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1.发明申请公开(公告)号：US20190204223A1
公开(公告)日：2019-07-04
申请号：US16088232
申请日：2016-04-20
申请人： TOTAL SA , UNIVERSITE CLAUDE BERNARD LYON 1 , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS
CPC分类号： G01N21/643 , C08G69/24 , C09K8/588 , G01N21/6408 , G01N21/85 , G01N33/2823
摘要： A method for the detection and quantification, in a complex aqueous fluid, of additives and water-soluble polymers used in the enhanced recovery of oil and shale gas.
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公开(公告)号：US20170349810A1
公开(公告)日：2017-12-07
申请号：US15536523
申请日：2014-12-15
申请人： TOTAL SA , UNIVERSITE CLAUDE BERNARD LYON 1 , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS-
发明人： Christian HURTEVENT , Salima BARAKA-LOKMANE , John-Richard ORDONEZ-VARELA , Olivier TILLEMENT , Arthur MARAIS , Albert MOUSSARON
CPC分类号： C09K8/532 , B01J13/14 , B82Y99/00 , C01F17/0043 , C08L83/08 , C09K8/035 , C09K8/528 , C09K2208/10
摘要： Novel hybrid nanoparticles, useful for inhibiting or slowing down the formation of sulfur deposits or minerals in a well during the extraction of gas or oil. Specifically, the nanoparticles each include (i) a polyorganosiloxane (POS) matrix; and, optionally as a coating over a lanthanide oxide core, (iii) at least one polymeric scale inhibitor during the extraction of gas or oil. The invention also relates to the method for obtaining the nanoinhibitors and the application of same.
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公开(公告)号：US20230173155A1
公开(公告)日：2023-06-08
申请号：US17997763
申请日：2021-04-30
申请人： MEXBRAIN , UNIVERSITE CLAUDE BERNARD LYON 1 , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , INSTITUT GUSTAVE ROUSSY , VETAGRO-SUP INSTITUT D'ENSEIGNEMENT SUPÉRIEUR ET DE RECHERCHE
发明人： Marco NATUZZI , Thomas BRICHART , Fabien ROSSETTI , Matteo MARTINI , François LUX , Olivier TILLEMENT , Jean-Luc PERFETTINI , Vanessa LOUZIER , Jeanne-Marie BONNET-GARIN , Jean-Yves AYOUB
IPC分类号： A61M1/16
CPC分类号： A61M1/1621 , A61M1/1654
摘要： The present invention relates to the field of medical devices, more particularly the field of devices for extracting circulating molecules from the blood of a mammal, and their therapeutic uses, in particular in treating sepsis, cytokine release syndrome and/or any other form of systemic inflammatory response or cytokine shock, caused by bacterial, parasitic, fungal or viral infections, in particular caused by a viral infection, for example coronaviruses with human respiratory tract tropism.
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公开(公告)号：US20210128730A1
公开(公告)日：2021-05-06
申请号：US16628611
申请日：2018-07-04
申请人： NH THERAGUIX , Universite Claude Bernard Lyon 1 , Centre National de La Recherche Scientifique - CNRS - , INSERM (Institut National de la Sante et de la Recherche Médicale) , Institut Gustave Roussy
发明人： François LUX , Olivier TILLEMENT , Jean-Luc PERFETTINI , Eric DEUTSCH , Frédéric LAW , Awatef ALLOUCH
摘要： The invention relates to methods for treating tumors. In particular, the invention provides novel use of nanoparticles in combination with ionizing radiations for treating tumors, wherein the combined effect of nanoparticles induces senescence and/or cannibalism of the tumor cells.
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公开(公告)号：US20200289623A1
公开(公告)日：2020-09-17
申请号：US16755866
申请日：2018-10-12
申请人： NH THERAGUIX , Universite Claude Bernard Lyon 1 , Centre National de La Recherche Scientifique - CNRS -
发明人： Olivier TILLEMENT , François LUX , Fabien ROSSETTI , Vu-Long TRAN , Clélia MATHIEU , Myleva DAHAN
IPC分类号： A61K38/31 , A61K31/704 , A61K47/69 , A61K49/00 , A61P35/00 , A61K49/12 , A61K49/18 , A61K9/14 , A61K33/243 , B82Y5/00
摘要： The present invention relates to the field of nanovectors for the delivery of active substances in the body, in particular for the treatment of tumours. In particular, the use of these nanovectors makes it possible to improve the pharmacokinetics of the active substances with a more selective delivery, for example in the tumour tissues.
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公开(公告)号：US20230405154A1
公开(公告)日：2023-12-21
申请号：US18253586
申请日：2021-11-19
申请人： NH THERAGUIX , UNIVERSITE CLAUDE BERNARD LYON 1 , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -
CPC分类号： A61K49/1881 , A61K51/1244 , B82Y5/00
摘要： The present disclosure relates to nanoparticles and the uses thereof in medicine, in particular for the treatment of tumours.
