoir operationally engageable with the housing. The bioreactor chamber assemblies may be selected depending on the end product option desired and may include, for example, a cell therapy bioreactor chamber, a single implant bioreactor chamber and a multiple (mosaic) implant bioreactor chamber.

    摘要翻译： 本发明是一种自动化的高级组织工程系统，其包括壳体，其中一个或多个组织工程模块与控制组织工程模块功能的中央微处理器一起容纳。 在一个实施例中，组织工程模块包括支撑一个或多个生物反应器室组件的壳体和可操作地与壳体接合的流体储存器。 可以根据期望的最终产品选择来选择生物反应器室组件，并且可以包括例如细胞治疗生物反应器室，单个植入物生物反应器室和多个（镶嵌）植入物生物反应器室。

    AUTOMATED TISSUE ENGINEERING SYSTEM
    3.
    发明申请
    AUTOMATED TISSUE ENGINEERING SYSTEM 有权
    自动组织工程系统

    公开(公告)号：US20140186937A1

    公开(公告)日：2014-07-03

    申请号：US13906719

    申请日：2013-05-31

    申请人： Timothy J.N. Smith ,  Sydney M. Pugh ,  Martin R. Pacaric ,  Rupert Hagg ,  Roberto Tommasini ,  Yves Larcher ,  Lowell D. Misener

    发明人： Timothy J.N. Smith ,  Sydney M. Pugh ,  Martin R. Pacaric ,  Rupert Hagg ,  Roberto Tommasini ,  Yves Larcher ,  Lowell D. Misener

    IPC分类号： C12M3/00

    CPC分类号： C12M21/08 ,  C12M23/28 ,  C12M23/42 ,  C12M23/52 ,  C12M25/14 ,  C12M29/04 ,  C12M41/46 ,  C12M41/48 ,  C12M45/09 ,  C12M47/06 ,  C12M47/12 ,  C12N5/0068 ,  C12N5/0618 ,  C12N5/0654 ,  C12N5/0655 ,  C12N2509/00

    摘要： The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.

    摘要翻译： 本发明提供用于组织工程产品的自动化培养，增殖，分化，生产和维护的系统，模块，生物反应器和方法。 一方面是一种自动化组织工程系统，其包括壳体，由壳体支撑的至少一个生物反应器，促进生理细胞功能的生物反应器和/或从细胞和/或组织来源产生一种或多种组织构建体。 流体容纳系统由壳体支撑并且与生物反应器流体连通。 一个或多个传感器与壳体，生物反应器或流体容纳系统中的一个或多个相关联，用于监测与生理细胞功能相关的参数和/或组织构建体的产生; 以及连接到一个或多个传感器的微处理器。 本发明的系统，方法和产品可用于各种临床和实验室设置。

    High temperature materials processing furnace
    4.
    发明授权
    High temperature materials processing furnace 失效
    高温材料加工炉

    公开(公告)号：US06361312B1

    公开(公告)日：2002-03-26

    申请号：US09605603

    申请日：2000-06-28

    申请人： Sydney M. Pugh ,  Timothy J. N. Smith ,  D. Lowell Misener ,  Reginald W. Smith

    发明人： Sydney M. Pugh ,  Timothy J. N. Smith ,  D. Lowell Misener ,  Reginald W. Smith

    IPC分类号： F27B912

    CPC分类号： F27B17/00 ,  F27B17/02

    摘要： The invention is directed to an automated materials processing furnace capable of high temperature operation. The furnace is moveable and enables sample insertion into either end and includes a stationary sample affixed to a replaceable tray. The furnace enables the processing of material samples under both terrestrial and microgravity conditions and also provides for the monitoring of process parameters.

    摘要翻译： 本发明涉及能够进行高温操作的自动化材料加工炉。 炉子是可移动的，并使得样品插入任一端并且包括固定在可替换托盘上的固定样品。 该炉能够在地球和微重力条件下处理材料样品，并且还提供对工艺参数的监测。

    Sintering process for producing thin films of calcium phosphate entities
    7.
    发明授权
    Sintering process for producing thin films of calcium phosphate entities 失效
    用于生产磷酸钙实体薄膜的烧结工艺

    公开(公告)号：US5766669A

    公开(公告)日：1998-06-16

    申请号：US960702

    申请日：1997-10-30

    申请人： Sydney M. Pugh ,  Timothy J. N. Smith

    发明人： Sydney M. Pugh ,  Timothy J. N. Smith

    IPC分类号： A61L27/00 ,  A61F2/00 ,  A61L27/32 ,  C01B25/32 ,  C03C17/25 ,  C04B35/447 ,  C04B41/50 ,  B05D3/02 ,  B05D5/00

    CPC分类号： A61L27/32 ,  C03C17/25 ,  C04B41/5048 ,  A61F2310/00796 ,  C03C2217/23 ,  C03C2218/113 ,  C03C2218/32

    摘要： An improved process for producing a thin film of calcium phosphate entities to support bone cell activity thereon. The material to be sintered is prepared by combining a solution of ammonium phosphate with a solution of calcium nitrate to form a sol-gel containing hydroxyapatite. A film of the sol gel is applied to at least one side of the substrate and the film coated on the substrate is sintered to form a solid film of calcium phosphate entities. The improvement in the process comprising sintering the film at temperatures selected from a range of temperatures which optimize a composition of calcium phosphate entities in the film. The sintering step converts hydroxyapatite to .alpha.-tricalcium phosphate where extent of such conversion is temperature dependent. The optimized composition comprises a ratio of hydroxyapatite to .alpha.-tricalcium phosphate in the range of 50:50 to 20:80. A sintering temperature is selected to provide these ratios. The sintering temperature is selected from a range of 920.degree. C. up to 1100.degree. C. where the higher the select temperature, the greater the amount of .alpha.-tricalcium phosphate in the ratio.

    摘要翻译： 一种用于生产磷酸钙实体薄膜以支持骨细胞活性的改进方法。 待烧结的材料通过将磷酸铵溶液与硝酸钙溶液组合以形成含羟基磷灰石的溶胶 - 凝胶来制备。 将溶胶凝胶膜施加到基材的至少一侧，并将涂覆在基材上的膜烧结以形成磷酸钙实体的固体膜。 该方法的改进包括在选自优化膜中磷酸钙实体的组成的温度范围内的温度下烧结膜。 烧结步骤将羟基磷灰石转化为α-磷酸三钙，其中这种转化的程度是温度依赖性的。 优化的组合物包含羟基磷灰石与α-磷酸三钙的比例为50:50至20:80。 选择烧结温度以提供这些比例。 烧结温度选择在920℃至1100℃的范围内，其中选择温度越高，α磷酸三钙的量越大。