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    Superior Molecular Vaccine Linking the Translocation Domain of a Bacterial Toxin to an Antigen
    4.
    发明申请
    Superior Molecular Vaccine Linking the Translocation Domain of a Bacterial Toxin to an Antigen 有权
    将细菌毒素的易位结构连接到抗原上的优异的分子疫苗

    公开(公告)号：US20120263748A1

    公开(公告)日：2012-10-18

    申请号：US13412206

    申请日：2012-03-05

    申请人： Tzyy-Choou Wu ,  Chien-Fu Hung

    发明人： Tzyy-Choou Wu ,  Chien-Fu Hung

    IPC分类号： A61K39/00 ,  A61P37/04 ,  A61P35/00 ,  C07K19/00

    CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/53 ,  C07K14/21 ,  C07K14/35 ,  C07K14/475 ,  C07K14/535 ,  C07K2319/00 ,  C12N2710/20022

    摘要： Nucleic acids encoding a chimeric or fusion polypeptide which polypeptide comprises a first domain comprising a translocation polypeptide; and a second domain comprising at least one antigenic peptide are disclosed. The preferred translocation polypeptide is a bacterial toxin translocation polypeptide, such as domain II of Pseudomonas aeruginosa exotoxin A (ETA(dII)). Such nucleic acids, expression vectors thereof, and cells expressing these vectors are used as vaccine compositions in a method for enhancing an antigen specific immune response, a method of increasing the numbers of CD8+ CTLs specific for a selected desired antigen in a subject, or a method of inhibiting the growth of a tumor in a subject.

    摘要翻译： 编码嵌合或融合多肽的核酸，所述多肽包含包含易位多肽的第一结构域; 并且公开了包含至少一种抗原肽的第二结构域。 优选的易位多肽是细菌毒素易位多肽，例如铜绿假单胞菌外毒素A（ETA（dII））的结构域II）。 或这些核酸，其表达载体和表达这些载体的细胞用作增强抗原特异性免疫应答的方法中的疫苗组合物，增加受试者中选定的所需抗原特异性的CD8 + CTL的数量的方法，或 抑制受试者肿瘤生长的方法。

    Molecular vaccine linking an endoplasmic chaperone polypeptide to an antigen
    5.
    发明授权
    Molecular vaccine linking an endoplasmic chaperone polypeptide to an antigen 有权
    将内质谱伴侣多肽与抗原连接的分子疫苗

    公开(公告)号：US07342002B2

    公开(公告)日：2008-03-11

    申请号：US10343448

    申请日：2001-08-02

    申请人： Tzyy-Choou Wu ,  Chien-Fu Hung

    发明人： Tzyy-Choou Wu ,  Chien-Fu Hung

    IPC分类号： A61K48/00 ,  C12N15/63 ,  A01N63/00

    CPC分类号： C07K19/00 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  A61K2039/5154 ,  A61K2039/6031 ,  C07K14/47 ,  C07K14/4725 ,  C07K14/70539 ,  C07K2319/00 ,  C07K2319/35

    摘要： This invention provides compositions and methods for inducing and enhancing immune responses, such as antigen-specific cytotoxic T lymphocyte (CTL) responses, using chimeric molecules comprising endoplasmic reticulum chaperone polypeptides and antigenic peptides. In particular, the invention provides compositions and methods for enhancing immune responses induced by polypeptides made in vivo by administered nucleic acid, such as naked DNA or expression vectors, encoding the chimeric molecules. The invention provides a method of inhibiting the growth of a tumor in an individual. The invention also provides novel self-replicating RNA virus constructs for enhancing immune responses induced by chimeric polypeptides made in vivo.

    摘要翻译： 本发明提供了使用包含内质网伴侣伴侣多肽和抗原肽的嵌合分子来诱导和增强免疫应答如抗原特异性细胞毒性T淋巴细胞（CTL）应答的组合物和方法。 特别地，本发明提供用于增强由通过施用的核酸例如裸DNA或表达载体在体内制备的由编码嵌合分子的免疫应答的组合物和方法。 本发明提供抑制个体肿瘤生长的方法。 本发明还提供了用于增强由体内制备的嵌合多肽诱导的免疫应答的新型自复制RNA病毒构建体。

    RNA interference that blocks expression of pro-apoptotic proteins potentiates immunity induced by DNA and transfected dendritic cell vaccines
    9.
    发明授权
    RNA interference that blocks expression of pro-apoptotic proteins potentiates immunity induced by DNA and transfected dendritic cell vaccines 有权
    阻断促凋亡蛋白表达的RNA干扰增强由DNA和转染的树突细胞疫苗诱导的免疫

    公开(公告)号：US09011866B2

    公开(公告)日：2015-04-21

    申请号：US11773162

    申请日：2007-07-03

    申请人： Tzyy-Choou Wu ,  Chien-Fu Hung

    发明人： Tzyy-Choou Wu ,  Chien-Fu Hung

    IPC分类号： A61K38/00 ,  C07H21/04 ,  C12N15/11 ,  A61K31/7088 ,  C12N15/113

    CPC分类号： C12N15/111 ,  A61K31/7088 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/31 ,  A61K2300/00

    摘要： An immunotherapeutic strategy is disclosed that combines antigen-encoding DNA vaccine compositions combined with siRNA directed to pro-apoptotic genes, primarily Bak and Bax, the products of which are known to lead to apoptotic death. Gene gun delivery (particle bombardment) of siRNA specific for Bak and/or Bax to antigen-expressing DCs prolongs the lives of such DCs and lead to enhanced generation of antigen-specific CD8+ T cell-mediated immune responses in vivo. Similarly, antigen-loaded DC's transfected with siRNA targeting Bak and/or Bax serve as improved immunogens and tumor immunotherapeutic agents.

    摘要翻译： 公开了免疫治疗策略，其将抗原编码DNA疫苗组合物与针对促凋亡基因的siRNA组合，主要是Bak和Bax，其产物已知导致凋亡死亡。 对Bak和/或Bax对抗原表达DCs的特异性siRNA的基因枪递送（粒子轰击）延长了这种DC的寿命，并导致体内抗原特异性CD8 + T细胞介导的免疫应答的增强产生。 类似地，用靶向Bak和/或Bax的siRNA转染的抗原负载的DC用作改进的免疫原和肿瘤免疫治疗剂。