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    Mesothelin vaccines and model systems
    4.
    发明申请
    Mesothelin vaccines and model systems 审中-公开
    间皮素疫苗和模型系统

    公开(公告)号：US20050175625A1

    公开(公告)日：2005-08-11

    申请号：US10618088

    申请日：2003-07-14

    申请人： Elizabeth Jaffee ,  Tzyy-Choou Wu ,  Chien-Fu Hung ,  Ralph Hruban

    发明人： Elizabeth Jaffee ,  Tzyy-Choou Wu ,  Chien-Fu Hung ,  Ralph Hruban

    IPC分类号： A61K39/00

    CPC分类号： A61K39/0011 ,  A61K2039/523 ,  A61K2039/53 ,  A61K2039/57 ,  A61K2039/6031 ,  Y02A50/484

    摘要： Mesothelin can be used as an immunotherapeutic target. It induces a cytolytic T cell response. Portions of mesothelin which induce such responses are identified. Vaccines can be either polynucleotide- or polypeptide-based. Carriers for raising a cytolytic T cell response include bacteria and viruses. A mouse model for testing vaccines and other anti-tumor therapeutics and prophylactics comprises a strongly mesothelin-expressing, transformed peritoneal cell line.

    摘要翻译： 间皮素可用作免疫治疗靶标。 它诱导细胞溶解性T细胞反应。 确定诱导这种反应的间皮素的部分。 疫苗可以是多核苷酸或基于多肽的。 提高溶细胞T细胞应答的载体包括细菌和病毒。 用于测试疫苗和其他抗肿瘤治疗剂和预防剂的小鼠模型包括强表达间皮素的转化的腹膜细胞系。

    RNA interference that blocks expression of pro-apoptotic proteins potentiates immunity induced by DNA and transfected dendritic cell vaccines
    7.
    发明授权
    RNA interference that blocks expression of pro-apoptotic proteins potentiates immunity induced by DNA and transfected dendritic cell vaccines 有权
    阻断促凋亡蛋白表达的RNA干扰增强由DNA和转染的树突细胞疫苗诱导的免疫

    公开(公告)号：US09011866B2

    公开(公告)日：2015-04-21

    申请号：US11773162

    申请日：2007-07-03

    申请人： Tzyy-Choou Wu ,  Chien-Fu Hung

    发明人： Tzyy-Choou Wu ,  Chien-Fu Hung

    IPC分类号： A61K38/00 ,  C07H21/04 ,  C12N15/11 ,  A61K31/7088 ,  C12N15/113

    CPC分类号： C12N15/111 ,  A61K31/7088 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/31 ,  A61K2300/00

    摘要： An immunotherapeutic strategy is disclosed that combines antigen-encoding DNA vaccine compositions combined with siRNA directed to pro-apoptotic genes, primarily Bak and Bax, the products of which are known to lead to apoptotic death. Gene gun delivery (particle bombardment) of siRNA specific for Bak and/or Bax to antigen-expressing DCs prolongs the lives of such DCs and lead to enhanced generation of antigen-specific CD8+ T cell-mediated immune responses in vivo. Similarly, antigen-loaded DC's transfected with siRNA targeting Bak and/or Bax serve as improved immunogens and tumor immunotherapeutic agents.

    摘要翻译： 公开了免疫治疗策略，其将抗原编码DNA疫苗组合物与针对促凋亡基因的siRNA组合，主要是Bak和Bax，其产物已知导致凋亡死亡。 对Bak和/或Bax对抗原表达DCs的特异性siRNA的基因枪递送（粒子轰击）延长了这种DC的寿命，并导致体内抗原特异性CD8 + T细胞介导的免疫应答的增强产生。 类似地，用靶向Bak和/或Bax的siRNA转染的抗原负载的DC用作改进的免疫原和肿瘤免疫治疗剂。

    Compositions and Methods for Enhancing Antigen-Specific Immune Responses
    9.
    发明申请
    Compositions and Methods for Enhancing Antigen-Specific Immune Responses 审中-公开
    用于增强抗原特异性免疫应答的组合物和方法

    公开(公告)号：US20120244173A1

    公开(公告)日：2012-09-27

    申请号：US13318028

    申请日：2010-04-28

    申请人： Tzyy-Choou Wu ,  Chien-Fu Hung

    发明人： Tzyy-Choou Wu ,  Chien-Fu Hung

    IPC分类号： A61K39/00 ,  A61P35/00

    CPC分类号： A61K39/0011 ,  A61K35/13 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/57 ,  C12N2710/16043 ,  C12N2710/20022 ,  C12N2710/24143

    摘要： Methods for treating or preventing recurrence of hyper proliferating diseases, e.g., cancer, are described. A method may comprise priming a mammal by administering to the mammal an effective amount of a nucleic acid composition encoding an antigen or a biologically active homo log thereof and boosting the mammal by administering to the mammal an effective amount of an oncolytic virus comprising a nucleic acid encoding the antigen or the biologically active homolog thereof.

    摘要翻译： 描述了用于治疗或预防高增殖性疾病例如癌症复发的方法。 一种方法可以包括通过向哺乳动物施用有效量的编码抗原或其生物活性同源物的核酸组合物来引发哺乳动物，并通过向哺乳动物施用有效量的包含核酸的溶瘤病毒来加强哺乳动物 编码抗原或其生物活性同源物。