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公开(公告)号：US20070265281A1
公开(公告)日：2007-11-15
申请号：US11697901
申请日：2007-04-09
申请人： Sylvain Cottens , Claus Ehrhardt , Jiping Fu , David Parker , Michael Patane , Branko Radetich , Prakash Raman , Stefan Randl , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic , Dongpeng Wan
发明人： Sylvain Cottens , Claus Ehrhardt , Jiping Fu , David Parker , Michael Patane , Branko Radetich , Prakash Raman , Stefan Randl , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic , Dongpeng Wan
IPC分类号： A61K31/4965 , A61K31/16 , A61K31/18 , C07C233/00 , C07D209/04 , C07D241/02 , C07C303/00 , A61P31/00 , A61K31/405
CPC分类号： C07K5/0812 , A61K38/00 , C07K5/06078 , C07K5/06165 , C07K5/0808 , C07K5/1016
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
摘要翻译： 本申请描述了可用于治疗，预防和/或改善人类疾病的有机化合物。
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公开(公告)号：US20080045530A1
公开(公告)日：2008-02-21
申请号：US11697889
申请日：2007-04-09
申请人： Trixi Brandl , Shawn Britt , Sylvain Cottens , Claus Ehrhardt , Jiping Fu , Subramanian Karur , Hongju Li , Peichao Lu , David Parker , Michael Patane , Branko Radetich , Prakash Raman , Stefan Randl , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic , Ritesh Tichkule , Yanyi Zhu
发明人： Trixi Brandl , Shawn Britt , Sylvain Cottens , Claus Ehrhardt , Jiping Fu , Subramanian Karur , Hongju Li , Peichao Lu , David Parker , Michael Patane , Branko Radetich , Prakash Raman , Stefan Randl , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic , Ritesh Tichkule , Yanyi Zhu
IPC分类号： A61K31/195 , A61K31/40 , A61K31/421 , A61K31/445 , A61K31/47 , A61K31/4965 , A61K31/497 , A61K31/5375 , A61P31/12 , C07D207/00 , C07D217/00 , C07D241/02
CPC分类号： C07D403/12 , C07D207/08 , C07D217/04 , C07D241/04 , C07D401/14 , C07D405/14 , C07D407/12 , C07D413/04 , C07D413/12 , C07D413/14
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
摘要翻译： 本申请描述了可用于治疗，预防和/或改善人类疾病的有机化合物。
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公开(公告)号：US20100240638A1
公开(公告)日：2010-09-23
申请号：US12527787
申请日：2008-02-19
申请人： Shawn D. Britt , Jiping Fu , David Thomas Parker , Michiael Patane , Parkash Raman , Branko Radetich , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng , Trixi Brand , Sylvain Cottens , Claus Ehrhardt , Stefan Andreas Randl , Pascal Rigollier , Nikolaus Schiering , Oliver Simic
发明人： Shawn D. Britt , Jiping Fu , David Thomas Parker , Michiael Patane , Parkash Raman , Branko Radetich , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng , Trixi Brand , Sylvain Cottens , Claus Ehrhardt , Stefan Andreas Randl , Pascal Rigollier , Nikolaus Schiering , Oliver Simic
IPC分类号： C07D285/00 , A61K38/13 , A61K31/33 , A61K31/00 , A61K31/551 , A61K31/5025 , A61K31/5377 , A61K31/50 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/4375 , A61K31/437 , A61K31/47 , A61K31/4523 , A61K31/4427 , A61K31/403 , A61P31/12 , A61P35/04 , A61P1/16 , A61P37/00
CPC分类号： C07D513/04 , C07D257/02 , C07D285/00 , C07D487/04 , C07D487/08 , C07D498/04 , C07D515/04 , C07D519/00 , C07K5/0202 , C07K5/0207 , C07K5/0804 , C07K5/0827 , C07K5/1008 , C07K5/1024
摘要： The present application describes macrocyclic compounds of formula (I) with NS3 protease inhibitory activity for treating hepatitis C virus infection.
