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公开(公告)号：US11130127B2
公开(公告)日：2021-09-28
申请号：US16777795
申请日：2020-01-30
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Ahmed Zobi , Justin Stovner , Hugo Salas , David Duarte , Jered Haun , Alan Widgerow , Derek Banyard
Abstract: Provided herein are devices and methods of processing a sample that include, in several embodiments, rotating one or more microfluidic chips that are mounted on a support plate using a motor driven rotational chuck. By spinning one or more of the microfluidic chips about a common center of rotation in a controlled manner, high flow rates (and high shear forces) are imparted to the sample in a controlled manner. Each microfluidic chip can be rotated 180° on the support plate so that the sample can be run back-and-forth through the microfluidic devices. Because the support plate can be driven at relatively high RPMs, high flow rates are generated within the microfluidic chips. This increases the shear forces on the sample and also decreases the processing time involved as the sample can quickly pass through the shear-inducing features of the microfluidic chip(s).
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公开(公告)号：US10722540B1
公开(公告)日：2020-07-28
申请号：US15421206
申请日：2017-01-31
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Jered Haun , Alan Widgerow , Derek Banyard , Xiaolong Qiu
Abstract: A method of processing a lipoaspirate sample includes mechanically processing the lipoaspirate sample to generate nanofat. The nanofat is then input into a microfluidic device comprising a plurality of serially arranged stages comprising one or more microfluidic channels having a plurality of expansion and constriction regions extending along the length of the one or more microfluidic channels, wherein each subsequent stage of the plurality has an increasing number of microfluidic channels of decreasing dimensions. The nanofat is flowed through the plurality of serially arranged stages in a plurality of cycles to generate sheared nanofat. The sheared nanofat is then collected after flowing through the plurality of serially arranged stages. The sheared nanofat may then be injected and/or applied to the subject. In an alternative embodiment, filtered or mechanically processed lipoaspirate may be run through the microfluidic device.
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公开(公告)号：US12201978B2
公开(公告)日：2025-01-21
申请号：US17412841
申请日：2021-08-26
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Ahmed Zobi , Justin Stovner , Hugo Salas , David Duarte , Jered Haun , Alan Widgerow , Derek Banyard
Abstract: Provided herein are devices and methods of processing a sample that include, in several embodiments, rotating one or more microfluidic chips that are mounted on a support plate using a motor driven rotational chuck. By spinning one or more of the microfluidic chips about a common center of rotation in a controlled manner, high flow rates (and high shear forces) are imparted to the sample in a controlled manner. Each microfluidic chip can be rotated 180° on the support plate so that the sample can be run back-and-forth through the microfluidic devices. Because the support plate can be driven at relatively high RPMs, high flow rates are generated within the microfluidic chips. This increases the shear forces on the sample and also decreases the processing time involved as the sample can quickly pass through the shear-inducing features of the microfluidic chip(s).
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Patent Agency Ranking
公开(公告)号：US20220097050A1
公开(公告)日：2022-03-31
申请号：US17412841
申请日：2021-08-26
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Ahmed Zobi , Justin Stovner , Hugo Salas , David Duarte , Jered Haun , Alan Widgerow , Derek Banyard
Abstract: Provided herein are devices and methods of processing a sample that include, in several embodiments, rotating one or more microfluidic chips that are mounted on a support plate using a motor driven rotational chuck. By spinning one or more of the microfluidic chips about a common center of rotation in a controlled manner, high flow rates (and high shear forces) are imparted to the sample in a controlled manner. Each microfluidic chip can be rotated 180° on the support plate so that the sample can be run back-and-forth through the microfluidic devices. Because the support plate can be driven at relatively high RPMs, high flow rates are generated within the microfluidic chips. This increases the shear forces on the sample and also decreases the processing time involved as the sample can quickly pass through the shear-inducing features of the microfluidic chip(s).
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公开(公告)号：US10589268B2
公开(公告)日：2020-03-17
申请号：US16101254
申请日：2018-08-10
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Ahmed Zobi , Justin Stovner , Hugo Salas , David Duarte , Jered Haun , Alan Widgerow , Derek Banyard
Abstract: Provided herein are devices and methods of processing a sample that include, in several embodiments, rotating one or more microfluidic chips that are mounted on a support plate using a motor driven rotational chuck. By spinning one or more of the microfluidic chips about a common center of rotation in a controlled manner, high flow rates (and high shear forces) are imparted to the sample in a controlled manner. Each microfluidic chip can be rotated 180° on the support plate so that the sample can be run back-and-forth through the microfluidic devices. Because the support plate can be driven at relatively high RPMs, high flow rates are generated within the microfluidic chips. This increases the shear forces on the sample and also decreases the processing time involved as the sample can quickly pass through the shear-inducing features of the microfluidic chip(s).
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公开(公告)号：US12023410B2
公开(公告)日：2024-07-02
申请号：US16615483
申请日：2018-05-22
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Alan D. Widgerow , Derek Banyard , Michael Klopfer , Lohrasb H. Sayadi
CPC classification number: A61K9/51 , A61K9/08 , A61K9/5089 , A61M1/85 , A61M3/0279 , A61M3/0283 , A61M35/30 , A61B2218/001 , A61M1/77 , A61M1/94 , A61M2205/3344
Abstract: The invention provides an apparatus for the generation and administration of a micro-nanobubble solution to a tissue, a method for the treatment of a tissue with a solution of micro-nanobubbles, and a kit for the treatment of tissue with micro-nanobubbles.
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公开(公告)号：US20200164374A1
公开(公告)日：2020-05-28
申请号：US16777795
申请日：2020-01-30
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Ahmed Zobi , Justin Stovner , Hugo Salas , David Duarte , Jered Haun , Alan Widgerow , Derek Banyard
Abstract: Provided herein are devices and methods of processing a sample that include, in several embodiments, rotating one or more microfluidic chips that are mounted on a support plate using a motor driven rotational chuck. By spinning one or more of the microfluidic chips about a common center of rotation in a controlled manner, high flow rates (and high shear forces) are imparted to the sample in a controlled manner. Each microfluidic chip can be rotated 180° on the support plate so that the sample can be run back-and-forth through the microfluidic devices. Because the support plate can be driven at relatively high RPMs, high flow rates are generated within the microfluidic chips. This increases the shear forces on the sample and also decreases the processing time involved as the sample can quickly pass through the shear-inducing features of the microfluidic chip(s).
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公开(公告)号：US20180361382A1
公开(公告)日：2018-12-20
申请号：US16101254
申请日：2018-08-10
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Ahmed Zobi , Justin Stovner , Hugo Salas , David Duarte , Jered Haun , Alan Widgerow , Derek Banyard
Abstract: Provided herein are devices and methods of processing a sample that include, in several embodiments, rotating one or more microfluidic chips that are mounted on a support plate using a motor driven rotational chuck. By spinning one or more of the microfluidic chips about a common center of rotation in a controlled manner, high flow rates (and high shear forces) are imparted to the sample in a controlled manner. Each microfluidic chip can be rotated 180° on the support plate so that the sample can be run back-and-forth through the microfluidic devices. Because the support plate can be driven at relatively high RPMs, high flow rates are generated within the microfluidic chips. This increases the shear forces on the sample and also decreases the processing time involved as the sample can quickly pass through the shear-inducing features of the microfluidic chip(s).
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