公开(公告)号：US07626030B2

公开(公告)日：2009-12-01

申请号：US11042398

申请日：2005-01-24

申请人： Tae-Seong Kim ,  Jean-Christophe Harmange ,  David Bauer ,  Shon Booker ,  Yuan Cheng ,  Shimin Xu ,  Ning Xi ,  Joseph L. Kim ,  Andrew Tasker

发明人： Tae-Seong Kim ,  Jean-Christophe Harmange ,  David Bauer ,  Shon Booker ,  Yuan Cheng ,  Shimin Xu ,  Ning Xi ,  Joseph L. Kim ,  Andrew Tasker

IPC分类号： C07D215/38

CPC分类号： C07D495/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：US20090176774A1

公开(公告)日：2009-07-09

申请号：US12157303

申请日：2008-06-09

申请人： Michele Potashman ,  Tae-Seong Kim ,  Steven Bellon ,  Shon Booker ,  Yuan Cheng ,  Joseph L. Kim ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Jean-Christophe Harmange ,  George Borg ,  Matthew Weiss ,  Brian L. Hodous ,  Russell Graceffa ,  William H. Buckner ,  Craig E. Masse ,  Deborah Choquette ,  Matthew W. Martin ,  Julie Germain ,  Lucian V. DiPietro ,  Stuart C. Chaffee ,  Joseph J. Nunes ,  John L. Buchanan ,  David C. McGowan ,  Douglas A. Whittington ,  Gregory J. Habgood ,  Vinod F. Patel ,  Daniel La

发明人： Michele Potashman ,  Tae-Seong Kim ,  Steven Bellon ,  Shon Booker ,  Yuan Cheng ,  Joseph L. Kim ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Jean-Christophe Harmange ,  George Borg ,  Matthew Weiss ,  Brian L. Hodous ,  Russell Graceffa ,  William H. Buckner ,  Craig E. Masse ,  Deborah Choquette ,  Matthew W. Martin ,  Julie Germain ,  Lucian V. DiPietro ,  Stuart C. Chaffee ,  Joseph J. Nunes ,  John L. Buchanan ,  David C. McGowan ,  Douglas A. Whittington ,  Gregory J. Habgood ,  Vinod F. Patel ,  Daniel La

IPC分类号： A61K31/536 ,  A61K31/517 ,  A61K31/502 ,  A61K31/498 ,  A61K31/4709

CPC分类号： C07D213/64 ,  C07D213/81 ,  C07D215/233 ,  C07D215/38 ,  C07D215/48 ,  C07D215/54 ,  C07D237/34 ,  C07D239/34 ,  C07D239/47 ,  C07D239/84 ,  C07D239/94 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：US07435823B2

公开(公告)日：2008-10-14

申请号：US11042634

申请日：2005-01-24

申请人： Michele Potashman ,  Tae-Seong Kim ,  Steven Bellon ,  Shon Booker ,  Yuan Cheng ,  Joseph L. Kim ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Jean-Christophe Harmange ,  George Borg ,  Matthew Weiss ,  Brian L. Hodous ,  Russell Graceffa ,  William H. Buckner ,  Craig E. Masse ,  Deborah Choquette ,  Matthew W. Martin ,  Julie Germain ,  Lucian V. DiPietro ,  Stuart C. Chaffee ,  Joseph J. Nunes ,  John L. Buchanan ,  Gregory J. Habgood ,  David C. McGowan ,  Douglas A. Whittington ,  Daniel La ,  Vinod F. Patel

发明人： Michele Potashman ,  Tae-Seong Kim ,  Steven Bellon ,  Shon Booker ,  Yuan Cheng ,  Joseph L. Kim ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Jean-Christophe Harmange ,  George Borg ,  Matthew Weiss ,  Brian L. Hodous ,  Russell Graceffa ,  William H. Buckner ,  Craig E. Masse ,  Deborah Choquette ,  Matthew W. Martin ,  Julie Germain ,  Lucian V. DiPietro ,  Stuart C. Chaffee ,  Joseph J. Nunes ,  John L. Buchanan ,  Gregory J. Habgood ,  David C. McGowan ,  Douglas A. Whittington ,  Daniel La ,  Vinod F. Patel

IPC分类号： C07D215/38 ,  C07D265/34

CPC分类号： C07D213/64 ,  C07D213/81 ,  C07D215/233 ,  C07D215/38 ,  C07D215/48 ,  C07D215/54 ,  C07D237/34 ,  C07D239/34 ,  C07D239/47 ,  C07D239/84 ,  C07D239/94 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：US08178557B2

公开(公告)日：2012-05-15

申请号：US12157303

申请日：2008-06-09

申请人： Michele Potashman ,  Tae-Seong Kim ,  Steven Bellon ,  Shon Booker ,  Yuan Cheng ,  Joseph L. Kim ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Jean-Christophe Harmange ,  George Borg ,  Matthew Weiss ,  Brian L. Hodous ,  Russell Graceffa ,  William H. Buckner ,  Craig E. Masse ,  Deborah Choquette ,  Matthew W. Martin ,  Julie Germain ,  Lucian V. DiPietro ,  Stuart C. Chaffee ,  Joseph J. Nunes ,  John L. Buchanan ,  David C. McGowan ,  Douglas A. Whittington ,  Gregory J. Habgood ,  Vinod F. Patel ,  Daniel La