摘要翻译： 本申请描述了式（I）的大环化合物与用于治疗丙型肝炎病毒感染的NS3蛋白酶抑制活性。
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公开(公告)号：US08445527B2
公开(公告)日：2013-05-21
申请号：US13477866
申请日：2012-05-22
申请人： Michael Patane , Prakash Raman , David Thomas Parker , Jiping Fu , Branko Radetich , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng , Trixi Brandl , Francois Lenoir , Pascal Rigollier , Oliver Simic
发明人： Michael Patane , Prakash Raman , David Thomas Parker , Jiping Fu , Branko Radetich , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng , Trixi Brandl , Francois Lenoir , Pascal Rigollier , Oliver Simic
IPC分类号： A61K31/5377 , A61K31/506 , A61K31/497 , A61K31/4439 , A61K31/454 , A61K31/427 , A61K31/422 , A61K31/4178 , A61K31/4155 , A61K31/403
CPC分类号： A61K38/07 , A61K38/00 , A61K38/06 , A61K45/06 , C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/10 , C07D491/20 , C07D495/10 , C07D498/04 , C07D498/10 , C07K5/06034 , C07K5/06078 , C07K5/06165 , C07K5/0808 , C07K5/0812 , C07K5/101 , C07K5/1016
摘要： The present invention provides a method of treating a HCV infection in a subject in need thereof by administering a compound of Formula I: or pharmaceutically acceptable salts thereof or stereoisomers thereof.
摘要翻译： 本发明提供了通过给予式I化合物或其药学上可接受的盐或其立体异构体来治疗有需要的受试者的HCV感染的方法。
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公开(公告)号：US20120231998A1
公开(公告)日：2012-09-13
申请号：US13477866
申请日：2012-05-22
申请人： Trixi Brandl , Jiping Fu , Francois Lenoir , David Thomas Parker , Michael Patane , Branko Radetich , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic , Aregahegn Yifru , Rui Zheng
发明人： Trixi Brandl , Jiping Fu , Francois Lenoir , David Thomas Parker , Michael Patane , Branko Radetich , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic , Aregahegn Yifru , Rui Zheng
CPC分类号： A61K38/07 , A61K38/00 , A61K38/06 , A61K45/06 , C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/10 , C07D491/20 , C07D495/10 , C07D498/04 , C07D498/10 , C07K5/06034 , C07K5/06078 , C07K5/06165 , C07K5/0808 , C07K5/0812 , C07K5/101 , C07K5/1016
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
摘要翻译： 本申请描述了可用于治疗，预防和/或改善人类疾病的有机化合物。
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公开(公告)号：US07825152B2
公开(公告)日：2010-11-02
申请号：US11697894
申请日：2007-04-09
申请人： Trixi Brandl , Jiping Fu , Francois Lenoir , David Thomas Parker , Michael Patane , Branko Radetich , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic , Aregahegn Yifru , Rui Zheng
发明人： Trixi Brandl , Jiping Fu , Francois Lenoir , David Thomas Parker , Michael Patane , Branko Radetich , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic , Aregahegn Yifru , Rui Zheng
IPC分类号： C07D417/12 , C07D403/12 , C07D401/12 , C07D409/12 , C07D417/14 , C07D405/12 , C07D413/12 , C07D405/04 , C07D403/04 , C07D413/14 , C07D409/14 , C07D405/14 , C07D207/00 , C07D209/96 , A61K31/5377 , A61K31/506 , A61K31/497 , A61K31/4439 , A61K31/454 , A61K31/427 , A61K31/422 , A61K31/4178 , A61K31/4155 , A61K31/403
CPC分类号： A61K38/07 , A61K38/00 , A61K38/06 , A61K45/06 , C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/10 , C07D491/20 , C07D495/10 , C07D498/04 , C07D498/10 , C07K5/06034 , C07K5/06078 , C07K5/06165 , C07K5/0808 , C07K5/0812 , C07K5/101 , C07K5/1016
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
摘要翻译： 本申请描述了可用于治疗，预防和/或改善人类疾病的有机化合物。
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公开(公告)号：US20100204159A1
公开(公告)日：2010-08-12
申请号：US12440139
申请日：2007-09-11
申请人： Trixl Brandl , Sylvain Cottens , Claus Ehrhardt , Jiping Fu , Subramanian Karur , David Thomas Parker , Michael A. Patane , Prakash Raman , Stefan Andreas Randl , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic
