公开(公告)号：US10161001B2

公开(公告)日：2018-12-25

申请号：US15178248

申请日：2016-06-09

申请人： The Trustees of Princeton University

发明人： Robert H. Austin ,  Zhaoning Yu ,  Jonas O. Tegenfeldt ,  Stephen Y. Chou ,  Han Cao

IPC分类号： C12Q1/6869 ,  B01L3/00 ,  B81B1/00 ,  B81C1/00 ,  B82Y30/00 ,  G01N21/64 ,  G01N33/487 ,  C12Q1/6837

摘要： Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods.

公开(公告)号：US20190285582A1

公开(公告)日：2019-09-19

申请号：US16367701

申请日：2019-03-28

申请人： The Trustees of Princeton University

发明人： Robert H. Austin ,  Zhaoning Yu ,  Jonas O. Tegenfeldt ,  Stephen Y. Chou ,  Han Cao

IPC分类号： G01N27/447

摘要： Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods.

公开(公告)号：US09678038B2

公开(公告)日：2017-06-13

申请号：US14081322

申请日：2013-11-15

申请人： The Trustees of Princeton University

发明人： Robert H. Austin ,  Zhaoning Yu ,  Jonas O. Tegenfeldt ,  Stephen Y. Chou ,  Han Cao

IPC分类号： G01N27/447

CPC分类号： G01N27/44791 ,  G01N27/447

摘要： Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods.

公开(公告)号：US20140206555A1

公开(公告)日：2014-07-24

申请号：US14223589

申请日：2014-03-24

申请人： THE TRUSTEES OF PRINCETON UNIVERSITY

发明人： Robert H. Austin ,  Zhaoning Yu ,  Jonas O. Tegenfeldt ,  Stephen Y. Chou ,  Han Cao

IPC分类号： G01N33/487

CPC分类号： C12Q1/6869 ,  B01J2219/00274 ,  B01L3/502707 ,  B01L2200/0663 ,  B01L2200/12 ,  B01L2300/0627 ,  B01L2300/0861 ,  B01L2300/0896 ,  B01L2400/0415 ,  B01L2400/0418 ,  B01L2400/086 ,  B81B1/002 ,  B81B2201/058 ,  B81B2203/0338 ,  B81C1/00071 ,  B82Y30/00 ,  C12Q1/6837 ,  G01N21/6428 ,  G01N21/648 ,  G01N33/48721 ,  Y10S977/704 ,  Y10S977/88 ,  Y10S977/883

摘要： Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods.

摘要翻译： 公开了能够实现高通量大分子分析的纳米通道阵列。 还公开了制备纳米通道阵列和纳米流体芯片的方法。 还公开了分析大分子的方法，例如基因组DNA的全部链，以及用于实施这些方法的系统。

公开(公告)号：US20170067102A1

公开(公告)日：2017-03-09

申请号：US15178248

申请日：2016-06-09

申请人： The Trustees of Princeton University

发明人： Robert H. Austin ,  Zhaoning Yu ,  Jonas O. Tegenfeldt ,  Stephen Y. Chou ,  Han Cao

IPC分类号： C12Q1/68 ,  B01L3/00 ,  B81C1/00 ,  G01N21/64 ,  B81B1/00 ,  G01N33/487 ,  B82Y30/00

CPC分类号： C12Q1/6869 ,  B01J2219/00274 ,  B01L3/502707 ,  B01L2200/0663 ,  B01L2200/12 ,  B01L2300/0627 ,  B01L2300/0861 ,  B01L2300/0896 ,  B01L2400/0415 ,  B01L2400/0418 ,  B01L2400/086 ,  B81B1/002 ,  B81B2201/058 ,  B81B2203/0338 ,  B81C1/00071 ,  B82Y30/00 ,  C12Q1/6837 ,  G01N21/6428 ,  G01N21/648 ,  G01N33/48721 ,  Y10S977/704 ,  Y10S977/88 ,  Y10S977/883

摘要： Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods.

摘要翻译： 公开了能够实现高通量大分子分析的纳米通道阵列。 还公开了制备纳米通道阵列和纳米流体芯片的方法。 还公开了分析大分子的方法，例如基因组DNA的全部链，以及用于实施这些方法的系统。

公开(公告)号：US09389217B2

公开(公告)日：2016-07-12

申请号：US14223589

申请日：2014-03-24

申请人： THE TRUSTEES OF PRINCETON UNIVERSITY

发明人： Robert H. Austin ,  Zhaoning Yu ,  Jonas O. Tegenfeldt ,  Stephen Y. Chou ,  Han Cao

IPC分类号： C12Q1/68 ,  C12M1/34 ,  G01N15/06 ,  G01N21/00 ,  C07H21/02 ,  B01D61/42 ,  C40B10/00 ,  C40B40/06 ,  G01N33/487 ,  B01L3/00 ,  B81B1/00 ,  B81C1/00 ,  B82Y30/00 ,  G01N21/64

CPC分类号： C12Q1/6869 ,  B01J2219/00274 ,  B01L3/502707 ,  B01L2200/0663 ,  B01L2200/12 ,  B01L2300/0627 ,  B01L2300/0861 ,  B01L2300/0896 ,  B01L2400/0415 ,  B01L2400/0418 ,  B01L2400/086 ,  B81B1/002 ,  B81B2201/058 ,  B81B2203/0338 ,  B81C1/00071 ,  B82Y30/00 ,  C12Q1/6837 ,  G01N21/6428 ,  G01N21/648 ,  G01N33/48721 ,  Y10S977/704 ,  Y10S977/88 ,  Y10S977/883

摘要： Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods.

摘要翻译： 公开了能够实现高通量大分子分析的纳米通道阵列。 还公开了制备纳米通道阵列和纳米流体芯片的方法。 还公开了分析大分子的方法，例如基因组DNA的全部链，以及用于实施这些方法的系统。

公开(公告)号：US10768142B2

公开(公告)日：2020-09-08

申请号：US16367701

申请日：2019-03-28

申请人： The Trustees of Princeton University

发明人： Robert H. Austin ,  Zhaoning Yu ,  Jonas O. Tegenfeldt ,  Stephen Y. Chou ,  Han Cao

IPC分类号： G01N27/447 ,  B01L3/00 ,  B81B1/00 ,  B81C1/00 ,  B82Y30/00 ,  C12Q1/6869 ,  G01N21/64 ,  G01N33/487 ,  C12Q1/6837

摘要： Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods.