公开(公告)号：US20120078527A1

公开(公告)日：2012-03-29

申请号：US13244095

申请日：2011-09-23

Applicant: Chang-eun YOO ,  Tae-jin AHN ,  Kyu-sang LEE ,  Jeo-young SHIM ,  Ki-eun KIM ,  Myoung-soon KIM ,  Sung-woo HONG ,  Tae-han JEON ,  Jhin-gook KIM ,  Se-hoon PARK ,  In-suk SOHN ,  Sin-ho JUNG

Inventor： Chang-eun YOO ,  Tae-jin AHN ,  Kyu-sang LEE ,  Jeo-young SHIM ,  Ki-eun KIM ,  Myoung-soon KIM ,  Sung-woo HONG ,  Tae-han JEON ,  Jhin-gook KIM ,  Se-hoon PARK ,  In-suk SOHN ,  Sin-ho JUNG

IPC: G06F19/00 ,  C12Q1/68 ,  C40B30/04

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156

Abstract: A kit and method for predicting the sensitivity of gastric cancer patient to an anti-cancer agent are disclosed.

Abstract translation: 公开了一种用于预测胃癌患者对抗癌剂敏感性的试剂盒和方法。

公开(公告)号：US20100204922A1

公开(公告)日：2010-08-12

申请号：US12623675

申请日：2009-11-23

Applicant: Tae-jin AHN ,  Kyu-sang LEE ,  Dae-soon SON ,  Kyung-hee PARK

Inventor： Tae-jin AHN ,  Kyu-sang LEE ,  Dae-soon SON ,  Kyung-hee PARK

IPC: G06F19/00 ,  G06F17/18

CPC classification number: G16B20/00

Abstract: Provided are a method and apparatus for selecting pharmacogenomic markers. The method includes calculating evaluation indexes for evaluating the degree of association between genetic markers of genes associated with at least one drug and the drug, and selecting some of the genetic markers based on the calculated evaluation indexes.

Abstract translation: 提供了用于选择药物基因组标记物的方法和装置。 该方法包括计算评估指标，以评估与至少一种药物和药物相关的基因的遗传标记之间的关联程度，以及基于所计算的评价指标来选择一些遗传标记。

公开(公告)号：US20100204057A1

公开(公告)日：2010-08-12

申请号：US12691053

申请日：2010-01-21

Applicant: Kyu-sang LEE ,  Dae-soon SON ,  Kyung-hee PARK ,  Tae-jin AHN

Inventor： Kyu-sang LEE ,  Dae-soon SON ,  Kyung-hee PARK ,  Tae-jin AHN

IPC: C40B30/04 ,  C40B40/00 ,  C40B40/06 ,  C40B50/18 ,  C40B60/14

CPC classification number: G01N21/6452 ,  G01N21/645 ,  G01N2021/6441

Abstract: Provided is a substrate that is used to produce a microarray, wherein the substrate includes; a fiducial mark disposed on the substrate, and a probe immobilization region disposed on the substrate, wherein a surface of the first fiducial mark is a hydrophobic and a probe immobilization compound is immobilized on the probe immobilization region.

Abstract translation: 提供了用于制造微阵列的基板，其中基板包括： 设置在基板上的基准标记和设置在基板上的探针固定区域，其中第一基准标记的表面是疏水性的，并且探针固定化合物固定在探针固定区域上。

公开(公告)号：US20110295858A1

公开(公告)日：2011-12-01

申请号：US13074860

申请日：2011-03-29

Applicant: Tae-jin AHN ,  Kyu-sang LEE

Inventor： Tae-jin AHN ,  Kyu-sang LEE

IPC: G06F17/30

CPC classification number: G06F17/30985 ,  G06F19/22

Abstract: A method and apparatus for searching compressed nucleic acid sequences are disclosed. In the method, a reference sequence is compared with a subject sequence to be encoded, the subject sequence is compressed, an index is created with respect to the reference sequence and the compressed subject sequence, a position corresponding to a query is searched for in the compressed subject sequence using the index, a character found at the position within the compressed sequence is converted into a sequence, and the sequence is output as the response to the query.

Abstract translation: 公开了一种用于搜索压缩的核酸序列的方法和装置。 在该方法中，将参考序列与要编码的主题序列进行比较，主题序列被压缩，相对于参考序列和压缩主题序列创建索引，在相关于查询的位置搜索与 使用该索引的压缩主题序列，将在压缩序列内的位置处找到的字符转换为序列，并且将该序列作为对该查询的响应输出。

公开(公告)号：US20100256002A1

公开(公告)日：2010-10-07

申请号：US12688938

申请日：2010-01-18

Applicant: Dae-soon SON ,  Kyu-sang LEE ,  Kyung-hee PARK ,  Tae-jin AHN ,  Jong-suk CHUNG

Inventor： Dae-soon SON ,  Kyu-sang LEE ,  Kyung-hee PARK ,  Tae-jin AHN ,  Jong-suk CHUNG

IPC: C40B30/00 ,  C40B60/12

CPC classification number: G06K9/0014 ,  G06T7/73 ,  G06T2207/30072

Abstract: In a method and apparatus for detecting positions of data spots on a microarray, images of the microarray are synthesized with a grid-pattern image to distinguish spots on the microarray and synthesized images are thereby generated, and a synthesized image is selected from the synthesized images based on statistics corresponding to light intensities of fiducial spots included in the synthesized images. Accordingly, the positions of the data spots are accurately detected from the selected synthesized image, and the data of the microarray is thereby analyzed.

