公开(公告)号：US5432262A

公开(公告)日：1995-07-11

申请号：US3297

申请日：1993-01-12

申请人： Tadashi Takemoto ,  Katsumi Sugiyama

发明人： Tadashi Takemoto ,  Katsumi Sugiyama

IPC分类号： C07K1/14 ,  C07K5/072 ,  C07K5/075 ,  A61K38/00 ,  C07K1/00 ,  C07K5/06 ,  C07C101/32

CPC分类号： C07K5/0613 ,  Y10S530/801

摘要： Mixture containing .alpha.-L-aspartyl-L-phenylalanine methyl ester and 3-benzyl-6-carboxymethyl-2,5-dioxopiperazine are brought into contact with hydrochloric acid in an aqueous solvent to precipitate .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride and 3-benzyl-6-carboxymethyl-2,5-dioxopiperazine, which are then separated from each other by classification.

摘要翻译： 将含有α--L-天冬氨酰基-L-苯丙氨酸甲酯和3-苄基-6-羧甲基-2,5-二氧代哌嗪的混合物与盐酸在水性溶剂中接触以沉淀α-L-天冬氨酰基-L-苯丙氨酸甲酯 酯盐酸盐和3-苄基-6-羧甲基-2,5-二氧代哌嗪，然后通过分类彼此分离。

公开(公告)号：US5225587A

公开(公告)日：1993-07-06

申请号：US864133

申请日：1992-04-06

申请人： Katsumi Sugiyama ,  Kiyo Adachi ,  Toshihide Yukawa

发明人： Katsumi Sugiyama ,  Kiyo Adachi ,  Toshihide Yukawa

IPC分类号： C07K5/072 ,  C07K5/075

CPC分类号： C07K5/0613

摘要： A method of purifying .alpha.-L-aspartyl-L-phenylalanine methyl ester as a hydrochloride salt thereof which comprises:i) contacting a mixture of .alpha.-L-aspartyl-L-phenylanaline methyl ester and .beta.-L-aspartyl-L-phenylalanine methyl ester with an aqueous medium containing (a) hydrogen chloride in an amount not more than ca. 2 mol., per liter of said aqueous medium, but not less than 1 mol., per mole of said of said mixture of .alpha.-L-aspartyl-L-phenylalanine methyl ester and .beta.-L-aspartyl-L-phenylalanine methyl ester, and (b) an inorganic chloride selected from the group consisting of NaCl, KCl, NH.sub.4 Cl, CaCl.sub.2, and ZnCl.sub.2 in an amount of at least ca. 50 g., per liter of said aqueous medium, to form crystals of .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride, andii) recovering the .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride crystals therefrom.

摘要翻译： 纯化α-L-天冬氨酰基-L-苯丙氨酸甲酯盐酸盐的方法，其包括：i）使α-L-天冬氨酰基-L-苯亚胺甲酯与β-L-天冬氨酰基-L-苯丙氨酸的混合物 甲酯与含有（a）氯化氢的含水介质的量不大于约 每摩尔所述所述α-L-天冬氨酰基-L-苯丙氨酸甲酯和β-L-天冬氨酰-L-苯丙氨酸甲酯的混合物每升所述水性介质2摩尔，但不小于1摩尔 ，和（b）选自NaCl，KCl，NH 4 Cl，CaCl 2和ZnCl 2的无机氯化物，其量至少约为。 50升，每升所述水性介质中，形成α-L-天冬氨酰基-L-苯丙氨酸甲酯盐酸盐的晶体，和ii）从其中回收α-L-天冬氨酰基-L-苯丙氨酸甲酯盐酸盐晶体。

公开(公告)号：US4634790A

公开(公告)日：1987-01-06

申请号：US700034

申请日：1985-02-11

申请人： Emiko Shinohara ,  Katsumi Sugiyama ,  Masanao Ozaki ,  Keizo Matsuda

发明人： Emiko Shinohara ,  Katsumi Sugiyama ,  Masanao Ozaki ,  Keizo Matsuda

IPC分类号： C07K1/12 ,  C07K5/075 ,  C07C101/32 ,  C07K5/06

CPC分类号： C07K5/0613

摘要： A process for producing .alpha.-L-aspartyl-L-phenylalanine methyl ester or its hydrohalide, which comprises subjecting 3-benzyl-6-carboxymethyl-2,5-diketopiperazine to partial hydrolysis with a strong acid in a solvent mixture of methanol and water.