发明人： Trixl Brandl , Sylvain Cottens , Claus Ehrhardt , Jiping Fu , Subramanian Karur , David Thomas Parker , Michael A. Patane , Prakash Raman , Stefan Andreas Randl , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic
IPC分类号： A61K38/06 , C07D417/14 , A61P31/14 , A61K38/05 , C07K5/083
CPC分类号： C07D417/14 , C07D401/12 , C07D419/14 , C07K5/06078 , C07K5/0808 , C07K5/0823 , C12N2770/24211
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
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公开(公告)号：US08211932B2
公开(公告)日：2012-07-03
申请号：US12879644
申请日：2010-09-10
申请人： Michael Patane , Prakash Raman , David Thomas Parker , Jiping Fu , Branko Radetich , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng , Trixi Brandl , Francois Lenoir , Pascal Rigollier , Oliver Simic
发明人： Michael Patane , Prakash Raman , David Thomas Parker , Jiping Fu , Branko Radetich , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng , Trixi Brandl , Francois Lenoir , Pascal Rigollier , Oliver Simic
IPC分类号： C07D417/12 , C07D403/12 , C07D401/12 , C07D409/12 , C07D417/14 , C07D405/12 , C07D413/12 , C07D405/04 , C07D403/04 , C07D413/14 , C07D409/14 , C07D405/14 , C07D207/00 , C07D209/96 , A61K31/5377 , A61K31/506 , A61K31/497 , A61K31/4439 , A61K31/454 , A61K31/427 , A61K31/422 , A61K31/4178 , A61K31/4155 , A61K31/403
CPC分类号： A61K38/07 , A61K38/00 , A61K38/06 , A61K45/06 , C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/10 , C07D491/20 , C07D495/10 , C07D498/04 , C07D498/10 , C07K5/06034 , C07K5/06078 , C07K5/06165 , C07K5/0808 , C07K5/0812 , C07K5/101 , C07K5/1016
摘要： The present application describes organic compounds of the Formula I that are useful for the treatment, prevention and/or amelioration of human diseases.
摘要翻译： 本申请描述了可用于治疗，预防和/或改善人类疾病的式I的有机化合物。
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公开(公告)号：US20100331243A1
公开(公告)日：2010-12-30
申请号：US12879644
申请日：2010-09-10
申请人： Trixi Brandl , Jiping Fu , Francois Lenoir , David Thomas Parker , Michael Patane , Branko Radetich , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic , Aregahegn Yifru , Rui Zheng
发明人： Trixi Brandl , Jiping Fu , Francois Lenoir , David Thomas Parker , Michael Patane , Branko Radetich , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic , Aregahegn Yifru , Rui Zheng
CPC分类号： A61K38/07 , A61K38/00 , A61K38/06 , A61K45/06 , C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/10 , C07D491/20 , C07D495/10 , C07D498/04 , C07D498/10 , C07K5/06034 , C07K5/06078 , C07K5/06165 , C07K5/0808 , C07K5/0812 , C07K5/101 , C07K5/1016
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
摘要翻译： 本申请描述了可用于治疗，预防和/或改善人类疾病的有机化合物。
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公开(公告)号：US20070286842A1
公开(公告)日：2007-12-13
申请号：US11697894
申请日：2007-04-09
申请人： Trixi Brandl , Jiping Fu , Francois Lenoir , David Parker , Michael Patane , Branko Redetich , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic , Aregahegn Yifru , Rui Zheng
发明人： Trixi Brandl , Jiping Fu , Francois Lenoir , David Parker , Michael Patane , Branko Redetich , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic , Aregahegn Yifru , Rui Zheng
IPC分类号： A61K38/21 , A61K31/40 , A61K31/421 , A61K31/44 , A61P31/12 , C07D207/00 , C07D239/02 , C07D251/02 , C07D295/00 , C12N9/99 , C12N7/06 , C07D263/52 , C07D241/02 , C07D213/02 , A61P7/00 , A61K31/495 , A61K31/53 , A61K31/5377
CPC分类号： A61K38/07 , A61K38/00 , A61K38/06 , A61K45/06 , C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/10 , C07D491/20 , C07D495/10 , C07D498/04 , C07D498/10 , C07K5/06034 , C07K5/06078 , C07K5/06165 , C07K5/0808 , C07K5/0812 , C07K5/101 , C07K5/1016
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
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