Abstract translation: 在用于检测微阵列上的数据点的位置的方法和装置中，利用网格图案合成微阵列的图像，以区分微阵列上的斑点，由此产生合成图像，并从合成图像中选择合成图像 基于对应于合成图像中包含的基准点的光强度的统计量。 因此，从所选择的合成图像中准确地检测数据点的位置，从而分析微阵列的数据。

公开(公告)号：US20080166729A1

公开(公告)日：2008-07-10

申请号：US11971585

申请日：2008-01-09

Applicant: Byung-chul KIM ,  Jhin-gook KIM ,  Nam HUR ,  Kyu-sang LEE ,  Dae-soon SON ,  Kyung-hee PARK ,  Tae-jin AHN

Inventor： Byung-chul KIM ,  Jhin-gook KIM ,  Nam HUR ,  Kyu-sang LEE ,  Dae-soon SON ,  Kyung-hee PARK ,  Tae-jin AHN

IPC: C12Q1/68 ,  C40B40/06

CPC classification number: C40B40/06 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C40B30/04 ,  Y10S977/792

Abstract: Provided is a method of predicting risk of lung cancer recurrence in a lung cancer patient or after a patient has lung cancer treatment, the method including: obtaining a biological sample from a lung cancer patient; measuring an expression level of at least one marker gene from the biological sample, the marker gene being selected from the group consisting of marker genes of Table 1, 2 or 3, to obtain data for the expression level of the marker gene; and determining whether the expression level of the marker gene corresponds to an expression level of a recurrence group or an expression level of a non-recurrence group.

Abstract translation: 本发明提供一种预测肺癌患者的肺癌复发风险或患者进行肺癌治疗后的方法，该方法包括从肺癌患者获得生物样品; 测定来自生物样品的至少一种标记基因的表达水平，所述标记基因选自表1,2或3的标记基因，以获得标记基因表达水平的数据; 确定标记基因的表达水平是否符合复发组的表达水平或非复发组的表达水平。

公开(公告)号：US20090163382A1

公开(公告)日：2009-06-25

申请号：US11863984

申请日：2007-09-28

Applicant: Ji-Young OH ,  Yeon-su LEE ,  Sang-hyun PAEK ,  Byung-chul KIM ,  Sook-young KIM ,  Kyung-hee PARK ,  Jung-nam LEE ,  Jong-suk CHUNG ,  Ah-gi KIM ,  Myo-yong LEE ,  Tae-jin AHN

Inventor： Ji-Young OH ,  Yeon-su LEE ,  Sang-hyun PAEK ,  Byung-chul KIM ,  Sook-young KIM ,  Kyung-hee PARK ,  Jung-nam LEE ,  Jong-suk CHUNG ,  Ah-gi KIM ,  Myo-yong LEE ,  Tae-jin AHN

IPC: C40B40/08 ,  C07H21/04

CPC classification number: C12Q1/689 ,  C12Q2600/16

Abstract: Provided are a primer set for amplifying target sequence(s) of antibiotic-resistant bacterial species, a probe or probe set specifically hybridizing with target sequence(s) of antibiotic-resistant bacterial species, a microarray immobilized with the probe or probe set, a kit comprising the primer set and a method of detecting at least one antibiotic-resistant bacterial species using the probe or probe set.

Abstract translation: 提供了用于扩增抗生素抗性细菌种类的靶序列的引物组，与抗生素抗性细菌种类的靶序列特异性杂交的探针或探针组，固定有探针或探针组的微阵列 包括引物组的试剂盒和使用探针或探针组检测至少一种抗生素抗性细菌物种的方法。

公开(公告)号：US20080139398A1

公开(公告)日：2008-06-12

申请号：US11739354

申请日：2007-04-24

Applicant: Tae-jin AHN ,  Ji-young OH ,  Jung-nam LEE ,  Jong-suk CHUNG

Inventor： Tae-jin AHN ,  Ji-young OH ,  Jung-nam LEE ,  Jong-suk CHUNG

IPC: C40B30/04 ,  G01N33/50 ,  C07H21/04

CPC classification number: C12Q1/6827 ,  C12Q1/6837 ,  C12Q1/689 ,  Y10T436/145555 ,  C12Q2521/501 ,  C12Q2525/161 ,  C12Q2525/185

