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公开(公告)号：US11647959B2
公开(公告)日：2023-05-16
申请号：US16958165
申请日：2019-01-02
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor： Duxin Sun , Yogesh B. Gianchandani , Tao Li , Jinhui Liao , Qisen Cheng , Johnathan Lewis , Ryan Meredith , Jeremy Felton
CPC classification number: A61B5/6861 , A61B5/01 , A61B5/036 , A61B5/073 , A61B5/14539 , A61B10/0045 , A61B5/4255 , A61B2010/0061 , A61B2560/0214 , A61B2562/06 , A61B2562/162
Abstract: An ingestible electronic capsule for the collection of samples along a gastric intestinal tract and methods relating thereto are provided. The ingestible electronic capsule includes a housing and a cap that form an interior chamber. The cap includes a sampling port and one or more sample collection chambers are disposed within the interior chamber. A motor is also disposed within the interior chamber and is configured to rotate one of the cap and the one or more sample collection chambers so to align one or the one or more sample collection chambers and the sampling port of the cap so to allow for sample collection. A microcontroller is also disposed within the interior chamber and is in communication with at least the motor. The microcontroller is configured to control the selective alignment of the sampling port and one of the one or more sample collection chambers and induce gastric intestinal fluid sampling.
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公开(公告)号：US11543465B2
公开(公告)日：2023-01-03
申请号：US16841323
申请日：2020-04-06
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor： Scott Green , Yogesh B. Gianchandani , Richard Kwon , Grace Elta , Jiqing Jiang , Ramprasad Nambisan
Abstract: Encapsulation packages for stent-deployable monitoring devices formed of resonator sensors and allowing for magnetic biasing elements that exhibit a targeted impact on the mechanical characteristics of a stent are provided. Encapsulation packages are formed of different types and include a longitudinal shield and curved end on profile for aligning the shield within the deployable stent, the shield having perforations such that a resonator can be positioned adjacent the perforations for allowing particulate within the stent to collect and be measured by the resonator during deployment.
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公开(公告)号：US09341604B2
公开(公告)日：2016-05-17
申请号：US14357157
申请日：2012-11-08
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor： Xudong Fan , Yogesh B. Gianchandani , Jing Liu
CPC classification number: G01N30/461 , G01N30/46 , G01N30/463 , G01N30/465 , G01N30/466 , G01N30/468 , G01N30/6095 , G01N30/72
Abstract: The present disclosure provides adaptive methods for gas chromatography analysis of a gas sample comprising one or more target analytes (such as a micro-gas chromatography) and adaptive gas chromatography devices for carrying out such analytical methods. Broadly, the system can regulate flow into a downstream chromatographic column by detecting one or more upstream conditions. For example, one adaptive chromatography device comprises a first column, a modulator component, and a second column. A first detector or sensor detects the presence of target analytes upstream from the second column, while a second detector detects the presence of target analytes eluted from the second column. The modulator component assembly is responsive to an output generated by the first detector and adaptively regulates fluid flow into the second column. Such adaptive chromatography (micro-GC) systems have higher separation speed, better analyte identification capability, and far greater energy savings.
Abstract translation: 本公开提供了用于气体样品的气相色谱分析的自适应方法，所述气体样品包含一种或多种靶分析物（例如微气相色谱）和用于进行这种分析方法的适应性气相色谱装置。 通常，系统可以通过检测一个或多个上游条件来调节流入下游色谱柱的流量。 例如，一个自适应色谱装置包括第一列，调制器组件和第二列。 第一检测器或传感器检测来自第二列上游的目标分析物的存在，而第二检测器检测从第二列洗脱的目标分析物的存在。 调制器部件组件响应于由第一检测器产生的输出并且自适应地调节流入第二列的流体流。 这种自适应色谱（micro-GC）系统具有更高的分离速度，更好的分析物识别能力和更大的能量节省。
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公开(公告)号：US20130053775A1
公开(公告)日：2013-02-28
申请号：US13665062
申请日：2012-10-31
Applicant: The Regents Of The University Of Michigan
Inventor： Srinivas Chiravuri , Allan Evans , Yogesh B. Gianchandani , Jong Moon Park
CPC classification number: A61M5/14276 , A61M5/148 , A61M5/1483 , A61M5/152 , A61M5/16813 , A61M5/16827 , A61M5/1684 , A61M5/16854 , A61M5/16881 , A61M5/1723 , A61M2005/14513 , A61M2205/332 , A61M2230/20 , A61M2230/63
Abstract: A liquid delivery apparatus for the intrathecal delivery of one or more medications to a patient is disclosed. The liquid delivery apparatus generally includes a liquid reservoir, a liquid metering unit fluidly connected to the liquid reservoir, and a catheter delivery tube fluidly connected to the liquid metering unit. Preferably, the liquid delivery apparatus includes two or more liquid reservoirs. In various embodiments, the liquid reservoir includes a deformable balloon and a compressive sleeve spring as a pressure source, the liquid metering unit is a piezoelectrically actuated microvalve, and/or diagnostic sensors are included in the apparatus. The disclosed apparatus are compact, volume-efficient, energy-efficient, capable of delivering accurate fluid volumes, and address problems associated with multi-medication therapies. Methods of operating the liquid delivery apparatus are also disclosed.