摘要翻译： 一种生产α-L-天冬氨酰-L-苯丙氨酸甲酯或其氢卤酸盐的方法，其包括在甲醇和水的溶剂混合物中，用强酸将3-苄基-6-羧甲基-2,5-二酮哌嗪部分水解 。

公开(公告)号：US3952011A

公开(公告)日：1976-04-20

申请号：US445771

申请日：1974-02-25

申请人： Miyoji Dazai ,  Katsumi Sugiyama ,  Masaaki Iida ,  Hideo Tazuke ,  Hiroo Kageyama

发明人： Miyoji Dazai ,  Katsumi Sugiyama ,  Masaaki Iida ,  Hideo Tazuke ,  Hiroo Kageyama

IPC分类号： C07D207/28

CPC分类号： C07D207/28

摘要： Hemi-alkali metal salts of 2-pyrrolidone-5-carboxylic acid, believed to have the formula: ##SPC1##Wherein Me is an alkali metal, is formed by reaction of 0.75 to 0.99 moles of an alkali metal hydroxide per mole of 2-pyrrolidone-5-carboxylic acid.

摘要翻译： 2-吡咯烷酮-5-羧酸的半碱金属盐，据信具有下式：

公开(公告)号：US20050088481A1

公开(公告)日：2005-04-28

申请号：US10972563

申请日：2004-10-26

申请人： Hitoshi Fujimoto ,  Katsumi Sugiyama ,  Masataka Naito ,  Masatoshi Ikkatai ,  Tsutomu Harada ,  Tatsuya Fukushima ,  Takefumi Tamura ,  Tsuyoshi Mikoshiba

发明人： Hitoshi Fujimoto ,  Katsumi Sugiyama ,  Masataka Naito ,  Masatoshi Ikkatai ,  Tsutomu Harada ,  Tatsuya Fukushima ,  Takefumi Tamura ,  Tsuyoshi Mikoshiba

IPC分类号： B41J2/165 ,  B41J2/17 ,  B41J2/175 ,  B41J3/407 ,  B41J11/48 ,  B41J15/04 ,  B41J29/377

CPC分类号： B41J15/048 ,  B41J2/16547 ,  B41J2/16588 ,  B41J2/1707 ,  B41J2/175 ,  B41J3/4075 ,  B41J11/48 ,  B41J29/377

摘要： A printer includes an ink jet head, a recovery unit, a moving unit, a conveying unit and a cover. The ink jet head performs printing on a printing medium and has an ink ejection port on an ejection port forming surface. The recovery unit is used for a recovery process for maintaining an ink ejection state of the ink jet head in a good condition. The recovery unit includes a cap for covering the ejection port forming surface, a wiping member for wiping the ejection port forming surface, and an absorbing member for receiving ink ejected from the ejection port of the ink jet head. The moving unit moves the recovery unit to a position where the recovery unit faces the ink jet head and to a position where the recovery unit does not face the ink jet head, the ejection forming surface of which is oriented toward the printing medium. The conveying unit conveys the printing medium to be printed by the ink jet head. The cover contains the ink jet head and the recovery unit. The cover is arranged to be opened so that a conveying path of the conveying unit appears and to be closed to cover the conveying path.

摘要翻译： 打印机包括喷墨头，回收单元，移动单元，输送单元和盖。 喷墨头在打印介质上执行打印，并且在喷射口形成表面上具有喷墨口。 恢复单元用于维持喷墨头的喷墨状态处于良好状态的恢复过程。 回收单元包括用于覆盖喷射口形成表面的盖，用于擦拭喷射口形成表面的擦拭构件和用于接收从喷墨头的喷射口喷射的墨的吸收构件。 移动单元将恢复单元移动到恢复单元面向喷墨头的位置，并且其恢复单元不面向喷墨头的位置，其喷射形成表面朝向打印介质。 输送单元输送要由喷墨头打印的打印介质。 该盖包含喷墨头和回收单元。 盖被布置成打开，使得输送单元的输送路径出现并且被封闭以覆盖输送路径。

公开(公告)号：US06637754B1

公开(公告)日：2003-10-28

申请号：US09709390

申请日：2000-11-13

申请人： Hisashi Ohtsuki ,  Takayuki Norimatsu ,  Eiji Funahashi ,  Koji Kametaka ,  Motoharu Niki ,  Katsumi Sugiyama

发明人： Hisashi Ohtsuki ,  Takayuki Norimatsu ,  Eiji Funahashi ,  Koji Kametaka ,  Motoharu Niki ,  Katsumi Sugiyama

IPC分类号： F16J1532

CPC分类号： F16J15/3264 ,  F16C19/186 ,  F16C33/64 ,  F16C33/768 ,  F16C33/783 ,  F16C33/7883 ,  F16C41/007 ,  F16C2240/40 ,  F16C2326/02 ,  F16J15/326