Abstract: A method of designing probes for detecting a target sequence and a method of detecting target sequence using the probes are provided. The method of designing probes for detecting target sequence includes: selecting an anchoring location in the target sequence, wherein the anchoring location is a location in the target sequence at which a first non-target sequence in a plurality of non-target sequences is different from the target sequence, wherein the first non-target sequence has a sequence similarity to the target sequence that is identical to or higher than the sequence similarity of other non-target sequences in the plurality of non-target sequences; selecting a first probe designing region, wherein the first probe designing region is a fixed region in the target sequence comprising the anchoring location; selecting a probe selection location, wherein the probe selection location is a location in the target sequence at which a second non-target sequence in the plurality of non-target sequences is different from the target sequence; selecting a matched probe, wherein the matched probe comprises a sequence complementary to the target sequence, wherein the probe selecting location is at the center of the sequence of the matched probe; and selecting a mismatched probe, wherein the mismatched probe is longer than the matched probe, wherein the mismatched probe comprises a sequence complementary to the target sequence at all locations except at a mismatched location, wherein the probe selection location is at a first location in the sequence of the mismatched probe and the mismatched location is at a second location in the sequence of the mismatched probe.

Abstract translation: 提供了一种设计用于检测靶序列的探针的方法和使用探针检测靶序列的方法。 设计用于检测目标序列的探针的方法包括：在目标序列中选择锚定位置，其中锚定位置是目标序列中多个非靶序列中的第一非靶序列不同于 所述靶序列，其中所述第一非靶序列与所述靶序列具有与所述多个非靶序列中的其他非靶序列的序列相似性相同或更高的序列相似性; 选择第一探针设计区域，其中所述第一探针设计区域是包括所述锚定位置的所述目标序列中的固定区域; 选择探针选择位置，其中所述探针选择位置是所述多个非靶序列中的第二非靶序列与所述靶序列不同的所述靶序列中的位置; 选择匹配的探针，其中所述匹配的探针包含与所述靶序列互补的序列，其中所述探针选择位置位于所述匹配探针的序列的中心; 以及选择不匹配的探针，其中所述不匹配的探针长于所述匹配的探针，其中所述不匹配的探针包括除所述不匹配位置之外的所有位置处与所述靶序列互补的序列，其中所述探针选择位置位于所述匹配探针的第一位置 不匹配探针和不匹配位置的序列位于错配探针序列中的第二个位置。

公开(公告)号：US20070128676A1

公开(公告)日：2007-06-07

申请号：US11626668

申请日：2007-01-24

Applicant: Yeon-su LEE ,  Kyung-hee PARK ,  Tae-jin AHN ,  Jong-hoon PARK

Inventor： Yeon-su LEE ,  Kyung-hee PARK ,  Tae-jin AHN ,  Jong-hoon PARK

IPC: G01N33/574

CPC classification number: C07H21/04 ,  C07K14/47 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57415

Abstract: An isolated protein having an amino acid sequence of SEQ ID No. 4 and having an activity inducing apoptosis, and a gene encoding the same are provided. Also, a microarray having a substrate on which the gene or fragment thereof is immobilized is provided. Also, a method of diagnosing breast cancer using an antibody specifically binding to the protein and a method of diagnosing breast cancer by determining whether the gene is expressed in a cell or not, are provided.

Abstract translation: 提供了具有SEQ ID No.4的氨基酸序列并且具有诱导细胞凋亡的活性的分离的蛋白质和编码该蛋白质的基因。 另外，提供了具有固定基因或其片段的底物的微阵列。 此外，提供了使用特异性结合蛋白质的抗体诊断乳腺癌的方法和通过确定该基因是否在细胞中表达来诊断乳腺癌的方法。

公开(公告)号：US20120173157A1

公开(公告)日：2012-07-05

申请号：US13303861

申请日：2011-11-23

Applicant: Tae-jin AHN ,  Soyeon AHN ,  Sung-ho WON ,  Su-hyeon KIM ,  Taesung PARK ,  Sung-young LEE ,  Seung-yeoun LEE ,  Bora YEON ,  Young-ho PARK

Inventor： Tae-jin AHN ,  Soyeon AHN ,  Sung-ho WON ,  Su-hyeon KIM ,  Taesung PARK ,  Sung-young LEE ,  Seung-yeoun LEE ,  Bora YEON ,  Young-ho PARK

IPC: G06F19/20

CPC classification number: G06F19/22

Abstract: A method of recovering a nucleic acid sequence using a probe map includes: aligning a probe onto a target sequence based on a result in which the probe is hybridized to the target sequence; determining a representative value representing each aligned position of the probe; and recovering a base sequence of the target sequence by using a probe map to which the determined representative values and base sequence information of the probe are mapped.

Abstract translation: 使用探针图回收核酸序列的方法包括：基于探针与靶序列杂交的结果将探针对准靶序列; 确定表示探针的每个对准位置的代表值; 以及通过使用映射了所述探测器的确定的代表值和碱基序列信息的探针图来恢复所述目标序列的碱基序列。