发明人： Michele Potashman ,  Tae-Seong Kim ,  Steven Bellon ,  Shon Booker ,  Yuan Cheng ,  Joseph L. Kim ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Jean-Christophe Harmange ,  George Borg ,  Matthew Weiss ,  Brian L. Hodous ,  Russell Graceffa ,  William H. Buckner ,  Craig E. Masse ,  Deborah Choquette ,  Matthew W. Martin ,  Julie Germain ,  Lucian V. DiPietro ,  Stuart C. Chaffee ,  Joseph J. Nunes ,  John L. Buchanan ,  David C. McGowan ,  Douglas A. Whittington ,  Gregory J. Habgood ,  Vinod F. Patel ,  Daniel La

IPC分类号： A61K31/04

CPC分类号： C07D213/64 ,  C07D213/81 ,  C07D215/233 ,  C07D215/38 ,  C07D215/48 ,  C07D215/54 ,  C07D237/34 ,  C07D239/34 ,  C07D239/47 ,  C07D239/84 ,  C07D239/94 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：US20050245547A1

公开(公告)日：2005-11-03

申请号：US11042398

申请日：2005-01-24

申请人： Tae-Seong Kim ,  Jean-Christophe Harmange ,  David Bauer ,  Shon Booker ,  Yuan Cheng ,  Shimin Xu ,  Ning Xi ,  Joseph Kim ,  Andrew Tasker

发明人： Tae-Seong Kim ,  Jean-Christophe Harmange ,  David Bauer ,  Shon Booker ,  Yuan Cheng ,  Shimin Xu ,  Ning Xi ,  Joseph Kim ,  Andrew Tasker

IPC分类号： A61K31/47 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/517 ,  A61K31/519 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D413/02 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/02 ,  C07D495/04

CPC分类号： C07D495/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：US20060241115A1

公开(公告)日：2006-10-26

申请号：US11042634

申请日：2005-01-24

申请人： Michele Potashman ,  Tae-Seong Kim ,  Steven Bellon ,  Shon Booker ,  Yuan Cheng ,  Joseph Kim ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Jean-Christophe Harmange ,  George Borg ,  Matthew Weiss ,  Brian Hodous ,  Russell Graceffa ,  William Buckner ,  Craig Masse ,  Deborah Choquette ,  Matthew Martin ,  Julie Germain ,  Lucian DiPietro ,  Stuart Chaffee ,  Joseph Nunes ,  John Buchanan ,  Gregory Habgood ,  David McGowan ,  Douglas Whittington

发明人： Michele Potashman ,  Tae-Seong Kim ,  Steven Bellon ,  Shon Booker ,  Yuan Cheng ,  Joseph Kim ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Jean-Christophe Harmange ,  George Borg ,  Matthew Weiss ,  Brian Hodous ,  Russell Graceffa ,  William Buckner ,  Craig Masse ,  Deborah Choquette ,  Matthew Martin ,  Julie Germain ,  Lucian DiPietro ,  Stuart Chaffee ,  Joseph Nunes ,  John Buchanan ,  Gregory Habgood ,  David McGowan ,  Douglas Whittington

IPC分类号： A61K31/517 ,  A61K31/502 ,  A61K31/498 ,  A61K31/4709 ,  C07D43/02

CPC分类号： C07D213/64 ,  C07D213/81 ,  C07D215/233 ,  C07D215/38 ,  C07D215/48 ,  C07D215/54 ,  C07D237/34 ,  C07D239/34 ,  C07D239/47 ,  C07D239/84 ,  C07D239/94 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：US08642624B2

公开(公告)日：2014-02-04

申请号：US13297213

申请日：2011-11-15

申请人： Guoqing Chen ,  Jeffrey A. Adams ,  Jean E. Bemis ,  Shon Booker ,  Guolin Cai ,  Lucian V. DiPietro ,  Celia Dominguez ,  Daniel Elbaum ,  Julie Germain ,  Stephanie Geuns-Meyer ,  Michael K. Handley ,  Qi Huang ,  Joseph L. Kim ,  Tae-Seong Kim ,  Alexander S. Kiselyov ,  Xiaohu Ouyang ,  Vinod F. Patel ,  Leon M. Smith ,  Markian M. Stec ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Chester Chenguang Yuan ,  Michael D. Croghan

发明人： Guoqing Chen ,  Jeffrey A. Adams ,  Jean E. Bemis ,  Shon Booker ,  Guolin Cai ,  Lucian V. DiPietro ,  Celia Dominguez ,  Daniel Elbaum ,  Julie Germain ,  Stephanie Geuns-Meyer ,  Michael K. Handley ,  Qi Huang ,  Joseph L. Kim ,  Tae-Seong Kim ,  Alexander S. Kiselyov ,  Xiaohu Ouyang ,  Vinod F. Patel ,  Leon M. Smith ,  Markian M. Stec ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Chester Chenguang Yuan ,  Michael D. Croghan

IPC分类号： A01N43/40 ,  A61K31/44 ,  A01N43/38 ,  A61K31/40 ,  A61K31/405

CPC分类号： C07D213/82 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/00 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like.