摘要： A wheel bearing includes a sealing device 5 positioned between inner and outer members 1 and 2. This sealing device 5 includes an elastic member 14, which eventually forms an encoder grid and is provided on a first annular sealing plate 11. A second annular sealing plate 12 is provided with sealing lips 16a to 16c. An engagement 18 between a cylindrical wall 11a of the first annular sealing plate 11 and the inner member 1 is provided with an elastic member 20 made of a material dissimilar to that for the elastic material 14. This elastic member 20 may be a rubber coated layer, resin paint layer, a thin film of adhesive material or a ring-shaped rubber member. Thereby, any possible ingress of water across an engagement surface of the annular sealing plate is prevented, accompanied by increase of the lifetime of the bearing, with no problem associated with separation and displacement of the annular sealing plates. The magnetic flux density can also be easily secured.

摘要翻译： 车轮轴承包括位于内部件1和外部件2之间的密封装置5.该密封装置5包括弹性构件14，弹性构件14最终形成编码器格栅并设置在第一环形密封板11上。第二环形密封板 12设有密封唇16a至16c。 第一环形密封板11的圆筒形壁11a和内部构件1之间的接合部18设置有由与弹性材料14不同的材料制成的弹性构件20.该弹性构件20可以是橡胶涂覆层 ，树脂漆层，粘合剂材料薄膜或环状橡胶构件。 因此，防止了环形密封板的接合表面的任何可能的进入水流，伴随着轴承寿命的增加，并没有与环形密封板的分离和移位有关的问题。 也可以容易地确保磁通密度。

公开(公告)号：US4822907A

公开(公告)日：1989-04-18

申请号：US56907

申请日：1987-06-03

申请人： Katsumi Sugiyama ,  Takashi Yamashita ,  Toshihide Yukawa

发明人： Katsumi Sugiyama ,  Takashi Yamashita ,  Toshihide Yukawa

IPC分类号： C07K1/14 ,  C07K1/26 ,  C07K5/072 ,  C07K5/075 ,  C07C103/52

CPC分类号： C07K5/0613

摘要： A process for recovering .alpha.-L-aspartyl-L-phenylalanine methyl ester from a solution containing various methyl ester or demethylated derivatives of .alpha.-L-aspartyl-L-phenylalanine methyl ester and chloride ions is disclosed. This process uses a reverse osmosis membrane having a specific chloride inhibition rate to desalt and concentrate a solution containing a specified ratio of .delta.-L-aspartyl-L-phenylalanine methyl ester to its derivatives until a specific weight ratio of organic chloride ion to the sum of .alpha.-L-aspartyl-L-phenylalanine methyl ester and its derivatives is obtained. This desalted and concentrated solution is then contacted with an aqueous solvent containing methanol and hydrochloride acid to recover high yields of .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride.

摘要翻译： 公开了从含有α-L-天冬氨酰-L-苯丙氨酸甲酯和氯离子的各种甲酯或去甲基化衍生物的溶液中回收α-L-天冬氨酰基-L-苯丙氨酸甲酯的方法。 该方法使用具有特定氯化物抑制速率的反渗透膜脱盐，并将含有特定比例的δ-L-天冬氨酰-L-苯丙氨酸甲酯的溶液浓缩至其衍生物，直到有机氯离子与总和的比重 的α-L-天冬氨酰基-L-苯丙氨酸甲酯及其衍生物。 然后将该脱盐浓缩溶液与含有甲醇和盐酸的含水溶剂接触，以回收高产率的α-L-天冬氨酰基-L-苯丙氨酸甲酯盐酸盐。

公开(公告)号：US4579747A

公开(公告)日：1986-04-01

申请号：US589005

申请日：1984-03-13

申请人： Katsumi Sugiyama ,  Toshiyuki Ozawa ,  Nobuya Nagashima ,  Yoshinobu Uchida

发明人： Katsumi Sugiyama ,  Toshiyuki Ozawa ,  Nobuya Nagashima ,  Yoshinobu Uchida

IPC分类号： A23L27/00 ,  A23L27/30 ,  C07C67/00 ,  C07C231/00 ,  C07K1/00 ,  C07K1/14 ,  C07K5/072 ,  C07K5/075 ,  A23L1/236

CPC分类号： C07K5/0613 ,  A23L27/31 ,  A23L27/32

摘要： .alpha.-L-aspartyl-L-phenylalanine methyl ester II type crystals consisting of two types of crystals, II.sub.A and II.sub.B type, which interconvert from one to the other depending upon the equilibrium moisture content of the crystals, wherein one type of crystal, II.sub.a, exhibits X-ray diffraction peaks at angles of diffraction of at least 20.6.degree., 21.2.degree., 5.0.degree. and 11.1.degree., and the other type of crystal, II.sub.B, exhibits X-ray diffraction peaks at angles of diffraction of at least 15.2.degree., 11.1.degree., 19.6.degree. and 4.5.degree., as measured by X-ray diffractometer using CuK.sub..alpha. radiation and wherein the equilibrium moisture content of either of the crystals at a relative humidity of 78% is not higher than about 3%.