Abstract translation: 公开了一种用于将鞘内递送一种或多种药物给患者的液体输送装置。 液体输送装置通常包括液体储存器，流体连接到液体储存器的液体计量单元和流体地连接到液体计量单元的导管输送管。 优选地，液体输送装置包括两个或更多个液体储存器。 在各种实施例中，液体储存器包括可变形气囊和作为压力源的压缩套筒弹簧，液体计量单元是压电致动的微型阀，和/或诊断传感器包括在该装置中。 所公开的装置是紧凑的，体积有效的，能量高效的，能够提供精确的流体体积，并解决与多药物疗法相关的问题。 还公开了操作液体输送装置的方法。
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公开(公告)号：US12044609B2
公开(公告)日：2024-07-23
申请号：US17763733
申请日：2020-10-02
Applicant: TOTAL S.E. , THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor： Yogesh B. Gianchandani , Tao Li , Partha Dutta , Alexander Benken , John-Richard Ordonez-Varela
CPC classification number: G01N15/0826 , G01L15/00 , G01L19/0038 , G01N15/0806 , G01N33/24 , G01N2203/0232 , G01N2203/0617
Abstract: Investigating the permeability and porosity of geological samples is a routine element of geological studies, and is of particular interest in the oil and gas industry. Core-flood experiments are commonly performed on rock samples to measure transport characteristics in the laboratory. This disclosure reports the design and implementation of a high resolution distributed pressure measurement system for core-flood experiments. A series of microfabricated pressure sensors can be embedded in bolts that are housed within the pressurized polymer sheath that encases a rock core. A feedthrough technology has been developed to provide lead transfer between the sensors and system electronics across a 230-bar pressure difference. The system has been successfully benchtop tested with fluids such as synthetic oil and/or gas. Pressure measurements were recorded over a dynamic range of 20 bar with a resolution as small as 0.3 mbar.
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Patent Agency Ranking
公开(公告)号：US11927574B2
公开(公告)日：2024-03-12
申请号：US17120920
申请日：2020-12-14
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor： Yogesh B. Gianchandani , Yutao Qin , Weilin Liao , Hsueh-Tsung Lu , Declan Winship
CPC classification number: G01N30/6095 , G01N30/08 , G01N30/461 , G01N2030/025 , G01N2030/085
Abstract: A progressive cellular architectures has been presented for vapor-phase chemical analyzers. The progressive cellular architecture consists of a series of heterogeneous micro-gas chromatography cells. Each individual cell targets vapor species within a specific volatility range by using a unique combination of a preconcentrator and a separation column. The cells are connected progressively in series to cover a broad range of volatile analyte chemical vapors. Valves may inadvertently absorb or adsorb and subsequently release target chemical analyte molecules, thereby interfering with quantitative analysis. Therefore, the inlet to the cells is configured without a valve.
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公开(公告)号：US20200319268A1
公开(公告)日：2020-10-08
申请号：US16841323
申请日：2020-04-06
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor： Scott Green , Yogesh B. Gianchandani , Richard Kwon , Grace Elta , Jiqing Jiang , Ramprasad Nambisan
Abstract: Encapsulation packages for stent-deployable monitoring devices formed of resonator sensors and allowing for magnetic biasing elements that exhibit a targeted impact on the mechanical characteristics of a stent are provided. Encapsulation packages are formed of different types and include a longitudinal shield and curved end on profile for aligning the shield within the deployable stent, the shield having perforations such that a resonator can be positioned adjacent the perforations for allowing particulate within the stent to collect and be measured by the resonator during deployment.