摘要翻译： 所选择的杂环化合物对于预防和治疗诸如血管生成介导的疾病等疾病是有效的。 本发明包括新型化合物，类似物，前药及其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。

公开(公告)号：US07101868B2

公开(公告)日：2006-09-05

申请号：US10823809

申请日：2004-04-12

申请人： Daniel Elbaum ,  Benny C. Askew, Jr. ,  Shon Booker ,  Julie Germain ,  Gregory J. Habgood ,  Michael Handley ,  Tae-Seong Kim ,  Aiwen Li ,  Nobuko Nishimura ,  Vinod F. Patel ,  Chester Chenguang Yuan ,  Joseph L. Kim ,  Guolin Cai ,  Guoqing Chen ,  Michael Croghan ,  Lucian V. Di Pietro ,  Celia Dominguez ,  Qi Huang ,  Leon M. Smith, II ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu

发明人： Daniel Elbaum ,  Benny C. Askew, Jr. ,  Shon Booker ,  Julie Germain ,  Gregory J. Habgood ,  Michael Handley ,  Tae-Seong Kim ,  Aiwen Li ,  Nobuko Nishimura ,  Vinod F. Patel ,  Chester Chenguang Yuan ,  Joseph L. Kim ,  Guolin Cai ,  Guoqing Chen ,  Michael Croghan ,  Lucian V. Di Pietro ,  Celia Dominguez ,  Qi Huang ,  Leon M. Smith, II ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu

IPC分类号： A61K31/33 ,  A61K31/44 ,  C07D211/62 ,  C07D213/72

CPC分类号： C07D213/81 ,  C04B35/632 ,  C07D213/82 ,  C07D237/04 ,  C07D237/24 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：US20120065185A1

公开(公告)日：2012-03-15

申请号：US13297213

申请日：2011-11-15

申请人： Guoqing CHEN ,  Jeffrey Adams ,  Jean Bemis ,  Shon Booker ,  Guolin Cai ,  Lucian Di Pietro ,  Celia Dominguez ,  Daniel Elbaum ,  Julie Germain ,  Stephanie Geuns-Meyer ,  Michael Handley ,  Qi Huang ,  Joseph L. Kim ,  Tae-Seong Kim ,  Alexander Kiselyov ,  Xiaohu Ouyang ,  Vinod F. Patel ,  Leon M. Smith ,  Markian Stec ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Chester Chenguang Yuan ,  Michael Croghan

发明人： Guoqing CHEN ,  Jeffrey Adams ,  Jean Bemis ,  Shon Booker ,  Guolin Cai ,  Lucian Di Pietro ,  Celia Dominguez ,  Daniel Elbaum ,  Julie Germain ,  Stephanie Geuns-Meyer ,  Michael Handley ,  Qi Huang ,  Joseph L. Kim ,  Tae-Seong Kim ,  Alexander Kiselyov ,  Xiaohu Ouyang ,  Vinod F. Patel ,  Leon M. Smith ,  Markian Stec ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Chester Chenguang Yuan ,  Michael Croghan

IPC分类号： A61K31/4436 ,  A61K31/4709 ,  A61K31/4725 ,  A61P3/00 ,  A61P7/00 ,  A61P35/00 ,  A61P31/00 ,  A61K31/444 ,  A61K31/5377

CPC分类号： C07D213/82 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/00 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like.

摘要翻译： 所选择的杂环化合物对于预防和治疗诸如血管生成介导的疾病等疾病是有效的。 本发明包括新型化合物，类似物，前药及其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。

公开(公告)号：US06995162B2

公开(公告)日：2006-02-07

申请号：US10046681

申请日：2002-01-10

申请人： Guoqing Chen ,  Jeffrey Adams ,  Jean Bemis ,  Shon Booker ,  Guolin Cai ,  Lucian Di Pietro ,  Celia Dominguez ,  Daniel Elbaum ,  Julie Germain ,  Stephanie Geuns-Meyer ,  Michael Handley ,  Qi Huang ,  Joseph L. Kim ,  Tae-Seong Kim ,  Alexander Kiselyov ,  Xiaohu Ouyang ,  Vinod F. Patel ,  Leon M. Smith ,  Markian Stec ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Chester Chenguang Yuan ,  Michael Croghan

发明人： Guoqing Chen ,  Jeffrey Adams ,  Jean Bemis ,  Shon Booker ,  Guolin Cai ,  Lucian Di Pietro ,  Celia Dominguez ,  Daniel Elbaum ,  Julie Germain ,  Stephanie Geuns-Meyer ,  Michael Handley ,  Qi Huang ,  Joseph L. Kim ,  Tae-Seong Kim ,  Alexander Kiselyov ,  Xiaohu Ouyang ,  Vinod F. Patel ,  Leon M. Smith ,  Markian Stec ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Chester Chenguang Yuan ,  Michael Croghan

IPC分类号： A61K31/435 ,  C07D213/82

CPC分类号： C07D213/82 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/00 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.