摘要翻译： 由两种晶体组成的α-L-天冬氨酰基-L-苯丙氨酸甲酯II型晶体，IIA和IIB型晶体，根据晶体的平衡水分含量从一个到另一个相互转变，其中一种晶体IIa 在衍射角至少为20.6°，21.2°，5.0°和11.1°的X射线衍射峰，其他类型的晶体IIB在衍射角呈现至少15.2°的X射线衍射峰 ，11.1°，19.6°和4.5°，通过使用CuKα辐射的X射线衍射仪测量，并且其中任一晶体在相对湿度78％下的平衡水分含量不高于约3％。

公开(公告)号：US20080008773A1

公开(公告)日：2008-01-10

申请号：US11819441

申请日：2007-06-27

申请人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： A61K36/886 ,  A61K36/00 ,  A61P19/00 ,  A61K36/28

CPC分类号： C07D311/80 ,  A23K20/121 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/353 ,  A61K36/23 ,  A61K36/232 ,  A61K36/282 ,  A61K36/8967 ,  A23V2200/306 ,  A23V2250/21

摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease requiring promotion of osteogenesis or enhancement of bone morphogenetic protein production, an agent for promotion of osteogenesis or an agent for enhancement of bone morphogenetic protein production, and a food, beverage or feed for promotion of osteogenesis or enhancement of bone morphogenetic protein production, characterized in that each comprises as an effective ingredient a processed product derived from a plant. Also, the present invention relates to a method for measuring an enhancing action for bone morphogenetic protein production, a method for screening a substance having an enhancing action for bone morphogenetic protein production, and a method for preparing a substance having an enhancing action for bone morphogenetic protein production, each method using a specified cell.

摘要翻译： 本发明涉及需要促进骨形成发生或增强骨形态发生蛋白质生成的疾病的治疗剂或预防剂，促进成骨的药剂或增强骨形态发生蛋白质生产的药剂，以及食品，饮料或饲料 用于促进成骨或增强骨形态发生蛋白质的生成，其特征在于，每种都包含作为有效成分的来自植物的加工产品。 另外，本发明涉及骨形态发生蛋白质生成增强作用的测定方法，骨形态发生蛋白质生成增强作用物质的筛选方法以及骨形态发生增强作用物质的制备方法 蛋白质生产，每种方法使用指定的细胞。

公开(公告)号：US20060039998A1

公开(公告)日：2006-02-23

申请号：US10529860

申请日：2003-09-29

申请人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： A61K36/282 ,  A61K36/232 ,  A61K36/896 ,  A61K36/886

CPC分类号： C07D311/80 ,  A23K20/121 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/353 ,  A61K36/23 ,  A61K36/232 ,  A61K36/282 ,  A61K36/8967 ,  A23V2200/306 ,  A23V2250/21

摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease requiring promotion of osteogenesis or enhancement of bone morphogenetic protein production, an agent for promotion of osteogenesis or an agent for enhancement of bone morphogenetic protein production, and a food, beverage or feed for promotion of osteogenesis or enhancement of bone morphogenetic protein production, characterized in that each comprises as an effective ingredient a processed product derived from a plant. Also, the present invention relates to a method for measuring an enhancing action for bone morphogenetic protein production, a method for screening a substance having an enhancing action for bone morphogenetic protein production, and a method for preparing a substance having an enhancing action for bone morphogenetic protein production, each method using a specified cell.

摘要翻译： 本发明涉及需要促进骨形成发生或增强骨形态发生蛋白质生成的疾病的治疗剂或预防剂，促进成骨的药剂或增强骨形态发生蛋白质生产的药剂，以及食品，饮料或饲料 用于促进成骨或增强骨形态发生蛋白质的生成，其特征在于，每种都包含作为有效成分的来自植物的加工产品。 另外，本发明涉及骨形态发生蛋白质生成增强作用的测定方法，骨形态发生蛋白质生成增强作用物质的筛选方法以及骨形态发生增强作用物质的制备方法 蛋白质生产，每种方法使用指定的细胞。