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7.发明申请公开(公告)号：US20190010413A1
公开(公告)日：2019-01-10
申请号：US16068258
申请日：2017-01-12
申请人： INOVENTEAM , UNIVERSITE CLAUDE BERNARD LYON 1 , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： Arthur MARAIS , Mahmoud OULD-METIDJI , Florian LEPOIVRE , Anatole COLLET , Matteo MARTINI , Fabien ROSSETTI , Olivier TILLEMENT , Antoine VANLAER , François GHILLEBAERT
IPC分类号： C10L1/00 , C10L1/30 , C10M171/00 , G01N21/64
摘要： The use, as markers of petroleum products, crude oils, biofuels or lubricants, of rare earth complexes or one of the constituents thereof chosen from rare earth ligands or salts, being capable of forming a rare earth complex after the addition of a developing solution. Preferably, the rare earth complex can be detected by time-resolved fluorescence. Also, a marking method and a method for detecting a rare earth complex as a marker of petroleum products, crude oils, biofuels or lubricants.
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公开(公告)号：US20230346971A1
公开(公告)日：2023-11-02
申请号：US18253694
申请日：2021-11-19
申请人： NH THERAGUIX , UNIVERSITE CLAUDE BERNARD LYON 1 , MEXBRAIN , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - , INSERM (Institut National de la Santé et de la Recherche Médicale) , HOSPICES CIVILS DE LYON , INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
发明人： Olivier TILLEMENT , François LUX , Delphine VERNOS , Claire RODRIGUEZ-LAFRASSE , Thomas BRICHART , Marco NATUZZI , Alain GELOEN , Simon CHAMPAGNE , Matteo MARTINI , Paul ROCCHI
CPC分类号： A61K47/6935 , A61K9/08 , A61P35/00 , A61N5/10 , A61N2005/1098
摘要： The present disclosure relates to nanoparticles and the uses thereof in medicine, in particular for the treatment of tumours.
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9.发明公开公开(公告)号：US20230263912A1
公开(公告)日：2023-08-24
申请号：US18007254
申请日：2021-07-29
申请人： MEXBRAIN , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS , UNIVERSITE CLAUDE BERNARD LYON 1
发明人： Olivier TILLEMENT , François LUX , Fabien ROSSETTI , Marco NATUZZI , Thomas BRICHART , Laurent DAVID , Paula NUNES DE OLIVEIRA , Alexandra MONTEBAULT
CPC分类号： A61K49/128 , C08B37/003
摘要： The invention relates to a statistical polysaccharide with a weight-average molecular weight of between 100 kDa and 1000 kDa of the following formula (I): in which: each Rc independently represents a group containing a chelating agent, each Z independently represents a binder which may be a single bond or a hydrocarbon chain containing between 1 and 12 carbon atoms, said chain able to be either linear or branched and being able to contain one or more unsaturations and being able to contain one or more heteroatoms, preferably chosen from nitrogen, oxygen, sulfur and atoms of the halogen family, x is between 0.005 and 0.7, preferably between 0.05 and 0.7, and preferentially between 0.2 and 0.6, y is between 0.01 and 0.7, preferably between 0.05 and 0.2, the ratio of y/x being greater than or equal to 0.05, preferably greater than or equal to 0.15, and the sum of x+y being greater than or equal to 0.30, preferably greater than or equal to 0.35. The invention also relates to the use of said polysaccharide in a dialysis process in order to capture at least one metal, in an MRI imaging process, in a brachytherapy process or in a process for marking foodstuffs to prevent forgeries.
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公开(公告)号：US20220118164A1
公开(公告)日：2022-04-21
申请号：US17425147
申请日：2020-01-24
申请人： MEXBRAIN , UNIVERSITE CLAUDE BERNARD LYON 1 , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS
发明人： Olivier TILLEMENT , François LUX , Marie VICTOR , Denise BECHET , Marco NATUZZI , Jules Tillement , Thomas BRICHART
摘要： The invention concerns the field of medical devices, more particularly devices for joint extraction, within an organism, of at least one metal cation and at least one target molecule. In order to do this, the device comprises: a) at least one ligand exhibiting specific affinity for the target molecule; b) at least one means for extraction of the metal cation, said means being a perfusion fluid comprising at least one chelating agent, the perfusion fluid being contained in a dialysis or microdialysis system. The use of these devices makes it possible, for example, to prevent and/or treat pathologies linked to dysregulation of the homeostasis of metals and/or target molecules in the organism, for example neurological diseases and/or proteinopathies.
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