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公开(公告)号：US08945052B2
公开(公告)日：2015-02-03
申请号：US13665062
申请日：2012-10-31
Applicant: The Regents of the University of Michigan
Inventor： Srinivas Chiravuri , Allan Evans , Yogesh B. Gianchandani , Jong Moon Park
CPC classification number: A61M5/14276 , A61M5/148 , A61M5/1483 , A61M5/152 , A61M5/16813 , A61M5/16827 , A61M5/1684 , A61M5/16854 , A61M5/16881 , A61M5/1723 , A61M2005/14513 , A61M2205/332 , A61M2230/20 , A61M2230/63
Abstract: A liquid delivery apparatus for the intrathecal delivery of one or more medications to a patient is disclosed. The liquid delivery apparatus generally includes a liquid reservoir, a liquid metering unit fluidly connected to the liquid reservoir, and a catheter delivery tube fluidly connected to the liquid metering unit. Preferably, the liquid delivery apparatus includes two or more liquid reservoirs. In various embodiments, the liquid reservoir includes a deformable balloon and a compressive sleeve spring as a pressure source, the liquid metering unit is a piezoelectrically actuated microvalve, and/or diagnostic sensors are included in the apparatus. The disclosed apparatus are compact, volume-efficient, energy-efficient, capable of delivering accurate fluid volumes, and address problems associated with multi-medication therapies. Methods of operating the liquid delivery apparatus are also disclosed.
Abstract translation: 公开了一种用于将鞘内递送一种或多种药物给患者的液体输送装置。 液体输送装置通常包括液体储存器，流体连接到液体储存器的液体计量单元和流体地连接到液体计量单元的导管输送管。 优选地，液体输送装置包括两个或更多个液体储存器。 在各种实施例中，液体储存器包括可变形气囊和作为压力源的压缩套筒弹簧，液体计量单元是压电致动的微型阀，和/或诊断传感器包括在该装置中。 所公开的装置是紧凑的，体积有效的，能量高效的，能够提供精确的流体体积，并解决与多药物疗法相关的问题。 还公开了操作液体输送装置的方法。
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公开(公告)号：US10132783B2
公开(公告)日：2018-11-20
申请号：US14890771
申请日：2014-05-16
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor： Yogesh B. Gianchandani , Yutao Qin
Abstract: A method is presented for fabricating a fluidic system for a gas chromatograph. The method includes: microfabricating a portion of a fluidic system of a gas chromatograph on a substrate using a first mask; microfabricating a portion of the fluidic system of the gas chromatograph using a second mask; and microfabricating a portion of the fluidic system of the gas chromatograph using a third mask, such that the first mask, the second mask and the third mask are different from each other and the microfabricating of the fluidic system of the gas chromatograph is completed using only the first, second and third masks. A gas chromatograph wherein a microfabricated Knudsen pump is arranged to operate in a first direction to draw carrier gas into a preconcentrator and in a second direction to draw gas out of the preconcentrator.
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公开(公告)号：US20140298990A1
公开(公告)日：2014-10-09
申请号：US14357157
申请日：2012-11-08
Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventor： Xudong Fan , Yogesh B. Gianchandani , Jing Liu
IPC: G01N30/46
CPC classification number: G01N30/461 , G01N30/46 , G01N30/463 , G01N30/465 , G01N30/466 , G01N30/468 , G01N30/6095 , G01N30/72
Abstract: The present disclosure provides adaptive methods for gas chromatography analysis of a gas sample comprising one or more target analytes (such as a micro-gas chromatography) and adaptive gas chromatography devices for carrying out such analytical methods. Broadly, the system can regulate flow into a downstream chromatographic column by detecting one or more upstream conditions. For example, one adaptive chromatography device comprises a first column, a modulator component, and a second column. A first detector or sensor detects the presence of target analytes upstream from the second column, while a second detector detects the presence of target analytes eluted from the second column. The modulator component assembly is responsive to an output generated by the first detector and adaptively regulates fluid flow into the second column. Such adaptive chromatography (micro-GC) systems have higher separation speed, better analyte identification capability, and far greater energy savings.
Abstract translation: 本公开提供了用于气体样品的气相色谱分析的自适应方法，所述气体样品包含一种或多种靶分析物（例如微气相色谱）和用于进行这种分析方法的适应性气相色谱装置。 通常，系统可以通过检测一个或多个上游条件来调节流入下游色谱柱的流量。 例如，一个自适应色谱装置包括第一列，调制器组件和第二列。 第一检测器或传感器检测来自第二列上游的目标分析物的存在，而第二检测器检测从第二列洗脱的目标分析物的存在。 调制器部件组件响应于由第一检测器产生的输出并且自适应地调节流入第二列的流体流。 这种自适应色谱（micro-GC）系统具有更高的分离速度，更好的分析物识别能力和更大的能量节省。
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